Status epilepticus induces p53 sequence-specific DNA binding in mature rat brain

Molecular Brain Research

Volumn 63, Issue 2, 1999, Pages 248-253

  Liu, Wei ^a   Rong, Yongqi ^a   Baudry, Michel ^a   Schreiber, Steven S ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Cycloheximide; DNA binding; Kainic acid; Neuronal apoptosis; P53; Seizure

Indexed keywords

CYCLOHEXIMIDE; KAINIC ACID; PROTEIN P53;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN; CONTROLLED STUDY; DNA BINDING; EPILEPTIC STATE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; MALE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN; CYCLOHEXIMIDE; GENE EXPRESSION REGULATION; GENES, P53; KAINIC ACID; MALE; NERVE DEGENERATION; PROTEIN SYNTHESIS INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; STATUS EPILEPTICUS; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0033534665     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(98)00285-X     Document Type: Article

References (35)

1. Bates S., Vousden K.H. p53 in signaling checkpoint arrest or apoptosis. Curr. Opin. Genet. Dev. 6:1996;12-18.
2. Canman C.E., Kastan M.B. Role of p53 in apoptosis. Adv. Pharmacol. 41:1997;429-460.
3. El Deiry W.S., Tokino T., Velculescu V.E., Levy D.B., Parsons R., Trent J.M., Lin D., Mercer W.E., Kinzler K.W., Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell. 75:1993;817-825.
4. Funk W.D., Pak D.T., Karas R.H., Wright W.E., Shay J.W. A transcriptionally active DNA-binding site for human p53 protein complexes. Mol. Cell. Biol. 12:1992;2866-2871.
5. Gillardon F., Wickert H., Zimmermann M. Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain. Neurosci. Lett. 192:1995;85-88.
6. Hansen R., Oren M. p53: from inductive signal to cellular effect. Curr. Opin. Genet. Dev. 7:1997;46-51.
7. Harper J.W., Adami G.R., Wei N., Keyomarsi K., Elledge S.J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 75:1993;805-816.
8. Haupt Y., Oren M. p53-mediated apoptosis: mechanisms and regulation. Behring Inst. Mitt. 97:1996;32-59.
9. Haupt Y., Rowan S., Shaulian E., Vousden K.H., Oren M. Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev. 9:1995;2170-2183.
10. Hollstein M., Rice K., Greenblatt M.S., Soussi T., Fuchs R., Sorlie T., Hovig E., Smith Sorensen B., Montesano R., Harris C.C. Database of p53 gene somatic mutations in human tumors and cell lines. Nucleic Acids Res. 22:1994;3551-3555.
11. Hughes P.E., Alexi T., Schreiber S.S. A role for the tumor suppressor gene p53 in regulating neuronal apoptosis. NeuroReport. 8:1997;5-12.
12. Hupp T.R., Meek D.W., Midgley C.A., Lane D.P. Regulation of the specific DNA binding function of p53. Cell. 71:1992;875-886.
13. Kastan M.B., Onyekwere O., Sidransky D., Vogelstein B., Craig R.W. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51:1991;6304-6311.
14. Kastan M.B., Zhan Q., El Deiry W.S., Carrier F., Jacks T., Walsh W.V., Plunkett B.S., Vogelstein B., Fornace A.J. Jr. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell. 71:1992;587-597.
15. Maiyar A.C., Huang A.J., Phu P.T., Cha H.H., Firestone G.L. p53 stimulates promoter activity of the sgk. serum/glucocorticoid-inducible serine/threonine protein kinase gene in rodent mammary epithelial cells. J. Biol. Chem. 271:1996;12414-12422.
16. Maltzman W., Czyzyk L. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol. Cell. Biol. 4:1984;1689-1694.
17. Miyashita T., Reed J.C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell. 80:1995;293-299.
18. Morrison R.S., Wenzel H.J., Kinoshita Y., Robbins C.A., Donehower L.A., Schwartzkroin P.A. Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death. J. Neurosci. 16:1996;1337-1345.
19. Nadler J.V., Okazaki M.M., Gruenthal M., Ault B., Armstrong D.R. Kainic acid seizures and neuronal cell death: insights from studies of selective lesions and drugs. Adv. Exp. Med. Biol. 203:1986;673-686.
20. Pavletich N.P., Chambers K.A., Pabo C.O. The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots. Genes Dev. 7:1993;2556-2564.
21. Pollard H., Cantagrel S., Charriaut Marlangue C., Moreau J., Ben Ari Y. Apoptosis associated DNA fragmentation in epileptic brain damage. NeuroReport. 5:1994;1053-1055.
22. Polyak K., Xia Y., Zweier J.L., Kinzler K.W., Vogelstein B. A model for p53-induced apoptosis. Nature. 389:1997;300-305.
23. Sabbatini P., Lin J., Levine A.J., White E. Essential role for p53-mediated transcription in E1A-induced apoptosis. Genes Dev. 9:1995;2184-2192.
24. Sakhi S., Bruce A., Sun N., Tocco G., Baudry M., Schreiber S.S. p53 induction is associated with neuronal damage in the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 91:1994;7525-7529.
25. Sakhi S., Sun N., Wing L.L., Mehta P., Schreiber S.S. Nuclear accumulation of p53 protein following kainic acid-induced seizures. NeuroReport. 7:1996;493-496.
26. Schreiber S.S., Tocco G., Najm I., Thompson R.F., Baudry M. Cycloheximide prevents kainate-induced neuronal death and c-fos expression in adult rat brain. J. Mol. Neurosci. 4:1993;149-159.
27. Simonian N.A., Getz R.L., Leveque J.C., Konradi C., Coyle J.T. Kainic acid induces apoptosis in neurons. Neuroscience. 75:1996;1047-1055.
28. Sionov R.V., Haupt Y. Apoptosis by p53: mechanisms, regulation, and clinical implications. Springer Semin. Immunopathol. 19:1998;345-362.
29. Smith M.L., Chen I.T., Zhan Q., Bae I., Chen C.Y., Gilmer T.M., Kastan M.B., PM O.C., Fornace A.J. Jr. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science. 266:1994;1376-1380.
30. Sonnenberg J.L., Mitchelmore C., Macgregor Leon P.F., Hempstead J., Morgan J.I., Curran T. Glutamate receptor agonists increase the expression of Fos, Fra, and AP-1 DNA binding activity in the mammalian brain. J. Neurosci. Res. 24:1989;72-80.
31. Ullrich S.J., Anderson C.W., Mercer W.E., Appella E. The p53 tumor suppressor protein, a modulator of cell proliferation. J. Biol. Chem. 267:1992;15259-15262.
32. Xiang H., Kinoshita Y., Knudson C.M., Korsmeyer S.J., Schwartzkroin P.A., Morrison R.S. Bax involvement in p53-mediated neuronal cell death. J. Neurosci. 18:1998;1363-1373.
33. Yonish Rouach E., Deguin V., Zaitchouk T., Breugnot C., Mishal Z., Jenkins J.R., May E. Transcriptional activation plays a role in the induction of apoptosis by transiently transfected wild-type p53. Oncogene. 11:1995;2197-2205.
34. Yonish Rouach E., Grunwald D., Wilder S., Kimchi A., May E., Lawrence J.J., May P., Oren M. p53-mediated cell death: relationship to cell cycle control. Mol. Cell. Biol. 13:1993;1415-1423.
35. Zhan Q., Carrier F., Fornace A.J. Jr. Induction of cellular p53 activity by DNA-damaging agents and growth arrest. Mol. Cell. Biol. 13:1993;4242-4250.