Proteases to die for

Genes and Development

Volumn 12, Issue 11, 1998, Pages 1551-1570

  Cryns, Vincent ^a   Yuan, Junying ^b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; PROTEINASE;

APOPTOSIS; CELL DEATH; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW;

EID: 2642689658     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.11.1551     Document Type: Review

References (238)

1. Ahmad, M., S.M. Srinivasula, L. Wang, R.V. Talanian, G. Litwack, T. Fernandes-Alnemri, and E. Alnemri. 1997. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Res. 57: 615-619.
2. Alnemri, E.S., D.J. Livingston, D.W. Nicholson, G. Salvesen, N.A. Thornberry, W.W. Wong, and J. Yuan. 1996. Human ICE/CED-3 protease nomenclature. Cell 87: 171.
3. Ambrosini, G., C. Adida, and D.C. Altieri. 1997. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nature Med. 3: 917-921.
4. Antonsson, B., F. Conti, A. Ciavatta, S. Montessuit, S. Lewis, I. Martinou, L. Bernasconi, A. Bernard, J.-J. Mermod, G. Mazzei, K. Maundrell, F. Gambale, R. Sadoul, and J.-C. Martinou. 1997. Inhibition of Bax channel-forming activity by Bcl-2. Science 277: 370-372.
5. Armstrong, R.C., T. Aja, J. Xiang, S. Gaur, J.F. Krebs, K. Hoang, X. Bai, S.J. Korsmeyer, D.S. Karanewsky, L.C. Fritz, and K.J. Tomaselli. 1996. Fas-induced activation of the cell death-related protease CPP32 is inhibited by Bcl-2 and by ICE family protease inhibitors. J. Biol. Chem. 271: 16850-16855.
6. Barkett, M., D. Xue, H.R. Horvitz, and T.D. Gilmore. 1997. Phosphorylation of IκB-α inhibits its cleavage by caspase CPP32 in vitro. J. Biol. Chem. 272: 29419-29422.
7. Bergeron, L., G.I. Perez, G. McDonald, L. Shi, Y. Sun, A. Jurisicova, S. Varmuza, K.E. Latham, J.A. Flaws, J.C.M. Salter, H. Hara, M.A. Moskowitz, E. Li, A.H. Greenberg, J. Tilly, and J. Yuan. 1998. Defects in regulation of apoptosis in caspase-2-deficient mice. Genes & Dev. 12: 1304-1314.
8. Bertin, J., S.M. Mendrysa, D.J. LaCount, S. Gaur, J.F. Krebs, R.C. Armstrong, K.J. Tomaselli, and P.D. Friesen. 1996. Apoptotic suppression by baculovirus P35 involves cleavage by and inhibition of a virus-induced CED-3/ICE-like protease. J. Virol. 70: 6251-6259.
9. Bertin, J., R. Armstrong, S. Ottilie, D. Martin, Y. Wang, S. Banks, G. Wang, T. Senkevich, E. Alnemri, B. Moss, M. Lenardo, K. Tomaselli, and J. Cohen. 1997. Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas-and TNFR1-induced apoptosis. Proc. Natl. Acad. Sci. 94: 1172-1176.
10. Beyaert, R., V.J. Kidd, S. Cornelis, M. Van de Craen, G. Denecker, J.M. Lahti, R. Gururajan, P. Vandenabeele, and W. Fiers. 1997. Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor. J. Biol. Chem. 272: 11694-11697.
11. L can inhibit apoptosis in cells that have undergone Fas-induced protease activation. Proc. Natl. Acad. Sci. 94: 3759-3764.
12. Boldin, M.P., T.M. Goncharov, Y.V. Goltsev, and D. Wallach. 1996. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1-and TNF receptor-induced cell death. Cell 85: 803-815.
13. Boldin, M.P., E.E. Varfolomeev, Z. Pancer, I.L. Mett, J.H. Camonis, and D. Wallach. 1995. A novel protein that interacts with the death domain of Fas/APO-1 contains a sequence motif related to the death domain. J. Biol. Chem. 270: 7795-7798.
14. Bossy-Wetzel, E., D.D. Newmeyer, and D.R. Green. 1998. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J. 17: 37-49.
15. Boudreau, N., C.J. Sympson, Z. Werb, and M.J. Bissell. 1995. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 267: 891-893.
