메뉴 건너뛰기




Volumn 74, Issue 4, 1996, Pages 1143-1160

Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation

Author keywords

Apoptosis; bcl 2; Gene expression; Programmed cell death

Indexed keywords

DNA FRAGMENT; EXCITOTOXIN; MESSENGER RNA; QUINOLINIC ACID;

EID: 0030272509     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(96)00174-1     Document Type: Article
Times cited : (109)

References (66)
  • 1
    • 0025862427 scopus 로고
    • N-methyl-D-aspartate receptor activation in the neostriatum increases c-Fos and Fos-related antigens selectively in medium-sized neurons
    • 1. Aronin N., Chase K., Sagar S. M., Sharp F. R. and DiFiglia M. (1991) N-methyl-D-aspartate receptor activation in the neostriatum increases c-Fos and Fos-related antigens selectively in medium-sized neurons. Neuroscience 44, 409-420.
    • (1991) Neuroscience , vol.44 , pp. 409-420
    • Aronin, N.1    Chase, K.2    Sagar, S.M.3    Sharp, F.R.4    DiFiglia, M.5
  • 2
    • 0029078067 scopus 로고
    • The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity
    • 2. Bayle J. H., Elenbaas B. and Levine A. J. (1995) The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity. Proc. natn. Acad. Sci. U.S.A. 92, 5729-5733.
    • (1995) Proc. Natn. Acad. Sci. U.S.A. , vol.92 , pp. 5729-5733
    • Bayle, J.H.1    Elenbaas, B.2    Levine, A.J.3
  • 3
    • 0021487174 scopus 로고
    • Analysis of the gene coding for the murine cellular tumour antigen p53
    • 3. Bienz B., Zakut-Houri R., Givol D. and Oren M. (1984) Analysis of the gene coding for the murine cellular tumour antigen p53. Eur. molec. Biol. Org. J. 3, 2179-2183.
    • (1984) Eur. Molec. Biol. Org. J. , vol.3 , pp. 2179-2183
    • Bienz, B.1    Zakut-Houri, R.2    Givol, D.3    Oren, M.4
  • 4
    • 0029153913 scopus 로고
    • Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures
    • 4. Bonfocco E., Kraine D., Ankarcrona M., Nicotera P. and Lipton S. A. (1995) Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. natn. Acad. Sci. U.S.A. 92, 7162-7166.
    • (1995) Proc. Natn. Acad. Sci. U.S.A. , vol.92 , pp. 7162-7166
    • Bonfocco, E.1    Kraine, D.2    Ankarcrona, M.3    Nicotera, P.4    Lipton, S.A.5
  • 5
    • 0027490681 scopus 로고
    • Protein chemical characterization and immunocytochemical localization of the NMDA receptor subunit NMDA R1
    • 5. Brose N., Gasic G. P., Vetter D. E., Sullivan J. M. and Heinemann S. F. (1993) Protein chemical characterization and immunocytochemical localization of the NMDA receptor subunit NMDA R1. J. biol. Chem. 268, 22663-22671.
    • (1993) J. Biol. Chem. , vol.268 , pp. 22663-22671
    • Brose, N.1    Gasic, G.P.2    Vetter, D.E.3    Sullivan, J.M.4    Heinemann, S.F.5
  • 6
    • 0011254074 scopus 로고
    • p53 tumor supressor gene is a mediator of methamphetamine-induced neurotoxicity in mice
    • 6. Cadet J. L. and Hirata H. (1995) p53 tumor supressor gene is a mediator of methamphetamine-induced neurotoxicity in mice. Soc. Neurosci. Abstr. 21, 574.2.
    • (1995) Soc. Neurosci. Abstr. , vol.21 , pp. 5742
    • Cadet, J.L.1    Hirata, H.2
  • 7
    • 0028070989 scopus 로고
    • p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
    • 7. Caelles C., Helmberg A. and Karin M. (1994) p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 370, 220-223.
    • (1994) Nature , vol.370 , pp. 220-223
    • Caelles, C.1    Helmberg, A.2    Karin, M.3
  • 8
    • 0026607994 scopus 로고
    • p53 expression in brain after middle cerebral artery occlusion in the rat
    • 8. Chopp M., Li Y., Zhang Z. G. and Freytag S. O. (1992) p53 expression in brain after middle cerebral artery occlusion in the rat. Biochem. biophys. Res. Commun. 182, 1201-1207.
