Expression of cell death-associated phospho-c-Jun and p53-activated gene 608 in hippocampal CA1 neurons following global ischemia

Molecular Brain Research

Volumn 73, Issue 1-2, 1999, Pages 138-143

  Gillardon, F ^a   Spranger, M ^b   Tiesler, C ^a   Hossmann, K A ^a  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

c Jun; Cerebral ischemia; JIP 1; JNK; p53; PAG608

Indexed keywords

PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CELL DEATH; CONTROLLED STUDY; GENE ACTIVATION; HIPPOCAMPUS; IMMUNOBLOTTING; IMMUNOREACTIVITY; MALE; NERVE CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BRAIN; CARRIER PROTEINS; CELL DEATH; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; ISCHEMIC ATTACK, TRANSIENT; MALE; NEURONS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, WISTAR; RNA, MESSENGER;

ANIMALIA; HIPPOCAMPUS HIPPOCAMPUS;

EID: 0032750216     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(99)00251-X     Document Type: Article

References (38)

1. Abe K., Aoki M., Kawagoe J., Yoshida T., Hattori A., Kogure K., Itoyama Y. Ischemic delayed neuronal death. A mitochondrial hypothesis. Stroke. 26:1995;1478-1489.
2. Adler V., Pincus M.R., Minamoto T., Fuchs S.Y., Bluth M.J., Brandt-Rauf P.W., Friedman F.K., Robinson R.C., Chen J.M., Wang X.W., Harris C.C., Ronai Z. Conformation-dependent phosphorylation of p53. Proc. Natl. Acad. Sci. U.S.A. 94:1997;1686-1691.
3. 2-terminal kinase kinase in the adult and developing rat brain: an in situ hybridization study. Neuroscience. 80:1997;147-160.
4. Cardone M.H., Salvesen G.S., Widmann C., Johnson G., Frisch S.M. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell. 90:1997;315-323.
5. Chen Y.R., Wang X., Templeton D., Davis R.J., Tan T.H. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ irradiation. Duration of JNK activation may determine cell death and proliferation. J. Biol. Chem. 271:1996;31929-31936.
6. Dickens M., Rogers J.S., Cavanagh J., Raitano A., Xia Z., Halpern J.R., Greenberg M.E., Sawyers C.L., Davis R.J. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science. 277:1997;693-696.
7. Elion E.A. Routing MAP kinase cascades. Science. 281:1998;1625-1626.
8. Frank L., Bruhn T., Diemer N.H. The effect of an AMPA antagonist (NBQX) on postischemic neuron loss and protein synthesis in the rat brain. Exp. Brain Res. 95:1993;70-76.
9. Fuchs S.Y., Adler V., Pincus M.R., Ronai Z. MEKK1/JNK signaling stabilizes and activates p53. Proc. Natl. Acad. Sci. U.S.A. 95:1998;10541-10546.
10. Gillardon F., Böttiger B., Hossmann K.-A. Expression of nuclear redox factor ref-1 in the rat hippocampus following global ischemia induced by cardiac arrest. Mol. Brain Res. 52:1997;194-200.
11. Gillardon F., Böttiger B., Schmitz B., Zimmermann M., Hossmann K.-A. Activation of CPP-32 protease in hippocampal neurons following ischemia and epilepsy. Mol. Brain Res. 50:1997;16-22.
12. Gillardon F., Krep H., Brinker G., Lenz C., Böttiger B., Hossmann K.-A. Induction of protein inhibitor of neuronal nitric oxide synthase/cytoplasmic dynein light chain following cerebral ischemia. Neuroscience. 84:1998;81-88.
13. Gillardon F., Kiprianova I., Sandkühler J., Hossmann K.-A., Spranger M., Inhibition of caspases prevents cell death of hippocampal CA1 neurons, but not impairment of hippocampal long-term potentiation following global ischemia, Neuroscience (in press).
14. Herdegen T., Claret F.-X., Kallunki T., Martin-Villalba A., Winter C., Hunter T., Karin M. Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury. J. Neurosci. 18:1998;5124-5135.
15. Hughes P.E., Alexi T., Schreiber S.S. A role for the tumour suppressor gene p53 in regulating neuronal apoptosis. NeuroReport. 8:1997;5-12.
