Activation of p53 and its target genes p21(WAF1/Cip1) and PAG608/Wig-1 in ischemic preconditioning

Molecular Brain Research

Volumn 70, Issue 2, 1999, Pages 304-313

  Tomasevic, Gregor ^a   Shamloo, Mehrdad ^a   Israeli, David ^b   Wieloch, Tadeusz ^a  

^a LUND UNIVERSITY   (Sweden)

^b GÉNÉTHON   (France)

Author keywords

DNA damage; Ischemic preconditioning; p21(WAF1 Cip1); p53; PAG608 Wig 1; Rat

Indexed keywords

MESSENGER RNA; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DNA DAMAGE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEART INFARCTION PREVENTION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL;

ANIMALS; APOPTOSIS; BRAIN; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA-BINDING PROTEINS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GENES, P53; IN SITU HYBRIDIZATION; ISCHEMIC ATTACK, TRANSIENT; ISCHEMIC PRECONDITIONING; MALE; NEURONS; NUCLEAR PROTEINS; RATS; RATS, WISTAR; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; ZINC FINGERS;

EID: 0032981214     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(99)00146-1     Document Type: Article

References (50)

1. Barak Y., Juven T., Haffner R., Oren M. mdm2 expression is induced by wild type p53 activity. Embo J. 12:1993;461-468.
2. Chihab R., Ferry C., Koziel V., Monin P., Jean-Luc D. Sequential activation of activator protein-1-related transcription factors and JNK protein kinases may contribute to apoptotic death induced by transient hypoxia in developing brain neurons. Mol. Brain Res. 63:1998;105-120.
3. Crumrine R.C., Thomas A.L., Morgan P.F. Attenuation of p53 expression protects against focal ischemic damage in transgenic mice. J. Cereb. Blood Flow Metab. 14:1994;887-891.
4. El Deiry W.S., Tokino T., Velculescu V.E., Levy D.B., Parsons R., Trent J.M., Lin D., Mercer W.E., Kinzler K.W., Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell. 75:1993;817-825.
5. El Deiry W.S., Tokino T., Waldman T., Oliner J.D., Velculescu V.E., Burrell M., Hill D.E., Healy E., Rees J.L., Hamilton S.R.et al. Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res. 55:1995;2910-2919.
6. Graeber T.G., Peterson J.F., Tsai M., Monica K., Fornace A.J. Jr., Giaccia A.J. Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol. Cell. Biol. 14:1994;6264-6277.
7. P.E. Hughes, T. Alexi, S.S. Schreiber, A role for the tumour suppressor gene p53 in regulating neuronal apoptosis, Neuroreport, 8 (1997) v-xii.
8. S.A. Imam, L. Young, B. Chaiwun, C.R. Taylor, Comparison of two microwave based antigen-retrieval solutions in unmasking epitopes in formalin-fixed tissue for immunostaining, Anticancer Res., 15 (1995).
9. Israeli D., Tessler E., Haupt Y., Elkeles A., Wilder S., Amson R., Telerman A., Oren M. A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis. Embo J. 16:1997;4384-4392.
10. Ito U., Spatz M., Walker J.T. Jr., Klatzo I. Experimental cerebral ischemia in mongolian gerbils. I. Light microscopic observations. Acta Neuropathol. (Berl.). 32:1975;209-223.
11. Jackson P., Ridgway P., Rayner J., Noble J., Braithwaite A. Transcriptional regulation of the PCNA promoter by p53. Biochem. Biophys. Res. Commun. 203:1994;133-140.
12. Janus F., Albrechtsen N., Dornreiter I., Wiesmuller L., Grosse F., Deppert W. The dual role model for p53 in maintaining genomic integrity. Cell Mol. Life Sci. 55:1999;12-27.
13. Jordan J., Galindo M.F., Prehn J.H., Weichselbaum R.R., Beckett M., Ghadge G.D., Roos R.P., Leiden J.M., Miller R.J. p53 expression induces apoptosis in hippocampal pyramidal neuron cultures. J. Neurosci. 17:1997;1397-1405.