    • (1992) Biochem. Biophys. Res. Commun. , vol.182 , pp. 1201-1207
    • Chopp, M.1    Li, Y.2    Zhang, Z.G.3    Freytag, S.O.4
  • 10
    • 0026555808 scopus 로고
    • Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis
    • 10. Collins R. J., Harmon B. V., Gobe G. C. and Kerr J. F. R. (1992) Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis. Int. J. Radiat. Biol. 61, 451-453.
    • (1992) Int. J. Radiat. Biol. , vol.61 , pp. 451-453
    • Collins, R.J.1    Harmon, B.V.2    Gobe, G.C.3    Kerr, J.F.R.4
  • 11
    • 0028217268 scopus 로고
    • Cellular localization and laminar distribution of NMDAR1 mRNA in the rat cerebral cortex
    • 11. Conti F., Minelli A., Molnar M. and Bracha N. C. (1994) Cellular localization and laminar distribution of NMDAR1 mRNA in the rat cerebral cortex. J. comp. Neurol. 343, 554-565.
    • (1994) J. Comp. Neurol. , vol.343 , pp. 554-565
    • Conti, F.1    Minelli, A.2    Molnar, M.3    Bracha, N.C.4
  • 12
    • 0029315510 scopus 로고
    • Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage
    • 12. Cox L. S. and Lane D. P. (1995) Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage. BioEssays 17, 501-508.
    • (1995) BioEssays , vol.17 , pp. 501-508
    • Cox, L.S.1    Lane, D.P.2
  • 13
    • 0027985453 scopus 로고
    • Attenuation of p53 expression protects against focal ischemic damage in transgenic mice
    • 13. Crumrine R. C., Thomas A. L. and Morgan P. F. (1994) Attenuation of p53 expression protects against focal ischemic damage in transgenic mice. J. cerebr. Blood Flow Metab. 14, 887-891.
    • (1994) J. Cerebr. Blood Flow Metab. , vol.14 , pp. 887-891
    • Crumrine, R.C.1    Thomas, A.L.2    Morgan, P.F.3
  • 14
    • 0029052332 scopus 로고
    • The Bcl-2 family of proteins, and the regulation of neuronal survival
    • 14. Davies A. M. (1995) The Bcl-2 family of proteins, and the regulation of neuronal survival. Trends Neurosci. 18, 355-358.
    • (1995) Trends Neurosci. , vol.18 , pp. 355-358
    • Davies, A.M.1
  • 15
    • 0027940391 scopus 로고
    • Neurons from mouse embryos with a null mutation in the tumour suppressor gene p53 undergo normal cell death in the absence of neurotrophins
    • 15. Davies A. M. and Rosenthal A. (1994) Neurons from mouse embryos with a null mutation in the tumour suppressor gene p53 undergo normal cell death in the absence of neurotrophins. Neurosci. Lett. 182, 112-114.
    • (1994) Neurosci. Lett. , vol.182 , pp. 112-114
    • Davies, A.M.1    Rosenthal, A.2
  • 16
    • 0028356223 scopus 로고
    • Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to the young rat brain
    • 16. Dragunow M., Beilharz E., Sirimanne E., Lawlor P., Williams C., Bravo R. and Gluckman P. (1994) Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to the young rat brain. Molec. Brain Res. 25, 19-33.
    • (1994) Molec. Brain Res. , vol.25 , pp. 19-33
    • Dragunow, M.1    Beilharz, E.2    Sirimanne, E.3    Lawlor, P.4    Williams, C.5    Bravo, R.6    Gluckman, P.7
  • 17
    • 0025306048 scopus 로고
    • MK-801 induces c-fos protein in thalamic and neocortical neurons of rat brain
    • 17. Dragunow M. and Faull R. L. M. (1990) MK-801 induces c-fos protein in thalamic and neocortical neurons of rat brain. Neurosci. Lett. 111, 39-45.
    • (1990) Neurosci. Lett. , vol.111 , pp. 39-45
    • Dragunow, M.1    Faull, R.L.M.2
  • 18
    • 0029040355 scopus 로고
    • In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes
    • 18. Dragunow M., Faull R. L. M., Lawlor P., Beilharz E. J., Singleton K., Walker E. B. and Mee E. (1995) In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes. NeuroReport 6, 1053-1057.