16. Brancolini, C., M. Benedetti, and C. Schneider. 1995. Microfilament reorganization during apoptosis: The role of Gas2, a possible substrate for ICE-like proteases. EMBO J. 14: 5179-5190.
17. Brancolini, C., D. Lazarevic, and C. Schneider. 1997. Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of β-catenin. J. Cell. Biol. 139: 759-771.
18. Bump, N.J., M. Hackett, M. Hugunin, S. Seshagiri, K. Brady, P. Chen, C. Ferenz, S. Franklin, T. Ghayur, P. Li, P. Licari, J. Mankovich, L. Shi, A.M. Greenberg, L.K. Miller, and W.W. Wong. 1995. Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35. Science 269: 1885-1888.
19. Cardone, M.H., G.S. Salvesen, C. Widmann, G. Johnson, and S.M. Frisch. 1997. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell 90: 315-323.
20. Casciola-Rosen, L.A., D.K. Miller, G.J. Anhalt, and A. Rosen. 1994. Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death. J. Biol. Chem. 269: 30757-30760.
21. Casciola-Rosen, L.A., G.J. Anhalt, and A. Rosen. 1995. DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. J. Exp. Med. 182: 1625-1634.
22. Casciola-Rosen, L., D.W. Nicholson, T. Chong, K.R. Rowan, N.A. Thornberry, D.K. Miller, and A. Rosen. 1996. Apopain/ CPP32 cleaves proteins that are essential for cellular repair: A fundamental principle of apoptotic death. J. Exp. Med. 183: 1957-1964.
23. Caulín, C., G.S. Salvesen, and R.G. Oshima. 1997. Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. J. Cell Biol. 138: 1379-1394.
24. Cerretti, D.P., C.J. Kozlosky, B. Mosley, N. Nelson, K. Van Ness, T.A. Greenstreet, C.J. March, S.R. Kronheim, T. Druck, L.A. Cannizzaro, K. Huebner, and R.A. Black. 1992. Molecular cloning of the interleukin-1β converting enzyme. Science 256: 97-100.
25. Chaudhary, P.M., M. Eby, A. Jasmin, A. Bookwalter, J. Murray, and L. Hood. 1997. Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-κB. Immunity 7: 821-830.
26. Chauhan, D., P. Pandey, A. Ogata, G. Teoh, N. Krett, R. Halgren, S. Rosen, D. Kufe, S. Kharbanda, and K. Anderson. 1997. Cytochrome c-dependent and -independent induction of apoptosis in multiple myeloma cells. J. Biol. Chem. 272: 29995-29997.
27. Chen, L., V. Marechal, J. Moreau, A.J. Levine, and J. Chen. 1997. Proteolytic cleavage of the mdm2 oncoprotein during apoptosis. J. Biol. Chem. 272: 22966-22973.
28. Chen, Y.R., C.F. Meyer, and T.H. Tan. 1996. Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis. J. Biol. Chem. 271: 631-634.
29. Cheng, E.H.Y., D.G. Kirsch, R.J. Clem, R. Ravi, M.B. Kastan, A. Bedi, K. Ueno, and J.M. Hardwick. 1997. Conversion of Bcl-2 to a Bax-like death effector by caspases. Science 278: 1966-1968.
30. Chinnaiyan, A.M., K. O'Rourke, M. Tewari, and V.M. Dixit. 1995. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81: 505-512.
31. Chinnaiyan, A.M., K. O'Rourke, G.-L. Yu, R.H. Lyons, M. Garg, D.R. Duan, L. Xing, R. Gentz, J. Ni, and V.M. Dixit. 1996a. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 274: 990-992.
32. L function upstream of the CED-3-like apoptotic proteases. J. Biol. Chem. 271: 4573-4576.
33. Chinnaiyan, A.M., C.G. Tepper, M.F. Seldin, K. O'Rourke, F.C. Kischkel, S. Hellbardt, P.H. Krammer, M.E. Peter, and V.M. Dixit. 1996c. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J. Biol. Chem. 271: 4961-4965.
34. Chinnaiyan, A.M., D. Chaudhary, K. O'Rourke, E.V. Koonin, and V.M. Dixit. 1997a. Role of CED-4 in the activation of CED-3. Nature 388: 728-729.
35. Chinnaiyan, A.M., K. O'Rourke, B.R. Lane, and V.M. Dixit. 1997b. Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death. Science 275: 1122-1126.
