메뉴 건너뛰기




Volumn 6, Issue 12, 1999, Pages 1146-1153

Structure, function and regulation of p63 and p73

Author keywords

Apoptosis; c Abl; p53; p73

Indexed keywords

DNA; DNA BINDING PROTEIN; ONCOPROTEIN; PROTEIN P53; PROTEIN P63; PROTEIN P73; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VIRUS PROTEIN;

EID: 0033368883     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400624     Document Type: Review
Times cited : (110)

References (43)
  • 2
    • 0029972806 scopus 로고    scopus 로고
    • p53: Puzzle and paradigm
    • Ko LJ and Prives C (1996) p53: puzzle and paradigm. Genes Dev. 10: 1054-1072
    • (1996) Genes Dev. , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 3
    • 0031817863 scopus 로고    scopus 로고
    • Apoptosis and the cell cycle: The p53 connection
    • Choisy-Rossi C and Yonish-Rouach E (1998) Apoptosis and the cell cycle: the p53 connection. Cell Death Differ. 5: 129-131
    • (1998) Cell Death Differ. , vol.5 , pp. 129-131
    • Choisy-Rossi, C.1    Yonish-Rouach, E.2
  • 4
    • 0032161624 scopus 로고    scopus 로고
    • p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
    • Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dotsch V, Andrews NC, Caput D, McKeon F (1998) p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol. Cell 2: 305-316
    • (1998) Mol. Cell , vol.2 , pp. 305-316
    • Yang, A.1    Kaghad, M.2    Wang, Y.3    Gillett, E.4    Fleming, M.D.5    Dotsch, V.6    Andrews, N.C.7    Caput, D.8    McKeon, F.9
  • 8
    • 0033517321 scopus 로고    scopus 로고
    • New p73 variants with altered C-terminal structures have varied transcriptional activities
    • Ueda Y, Hijikata M, Takagi S, Chiba T, Shimotohno K (1999) New p73 variants with altered C-terminal structures have varied transcriptional activities. Oncogene 18: 4993-4998
    • (1999) Oncogene , vol.18 , pp. 4993-4998
    • Ueda, Y.1    Hijikata, M.2    Takagi, S.3    Chiba, T.4    Shimotohno, K.5
  • 9
    • 0033168066 scopus 로고    scopus 로고
    • Overexpression of the wild type p73 gene in breast cancer tissues and cell lines
    • Zaika Al, Kovalev S, Marchenko ND and Moll UM (1999) Overexpression of the wild type p73 gene in breast cancer tissues and cell lines. Cancer Res. 59: 3257-3263
    • (1999) Cancer Res. , vol.59 , pp. 3257-3263
    • Zaika, Al.1    Kovalev, S.2    Marchenko, N.D.3    Moll, U.M.4
  • 10
    • 0033026954 scopus 로고    scopus 로고
    • Different p73 splicing variants are expressed in distinct tumour areas of a multifocal neuroblastoma
    • Casciano I, Ponzoni M, Cunsolo C, Tonini G, Romani M (1999) Different p73 splicing variants are expressed in distinct tumour areas of a multifocal neuroblastoma. Cell Death Differ. 6: 391-393
    • (1999) Cell Death Differ. , vol.6 , pp. 391-393
    • Casciano, I.1    Ponzoni, M.2    Cunsolo, C.3    Tonini, G.4    Romani, M.5
  • 11
    • 0033603494 scopus 로고    scopus 로고
    • p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53
    • Davison TS, Vagner C, Kaghad M, Ayed A, Caput D, Arrowsmith CH (1999) p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53. J. Biol. Chem. 274: 18709-18714
    • (1999) J. Biol. Chem. , vol.274 , pp. 18709-18714
    • Davison, T.S.1    Vagner, C.2    Kaghad, M.3    Ayed, A.4    Caput, D.5    Arrowsmith, C.H.6
  • 12
    • 0032951530 scopus 로고    scopus 로고
    • p73 function is inhibited by tumor-derived p53 mutants in mammalian cells
    • Di Como CJ, Gaiddon C and Prives C (1999) p73 function is inhibited by tumor-derived p53 mutants in mammalian cells. Mol. Cell. Biol. 19: 1438-1449
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1438-1449
    • Di Como, C.J.1    Gaiddon, C.2    Prives, C.3
  • 13
    • 0033575719 scopus 로고    scopus 로고
    • Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain
    • Chi S-W, Ayeda A and Arrowsmith CH (1999) Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain. EMBO J. 18: 4438-4445
    • (1999) EMBO J. , vol.18 , pp. 4438-4445
    • Chi, S.-W.1    Ayeda, A.2    Arrowsmith, C.H.3
  • 14
    • 0031022602 scopus 로고    scopus 로고
    • SAM as a protein interaction domain involved in developmental regulation