    • (1995) NeuroReport , vol.6 , pp. 1053-1057
    • Dragunow, M.1    Faull, R.L.M.2    Lawlor, P.3    Beilharz, E.J.4    Singleton, K.5    Walker, E.B.6    Mee, E.7
  • 19
    • 0025228658 scopus 로고
    • Induction of c-fos mRNA and protein in neurons and glia after traumatic brain injury: Pharmacological characterization
    • 19. Dragunow M., Goulding M., Faull R. L. M., Ralph R., Mee E. and Frith R. (1990) Induction of c-fos mRNA and protein in neurons and glia after traumatic brain injury: Pharmacological characterization. Expl Neurol. 107, 236-248.
    • (1990) Expl Neurol. , vol.107 , pp. 236-248
    • Dragunow, M.1    Goulding, M.2    Faull, R.L.M.3    Ralph, R.4    Mee, E.5    Frith, R.6
  • 20
    • 0029123107 scopus 로고
    • DNA fragmentation and immediate early gene expression in rat striatum following quinolinic acid administration
    • 19a. Dure L. S. IV, Wiess S., Standaert D. G., Rudolf G., Testa C. M. and Young A. B. (1995) DNA fragmentation and immediate early gene expression in rat striatum following quinolinic acid administration. Expl Neurol. 133, 207-214.
    • (1995) Expl Neurol. , vol.133 , pp. 207-214
    • Dure L.S. IV1    Wiess, S.2    Standaert, D.G.3    Rudolf, G.4    Testa, C.M.5    Young, A.B.6
  • 24
    • 0022446150 scopus 로고
    • Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid
    • 23. Flint Beal M., Kowall N. W., Elison D. W., Mazurek M. F., Swartz K. J. and Martin J. B. (1986) Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid. Nature 321, 168-171.
    • (1986) Nature , vol.321 , pp. 168-171
    • Flint Beal, M.1    Kowall, N.W.2    Elison, D.W.3    Mazurek, M.F.4    Swartz, K.J.5    Martin, J.B.6
  • 25
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • 24. Gavrieli Y., Sherman Y. and Ben-Sasson S. A. (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119, 493-501.
    • (1992) J. Cell Biol. , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 26
    • 0029001403 scopus 로고
    • Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain
    • 25. Gillardon F., Wickert H. and Zimmermann M. (1995) Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain. Neurosci. Lett. 192, 85-88.
    • (1995) Neurosci. Lett. , vol.192 , pp. 85-88
    • Gillardon, F.1    Wickert, H.2    Zimmermann, M.3
  • 27
    • 0029078067 scopus 로고
    • The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding activity through its nonspecific nucleic acid-binding activity
    • 26. Henri Bayle J., Elenbaas B. and Levine A. J. (1995) The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding activity through its nonspecific nucleic acid-binding activity. Proc. natn. Acad. Sci. U.S.A. 92, 5729-5733.
    • (1995) Proc. Natn. Acad. Sci. U.S.A. , vol.92 , pp. 5729-5733
    • Henri Bayle, J.1    Elenbaas, B.2    Levine, A.J.3
  • 30
    • 0028887868 scopus 로고
    • Focal brain injury induces multiple immediate-early genes encoding zinc finger transcripton factors
    • 29. Honkaniemi J., Sagar S. M., Pyykonen I., Hicks K. J. and Sharp F. R. (1995) Focal brain injury induces multiple immediate-early genes encoding zinc finger transcripton factors. Molec. Brain Res. 28, 157-163.
    • (1995) Molec. Brain Res. , vol.28 , pp. 157-163
    • Honkaniemi, J.1    Sagar, S.M.2    Pyykonen, I.3    Hicks, K.J.4    Sharp, F.R.5
  • 31
    • 0027362029 scopus 로고
    • Brain-derived neurotrophic factor is induced as an immediate-early gene following N-methyl-D-aspartate receptor activation
    • 30. Hughes P., Beilharz E., Gluckman P. and Dragunow M. (1993) Brain-derived neurotrophic factor is induced as an immediate-early gene following N-methyl-D-aspartate receptor activation. Neuroscience 57, 319-328.
    • (1993) Neuroscience , vol.57 , pp. 319-328
    • Hughes, P.1    Beilharz, E.2    Gluckman, P.3    Dragunow, M.4
  • 32
    • 0026448672 scopus 로고
    • Regulation of the specific DNA binding function of p53
    • 31. Hupp T. R., Meek D. W., Midgley C. A. and Lane D. P. (1992) Regulation of the specific DNA binding function of p53. Cell 71, 875-886.