36. Chu, Z.-L., T.A. McKinsey, L. Liu, J.J. Gentry, M.H. Malim, and D.W. Ballard. 1997. Suppression of tumor necrosis factor-induced cell death by inhibitor or apoptosis C-IAP2 is under NF-κB control. Proc. Natl. Acad. Sci. 94: 10057-1062.
37. Clem, R.J. and L.K. Miller. 1994. Control of programmed cell death by the baculovirus genes p35 and iap. Mol. Cell. Biol. 14: 5212-5222.
38. L through caspase interaction. Proc. Natl. Acad. Sci. 95: 554-559.
39. Cosulich, S.C., H. Horiuchi, M. Zerial, P.R. Clarke, and P.G. Woodman. 1997. Cleavage of rabaptin-5 blocks endosome fusion during apoptosis. EMBO J. 16: 6182-6191.
40. Crook, N.E., R.J. Clem, and L.K. Miller. 1993. An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif. J. Virol. 67: 2168-2174.
41. Cryns, V. and J. Yuan. 1998. The cutting edge: Caspases in apoptosis and disease. In When cells die: A comprehensive evaluation of apoptosis and programmed cell death (ed. Z. Zakeri, J. Tilly, and R. Lockshin), pp. 177-210. John Wiley & Sons, New York, NY.
42. Cryns, V.L., L. Bergeron, H. Zhu, H. Li, and J. Yuan. 1996. Specific cleavage of α-fodrin during Fas-and tumor necrosis factor-induced apoptosis is mediated by an interleukin-1β-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease. J. Biol. Chem. 271: 31277-31282.
43. Cryns, V., Y. Byun, A. Rana, H. Mellor, K. Lustig, P. Parker, M. Kirschner, and J. Yuan. 1997. Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis: Identification by a novel small pool expression cloning strategy. J. Biol. Chem. 272: 29449-29453.
44. Datta, R., H. Kojima, K. Yoshida, and D. Kufe. 1997. Caspase-3-mediated cleavage of protein kinase C θ in induction of apoptosis. J. Biol. Chem. 272: 20317-20320.
45. Degli-Esposti, M.A., W.C. Dougall, P.J. Smolak, J.Y. Waugh, C.A. Smith, and R.G. Goodwin. 1997. The novel receptor TRAIL-R4 induces NF-κB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity 7: 813-820.
46. Deveraux, Q.L., R. Takahashi, G.S. Salvesen, and J.C. Reed. 1997. X-linked IAP is a direct inhibitor of cell-death proteases. Nature 388: 300-304.
47. Dimmeler, S. and A.M. Zeiher. 1997. Nitric oxide and apoptosis: Another paradigm for the double-edged role of nitric oxide. Nitric Oxide 1: 275-281.
48. Duan, H. and V.M. Dixit. 1997. RAIDD is a new 'death' adaptor molecule. Nature 385: 86-89.
49. Duan, H., A.M. Chinnaiyan, P.L. Hudson, J.P. Wing, W.-W. He, and V.M. Dixit. 1996. ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas-and tumor necrosis factor-induced apoptosis. J. Biol. Chem. 271: 1621-1625.
50. Duckett, C.S., V.E. Nava, R.W. Gedrich, R.J. Clem, J.L. Van Dongen, M.C. Gilfillan, H. Shiels, J.M. Hardwick, and C.B. Thompson. 1996. A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. EMBO J. 15: 2685-2694.
51. L and cytochrome c. Mol. Cell Biol. 18: 608-615.
52. Emoto, Y., Y. Manome, G. Meinhardt, H. Kisaki, S. Kharbanda, M. Robertson, T. Ghayur, W.W. Wong, R. Kamen, R. Weichselbaum, and D. Kufe. 1995. Proteolytic activation of protein kinase C δ by an ICE-like protease in apoptotic cells. EMBO J. 14: 6148-6156.
53. Enari, M., H. Hug, and S. Nagata. 1995. Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature 375: 78-81.
54. Enari, M., R.V. Talanian, W.W. Wong, and S. Nagata. 1996. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 380: 723-726.
55. Enari, M., H. Sakahira, H. Yokoyama, K. Okawa, A. Iwamatsu, and S. Nagata. 1998. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391: 43-50.
56. Erhardt, P., K. Tomaselli, and G. Cooper. 1997. Identification of the MDM2 oncoprotein as a substrate for CPP32-like apoptotic proteases. J. Biol. Chem. 272: 15049-15052.
