메뉴 건너뛰기




Volumn 20, Issue 9, 2000, Pages 3104-3114

Involvement of retinoblastoma family members and E2F/DP complexes in the death of neurons evoked by DNA damage

Author keywords

Apoptosis; Cyclin; DP1; E2F; Neuronal; PRb

Indexed keywords

CAMPTOTHECIN; CELL DNA; CYCLIN DEPENDENT KINASE 4; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

EID: 0034192510     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-09-03104.2000     Document Type: Article
Times cited : (144)

References (61)
  • 1
    • 0029976253 scopus 로고    scopus 로고
    • DNA damage and apoptosis in Alzheimer's discase: Colocalization with c-jun immunoreactivity, relationship to brain area, and effect of postmortem delay
    • Anderson AJ, Su JH, Cotman CW (1996) DNA damage and apoptosis in Alzheimer's discase: colocalization with c-jun immunoreactivity, relationship to brain area, and effect of postmortem delay. J Neurosci 16:1710-1719.
    • (1996) J Neurosci , vol.16 , pp. 1710-1719
    • Anderson, A.J.1    Su, J.H.2    Cotman, C.W.3
  • 2
    • 0033556356 scopus 로고    scopus 로고
    • A role for MAPK/ERK in sympathetic neuron survival: Protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside
    • Anderson CNG, Tolkovsky AM (1999) A role for MAPK/ERK in sympathetic neuron survival: protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside. J Neurosci 19:664-673.
    • (1999) J Neurosci , vol.19 , pp. 664-673
    • Anderson, C.N.G.1    Tolkovsky, A.M.2
  • 3
    • 0027434084 scopus 로고
    • Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTFI/E2F
    • Bandara LR, Buck VM, Zamanian M, Johnston LH, La Thangue NB (1993) Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTFI/E2F. EMBO J 12:4317-4324.
    • (1993) EMBO J , vol.12 , pp. 4317-4324
    • Bandara, L.R.1    Buck, V.M.2    Zamanian, M.3    Johnston, L.H.4    La Thangue, N.B.5
  • 4
    • 0029031349 scopus 로고
    • Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes
    • Beijersbergen RL, Carlee L, Kerkhoven RM, Bernards R (1995) Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes. Genes Dev 9:1340-1350.
    • (1995) Genes Dev , vol.9 , pp. 1340-1350
    • Beijersbergen, R.L.1    Carlee, L.2    Kerkhoven, R.M.3    Bernards, R.4
  • 6
    • 0032931991 scopus 로고    scopus 로고
    • Cumulative effect of phosphorylation of pRB on regulation of E2F activity
    • Brown VD, Phillips RA, Gallie BL (1999) Cumulative effect of phosphorylation of pRB on regulation of E2F activity. Mol Cell Biol 19:3246-3256.
    • (1999) Mol Cell Biol , vol.19 , pp. 3246-3256
    • Brown, V.D.1    Phillips, R.A.2    Gallie, B.L.3
  • 7
    • 0032522911 scopus 로고    scopus 로고
    • Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzhcimer's disease brain
    • Busser J, Gelmacher DS, Herrup K (1998) Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzhcimer's disease brain. J Neurosci 18:2801-2807.
    • (1998) J Neurosci , vol.18 , pp. 2801-2807
    • Busser, J.1    Gelmacher, D.S.2    Herrup, K.3
  • 8
    • 0025905183 scopus 로고
    • The E2F transcription factor is a cellular target for the RB protein
    • Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR (1991) The E2F transcription factor is a cellular target for the RB protein. Cell 65:1053-1061.
    • (1991) Cell , vol.65 , pp. 1053-1061
    • Chellappan, S.P.1    Hiebert, S.2    Mudryj, M.3    Horowitz, J.M.4    Nevins, J.R.5
  • 9
    • 0032124903 scopus 로고    scopus 로고
    • Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia
    • Chen J, Nagayama T, Jin K, Stetler A, Zhu RL, Graham SH, Simon RP (1998) Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J Neurosci 18:4914-4928.
    • (1998) J Neurosci , vol.18 , pp. 4914-4928
