메뉴 건너뛰기




Volumn 19, Issue 2, 1999, Pages 664-673

A role for MAPK/ERK in sympathetic neuron survival: Protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside

Author keywords

C Jun phosphorylation; CNTF; DNA damage; JNK; MAPK ERK; P53; PD98059; PKB Akt; Signal transduction; Superior cervical ganglion neurons

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CILIARY NEUROTROPHIC FACTOR; CYTARABINE; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE;

EID: 0033556356     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-02-00664.1999     Document Type: Article
Times cited : (230)

References (53)
  • 2
    • 0029942186 scopus 로고    scopus 로고
    • Activation and phosphorylation of a pleckstrin homology domain-containing protein-kinase (RAC-PK/PKB) promoted by serum and protein phospatase inhibitors
    • Andjelkovic M, Jakubowicz T, Cron P, Ming XF, Han JW, Hemmings BA (1996) Activation and phosphorylation of a pleckstrin homology domain-containing protein-kinase (RAC-PK/PKB) promoted by serum and protein phospatase inhibitors. Proc Natl Acad Sci USA 93:5699-5704.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5699-5704
    • Andjelkovic, M.1    Jakubowicz, T.2    Cron, P.3    Ming, X.F.4    Han, J.W.5    Hemmings, B.A.6
  • 4
    • 0025764353 scopus 로고
    • NGF is required for induction of c-fos immunoreactivity by serum, depolarisation, cyclic AMP or trauma in cultured rat sympathetic neurons
    • Buckmaster A, Nobes CD, Edwards SN, Tolkovsky AM (1991) NGF is required for induction of c-fos immunoreactivity by serum, depolarisation, cyclic AMP or trauma in cultured rat sympathetic neurons. Eur J Neurosci 3:698-707.
    • (1991) Eur J Neurosci , vol.3 , pp. 698-707
    • Buckmaster, A.1    Nobes, C.D.2    Edwards, S.N.3    Tolkovsky, A.M.4
  • 6
    • 0029834669 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase-independent pathways mediate the effects of nerve growth factor and cAMP on neuronal survival
    • Creedon DJ, Johnson Jr EM, Lawrence JC (1996) Mitogen-activated protein kinase-independent pathways mediate the effects of nerve growth factor and cAMP on neuronal survival. J Biol Chem 271:20713-20718.
    • (1996) J Biol Chem , vol.271 , pp. 20713-20718
    • Creedon, D.J.1    Johnson E.M., Jr.2    Lawrence, J.C.3
  • 7
    • 0032522924 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor dependent sympathetic neurons
    • Crowder RJ, Freeman RS (1998) Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor dependent sympathetic neurons. J Neurosci 18:2933-2943.
    • (1998) J Neurosci , vol.18 , pp. 2933-2943
    • Crowder, R.J.1    Freeman, R.S.2
  • 8
    • 0027940391 scopus 로고
    • Neurons from mouse embryos with a null mutation in the tumour-suppressor gene p53 undergo normal cell death in the absence of neurotrophins
    • Davies AM, Rosenthal A (1994) Neurons from mouse embryos with a null mutation in the tumour-suppressor gene p53 undergo normal cell death in the absence of neurotrophins. Neurosci Lett 182:112-114.
    • (1994) Neurosci Lett , vol.182 , pp. 112-114
    • Davies, A.M.1    Rosenthal, A.2
  • 9
    • 0027485950 scopus 로고
    • Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor
    • Deckwerth TL, Johnson Jr EM (1993) Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor. J Cell Biol 123:1207-1222.