57. Faleiro, L., R. Kobayashi, H. Fearnhead, and Y. Lazebnick. 1997. Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells. EMBO J. 16: 2271-2281.
58. Fernandes-Alnemri, T., G. Litwack, and E.S. Alnemri. 1994. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein ced-3 and mammalian interleukin-1B-converting enzyme. J. Biol. Chem. 269: 30761-30764.
59. Fernandes-Alnemri, T., R.C. Armstrong, J. Krebs, S.M. Sririvasula, L. Wang, F. Bullrich, L.C. Fritz, J.A. Trapani, K.J. Tomaselli, G. Litwack, and E.S. Alnemri. 1996. In vitro activation of CPP32 and Mch3 by Mch4, a novel apoptotic cysteine protease containing two FADD-like domains. Proc. Natl. Acad. Sci. 93: 7464-7469.
60. Fraser, A. and G. Evan. 1996. A license to kill. Cell 85: 781-784.
61. Friedlander, R.M., V. Gagliardini, R.J. Rotello, and J. Yuan. 1996. Functional role of interleukin 1β (IL-1β) in IL-1β-converting enzyme-mediated apoptosis. J. Exp. Med. 184: 717-724.
62. Friedlander, R.M., R.H. Brown, V. Gagliardini, J. Wang, and J. Yuan. 1997a. Inhibition of ICE slows ALS in mice. Nature 388: 31.
63. Friedlander, R.M., V. Gagliardini, H. Hara, K.B. Fink, W. Li, G. MacDonald, M.C. Fishman, A.H. Greenberg, M.A. Moskowitz, and J. Yuan. 1997b. Expression of a dominant negative mutant of interleukin-1 β converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury. J. Exp. Med. 185: 933-940.
64. Gagliardini, V., P.-A. Fernandez, R.K.K. Lee, H.C.A. Drexler, R.J. Rotello, M.C. Fishman, and J. Yuan. 1994. Prevention of vertebrate neuronal death by the crmA gene. Science 263: 826-828.
65. Ghayur, T., M. Hugunin, R.V. Talanian, S. Ratnofsky, C. Quinlan, Y. Emoto, P. Pandey, R. Datta, Y. Huang, S. Kharbanda, H. Allen, R. Kamen, W. Wong, and D. Kufe. 1996. Proteolytic activation of protein kinase C δ by an ICE/CED 3-like protease induces characteristics of apoptosis. J. Exp. Med. 184: 2399-2404.
66. Goldberg, Y.P., D.W. Nicholson, D.M. Rasper, M.A. Kalchman, H.B. Koide, R.K. Graham, M. Bromm, P. Kazemi-Esfarjani, N.A. Thornberry, J.P. Vaillancourt, and M.R. Hayden. 1996. Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. Nature Genet. 13: 442-449.
67. Golstein, P. 1997a. Controlling cell death. Science 275: 1081-1082.
68. _. 1997b. TRAIL and its receptors. Curr. Biol. 7: R750-R753.
69. Goltsev, Y.V., A.V. Kovalenko, E. Arnold, E.E. Varfolomeev, V.M. Brodianksi, and D. Wallach. 1997. CASH, a novel caspase homolog with death effector domains. J. Biol. Chem. 272: 19641-19644.
70. Gottlieb, R.A., J. Nordberg, E. Skowronski, and B.M. Babior. 1996. Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification. Proc. Natl. Acad. Sci. 93: 654-658.
71. Grandgirard, D., E. Studer, L. Monney, T. Belser, I. Fellay, C. Borner, and M.R. Michel. 1998. Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: Evidence for a caspase-mediated, proteolytic inactivation of Bcl-2. EMBO J. 17: 1268-1278.
72. Greidinger, E.L., D.K. Miller, T.-T. Yamin, L. Casciola-Rosen, and A. Rosen. 1996. Sequential activation of three distinct ICE-like activities in Fas-ligated Jurkat cells. FEBS Lett. 390: 299-303.
73. Han, D.K.M., P.M. Chaudhary, M.E. Wright, C. Friedman, B.J. Trask, R.T. Riedel, D.G. Baskin, S.M. Schwartz, and L. Hood. 1997. MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death. Proc. Natl. Acad. Sci. 94: 11333-11338.
