The tumor-suppressor gene, p53, is induced in injured brain regions following experimental traumatic brain injury

Molecular Brain Research

Volumn 71, Issue 1, 1999, Pages 78-86

  Napieralski, Julie A ^a   Raghupathi, Ramesh ^a   McIntosh, Tracy K ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Apoptosis; Cell cycle; Cell death; Cyclin D1; p53; Traumatic brain injury

Indexed keywords

CYCLIN D1; MESSENGER RNA; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INJURY; CELL CYCLE; CELL DEATH; CONTROLLED STUDY; GENE INDUCTION; HIPPOCAMPUS; HISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THALAMUS; TUMOR SUPPRESSOR GENE;

ANIMALS; BRAIN; BRAIN INJURIES; CEREBRAL CORTEX; FUNCTIONAL LATERALITY; GENE EXPRESSION REGULATION; GENES, P53; GENICULATE BODIES; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; NEURONS; ORGAN SPECIFICITY; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES; RNA, MESSENGER; THALAMUS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0033059025     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(99)00155-2     Document Type: Article

References (48)

1. Bienz B., Kakut-Houri R., Givol D., Oren M. Analysis of the gene coding for the murine cellular tumor antigen p53. EMBO J. 3:1984;2179-2183.
2. Bramlett H.M., Dietrich W.D., Green E.J., Busto R. Chronic histopathological consequences of fluid-percussion brain injury in rats: effects of post-traumatic hypothermia. Acta Neuropathol. 93:1997;190-199.
3. Bredesen D.E. Neural apoptosis. Ann. Neurol. 38:1995;839-851.
4. M.F. Chesselet, L. MacKenzie, K. Eberle-Wang, In situ hybridization with 35S- and digoxigenin-labeled RNA probes, in: Z. Henderson (Ed.), In Situ Hybridization Techniques for the Brain, Wiley, 1996, pp. 79-110.
5. Chopp M., Li Y., Zhang Z.G., Freytag S.O. p53 expression in brain after middle cerebral artery occlusion in the rat. Biochem. Biophys. Res. Commun. 182:1999;1201-1207.
6. Clark R.S.B., Chen J., Watkins S.C., Kochanek P.M., Chen M., Stetler R.A., Loeffert J.E., Graham S.H. Apoptosis-suppressor gene bcl-2 expression after traumatic brain injury in rats. J. Neurosci. 17:1997;9172-9182.
7. Clarke A.R., Purdie C.A., Harrison D.J., Morris R.G., Bird C.C., Hooper M.L., Wyllie A.H. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature. 362:1993;849-852.
8. Colicos M.A., Dash P.K. Apoptotic morphology of dentate gyrus granule cells following experimental cortical impact injury in rats: possible role in spatial memory deficits. Brain Res. 739:1996;120-131.
9. Conti A.C., Raghupathi R., Trojanowski J.Q., McIntosh T.K. Experimental brain injury induces regionally distinct apoptosis during the acute and delayed post-traumatic period. J. Neurosci. 18:1998;5663-5672.
10. Crumrine R.C., Thomas A.L., Morgan P.F. Attenuation of p53 expression protects against focal ischemic damage in transgenic mice. J. Cereb. Blood Flow Metab. 14:1994;887-891.
11. Dietrich W.D., Alonso O., Halley M. Early microvascular and neuronal consequences of traumatic brain injury: a light and electron microscopic study in rats. J. Neurotrauma. 11:1994;289-301.
12. el Deiry W.S., Tokino T., Velculescu V.E., Levy D.B., Parsons R., Trent J.M., Lin D., Mercer W.E., Kinzler K.W., Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell. 75:1993;817-825.
13. Fan L., Young P.R., Barone F.C., Feuerstein G.Z., Smith D.H., McIntosh T.K. Experimental brain injury induces expression of interleukin-1β mRNA in the rat brain. Mol. Brain Res. 30:1995;125-130.
14. Fan L., Young P.R., Barone F.C., Feuerstein G.Z., Smith D.H., McIntosh T.K. Experimental brain injury induces differential expression of tumor necrosis factor-α mRNA in the CNS. Mol. Brain Res. 36:1996;287-291.
15. Freeman R.S., Estus S., Johnson E.M. Analysis of cell cycle related gene expression in postmitotic neurons: selective induction of cyclin D1 during programmed cell death. Neuron. 12:1994;343-355.
16. Guegan C., Levy V., David J.-P., Ajchenbaum-Cymbalista F., Sola B. c-jun and cyclin D1 proteins as mediators of neuronal death after a focal ischemic insult. NeuroReport. 8:1997;1003-1007.
17. Hicks R.R., Soares H.D., Smith D.H., McIntosh T.K. Temporal and spatial characterization of neuronal injury following lateral fluid-percussion brain injury in the rat. Acta Neuropathol. 91:1996;236-246.
18. Hughes P.E., Alexi T., Yoshida T., Schreiber S.S., Knusel B. Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 mRNA and protein and p53-inducible genes Bax and Gadd45 in brain areas showing DNA fragmentation. Neuroscience. 74:1996;1143-1160.
19. Hupp T.R., Meek D.W., Midgley C.A., Lane D.P. Regulation of the specific DNA binding function of p53. Cell. 71:1992;875-886.
20. Jordan J., Galindo M.F., Prehn J.H.M., Weichselbaum R.R., Beckett M., Ghadge G.D., Roos R.P., Leiden J.M., Miller R.J. p53 expression induces apoptosis in hippocampal pyramidal neuron cultures. J. Neurosci. 17:1996;1405.