    • (1993) J Cell Biol , vol.123 , pp. 1207-1222
    • Deckwerth, T.L.1    Johnson E.M., Jr.2
  • 13
    • 0030890944 scopus 로고    scopus 로고
    • Rapid suppression of free radical formation by nerve growth factor involves the mitogen-activated protein kinase pathway
    • Dugan LL, Creedon DJ, Johnson EM Jr, Holtzman DM (1997) Rapid suppression of free radical formation by nerve growth factor involves the mitogen-activated protein kinase pathway. Proc Natl Acad Sci USA 94:4086-4091.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4086-4091
    • Dugan, L.L.1    Creedon, D.J.2    Johnson E.M., Jr.3    Holtzman, D.M.4
  • 14
    • 0028123667 scopus 로고
    • Characterisation of apoptosis in cultured rat sympathetic neurons after nerve growth factor (NGF) withdrawal
    • Edwards SN, Tolkovsky AM (1994) Characterisation of apoptosis in cultured rat sympathetic neurons after nerve growth factor (NGF) withdrawal. J Cell Biol 124:537-546.
    • (1994) J Cell Biol , vol.124 , pp. 537-546
    • Edwards, S.N.1    Tolkovsky, A.M.2
  • 15
    • 0032032404 scopus 로고    scopus 로고
    • Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons
    • Eilers A, Whitfield J, Babij C, Rubin LL, Ham J (1998) Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons. J Neurosci 18:1713-1724.
    • (1998) J Neurosci , vol.18 , pp. 1713-1724
    • Eilers, A.1    Whitfield, J.2    Babij, C.3    Rubin, L.L.4    Ham, J.5
  • 16
    • 0030031650 scopus 로고    scopus 로고
    • p53 involves cytosine arabinoside-induced apoptosis in cultured cerebellar granule neurons
    • Enokido Y, Araki T, Shinichi A, Hatanaka H (1996a) p53 involves cytosine arabinoside-induced apoptosis in cultured cerebellar granule neurons. Neurosci Lett 203:1-4.
    • (1996) Neurosci Lett , vol.203 , pp. 1-4
    • Enokido, Y.1    Araki, T.2    Shinichi, A.3    Hatanaka, H.4
  • 17
    • 0029745387 scopus 로고    scopus 로고
    • Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons
    • Enokido Y, Araki T, Tanaka K, Aizawa S, Hatanaka H (1996b) Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons. Eur J Neurosci 8:1812-1821.
    • (1996) Eur J Neurosci , vol.8 , pp. 1812-1821
    • Enokido, Y.1    Araki, T.2    Tanaka, K.3    Aizawa, S.4    Hatanaka, H.5
  • 18
    • 0027946686 scopus 로고
    • Altered gene-expression in neurons during programmed cell-death: Identification of c-jun as necessary for neuronal apoptosis
    • Estus S, Zaks WJ, Freeman RS, Gruda M, Bravo R, Johnson Jr EM (1994) Altered gene-expression in neurons during programmed cell-death: identification of c-jun as necessary for neuronal apoptosis. J Cell Biol 127:1717-1727.
    • (1994) J Cell Biol , vol.127 , pp. 1717-1727
    • Estus, S.1    Zaks, W.J.2    Freeman, R.S.3    Gruda, M.4    Bravo, R.5    Johnson E.M., Jr.6
  • 19
    • 0025028911 scopus 로고
    • Microtubule-associated-protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells. Identity with the mitogen activated MAP kinase of fibroblastic cells
    • Gotoh Y, Nishida E, Yamashita T, Hoshi M, Kawakami M, Sakai H (1990) Microtubule-associated-protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells. Identity with the mitogen activated MAP kinase of fibroblastic cells. Eur J Biochem 193:661-669.
    • (1990) Eur J Biochem , vol.193 , pp. 661-669
    • Gotoh, Y.1    Nishida, E.2    Yamashita, T.3    Hoshi, M.4    Kawakami, M.5    Sakai, H.6
  • 20
    • 0031972535 scopus 로고    scopus 로고
    • Ara-C: Cellular and molecular pharmacology
    • Grant S (1998) Ara-C: cellular and molecular pharmacology. Adv Cancer Res 72:197-233.
    • (1998) Adv Cancer Res , vol.72 , pp. 197-233
    • Grant, S.1
  • 21
    • 0028893492 scopus 로고
    • Superoxide-dismutase delays neuronal apoptosis - A role for reactive oxygen species in programmed neuronal death
    • Greenlund LJS, Deckwerth TL, Johnson Jr EM (1995) Superoxide-dismutase delays neuronal apoptosis - a role for reactive oxygen species in programmed neuronal death. Neuron 14:303-315.