74. Han, Z., N. Malik, T. Carter, W.H. Reeves, J.H. Wyche, and E.A. Hendrickson. 1996. DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease. J. Biol. Chem. 271: 25035-25040.
75. Hara, H., R.M. Friedlander, V. Gagliardini, C. Ayata, K. Fink, Z. Huang, M. Shimizu-Sasamata, J. Yuan, and M.A. Moskowitz. 1997. Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc. Natl. Acad. Sci. 94: 2007-2012.
76. Hawkins, C.J., A.G. Uren, G. Hacker, R.L. Medcalf, and D.L. Vaux. 1996. Inhibition of interleukin 1 β-converting enzyme-mediated apoptosis of mammalian cells by baculovirus IAP. Proc. Natl. Acad. Sci. 93: 13786-13790.
77. Hengartner, M. 1997. CED-4 is a stranger no more. Nature 388: 714-715.
78. _. 1998. Death cycle and Swiss army knives. Nature 391: 441.
79. Hengartner, M.O. and H.R. Horvitz. 1994. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 76: 665-676.
80. Hengartner, M., R.E. Ellis, and H.R. Horvitz. 1992. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature 356: 494-499.
81. Hockenbery, D.M., Z.N. Oltvai, X.-M. Yin, C.L. Milliman, and S.J. Korsmeyer. 1993. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75: 241-251.
82. Hofmann, K., P. Bucher, and J. Tschopp. 1997. The CARD domain: A new apoptotic signalling motif. Trends Biochem. Sci. 22: 155-156.
83. Hsu, H., J. Xiong, and D.V. Goeddel. 1995. The TNF receptor1-associated protein TRADD signals cell death and NF-κB activation. Cell 81: 495-504.
84. Hsu, H., H.-B. Shu, M.-P. Pan, and D.V. Goeddel. 1996. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor-1 signal transduction pathways. Cell 84: 299-308.
85. Hu, S., C. Vincenz, J. Ni, R. Gentz, and V.M. Dixit. 1997. I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95-induced apoptosis. J. Biol. Chem. 272: 17255-17257.
86. Inohara, N., T. Koseki, Y. Hu, S. Chen, and G. Núñez. 1997. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis. Proc. Natl. Acad. Sci. 94: 10717-10722.
87. Irmler, M., K. Hofmann, D. Vaux, and J. Tschopp. 1997a. Direct physical interaction between the Caenorhabditis elegans "death proteins" CED-3 and CED-4. FEBS Lett. 406: 189-190.
88. Irmler, M., M. Thome, M. Hahne, P. Schneider, K. Hofmann, V. Steiner, J.-L. Bodmer, M. Schröter, K. Bums, C. Mattmann, D. Rimoldi, L. French, and J. Tschopp. 1997b. Inhibition of death receptor signals by cellular FLIP. Nature 388: 190-195.
89. Janicke, R.U., P.A. Walker, X.Y. Lin, and A.G. Porter. 1996. Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis. EMBO J. 15: 6969-7698.
90. Kayalar, C., T. Örd, M.P. Testa, L.-T. Zhong, and D.E. Bredesen. 1996. Cleavage of actin by interleukin 1β-converting enzyme to reverse DNase I inhibition. Proc. Natl. Acad. Sci. 93: 2234-2238.
91. Kerr, J.F.R., A.H. Wyllie, and A.R. Currie. 1972. Apoptosis: A basic biological phenomenon with wide-ranging implication in tissue kinetics. Br. J. Cancer 26: 239-257.
92. L as an inhibitor of cytosolic cytochrome c accumulation in DNA-damage induced apoptosis. Proc. Natl. Acad. Sci. 94: 6939-6942.
93. Kim, T.-W., W.H. Pettingell, Y.-K. Jung, D.M. Kovacs, and R.E. Tanzi. 1997a. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 277: 373-376.
94. Kim, Y.-M., R.V. Talanian, and T.R. Billiar. 1997b. Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. J. Biol. Chem. 272: 31138-31148.
95. Kitson, J., T. Raven, Y.-P. Jiang, D.V. Goeddel, K.M. Giles, K.-T. Pun, C.J. Grinham, R. Brown, and S.N. Farrow. 1996. A death-domain-containing receptor that mediates apoptosis. Nature 384: 372-375.
96. Kluck, R.M., E. Bossy-Wetzel, D.R. Green, and D.D. Newmeyer. 1997a. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science 275: 1132-1136.