    • Schultz J, Pointing CP, Hofman K and Bork P (1997) SAM as a protein interaction domain involved in developmental regulation. Protein Sci. 6: 249-253
    • (1997) Protein Sci. , vol.6 , pp. 249-253
    • Schultz, J.1    Pointing, C.P.2    Hofman, K.3    Bork, P.4
  • 15
    • 0031897589 scopus 로고    scopus 로고
    • Predicting functions from protein sequences-where are the bottlenecks?
    • Bork P, Koonin EV (1998) Predicting functions from protein sequences-where are the bottlenecks? Nature Genetics 18: 313-318
    • (1998) Nature Genetics , vol.18 , pp. 313-318
    • Bork, P.1    Koonin, E.V.2
  • 16
    • 0033564513 scopus 로고    scopus 로고
    • Identification of a transactivation activity in the COOH-terminal region of p73 which is impaired in the naturally occurring mutants found in human neuroblastomas
    • Takada N, Ozaki T, Ichimiya S, Todo S and Nakagawara A (1999) Identification of a transactivation activity in the COOH-terminal region of p73 which is impaired in the naturally occurring mutants found in human neuroblastomas. Cancer Res. 59: 2810-2814
    • (1999) Cancer Res. , vol.59 , pp. 2810-2814
    • Takada, N.1    Ozaki, T.2    Ichimiya, S.3    Todo, S.4    Nakagawara, A.5
  • 17
    • 0031564954 scopus 로고    scopus 로고
    • p73 is a human p53 related protein that can induce apoptosis
    • Jost CA, Marin MC and Kaelin Jr WG (1997) p73 is a human p53 related protein that can induce apoptosis. Nature 389: 191-194
    • (1997) Nature , vol.389 , pp. 191-194
    • Jost, C.A.1    Marin, M.C.2    Kaelin W.G., Jr.3
  • 18
    • 0032533514 scopus 로고    scopus 로고
    • The potential tumor suppressor p73 differentially regulates cellular p53 target genes
    • Zhu J, Jiang J, Zhou W, Chen X (1998) The potential tumor suppressor p73 differentially regulates cellular p53 target genes. Cancer Res. 58: 5061-5065
    • (1998) Cancer Res. , vol.58 , pp. 5061-5065
    • Zhu, J.1    Jiang, J.2    Zhou, W.3    Chen, X.4
  • 19
    • 0033595124 scopus 로고    scopus 로고
    • Promoter specificity and stability control of the p53-related protein p73
    • Lee CW and La Thangue NB (1999) Promoter specificity and stability control of the p53-related protein p73. Oncogene 18: 44171-44181
    • (1999) Oncogene , vol.18 , pp. 44171-44181
    • Lee, C.W.1    La Thangue, N.B.2
  • 20
    • 0033600234 scopus 로고    scopus 로고
    • The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
    • Gong JG, Costanzo A, Tamg HQ, Melino G, Kaelin WG, Levrero M and Wang JYJ (1999) The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399: 806-809
    • (1999) Nature , vol.399 , pp. 806-809
    • Gong, J.G.1    Costanzo, A.2    Tamg, H.Q.3    Melino, G.4    Kaelin, W.G.5    Levrero, M.6    Wang, J.Y.J.7
  • 21
    • 0033600240 scopus 로고    scopus 로고
    • Interaction of c-Abl and p73a and their collaboration to induce apoptosis
    • Agami R, Blandino G, Oren M, Shaul Y (1999) Interaction of c-Abl and p73a and their collaboration to induce apoptosis. Nature 399: 809-813
    • (1999) Nature , vol.399 , pp. 809-813
    • Agami, R.1    Blandino, G.2    Oren, M.3    Shaul, Y.4
  • 25
    • 0033536230 scopus 로고    scopus 로고
    • Mdm2 binds p73 alpha without targeting degradation
    • Balint E, Bates S, Vousden KH (1999) Mdm2 binds p73 alpha without targeting degradation. Oncogene 18: 3923-3929
    • (1999) Oncogene , vol.18 , pp. 3923-3929
    • Balint, E.1    Bates, S.2    Vousden, K.H.3
  • 28
    • 0032931517 scopus 로고    scopus 로고
    • The p53 pathway
    • Prives C and Hall PA. (1999) The p53 pathway. J. Pathol. 187: 112-126
    • (1999) J. Pathol. , vol.187 , pp. 112-126
    • Prives, C.1    Hall, P.A.2
  • 30
    • 0031596434 scopus 로고    scopus 로고
    • p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells int
    • Prabhu NS, Somasundaram K, Satyamoorthy K, Herlyn M, El-Deiry WS (1998) p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells Int. J. Oncol. 13: 5-9
    • (1998) J. Oncol. , vol.13 , pp. 5-9
    • Prabhu, N.S.1    Somasundaram, K.2    Satyamoorthy, K.3    Herlyn, M.4    El-Deiry, W.S.5
  • 31
    • 0032407889 scopus 로고    scopus 로고