    • (1995) Neuron , vol.14 , pp. 303-315
    • Greenlund, L.J.S.1    Deckwerth, T.L.2    Johnson E.M., Jr.3
  • 22
    • 0029012476 scopus 로고
    • A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death
    • Ham J, Babij C, Pfarr CM, Lallemand D, Yaniv M, Rubin LL (1995) A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 14:927-939.
    • (1995) Neuron , vol.14 , pp. 927-939
    • Ham, J.1    Babij, C.2    Pfarr, C.M.3    Lallemand, D.4    Yaniv, M.5    Rubin, L.L.6
  • 23
    • 0018322590 scopus 로고
    • Long-term culture of dissociated sympathetic neurons
    • Hawrot E, Patterson P (1979) Long-term culture of dissociated sympathetic neurons. Methods Enzymol 58:574-584.
    • (1979) Methods Enzymol , vol.58 , pp. 574-584
    • Hawrot, E.1    Patterson, P.2
  • 24
    • 0030054709 scopus 로고    scopus 로고
    • Generation of reactive oxygen intermediates after treatment of blasts of acute myeloblastic leukemia with cytosine arabinoside: Role of bcl-2
    • Hedley DW, McCulloch EA (1996) Generation of reactive oxygen intermediates after treatment of blasts of acute myeloblastic leukemia with cytosine arabinoside: role of bcl-2. Leukemia 10:1143-1149.
    • (1996) Leukemia , vol.10 , pp. 1143-1149
    • Hedley, D.W.1    McCulloch, E.A.2
  • 28
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88:323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 29
    • 0031573032 scopus 로고    scopus 로고
    • NGF-mediated survival depends on p21ras in chick sympathetic neurons from the superior cervical but not from lumbosacral ganglia
    • Markus A, von Holst A, Rohrer H, Heumann R (1997) NGF-mediated survival depends on p21ras in chick sympathetic neurons from the superior cervical but not from lumbosacral ganglia. Dev Biol 191:306-310.
    • (1997) Dev Biol , vol.191 , pp. 306-310
    • Markus, A.1    Von Holst, A.2    Rohrer, H.3    Heumann, R.4
  • 31
    • 0025017561 scopus 로고
    • Cytosine arabinoside kills postmitotic neurons in a fashion resembling trophic factor deprivation: Evidence that a deoxycytidine-dependent process may be required for nerve growth factor signal transduction
    • Martin DP, Wallace TL, Johnson Jr EM (1990) Cytosine arabinoside kills postmitotic neurons in a fashion resembling trophic factor deprivation: evidence that a deoxycytidine-dependent process may be required for nerve growth factor signal transduction. J Neurosci 10:184-193.
    • (1990) J Neurosci , vol.10 , pp. 184-193
    • Martin, D.P.1    Wallace, T.L.2    Johnson E.M., Jr.3
  • 32
    • 0017028064 scopus 로고
    • Characterization and isolation of proteolytically modified nerve growth factor
    • Mobley WC, Schenker A, Shooter EM (1976) Characterization and isolation of proteolytically modified nerve growth factor. Biochemistry 15:5543-5551.
    • (1976) Biochemistry , vol.15 , pp. 5543-5551
    • Mobley, W.C.1    Schenker, A.2    Shooter, E.M.3
  • 33
    • 0028985259 scopus 로고
    • Neutralizing anti-p21(Ras) fabs suppress rat sympathetic neuron survival induced by NGF, LIF, CNTF and cAMP
    • Nobes CD, Tolkovsky AM (1995) Neutralizing anti-p21(Ras) fabs suppress rat sympathetic neuron survival induced by NGF, LIF, CNTF and cAMP. Eur J Neurosci 7:344-350.