97. Kluck, R.M., S.J. Martin, B.M. Hoffman, J.S. Zhou, D.R. Green, and D.D. Newmeyer. 1997b. Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system. EMBO J. 16: 4639-4649.
98. Knaus, U., S. Morris, H. Dong, J. Chernoff, and G. Bokoch. 1995. Regulation of human leukocyte p21-activated kinases through G-protein-coupled receptors. Science 269: 221-223.
99. Komiyama, T., C.A. Ray, D.J. Pickup, A.D. Howard, N.A. Thornberry, E.P. Peterson, and G. Salvesen. 1994. Inhibition of the interleukin-1β converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. J. Biol. Chem. 269: 19331-19337.
100. Kothakota, S., T. Azuma, C. Reinhard, A. Klippel, J. Tang, K. Chu, T.J. McGarry, M.W. Kirschner, K. Koths, D.J. Kwiatkowski, and L.T. Williams. 1997. Caspase-3-generated fragment of gelsolin: Effector of morphological change in apoptosis. Science 278: 294-298.
101. Krajewski, S., S. Tanaka, S. Takayama, M.J. Schibler, W. Fenton, and J.C. Reed. 1993. Investigation of the subcellular distribution of the Bcl-2 oncoprotein: Residence in the nuclear envelop, endoplasmic reticulum, and the outer mitochondrial membranes. Cancel Res. 53: 4701-4714.
102. Ku, N.-O., J. Liao, and M.B. Omary. 1997. Apoptosis generates stable fragments of human type I keratins. J. Biol. Chem. 272: 33197-33203.
103. Kuida, K., J.A. Lippke, G. Ku, M.W. Harding, D.J. Livingston, M.S.-S. Su, and R.A. Flavell. 1995. Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme. Science 267: 2000-2002.
104. Kuida, K., T.S. Zheng, S. Na, C.-y. Kuan, D. Yang, H. Karasuyama, P. Rakic, and R.A. Flavell. 1996. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384: 368-372.
105. Kumar, S., M. Kinoshita, M. Noda, N.G. Copeland, and N.A. Jenkins. 1994. Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1β-converting enzyme. Genes & Dev. 8: 1613-1626.
106. Kwiatkowski, D., T. Stossel, S. Orkin, J. Mole, H. Colten, and H. Yin. 1986. Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain. Nature 323: 455-458.
107. Lahti, J.M., J. Xiang, L.S. Heath, D. Campana, and V.J. Kidd. 1995. PITSLRE protein kinase activity is associated with apoptosis. Mol. Cell. Biol. 15: 1-11.
108. Lazebnik, Y.A., S.H. Kaufmann, S. Desnoyers, G.G. Poirier, and W.C. Earnshaw. 1994. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371: 346-347.
109. Lazebnik, Y.A., A. Takahashi, R.D. Moir, R.D. Goldman, G.G. Poirier, S.H. Kaufmann, and W.C. Earnshaw. 1995. Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc. Natl. Acad. Sci. 92: 9042-9046.
110. Lee, N., H. MacDonald, C. Reinhard, R. Halenbeck, A. Roulston, T. Shi, and L.T. Williams. 1997. Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis. Proc. Natl. Acad. Sci. 94: 13642-13647.
111. L has activity independent of cytochrome c release. J. Biol. Chem. 272: 30299-30305.
112. Li, H., L. Bergeron, V. Cryns, M. Pasternack, H. Zhu, L. Shi, A. Greenberg, and J. Yuan. 1997. Activation of caspase-2 in apoptosis. J. Biol. Chem. 272: 21010-21017.
113. Li, J., T.R. Billiar, R.V. Talanian, and Y.M. Kim. 1997. Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation. Biochem. Biophys. Res. Commun. 240: 419-424.
114. Li, P., H. Allen, S. Banerjee, S. Franklin, L. Herzog, C. Johnston, J. McDowell, M. Paskind, L. Rodman, J. Salfeld, E. Towne, D. Tracey, S. Wardwell, F.-Y. Wei, W. Wong, R. Kamen, and T. Seshadri. 1995. Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock. Cell 80: 401-411.
115. Li, P., D. Nijhawan, I. Budihardjo, S.M. Srinivasula, M. Ahmad, E.S. Alnemri, and X. Wang. 1997. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489.