14. Kastan M.B., Onyekwere O., Sidransky D., Vogelstein B., Craig R.W. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51:1991;6304-6311.
15. Kastan M.B., Zhan Q., El Deiry W.S., Carrier F., Jacks T., Walsh W.V., Plunkett B.S., Vogelstein B., Fornace A.J. Jr. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell. 71:1992;587-597.
16. Kato H., Kogure K., Araki T., Itoyama Y. Induction of Jun-like immunoreactivity in astrocytes in gerbil hippocampus with ischemic tolerance. Neurosci. Lett. 189:1995;13-16.
17. Kato H., Liu Y., Araki T., Kogure K. Temporal profile of the effects of pretreatment with brief cerebral ischemia on the neuronal damage following secondary ischemic insult in the gerbil: cumulative damage and protective effects. Brain Res. 553:1991;238-242.
18. Kato H., Liu Y., Kogure K., Kato K. Induction of 27-kDa heat shock protein following cerebral ischemia in a rat model of ischemic tolerance. Brain Res. 634:1994;235-244.
19. Kitagawa K., Matsumoto M., Tagaya M., Hata R., Ueda H., Niinobe M., Handa N., Fukunaga R., Kimura K., Mikoshiba K.et al. 'Ischemic tolerance' phenomenon found in the brain. Brain Res. 528:1990;21-24.
20. Kobayashi S., Harris V.A., Welsh F.A. Spreading depression induces tolerance of cortical neurons to ischemia in rat brain. J. Cereb. Blood Flow Metab. 15:1995;721-727.
21. Lassus P., Ferlin M., Piette J., Hibner U. Anti-apoptotic activity of low levels of wild-type p53. Embo J. 15:1996;4566-4573.
22. Li Y., Chopp M., Powers C. Granule cell apoptosis and protein expression in hippocampal dentate gyrus after forebrain ischemia in the rat. J. Neurol. Sci. 150:1997;93-102.
23. Li Y., Chopp M., Zhang Z.G., Zaloga C., Niewenhuis L., Gautam S. p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats. Stroke. 25:1994;849-855.
24. Liu P.K., Hsu C.Y., Dizdaroglu M., Floyd R.A., Kow Y.W., Karakaya A., Rabow L.E., Cui J.K. Damage, repair, and mutagenesis in nuclear genes after mouse forebrain ischemia-reperfusion. J. Neurosci. 16:1996;6795-6806.
25. Liu Y., Kato H., Nakata N., Kogure K. Temporal profile of heat shock protein 70 synthesis in ischemic tolerance induced by preconditioning ischemia in rat hippocampus. Neuroscience. 56:1993;921-927.
26. McDonald E.R.R., Wu G.S., Waldman T., El Deiry W.S. Repair Defect in p21 WAF1/CIP1 -/- human cancer cells. Cancer Res. 56:1996;2250-2255.
27. Miyashita T., Reed J.C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell. 80:1995;293-299.
28. Morrison R.S., Wenzel H.J., Kinoshita Y., Robbins C.A., Donehower L.A., Schwartzkroin P.A. Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death. J. Neurosci. 16:1996;1337-1345.
29. Nakagomi T., Kirino T., Kanemitsu H., Tsujita Y., Tamura A. Early recovery of protein synthesis following ischemia in hippocampal neurons with induced tolerance in the gerbil. Acta Neuropathol. (Berl.). 86:1993;10-15.
30. Nakata N., Kato H., Kogure K. Ischemic tolerance and extracellular amino acid concentrations in gerbil hippocampus measured by intracerebral microdialysis. Brain Res. Bull. 35:1994;247-251.
31. Park D.S., Levine B., Ferrari G., Greene L.A. Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons. J. Neurosci. 17:1997;8975-8983.
32. Park D.S., Morris E.J., Stefanis L., Troy C.M., Shelanski M.L., Geller H.M., Greene L.A. Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress. J. Neurosci. 18:1998;830-840.