    • (1995) Eur J Neurosci , vol.7 , pp. 344-350
    • Nobes, C.D.1    Tolkovsky, A.M.2
  • 34
    • 0030024318 scopus 로고    scopus 로고
    • Active p21ras is sufficient for rescue of NGF-dependent rat sympathetic neurons
    • Nobes CD, Reppas JB, Markus A, Tolkovsky AM (1996) Active p21ras is sufficient for rescue of NGF-dependent rat sympathetic neurons. Neuroscience 70:1067-1079.
    • (1996) Neuroscience , vol.70 , pp. 1067-1079
    • Nobes, C.D.1    Reppas, J.B.2    Markus, A.3    Tolkovsky, A.M.4
  • 36
    • 0000467722 scopus 로고    scopus 로고
    • Activation of Akt by nerve growth factor via phosphatidylinositol 3-kinase in PC12 pheochromocytoma cells
    • Park EK, Yang SI, Kang SS (1996) Activation of Akt by nerve growth factor via phosphatidylinositol 3-kinase in PC12 pheochromocytoma cells. Mol Cells 6:494-498.
    • (1996) Mol Cells , vol.6 , pp. 494-498
    • Park, E.K.1    Yang, S.I.2    Kang, S.S.3
  • 37
    • 0030694175 scopus 로고    scopus 로고
    • Activated phoshpatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons
    • Philpott KL, McCarthy MJ, Klippel A, Rubin LL (1997) Activated phoshpatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons. J Cell Biol 139:809-815.
    • (1997) J Cell Biol , vol.139 , pp. 809-815
    • Philpott, K.L.1    McCarthy, M.J.2    Klippel, A.3    Rubin, L.L.4
  • 39
    • 0001589410 scopus 로고
    • Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo
    • Ray LB, Sturgill TW (1988) Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo. Proc Natl Acad Sci USA 85:3753-3757.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 3753-3757
    • Ray, L.B.1    Sturgill, T.W.2
  • 40
    • 0029670172 scopus 로고    scopus 로고
    • p53 protein in sympathetic neurons - Cytoplasmic localization and no apparent function in apoptosis
    • Sadoul R, Quiquerez AL, Martinou I, Fernandez PA, Martinou JC (1996) p53 protein in sympathetic neurons - cytoplasmic localization and no apparent function in apoptosis. J Neurosci Res 43:594-601.
    • (1996) J Neurosci Res , vol.43 , pp. 594-601
    • Sadoul, R.1    Quiquerez, A.L.2    Martinou, I.3    Fernandez, P.A.4    Martinou, J.C.5
  • 41
    • 0031047094 scopus 로고    scopus 로고
    • Cytosine arabinoside is neurotoxic to chick embryo spinal motoneurons in culture
    • Sanz-Rodriguez C, Boix J, Comella JX (1997) Cytosine arabinoside is neurotoxic to chick embryo spinal motoneurons in culture. Neurosci Lett 223:141-144.
    • (1997) Neurosci Lett , vol.223 , pp. 141-144
    • Sanz-Rodriguez, C.1    Boix, J.2    Comella, J.X.3
  • 42
    • 0029925683 scopus 로고    scopus 로고
    • Intracellular signaling pathways activated by neurotrophic factors
    • Segal RA, Greenberg ME (1996) Intracellular signaling pathways activated by neurotrophic factors. Annu Rev Neurosci 19:463-489.
    • (1996) Annu Rev Neurosci , vol.19 , pp. 463-489
    • Segal, R.A.1    Greenberg, M.E.2
  • 43
    • 0031978372 scopus 로고    scopus 로고
    • Neurotrophins rescue cerebellar granule neurons from oxidative stress-mediated apoptotic death: Selective involvement of phosphatidylinositol 3-kinase and the mitogen-activated protein kinase pathway
    • Skaper SD, Floreani M, Negro A, Facci L, Giusti P (1998) Neurotrophins rescue cerebellar granule neurons from oxidative stress-mediated apoptotic death: selective involvement of phosphatidylinositol 3-kinase and the mitogen-activated protein kinase pathway. J Neurochem 70:1859-1868.