    • (1992) Cell , vol.71 , pp. 875-886
    • Hupp, T.R.1    Meek, D.W.2    Midgley, C.A.3    Lane, D.P.4
  • 33
    • 0028333589 scopus 로고
    • Homolateral cerebrocortical increase of immediate early gene and neurotransmitter messenger RNAs after minimal cortical lesion: Blockade by N-methyl-D-aspartate antagonist
    • 32. Jacobs O., Van Bree L., Mailleux P., Zhang F., Schiffmann S. N., Halleux P., Albala N. and Vanderhaeghen J.-J. (1994) Homolateral cerebrocortical increase of immediate early gene and neurotransmitter messenger RNAs after minimal cortical lesion: blockade by N-methyl-D-aspartate antagonist. Neuroscience 59, 827-836.
    • (1994) Neuroscience , vol.59 , pp. 827-836
    • Jacobs, O.1    Van Bree, L.2    Mailleux, P.3    Zhang, F.4    Schiffmann, S.N.5    Halleux, P.6    Albala, N.7    Vanderhaeghen, J.-J.8
  • 36
    • 0002204915 scopus 로고
    • Definition and incidence of apoptosis: An historical perspective
    • eds Tomei L. D. and Cope F. O. Cold Springs Harbor Laboratory, Cold Springs Harbor, NY
    • 35. Kerr J. F. R. and Harmon B. V. (1991) Definition and incidence of apoptosis: an historical perspective. In Apoptosis (eds Tomei L. D. and Cope F. O.), pp. 5-29. Cold Springs Harbor Laboratory, Cold Springs Harbor, NY.
    • (1991) Apoptosis , pp. 5-29
    • Kerr, J.F.R.1    Harmon, B.V.2
  • 37
    • 0028036895 scopus 로고
    • Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2
    • 36. Krajewski S., Krajewsha M., Shabaik A., Miyasita T., Wang H. G. and Reed J. C. (1994) Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am. J. Path. 145, 1323-1336.
    • (1994) Am. J. Path. , vol.145 , pp. 1323-1336
    • Krajewski, S.1    Krajewsha, M.2    Shabaik, A.3    Miyasita, T.4    Wang, H.G.5    Reed, J.C.6
  • 38
    • 0028126775 scopus 로고
    • Distinction of apoptotic and necrotic cell death by in situ labelling of fragmented DNA
    • 37. Kressel M. and Groscurth P. (1994) Distinction of apoptotic and necrotic cell death by in situ labelling of fragmented DNA. Cell Tiss. Res. 278, 549-556.
    • (1994) Cell Tiss. Res. , vol.278 , pp. 549-556
    • Kressel, M.1    Groscurth, P.2
  • 39
    • 0027109075 scopus 로고
    • p53, guardian of the genome
    • 38. Lane D. P. (1992) p53, guardian of the genome. Nature 358, 15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 40
    • 0025876591 scopus 로고
    • The p53 tumor suppressor gene
    • 39. Levine A. J., Momand J. and Finlay C. A. (1991) The p53 tumor suppressor gene. Nature 351, 453-456.
    • (1991) Nature , vol.351 , pp. 453-456
    • Levine, A.J.1    Momand, J.2    Finlay, C.A.3
  • 41
    • 0028263192 scopus 로고
    • p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats
    • 40. Li Y., Chopp M., Zhang Z. G., Zaloga C., Niewenhuis L. and Gautam S. (1994) p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats. Stroke 25, 849-855.
    • (1994) Stroke , vol.25 , pp. 849-855
    • Li, Y.1    Chopp, M.2    Zhang, Z.G.3    Zaloga, C.4    Niewenhuis, L.5    Gautam, S.6
  • 42
    • 0027319521 scopus 로고
    • p53 is required for radiation-induced apoptosis in mouse thymocytes
    • 41. Lowe S. W., Schmitt E. M., Smith S. W., Osbourne B. A. and Jacks T. (1993) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849.
    • (1993) Nature , vol.362 , pp. 847-849
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osbourne, B.A.4    Jacks, T.5
  • 43
    • 0028567078 scopus 로고
    • Photochemical brain injury in rats triggers DNA fragmentation, p53 and HSP72
    • 42. Manev H., Kharlamov A. and Armstrong D. M. (1994) Photochemical brain injury in rats triggers DNA fragmentation, p53 and HSP72. NeuroReport 5, 2661-2664.
    • (1994) NeuroReport , vol.5 , pp. 2661-2664
    • Manev, H.1    Kharlamov, A.2    Armstrong, D.M.3
  • 44
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • 43. Miyashita T. and Reed J. C. (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80, 293-299.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 46
    • 0029010352 scopus 로고
    • An apoptotic defect in lens differentiation caused by human p53 is rescued by a mutant allele
    • 45. Nakamura T., Pichel J. G., Williams-Simons L. and Westphal H. (1995) An apoptotic defect in lens differentiation caused by human p53 is rescued by a mutant allele. Proc. natn. Acad. Sci. U.S.A. 92, 6142-6146.