116. Liston, P., N. Roy, K. Tamai, C. Lefebvre, S. Baird, G. Cherton-Horvat, R. Farahani, M. McLean, J.E. Ikeda, A. MacKenzie, and R.G. Korneluk. 1996. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature 379: 349-353.
117. Liu, X., C.N. Kim, J. Yang, R. Jemmerson, and X. Wang. 1996. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c. Cell 86: 147-157.
118. Liu, X., H. Zou, C. Slaughter, and X. Wang. 1997. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89: 175-184.
119. Loddick, S.A., A. MacKenzie, and N.J. Rothwell. 1996. An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat. NeuroReport 7: 1465-1468.
120. Loetscher, H., U. Deuschle, M. Brockhaus, D. Reinhardt, P. Nelboeck, J. Mous, J. Grünberg, C. Haass, and H. Jacobsen. 1997. Presenilins are processed by caspase-type proteases. J. Biol. Chem. 272: 20655-20659.
121. Los, M., M. Van de Craen, L.C. Penning, H. Schenk, M. Westendorp, P.A. Baeuerle, W. Dröge, P.H. Krammer, W. Fiers, and K. Schulze-Osthoff. 1995. Requirement of an ICE/ CED-3 protease for Fas/APO-1-mediated apoptosis. Nature 375: 81-83.
122. Lustig, K.D., T. Stukenberg, T. McGarry, R.W. King, V.L. Cryns, P. Mead, L. Zon, I. Yuan, and M.W. Kirschner. 1997. Small pool expression screening: a novel strategy for the identification of genes involved in cell cycle control, apoptosis and early development. Methods Enzymol. 283: 83-99.
123. MacFarlane, M., M. Ahmad, S. Srinivasula, T. Fernandes-Alnemri, G. Cohen, and E. Alnemri. 1997a. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J. Biol. Chem. 272: 25417-25420.
124. MacFarlane, M., K. Cain, X.M. Sun, E.S. Alnemri, and G.M. Cohen. 1997b. Processing/activation of at least four interleukin-1β converting enzyme-like proteases occurs during the execution phase of apoptosis in human monocytic tumor cells. J. Cell Biol. 137: 469-479.
125. Manji, G.A., R.R. Hozak, D.J. LaCount, and P.D. Friesen. 1997. Baculovirus inhibitor of apoptosis functions at or upstream of the apoptotic suppressor P35 to prevent programmed cell death. J. Virol. 71: 45009-45016.
126. Mannick, J., K. Asano, K. Izumi, E. Kieff, and J. Stamler. 1994. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation. Cell 79: 1137-1146.
127. Mannick, J.B., X.Q. Miao, and J.S. Stamler. 1997. Nitric oxide inhibits Fas-induced apoptosis. J. Biol. Chem. 272: 24125-24128.
128. Marsters, S.A., R.M. Pitti, C.J. Donahue, S. Ruppert, K.D. Bauer, and A. Ashkenazi. 1996. Activation of apoptosis by Apo-2 ligand is independent of FADD but blocked by CrmA. Curr. Biol. 6: 750-752.
129. Marsters, S.A., J.P. Sheridan, R.M. Pitti, A. Huang, M. Skubatch, D. Baldwin, A. Gurney, A.D. Goddard, P. Godowski, and A. Ashkenazi. 1997. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr. Biol. 7: 1003-1006.
130. Martin, D.A., R.M. Siegel, L. Zheng, and M.J. Lenardo. 1998. Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHα1) death signal. J. Biol. Chem. 273: 4345-4349.
131. Martin, S.J., G.A. O'Brien, W.K. Nishioka, A.J. McGahon, A. Mahboubi, T.C. Saido, and D.R. Green. 1995a. Proteolysis of fodrin (non-erythroid spectrin) during apoptosis. J. Biol. Chem. 270: 6425-6428.
132. Martin, S., C. Reutelingsperger, A. McGahon, J. Rader, R. van Schie, D. LaFace, and D. Green. 1995b. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl. J. Exp. Med. 182: 1545-1556.
133. Martinou, J., M. Dubois-Dauphin, J. Staple, I. Rodriguez, H. Frankowski, M. Missotten, P. Albertini, D. Talabot, S. Catsicas, C. Pietra, and J. Huarte. 1994. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 13: 1017-1030.
134. Mashima, T., M. Naito, N. Fujita, K. Noguchi, and T. Tsuruo. 1995. Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis. Biochem. Biophys. Res. Commun. 217: 1185-1192.
