Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons

European Journal of Neuroscience

Volumn 8, Issue 9, 1996, Pages 1812-1821

  Enokido, Yasushi ^a   Araki, Toshiyuki ^a   Tanaka, Kiyoji ^a   Aizawa, Shinichi ^b   Hatanaka, Hiroshi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Cell cycle; Neurotrophic factor; Oxidative stress; Programmed cell death

Indexed keywords

BLEOMYCIN; ETOPOSIDE; PROTEIN P53;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CONTROLLED STUDY; CULTURE MEDIUM; DNA DAMAGE; DNA STRAND BREAKAGE; DNA SYNTHESIS; EMBRYO; GAMMA RADIATION; IONIZING RADIATION; MITOSIS; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0029745387     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.1996.tb01325.x     Document Type: Article

References (22)

1. Al-Ubaidi, M. R., Hollyfield, J. G., Overbeek, P. A. and Baeher, W. (1992) Photoreceptor degeneration induced by the expression of simian virus 40 large tumor antigen in the retina of transgenic mice. Proc. Natl Acad. Sci. USA, 89, 1194-1198.
2. Barde, Y.-A. (1989) Trophic factors and neuronal survival. Neuron, 2, 1525-1534.
3. Behl, C., Davis, J. B., Lesley, R. and Schubert, D. (1994) Hydrogen peroxide mediates amyloid β protein toxicity. Cell, 77, 817-827.
4. Blok, J. and Loman, H. (1986) Bacteriophage DNA as a model for correlation of radical damage to DNA damage and biological effects. In Simic, M. G. (ed.). Mechanisms of DNA Damage and Repair. Plenum Press, New York, pp. 75-87.
5. Chopp, M., Li, Y., Zhang, Z. G. and Freytag, S. O. (1992) p53 expression in brain after middle cerebral artery occlusion in the rat. Biochem. Blophys. Res. Commun., 182, 1201-1207.
6. Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L. and Wyllie, A. H. (1993) Thymocyte apoptosis induced by p53-dependent and independent pathway. Nature, 362, 849-852.
7. Clarke, P. G. H. (1990) Developmental cell death: morphological diversity and multiple mechanisms. Anat. Embryol., 181, 195-213.
8. Colombel, M., Olsson, C. A., Ng, P.-Y. and Buttyan, R. (1992) Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle. Cancer Res., 52, 4313-4319.
9. Davies, A. M. and Rothenthal, A. (1994) Neurons from mouse embryo with a null mutation in the tumor suppressor gene p53 undergo normal cell death in the absence of neurotrophins. Neurosci. Lett., 182, 112-114.
10. Diller, L., Kassel, J., Nelson, C. E., Gryka, M. A., Litwak., Gebhardt, M., Bressac, B., Ozturk, M., Baker, S. J., Vogelstein, B. and Friend, S. H. (1990) p53 functions as a cell cycle control protein in osteosarcomas. Mol. Cell. Biol., 10, 5772-5881.
11. D'Mello, S. R., Galli, C., Ciotti, T. and Calissano, P. (1993) Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc. Natl Acad. Sci. USA, 90, 10989-10993.
12. Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A. J., Butel, J. S. and Bradley, A. (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature, 356, 215-221.
13. El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W. and Vogelstein, B. (1992) Definition of a consensus binding site for p53. Nature Genet., 1, 45-49.
14. El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J., Lin, D., Mercer, W. E., Kinzler, K. W. and Vogelstein, B. (1993) WAF1, a potential mediator of p53 tumor suppression. Cell, 75, 817-825.
15. Enokido, Y. and Hatanaka, H. (1993) Apoptotic cell death occurs in hippocampal neurons cultured in a high oxygen atmosphere. Neuroscience, 57, 965-972.
16. Feddersen, R. M., Ehlenfeldt, R., Yunis, W. S., Clark, H. B. and Orr, H. T. (1992) Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice. Neuron, 9, 955-966.
17. Forloni, G., Chiesa, R., Smiroldo, S., Verga, L., Salmona, M., Tagliavini, F. and Angeretti, N. (1993) Apoptosis mediated neurotoxicity induced by chronic application of β-amyloid fragment 25-35. NeuroReport, 4, 523-526.
18. Franklin, J. L. and Johnson, E. M., Jr (1992) Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium. Trends Neurosci, 15, 501-508.
19. Freeman, R. S., Estus, S. and Johnson, E. M., Jr (1994) Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of cyclin D1 during programmed cell death. Neuron, 12, 343-355.
20. 3H-thymidine autoradiographic studies on the cell proliferation and differentiation in the external and internal granular layers of the mouse cerebellum. J. Comp. Neurol., 128, 191-208.
21. Gallo, V., Kinsbury, A., Balazs, R. and Jorgensen, R. O. (1987) The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J. Neurosci., 1, 2203-2213.
22. Greenlund, L. J. S., Deckwerth, T. L. and Johnson, E. M., Jr (1995) Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death. Neuron, 14, 303-315.