    • The large T antigen of simian virus 40 binds and inactivates p53 but not p73
    • Dobbelstein M and Roth J (1998) The large T antigen of simian virus 40 binds and inactivates p53 but not p73. J. Gen. Virol. 79: 3079-3083
    • (1998) J. Gen. Virol. , vol.79 , pp. 3079-3083
    • Dobbelstein, M.1    Roth, J.2
  • 32
    • 0032417530 scopus 로고    scopus 로고
    • Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73
    • Higashino F, Pipas JM and Shenk T (1998) Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73. Proc. Natl. Acad. Sci. USA 95: 15683-15687
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 15683-15687
    • Higashino, F.1    Pipas, J.M.2    Shenk, T.3
  • 33
    • 0032933627 scopus 로고    scopus 로고
    • Distinct regulation of p53 and p73 activity by adenovirus E1A, E1B, and E4orf6 proteins
    • Steegenga WT, Shvarts A, Riteco N, Bos JL, Jochemsen AG (1999) Distinct regulation of p53 and p73 activity by adenovirus E1A, E1B, and E4orf6 proteins. Mol. Cell. Biol. 19: 3885-3894
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3885-3894
    • Steegenga, W.T.1    Shvarts, A.2    Riteco, N.3    Bos, J.L.4    Jochemsen, A.G.5
  • 34
    • 0030001373 scopus 로고    scopus 로고
    • Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor
    • Dobner T, Horikoshi N, Rubenwolf S, Shenk T (1996) Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor. Science 272: 1470-1473
    • (1996) Science , vol.272 , pp. 1470-1473
    • Dobner, T.1    Horikoshi, N.2    Rubenwolf, S.3    Shenk, T.4
  • 35
    • 0033536063 scopus 로고    scopus 로고
    • P19(ARF) stabilizes p53 by blocking nucleocytoplasmic shuttling of Mdm2
    • Tao W and Levine AJ (1999) P19(ARF) stabilizes p53 by blocking nucleocytoplasmic shuttling of Mdm2. Proc. Natl. Acad. Sci. USA 96: 6937-6941
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 6937-6941
    • Tao, W.1    Levine, A.J.2
  • 36
    • 0033000482 scopus 로고    scopus 로고
    • Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
    • Zhang Y and Xiong Y (1999) Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. Mol. Cell 5: 579-591
    • (1999) Mol. Cell , vol.5 , pp. 579-591
    • Zhang, Y.1    Xiong, Y.2
  • 38
    • 0032053793 scopus 로고    scopus 로고
    • Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers
    • Nomoto S, Haruki N, Kondo M, Konishi H, Takahashi T, Takahashi T and Takahashi T (1998) Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers. Cancer Res. 58, 1380-1383
    • (1998) Cancer Res. , vol.58 , pp. 1380-1383
    • Nomoto, S.1    Haruki, N.2    Kondo, M.3    Konishi, H.4    Takahashi, T.5    Takahashi, T.6    Takahashi, T.7
  • 39
    • 0032953808 scopus 로고    scopus 로고
    • Mutational and expression analysis of the p73 gene in melanoma cell lines
    • Tsao H, Zhang X, Majewski P and Haluska F (1999) Mutational and expression analysis of the p73 gene in melanoma cell lines. Cancer Res. 59: 172-174
    • (1999) Cancer Res. , vol.59 , pp. 172-174
    • Tsao, H.1    Zhang, X.2    Majewski, P.3    Haluska, F.4
  • 40
    • 0033379005 scopus 로고    scopus 로고
    • p53 family genes: Structural comparison, expression and mutation
    • Ikawa S, Nakagawara A, Ikawa Y (1999) p53 family genes: structural comparison, expression and mutation. Cell Death Differ. 6: 1154-1161
    • (1999) Cell Death Differ. , vol.6 , pp. 1154-1161
    • Ikawa, S.1    Nakagawara, A.2    Ikawa, Y.3
  • 41
    • 0033594491 scopus 로고    scopus 로고
    • p63 is a p53 homologue required for limb and epidermal morphogenesis
    • Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR and Bradley A(1999) p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398: 708-713
    • (1999) Nature , vol.398 , pp. 708-713
    • Mills, A.A.1    Zheng, B.2    Wang, X.J.3    Vogel, H.4    Roop, D.R.5    Bradley, A.6
  • 43
    • 0017698493 scopus 로고
    • Chromosomal aberrations in human neuroblastomas
    • Brodeur GM, Sekhon G and Goldestein MN (1977) Chromosomal aberrations in human neuroblastomas. Cancer 40: 2256-2263
    • (1977) Cancer , vol.40 , pp. 2256-2263
    • Brodeur, G.M.1    Sekhon, G.2    Goldestein, M.N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.