    • (1998) J Neurochem , vol.70 , pp. 1859-1868
    • Skaper, S.D.1    Floreani, M.2    Negro, A.3    Facci, L.4    Giusti, P.5
  • 45
    • 0028206102 scopus 로고
    • Apoptosis is induced In postmitotic rat sympathetic neurons by arabinosides and topoisomerase-II inhibitors in the presence of NGF
    • Tomkins CE, Edwards SN, Tolkovsky AM (1994) Apoptosis is induced In postmitotic rat sympathetic neurons by arabinosides and topoisomerase-II inhibitors in the presence of NGF. J Cell Sci 107:1499-1507.
    • (1994) J Cell Sci , vol.107 , pp. 1499-1507
    • Tomkins, C.E.1    Edwards, S.N.2    Tolkovsky, A.M.3
  • 47
    • 0029125589 scopus 로고
    • Activation of p44 and p42 MAP kinases is not essential for the survival of rat sympathetic neurons
    • Virdee K, Tolkovsky AM (1995) Activation of p44 and p42 MAP kinases is not essential for the survival of rat sympathetic neurons. Eur J Neurosci 7:2159-2169.
    • (1995) Eur J Neurosci , vol.7 , pp. 2159-2169
    • Virdee, K.1    Tolkovsky, A.M.2
  • 48
    • 0029800940 scopus 로고    scopus 로고
    • Inhibition of p42 and p44 mitogen activated protein kinase activity by PD98059 does not suppress nerve growth factor-induced survival of sympathetic neurones
    • Virdee K, Tolkovsky AM (1996) Inhibition of p42 and p44 mitogen activated protein kinase activity by PD98059 does not suppress nerve growth factor-induced survival of sympathetic neurones. J Neurochem 67:1801-1805.
    • (1996) J Neurochem , vol.67 , pp. 1801-1805
    • Virdee, K.1    Tolkovsky, A.M.2
  • 49
    • 0030751556 scopus 로고    scopus 로고
    • Comparison between the timing and onset of JNK activation, c-Jun phosphorylation, and onset of death commitment in sympathetic neurones
    • Virdee K, Bannister AJ, Hunt SP, Tolkovsky AM (1997) Comparison between the timing and onset of JNK activation, c-Jun phosphorylation, and onset of death commitment in sympathetic neurones. J Neurochem 69:550-561.
    • (1997) J Neurochem , vol.69 , pp. 550-561
    • Virdee, K.1    Bannister, A.J.2    Hunt, S.P.3    Tolkovsky, A.M.4
  • 50
    • 0031860507 scopus 로고    scopus 로고
    • Sympathetic neuron survival and proliferation are prolonged by loss of p53 and neurofibromin
    • Vogel KS, Parada LF (1998) Sympathetic neuron survival and proliferation are prolonged by loss of p53 and neurofibromin. Mol Cell Neurosci 11:19-28.
    • (1998) Mol Cell Neurosci , vol.11 , pp. 19-28
    • Vogel, K.S.1    Parada, L.F.2
  • 51
    • 0024546693 scopus 로고
    • Cytosine arabinoside kills postmitotic neurons: Evidence that deoxycytidine may have a role in neuronal survival that is independent of DNA synthesis
    • Wallace TL, Johnson Jr EM (1989) Cytosine arabinoside kills postmitotic neurons: evidence that deoxycytidine may have a role in neuronal survival that is independent of DNA synthesis. J Neurosci 9:115-124.
    • (1989) J Neurosci , vol.9 , pp. 115-124
    • Wallace, T.L.1    Johnson E.M., Jr.2
  • 52
    • 0031972678 scopus 로고    scopus 로고
    • Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons
    • Watson A, Eilers A, Lallemand D, Kyriakis J, Rubin LL, Ham J (1998) Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons. J Neurosci 18:751-762.
    • (1998) J Neurosci , vol.18 , pp. 751-762
    • Watson, A.1    Eilers, A.2    Lallemand, D.3    Kyriakis, J.4    Rubin, L.L.5    Ham, J.6
  • 53


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.