16. Iadecola C. Bright and dark sides of nitric oxide in ischemic brain injury. Trends Neurosci. 20:1997;132-139.
17. Israeli D., Tessler E., Haupt Y., Elkeles A., Wilder S., Amson R., Telerman A., Oren M. A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis. EMBO J. 16:1997;4384-4392.
18. Kindy M.S. Inhibition of tyrosine phosphorylation prevents delayed neuronal cell death following cerebral ischemia. J. Cereb. Blood Flow Metab. 13:1993;372-377.
19. Kiprianova I., Freimann T., Desiderato S., Schwab S., Galmbacher R., Gillardon F., Spranger M. BDNF prevents neuronal death and glial activation after global ischemia in the rat. J. Neurosci. Res. 56:1999;21-27.
20. Kristián T., Siesjö B.K. Calcium in ischemic cell death. Stroke. 29:1998;705-718.
21. Kyriakis J.M., Avruch J. Sounding the alarm: protein kinase cascades activated by stress and inflammation. J. Biol. Chem. 271:1996;24313-24316.
22. Lander H.M., Jacovina A.T., Davis R.J., Tauras J.M. Differential activation of mitogen-activated protein kinases by nitric oxide-related species. J. Biol. Chem. 271:1996;19705-19709.
23. 2-terminal kinases. J. Biol. Chem. 271:1996;15703-15707.
24. Lowry O.H., Rosenbrough N.J., Farr A.L., Randall R.J. Protein measurements with the folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
25. MacManus J.P., Linnik M.D. Gene expression induced by cerebral ischemia: an apoptotic perspective. J. Cereb. Blood Flow Metab. 17:1997;815-832.
26. Maroney A.C., Glicksman M.A., Basma A.N., Walton K.M., Knight E., Murphy C.A., Bartlett B.A., Finn J.P., Angeles T., Matsuda Y., Neff N.T., Dionne C.A. Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway. J. Neurosci. 18:1998;104-111.
27. 3F12 SAP kinase. Mol. Brain Res. 35:1996;47-57.
28. McGahan L., Hakim A.M., Robertson G.S. Hippocampal myc and p53 expression following transient global ischemia. Mol. Brain Res. 56:1998;133-145.
29. Minden A., Lin A., Smeal T., Dérijard B., Cobb M., Davis R., Karin M. c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol. Cell. Biol. 14:1994;6683-6688.
30. Neumann-Haefelin T., Wiessner C., Vogel P., Back T., Hossmann K.-A. Differential expression of the immediate-early genes c-fos, c-jun, junB, and NGFI-B in the rat brain following transient forebrain ischemia. J. Cereb. Blood Flow Metab. 14:1994;206-216.
31. Sánchez-Perez I., Murguía J.R., Perona R. Cisplatin induces a persistent activation of JNK that is related to cell death. Oncogene. 16:1998;533-540.
32. Schwarzschild M.A., Cole R.L., Hyman S.E. Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1 mediated transcription in striatal neurons. J. Neurosci. 17:1997;3455-3466.
33. Varmeh-Ziaie S., Okan I., Wang Y., Magnusson K.P., Warthoe P., Strauss M., Widman K.G. Wig-1, a new p53-induced gene encoding a zinc finger protein. Oncogene. 15:1997;2699-2704.
34. Virdee K., Bannister A.J., Hunt S.P., Tolkovsky A.M. Comparison between the timing of JNK activation, c-Jun phosphorylation, and onset of death commitment in sympathetic neurones. J. Neurochem. 69:1997;550-561.
35. Watson A., Eilers A., Lallemand D., Kyriakis J., Rubin L.L., Ham J. Phosphorylation of c-jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons. J. Neurosci. 18:1998;751-762.
36. Whitmarsh A.J., Cavanagh J., Tournier C., Yasuda J., Davis R.J. A mammalian scaffold complex that selectively mediates MAP kinase activation. Science. 281:1998;1671-1674.
37. Xia Z., Dickens M., Raingeaud J., Davis R.J., Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 270:1995;1326-1331.
38. Yang D.D., Kuan C.Y., Whitmarsh A.j., Rincón M., Zheng T.S., Davis R.J., Rakic P., Flavell R.A. Absence of exitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature. 389:1997;865-870.