    • Chen, J.1    Nagayama, T.2    Jin, K.3    Stetler, A.4    Zhu, R.L.5    Graham, S.H.6    Simon, R.P.7
  • 10
    • 0031958152 scopus 로고    scopus 로고
    • Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease
    • Cotman CW (1998) Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease. Neurobiol Aging 19:S29-S32.
    • (1998) Neurobiol Aging , vol.19
    • Cotman, C.W.1
  • 11
    • 0029745387 scopus 로고    scopus 로고
    • Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons
    • Enokido Y, Araki T, Tanaka K, Aizawa S, Hatanaka H (1996) Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons. Eur J Neurosci 8:1812-1821.
    • (1996) Eur J Neurosci , vol.8 , pp. 1812-1821
    • Enokido, Y.1    Araki, T.2    Tanaka, K.3    Aizawa, S.4    Hatanaka, H.5
  • 12
    • 0027946686 scopus 로고
    • Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis
    • Estus S, Zaks WJ, Freeman RS, Gruda M, Bravo R, Johnson Jr EM (1994) Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J Cell Biol 127:1717-1727.
    • (1994) J Cell Biol , vol.127 , pp. 1717-1727
    • Estus, S.1    Zaks, W.J.2    Freeman, R.S.3    Gruda, M.4    Bravo, R.5    Johnson E.M., Jr.6
  • 13
    • 0029883399 scopus 로고    scopus 로고
    • The retinoblastoma gene product inhibits TGF-b1 induced apoptosis in rat hepatocyte and human HuH-7 hepatoma colls
    • Fan G, Ma X, Kren BT, Steer CJ (1996) The retinoblastoma gene product inhibits TGF-b1 induced apoptosis in rat hepatocyte and human HuH-7 hepatoma colls. Oncogene 12:1909-1919.
    • (1996) Oncogene , vol.12 , pp. 1909-1919
    • Fan, G.1    Ma, X.2    Kren, B.T.3    Steer, C.J.4
  • 14
    • 0029972440 scopus 로고    scopus 로고
    • Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support
    • Farinelli SE, Greene LA (1996) Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support. J Neurosci 16:1150-1162.
    • (1996) J Neurosci , vol.16 , pp. 1150-1162
    • Farinelli, S.E.1    Greene, L.A.2
  • 16
    • 0028324310 scopus 로고
    • Analysis of cell-related gene expression in postmitotic neurons: Selective induction of Cyclin D1 during programmed cell death
    • Freeman RF, Estus S, Johnson EM (1994) Analysis of cell-related gene expression in postmitotic neurons: selective induction of Cyclin D1 during programmed cell death. Neuron 12:343-355.
    • (1994) Neuron , vol.12 , pp. 343-355
    • Freeman, R.F.1    Estus, S.2    Johnson, E.M.3
  • 17
    • 0029128927 scopus 로고
    • Induction of cyclin B and H1 kinase activity in apoptotic PC12 cells
    • Gao CY, Zelenka PS (1995) Induction of cyclin B and H1 kinase activity in apoptotic PC12 cells. Exp Cell Res 219:612-618.
    • (1995) Exp Cell Res , vol.219 , pp. 612-618
    • Gao, C.Y.1    Zelenka, P.S.2
  • 18
    • 0032526263 scopus 로고    scopus 로고
    • Cisplatin-induced apoptosis in rat dorsal root ganglion neurons is associated with attempted entry into the cell cycle
    • Gill JS, Windebank AJ (1998) Cisplatin-induced apoptosis in rat dorsal root ganglion neurons is associated with attempted entry into the cell cycle. J Clin Invest 101:2842-2850.
    • (1998) J Clin Invest , vol.101 , pp. 2842-2850
    • Gill, J.S.1    Windebank, A.J.2
  • 20
    • 0029012476 scopus 로고
    • A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death
    • Ham J, Babij C, Whitfield J, Pfarr CM, Lallemand D, Yaniv M, Rubin LL (1995) A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 14:927-939.
    • (1995) Neuron , vol.14 , pp. 927-939
    • Ham, J.1    Babij, C.2    Whitfield, J.3    Pfarr, C.M.4    Lallemand, D.5    Yaniv, M.6    Rubin, L.L.7
  • 21
    • 0026569054 scopus 로고