    • (1995) Proc. Natn. Acad. Sci. U.S.A. , vol.92 , pp. 6142-6146
    • Nakamura, T.1    Pichel, J.G.2    Williams-Simons, L.3    Westphal, H.4
  • 48
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • 47. Oltvai Z., Milliman C. and Korsmeyer S. J. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74, 609-619.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.1    Milliman, C.2    Korsmeyer, S.J.3
  • 50
    • 0022637380 scopus 로고
    • Specific interaction between the p53 cellular tumour antigen and major heat shock proteins
    • 49. Pinhasi-Kimhi O., Michalovitz D., Ben-Zeev A. and Oren M. (1986) Specific interaction between the p53 cellular tumour antigen and major heat shock proteins. Nature 320, 182-184.
    • (1986) Nature , vol.320 , pp. 182-184
    • Pinhasi-Kimhi, O.1    Michalovitz, D.2    Ben-Zeev, A.3    Oren, M.4
  • 51
    • 0029072690 scopus 로고
    • Evidence for apoptotic cell death in Huntington's Disease and excitotoxic animal models
    • 50. Portera-Cailliau C., Hedreen J. C., Price D. L. and Koliatsos V. E. (1995) Evidence for apoptotic cell death in Huntington's Disease and excitotoxic animal models. J. Neurosci. 15, 3775-3787.
    • (1995) J. Neurosci. , vol.15 , pp. 3775-3787
    • Portera-Cailliau, C.1    Hedreen, J.C.2    Price, D.L.3    Koliatsos, V.E.4
  • 52
    • 0027746296 scopus 로고
    • Immediate-early gene expression in the rat forebrain following striatal infusion of quinolinic acid
    • 51. Purkiss R. J., Legg M. D., Hunt S. P. and Davies S. W. (1993) Immediate-early gene expression in the rat forebrain following striatal infusion of quinolinic acid. Eur. J. Neurosci. 5, 1653-1662.
    • (1993) Eur. J. Neurosci. , vol.5 , pp. 1653-1662
    • Purkiss, R.J.1    Legg, M.D.2    Hunt, S.P.3    Davies, S.W.4
  • 54
    • 0011795016 scopus 로고
    • Excitotoxin-induced apoptosis in organotypic hippocampal cultures. DNA fragmentation and p53 induction
    • 53. Sakhi S., Bruce A., Sun N., Tocco G., Baudry M. and Schreiber S. S. (1995) Excitotoxin-induced apoptosis in organotypic hippocampal cultures. DNA fragmentation and p53 induction. Soc. Neurosci. Abstr. 21, 127.12.
    • (1995) Soc. Neurosci. Abstr. , vol.21 , pp. 12712
    • Sakhi, S.1    Bruce, A.2    Sun, N.3    Tocco, G.4    Baudry, M.5    Schreiber, S.S.6
  • 55
    • 0028641624 scopus 로고
    • Tumor supressor p53 induction and DNA damage in hippocampal granule cells after adrenalectomy
    • 54. Schreiber S. S., Sakhi S., Dugich-Djordjevic M. M. and Nichols N. R. (1994) Tumor supressor p53 induction and DNA damage in hippocampal granule cells after adrenalectomy. Expl Neurol. 130, 368-376.
    • (1994) Expl Neurol. , vol.130 , pp. 368-376
    • Schreiber, S.S.1    Sakhi, S.2    Dugich-Djordjevic, M.M.3    Nichols, N.R.4
  • 56
    • 0011840397 scopus 로고
    • p53 protein accumulation in nuclei of injured neurons following kainic acid treatment
    • 55. Schreiber S. S., Sakhi S., Mehta P. and Wing L. (1995) p53 protein accumulation in nuclei of injured neurons following kainic acid treatment. Soc. Neurosci. Abstr. 21, 127.3.
    • (1995) Soc. Neurosci. Abstr. , vol.21 , pp. 1273
    • Schreiber, S.S.1    Sakhi, S.2    Mehta, P.3    Wing, L.4
  • 58
    • 0028238213 scopus 로고
    • Immediate early up-regulation of bax expression by p53 but not TGFb1: A paradigm for distinct apoptotic pathways
    • 57. Selvakumaran M., Lin H.-K., Miyashita T., Wang H. G., Krajewski S., Reed J., Hoffman B. and Liebermann D. (1994) Immediate early up-regulation of bax expression by p53 but not TGFb1: a paradigm for distinct apoptotic pathways. Oncogene 9, 1791-1798.