21. Kastan M.B., Zhan Q., el Deiry W.S., Carrier F., Jacks T., Walsh W.V., Plunkett B.S., Vogelstein B., Fornace A.J. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell. 71:1992;587-597.
22. Kranenberg O., van der Erb A.J., Zantema A. Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J. 15:1996;46-54.
23. Li Y., Chopp M., Powers C. Granule cell apoptosis and protein expression in hippocampal dentate gyrus after forebrain ischemia in the rat. J. Neurol. Sci. 150:1997;93-102.
24. Li Y., Chopp M., Zhang Z.G., Zaloga C., Niewenhuis L., Gautam S. p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats. Stroke. 25:1994;849-856.
25. Liu W., Bi X., Tocco G., Baudry M., Schreiber S.S. Increased expression of cyclin D1 in the adult rat brain following kainic acid treatment. NeuroReport. 7:1996;2785-2789.
26. Lowe S.W., Schmitt E.M., Smith S.W., Osborne B.A., Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature. 362:1993;847-849.
27. Manev H., Kharlomov A., Armstrong D.M. Photochemical brain injury in rats triggers DNA fragmentation, p53 and HSP72. NeuroReport. 5:1994;2661-2664.
28. Matsushime H., Roussel M.F., Ashmun R.A., Sherr C.J. Colony-stimulating factor 1 regulates cyclins during the G1 phase of the cell cycle. Cell. 65:1991;701-713.
29. McIntosh T.K., Juhler M., Wieloch T. Novel pharmacologic strategies in the treatment of experimental traumatic brain injury: 1998. J. Neurotrauma. 15:1998;731-769.
30. McIntosh T.K., Vink R., Noble L., Yamakami I., Fernyak S., Faden A.I. Traumatic brain injury in the rat: characterization of a lateral fluid percussion model. Neuroscience. 28:1989;233-244.
31. Miyashita T., Reed J.C. Tumor-suppressor p53 is a direct transcriptional activator of the human bax gene. Cell. 80:1995;293-299.
32. Morrison R.S., Wenzel H.J., Kinoshita Y., Robbins C.A., Donehower L.A., Schwartzkroin P.A. Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death. J. Neurosci. 16:1996;1337-1345.
33. Nelson W.G., Kastan M.B. DNA strand breaks: the DNA template alterations that trigger p53-dependent damage response pathways. Mol. Biol. Cell. 14:1994;1815-1823.
34. Oltvai Z.N., Milliman C.L., Korsmeyer S.J. Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell. 74:1993;619.
35. G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, Academic Press, New York, 1994.
36. Phillips L.L., Belardo E.T. Expression of c-fos in the hippocampus following mild and moderate fluid percussion brain injury. J. Neurotrauma. 9:1993;323-333.
37. Pinhasi-Kimhi O., Michalovitz D., Ben-Zeev A., Oren M. Specific interaction between the p53 cellular tumor antigen and major heat shock proteins. Nature. 320:1986;182-184.
38. Polyak K., Xia Y., Zweler J.L., Kinzler K.W., Vogelstein B. A model for p53-induced apoptosis. Nature. 389:1997;300-305.
39. Postigo J.A., Van der Werf Y.D., Korf J., Krugers H.J. Altered expression of the cell cycle regulatory protein cyclin D1 in the rat dentate gyrus after adrenalectomy-induced granular cell loss. Neurosci. Lett. 241:1998;107-110.
40. Preston G.A., Lyon T.T., Yin Y., Lang J.E., Solomon G., Annab L., Srinivasan D.G., Alcorta D.A., Barrett J.C. Induction of apoptosis by c-fos protein. Mol. Biol. Cell. 16:1996;211-218.
41. Raghupathi R., McIntosh T.K. Regionally and temporally distinct patterns of induction of c-fos, c-jun and junB mRNAs following experimental brain injury in the rat. Mol. Brain Res. 37:1996;134-144.
42. Raghupathi R., Strauss K.I., Krajewski S., Reed J.C., McIntosh T.K. Regional alterations in the expression of BCL-2 and BCL-X proteins and BAX mRNA following experimental brain injury in the rat. J. Cereb. Blood Flow Metab. 17(1):1997;S494-S494. Suppl.
43. Raghupathi R., Welsh F.A., Lowenstein D.H., Gennarelli T.A., McIntosh T.K. Regional induction of c-fos and heat-shock protein-72 mRNA following fluid-percussion brain injury in the rat. J. Cereb. Blood Flow Metab. 15:1995;467-473.
44. Rink A., Fung K.-M., Trojanowski J.Q., Lee V.M.Y., Neugebauer E., McIntosh T.K. Evidence of apoptotic cell death after experimental traumatic brain injury in the rat. Am. J. Pathol. 147:1995;1575-1583.
45. Sakhi S., Bruce A., Sun N., Tocco G., Baudry M., Schreiber S.S. p53 induction is associated with neuronal damage in the CNS. Proc. Natl. Acad. Sci. U.S.A. 91:1994;7525-7529.
46. Ullrich S.J., Anderson C.W., Mercer W.E., Apella E. The p53 tumor suppressor protein, a modulator of cell proliferation. J. Biol. Chem. 267:1992;15259-15262.
47. Wiessner C., Brink I., Lorenz P., Neumann-Haefelin T., Vogel P., Yamashita K. Cyclin D1 messenger RNA is induced following transient forebrain ischemia. Neuroscience. 72:1996;947-958.
48. Yakovlev A.G., Knoblach S., Fan L., Fox G.B., Goodnight R., Faden A.I. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J. Neurosci. 17:1997;7415-7424.