    • Regions controlling hyperphosphorylation and conformation of the retinoblastoma gene product are independent of domains required for transcriptional repression
    • Hamel PA, Gill RM, Phillips RA, Gallie BL (1992) Regions controlling hyperphosphorylation and conformation of the retinoblastoma gene product are independent of domains required for transcriptional repression. Oncogene 7:693-701.
    • (1992) Oncogene , vol.7 , pp. 693-701
    • Hamel, P.A.1    Gill, R.M.2    Phillips, R.A.3    Gallie, B.L.4
  • 24
    • 0030850752 scopus 로고    scopus 로고
    • E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction
    • Hsieh JK, Fredersdorf S, Kouzarides T, Martin K, Lu X (1997) E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev 11:1840-1852.
    • (1997) Genes Dev , vol.11 , pp. 1840-1852
    • Hsieh, J.K.1    Fredersdorf, S.2    Kouzarides, T.3    Martin, K.4    Lu, X.5
  • 26
    • 0029819345 scopus 로고    scopus 로고
    • Dominant inhibitory Ras delays sindbis virus-induced apoptosis in neuronal cells
    • Joe AK, Ferrari G, Jiang HH, Liang XH, Levine B (1996) Dominant inhibitory Ras delays sindbis virus-induced apoptosis in neuronal cells. J Virol 70:7744-7751.
    • (1996) J Virol , vol.70 , pp. 7744-7751
    • Joe, A.K.1    Ferrari, G.2    Jiang, H.H.3    Liang, X.H.4    Levine, B.5
  • 27
    • 0032534625 scopus 로고    scopus 로고
    • Evidence for involvement of BAX and p53, but not caspases, in radiation-induced cell death of cultured postnatal hippocampal neurons
    • Johnson MD, Xiang H, London S, Kinoshita Y, Knudson M, Mayberg M, Korsmeyer SJ, Morrison RS (1998) Evidence for involvement of BAX and p53, but not caspases, in radiation-induced cell death of cultured postnatal hippocampal neurons. J Neurosci Res 54:721-733.
    • (1998) J Neurosci Res , vol.54 , pp. 721-733
    • Johnson, M.D.1    Xiang, H.2    London, S.3    Kinoshita, Y.4    Knudson, M.5    Mayberg, M.6    Korsmeyer, S.J.7    Morrison, R.S.8
  • 29
    • 0028267869 scopus 로고
    • DTRF1/E2F: An extended family of heterodimeric factors implicated in cell cycle control
    • La Thangue NB (1994) DTRF1/E2F: an extended family of heterodimeric factors implicated in cell cycle control. Trends Biochem Sci 19:108-114.
    • (1994) Trends Biochem Sci , vol.19 , pp. 108-114
    • La Thangue, N.B.1
  • 30
  • 31
    • 0029879510 scopus 로고    scopus 로고
    • Induction of DNA synthesis and apoptosis in cardiac myocytes by E1A oncoprotein
    • Liu Y, Kitsis RN (1996) Induction of DNA synthesis and apoptosis in cardiac myocytes by E1A oncoprotein. J Cell Biol 133:325-334.
    • (1996) J Cell Biol , vol.133 , pp. 325-334
    • Liu, Y.1    Kitsis, R.N.2
  • 32
    • 0029910628 scopus 로고    scopus 로고
    • Loss of RB activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
    • Macleod KF, Hu Y, Jacks T (1996) Loss of RB activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J 15:6178-6188.
    • (1996) EMBO J , vol.15 , pp. 6178-6188
    • Macleod, K.F.1    Hu, Y.2    Jacks, T.3
  • 33
    • 0032692497 scopus 로고    scopus 로고
    • CEP-1347 (KT7515). An inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by three distinct insults
    • Maroney A, Finn JP, Bozyczko-Coyne D, Kane T, Neff NT, Tolkovsky AM, Park DS, Yan CYI, Troy CM, Greene LA (1999) CEP-1347 (KT7515). an inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by three distinct insults. J Neurochem 73:1901-1912.
    • (1999) J Neurochem , vol.73 , pp. 1901-1912
    • Maroney, A.1    Finn, J.P.2    Bozyczko-Coyne, D.3    Kane, T.4    Neff, N.T.5    Tolkovsky, A.M.6    Park, D.S.7    Yan, C.Y.I.8    Troy, C.M.9    Greene, L.A.10
  • 35
    • 0030921323 scopus 로고    scopus 로고
    • Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease
    • McShea A, Harris PL, Webster KR, Wahl AF, Smith MA (1997) Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease. Am J Pathol 150:1933-1939.
    • (1997) Am J Pathol , vol.150 , pp. 1933-1939
    • McShea, A.1    Harris, P.L.2    Webster, K.R.3    Wahl, A.F.4    Smith, M.A.5
  • 36
    • 0029738086 scopus 로고    scopus 로고
    • Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: Evidence for cell-cycle independent toxicity
    • Morris EJ, Geller HM (1996) Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell-cycle independent toxicity. J Cell Biol 134:757-770.
    • (1996) J Cell Biol , vol.134 , pp. 757-770
    • Morris, E.J.1    Geller, H.M.2
  • 39
    • 0026526437 scopus 로고
    • E2F, a link between the Rb tumour suppressor protein and viral oncoproteins
    • Nevins JR (1992) E2F, a link between the Rb tumour suppressor protein and viral oncoproteins. Science 258:424-429.
    • (1992) Science , vol.258 , pp. 424-429
    • Nevins, J.R.1
  • 40
    • 0029615315 scopus 로고
    • Physical and functional interactions between p53 and cell cycle co-operating factors, E2F1 and DPI
    • O'Connor DJ, Lam E, Griffin S, Zhong S, Leighton LC, Burbidge SA, Lu X (1995) Physical and functional interactions between p53 and cell cycle co-operating factors, E2F1 and DPI. EMBO J 14:6184-6192.
    • (1995) EMBO J , vol.14 , pp. 6184-6192
    • O'Connor, D.J.1    Lam, E.2    Griffin, S.3    Zhong, S.4    Leighton, L.C.5    Burbidge, S.A.6    Lu, X.7
  • 41
    • 0026058318 scopus 로고
    • Cell death during development of the nervous system
    • Oppenheim RW (1991) Cell death during development of the nervous system. Annu Rev Neurosci 14:453-501.
    • (1991) Annu Rev Neurosci , vol.14 , pp. 453-501
    • Oppenheim, R.W.1
  • 42
    • 0033570320 scopus 로고    scopus 로고
    • Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis
    • Padmanabhan J, Park DS, Greene LA, Shelanski ML (1999) Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis. J Neurosci 19:8747-8756.
    • (1999) J Neurosci , vol.19 , pp. 8747-8756
    • Padmanabhan, J.1    Park, D.S.2    Greene, L.A.3    Shelanski, M.L.4
  • 43
    • 0029913242 scopus 로고    scopus 로고
    • Inhibitors of cyclindependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons
    • Park DS, Farinelli SE, Greene LA (1996a) Inhibitors of cyclindependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons. J Biol Chem 271:8161-8170.
    • (1996) J Biol Chem , vol.271 , pp. 8161-8170
    • Park, D.S.1    Farinelli, S.E.2    Greene, L.A.3
  • 44
    • 0029838165 scopus 로고    scopus 로고
    • Ordering the cell death pathway: Differential effects of Bcl-2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum/nerve growth factor-deprived PC12 cells
    • Park DS, Stefanis L, Van CYI, Farinclli SE, Greene LA (1996b) Ordering the cell death pathway: differential effects of Bcl-2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum/nerve growth factor-deprived PC12 cells. J Biol Chem 271:21898-21905.
    • (1996) J Biol Chem , vol.271 , pp. 21898-21905
    • Park, D.S.1    Stefanis, L.2    Van, C.Y.I.3    Farinclli, S.E.4    Greene, L.A.5
  • 45
    • 0031016498 scopus 로고    scopus 로고
    • G1/S cell cycle blockers and inhibitors of cyclin dependent kinases suppress camptothecin-induccd apoptosis
    • Park DS, Morris EJ, Greene LA, Geller HM (1997a) G1/S cell cycle blockers and inhibitors of cyclin dependent kinases suppress camptothecin-induccd apoptosis. J Neurosci 17:1256-1270.
    • (1997) J Neurosci , vol.17 , pp. 1256-1270
    • Park, D.S.1    Morris, E.J.2    Greene, L.A.3    Geller, H.M.4
  • 46
    • 0030694346 scopus 로고    scopus 로고
    • Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons
    • Park DS, Levine B, Ferrari G, Greene LA (1997b) Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons. J Neurosci 17:8975-8983.
    • (1997) J Neurosci , vol.17 , pp. 8975-8983
    • Park, D.S.1    Levine, B.2    Ferrari, G.3    Greene, L.A.4
  • 49
    • 0027173109 scopus 로고
    • Cyclins and cyclin-dependent kinases: Take your partners
    • Pines J (1993) Cyclins and cyclin-dependent kinases: take your partners. Trends Biochem Sci 18:195-197.
    • (1993) Trends Biochem Sci , vol.18 , pp. 195-197
    • Pines, J.1
  • 50
    • 0027947383 scopus 로고
    • Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
    • Qin XQ, Livingston DM, Kaclin Jr WG, Adams PD (1994) Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc Natl Acad Sci USA 91:10918-10922.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10918-10922
    • Qin, X.Q.1    Livingston, D.M.2    Kaclin W.G., Jr.3    Adams, P.D.4
  • 51
    • 0030069682 scopus 로고    scopus 로고
    • Disruption of RB/E2f-1 interaction by a single point mutation in E2f-1 enhances s-phase entry and apoptosis
    • Shan B, Durfee T. Lee W-H (1996) Disruption of RB/E2f-1 interaction by a single point mutation in E2f-1 enhances s-phase entry and apoptosis. Proc Natl Acad Sci USA 93:679-684.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 679-684
    • Shan, B.1    Durfee, T.2    Lee, W.-H.3
  • 54
    • 0033178444 scopus 로고    scopus 로고
    • Caspase-dependent and -independent death of camptothecin-treated embryonic cortical neurons
    • Stefanis L, Park DS, Friedman WJ, Greene LA (1999) Caspase-dependent and -independent death of camptothecin-treated embryonic cortical neurons. J Neurosci 19:6235-6247.
    • (1999) J Neurosci , vol.19 , pp. 6235-6247
    • Stefanis, L.1    Park, D.S.2    Friedman, W.J.3    Greene, L.A.4
  • 56
    • 0030899360 scopus 로고    scopus 로고
    • Degradation of retinoblastoma protein in tumor necrosis factor-and CD95-induced cell death
    • Tan X, Martin SJ, Green DR, Wang JY (1997) Degradation of retinoblastoma protein in tumor necrosis factor-and CD95-induced cell death. J Biol Chem 272:9613-9616.
    • (1997) J Biol Chem , vol.272 , pp. 9613-9616
    • Tan, X.1    Martin, S.J.2    Green, D.R.3    Wang, J.Y.4
  • 57
    • 0030667320 scopus 로고    scopus 로고
    • E2F activity is regulated by cell cycle-dependent changes in subcellular localization
    • Verona R, Moberg K, Estes S, Starz M, Vernon JP, Lees JA (1997) E2F activity is regulated by cell cycle-dependent changes in subcellular localization. Mol Cell Biol 17:7268-7282.
    • (1997) Mol Cell Biol , vol.17 , pp. 7268-7282
    • Verona, R.1    Moberg, K.2    Estes, S.3    Starz, M.4    Vernon, J.P.5    Lees, J.A.6
  • 58
    • 0031006939 scopus 로고    scopus 로고
    • Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain
    • Vincent I, Jicha G, Rosado M, Dickson DW (1997) Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain. J Neurosci 17:3588-3598.
    • (1997) J Neurosci , vol.17 , pp. 3588-3598
    • Vincent, I.1    Jicha, G.2    Rosado, M.3    Dickson, D.W.4
  • 59
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81:323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 60
    • 0030008768 scopus 로고    scopus 로고
    • Expression of dominant negative mutant DP-1 block cell cycle progression in G1
    • Wu C-L, Classon M, Dyson N, Harlow E (1996) Expression of dominant negative mutant DP-1 block cell cycle progression in G1. Mol Cell Biol 16:3698-3706.
    • (1996) Mol Cell Biol , vol.16 , pp. 3698-3706
    • Wu, C.-L.1    Classon, M.2    Dyson, N.3    Harlow, E.4
  • 61


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.