    • (1994) Oncogene , vol.9 , pp. 1791-1798
    • Selvakumaran, M.1    Lin, H.-K.2    Miyashita, T.3    Wang, H.G.4    Krajewski, S.5    Reed, J.6    Hoffman, B.7    Liebermann, D.8
  • 59
    • 0025065439 scopus 로고
    • The NMDA receptor mediates cortical induction of fos and fos-related antigens following cortical injury
    • 58. Sharp J. W., Sagar S. M., Hisanaga K., Jasper P. and Sharp F. R. (1990) The NMDA receptor mediates cortical induction of fos and fos-related antigens following cortical injury. Expl Neurol. 109, 323-332.
    • (1990) Expl Neurol. , vol.109 , pp. 323-332
    • Sharp, J.W.1    Sagar, S.M.2    Hisanaga, K.3    Jasper, P.4    Sharp, F.R.5
  • 61
    • 0028362474 scopus 로고
    • Intrastriatal infusion of nerve growth factor after quinolinic acid prevents reduction of cellular expression of choline acetyltransferase messenger RNA and trkA messenger RNA, but not glutamate decarboxylase messenger RNA
    • 60. Venero J. L., Beck K. D. and Hefti F. (1994) Intrastriatal infusion of nerve growth factor after quinolinic acid prevents reduction of cellular expression of choline acetyltransferase messenger RNA and trkA messenger RNA, but not glutamate decarboxylase messenger RNA. Neuroscience 61, 257-268.
    • (1994) Neuroscience , vol.61 , pp. 257-268
    • Venero, J.L.1    Beck, K.D.2    Hefti, F.3
  • 62
    • 0029087477 scopus 로고
    • Augmented DNA-binding activity of p53 protein encoded by a carboxy-terminal alternatively spliced mRNA is blocked by p53 protein encoded by the regulatory spliced form
    • 61. Wolkowicz R., Peled A., Barry Elkind N. and Rotter V. (1995) Augmented DNA-binding activity of p53 protein encoded by a carboxy-terminal alternatively spliced mRNA is blocked by p53 protein encoded by the regulatory spliced form. Proc. natn. Acad. Sci. U.S.A. 92, 6842-6846.
    • (1995) Proc. Natn. Acad. Sci. U.S.A. , vol.92 , pp. 6842-6846
    • Wolkowicz, R.1    Peled, A.2    Barry Elkind, N.3    Rotter, V.4
  • 63
    • 0027495786 scopus 로고
    • In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum
    • 62. Wood K., Dipasquale B. and Youle R. (1993) In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum. Neuron 11, 621-632.
    • (1993) Neuron , vol.11 , pp. 621-632
    • Wood, K.1    Dipasquale, B.2    Youle, R.3
  • 64
    • 0029086989 scopus 로고
    • The role of free radicals and p53 in neuron apoptosis in vivo
    • 63. Wood K. A. and Youle R. J. (1995) The role of free radicals and p53 in neuron apoptosis in vivo. J. Neurosci. 15, 5851-5857.
    • (1995) J. Neurosci. , vol.15 , pp. 5851-5857
    • Wood, K.A.1    Youle, R.J.2
  • 65
    • 0028608817 scopus 로고
    • Cloning of the rat Gadd45 cDNA and its mRNA expression in the brain
    • 64. Yoshida T., Schneider E. L. and Mori N. (1994) Cloning of the rat Gadd45 cDNA and its mRNA expression in the brain. Gene 151, 253-255.
    • (1994) Gene , vol.151 , pp. 253-255
    • Yoshida, T.1    Schneider, E.L.2    Mori, N.3
  • 66
    • 0030026091 scopus 로고    scopus 로고
    • Cloning of the rat GADD45 gene and induction analysis following ionizing radiation in vivo
    • 64a. Yoshida T., Okazaki T., Hughes P. E., Schneider E. L. and Mori N. (1996) Cloning of the rat GADD45 gene and induction analysis following ionizing radiation in vivo. Fedn Eur. biochem. Socs Lett. 380, 87-92.
    • (1996) Fedn Eur. Biochem. Socs Lett. , vol.380 , pp. 87-92
    • Yoshida, T.1    Okazaki, T.2    Hughes, P.E.3    Schneider, E.L.4    Mori, N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.