33. Raghupathi R., Napieralski J.A., McIntosh T.K. Acute upregulation of p53, but not cyclin D1, following experimental brain injury. J. Neurotrauma. 15:1998;892.
34. Riepe M.W., Esclaire F., Kasischke K., Schreiber S., Nakase H., Kempski O., Ludolph A.C., Dirnagl U., Hugon J. Increased hypoxic tolerance by chemical inhibition of oxidative phosphorylation: "chemical preconditioning" J. Cereb. Blood Flow Metab. 17:1997;257-264.
35. Sakhi S., Bruce A., Sun N., Tocco G., Baudry M., Schreiber S.S. p53 induction is associated with neuronal damage in the central nervous system. Proc. Natl. Acad. Sci. USA. 91:1994;7525-7529.
36. Sakhi S., Sun N., Wing L.L., Mehta P., Schreiber S.S. Nuclear accumulation of p53 protein following kainic acid-induced seizures. Neuroreport. 7:1996;493-496.
37. Schreiber S.S., Sakhi S., Dugich Djordjevic M.M., Nichols N.R. Tumor suppressor p53 induction and DNA damage in hippocampal granule cells after adrenalectomy. Exp. Neurol. 130:1994;368-376.
38. M. Shamloo, T. Wieloch, Changes in protein tyrosine phosphorylation in the rat brain following cerebral ischemia in a model of ischemic tolerance, J. Cereb. Blood Flow Metab. (1998), in press.
39. Shim J., Lee H., Park J., Kim H., Choi E.J. A non-enzymatic p21 protein inhibitor of stress-activated protein kinases. Nature. 381:1996;804-806.
40. Smith M.L., Bendek G., Dahlgren N., Rosen I., Wieloch T., Siesjo B.K. Models for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model. Acta. Neurol. Scand. 69:1984;385-401.
41. Soussi T., Caron de Fromentel C., Breugnot C., May E. Nucleotide sequence of a cDNA encoding the rat p53 nuclear oncoprotein. Nucleic Acids Res. 16:1988;11384.
42. Taylor C.R., Shi S.R., Chaiwun B., Young L., Imam S.A., Cote R.J. Strategies for improving the immunohistochemical staining of various intranuclear prognostic markers in formalin-paraffin sections: androgen receptor, estrogen receptor, progesterone receptor, p53 protein, proliferating cell nuclear antigen, and Ki-67 antigen revealed by antigen retrieval techniques. Hum. Pathol. 25:1994;263-270.
43. Tomasevic G., Kamme F., Stubberöd P., Wieloch M., Wieloch T. The tumor suppressor p53 and its response gene p21WAF1/Cip1 are not markers of neuronal death following transient global cerebral ischemia. Neuroscience. 90:1998;781-792.
44. Tomasevic G., Kamme F., Wieloch T. Changes in PCNA, a protein involved in DNA repair, in vulnerable hippocampal neurons following global cerebral ischemia. Mol. Brain Res. 60(2):1998;168-176.
45. Tomasevic G., Philips M.F., McIntosh T.K., Wieloch T. Regulation of the p53 and PAG608 genes following lateral fluid percussion brain injury. J. Neurotrauma. 15:1998;899.
46. Varmeh-Ziaie S., Okan I., Wang Y., Magnusson K.P., Warthoe P., Strauss M., Wiman K.G. Wig-1, a new p53-induced gene encoding a zinc finger protein. Oncogene. 15:1997;2699-2704.
47. Woo R.A., McLure K.G., Lees-Miller S.P., Rancourt D.E., Lee P.W. DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature. 394:1998;700-704.
48. Xiang H., Hochman D.W., Saya H., Fujiwara T., Schwartzkroin P.A., Morrison R.S. Evidence for p53-mediated modulation of neuronal viability. J. Neurosci. 16:1996;6753-6765.
49. Xiong Y., Hannon G.J., Zhang H., Casso D., Kobayashi R., Beach D. p21 is a universal inhibitor of cyclin kinases. Nature. 366:1993;701-704.
50. Yonish Rouach E., Resnitzky D., Lotem J., Sachs L., Kimchi A., Oren M. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature. 352:1991;345-347.