135. Mayer, B. and B. Hemmens. 1997. Biosynthesis and action of nitric oxide in mammalian cells. Trends Biochem. Sci. 22: 477-481.
136. McCarthy, N.J., M.K. Whyte, C.S. Gilbert, and G.I. Evan. 1997. Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homolog Bak. J. Cell Biol. 136: 215-227.
137. L acts downstream of caspase-8 activation by the CD95 death-inducing signaling complex. J. Biol. Chem. 273: 3383-3393.
138. L forms an ion channel in synthetic lipid membranes. Nature 385: 353-357.
139. Miossec, C., V. Dutilleul, F. Fassy, and A. Diu-Hercend. 1997. Evidence for CPP32 activation in the absence of apoptosis during T lymphocyte stimulation. J. Biol. Chem. 272: 13459-13462.
140. Miyashita, T., Y. Okamura-Oho, Y. Mito, S. Nagafuchi, and M. Yamada. 1997. Dentatorubral pallidoluysian atrophy (DRPLA) protein cleaved by caspase-3 during apoptosis. J. Biol. Chem. 272: 29238-29242.
141. Miura, M., H. Zhu, R. Rotello, E.A. Hartwieg, and J. Yuan. 1993. Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75: 653-660.
142. Miura, M., R.M. Friedlander, and J. Yuan. 1995. Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway. Proc. Natl. Acad. Sci. 92: 8318-8322.
143. Mohr, S., B. Zech, E.G. Lapetina, and B. Brüne. 1997. Inhibition of caspase-3 by S-nitrosation and oxidation caused by nitric oxide Biochem. Biophys. Res. Commun. 238: 387-391.
144. Muzio, M., A.M. Chinnaivan, F.C. Kischkel, K. O'Rourke, A. Shevchenko, J. Ni, C. Scaffidi, J.D. Bretz, M. Zhang, R. Gentz, M. Mann, P.H. Kreammer, M.E. Peter, and V.M. Dixit. 1996. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85: 817-827.
145. Muzio, M., G.S. Salvesen, and V.M. Dixit. 1997. FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens. J. Biol. Chem. 272: 2952-2956.
146. Muzio, M., B.R. Stockwell, G.S. Salvesen, and V.M. Dixit. 1998. An induced proximity model for caspase-8 activation. J. Biol. Chem. 273: 2926-2930.
147. Na, S., T.H. Chuang, A. Cunningham, T.G. Tun, J.H. Hanke, G.M. Bokoch, and D.E. Danley. 1996. D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis. J. Biol. Chem. 271: 11209-11213.
148. Nagata, S. 1997. Apoptosis hy death factor. Cell 88: 355-365.
149. L cooperatively associates with the Bap31 complex in the endoplasmic reticulum, dependent on procaspase-8 and Ced-4 adaptor. J. Biol. Chem. 273: 3140-3143.
150. L-and procaspase-8-associated protein in the endoplasmic reticulum. J. Cell Biol. 139: 327-338.
151. Nicholson, D.W. 1996. ICE/CED-3-like proteases as therapeutic targets for the control of inappropriate apoptosis. Nature Biotechnol. 14: 297-301.
152. Nicholson, D.W. and N. Thornberry. 1997. Caspases: killer proteases. Trends Biochem. Sci. 22: 299-306.
153. Nicholson, D.W., A. Ali, N.A. Thornberry, J.P. Vaillancourt, C.K. Ding, M. Gallant, Y. Gareau, P.R. Griffin, M. Labelle, Y.A. Lazebnick, N.A. Munday, S.M. Raju, M.E. Smulson, T.-T. Yamin, V.L. Yu, and D.K. Miller. 1995. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376: 37-43.
154. Orth, K., A.M. Chinnaiyan, M. Garg, C.J. Froelich, and V.M. Dixit. 1996a. The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. J. Biol. Chem. 271: 16443-16446.
155. Orth, K., K. O'Rourke, G.S. Salvesen, and V.M. Dixit. 1996b. Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases. J. Biol. Chem. 271: 20977-20980.
156. Pan, G., J. Ni, Y.-F. Wei, G.-l. Yu, R. Gentz, and V.M. Dixit. 1997a. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277: 815-818.
157. Pan, G., K. O'Rourke, A.M. Chinnaiyan, R. Gentz, R. Ebner, J. Ni, and V.M. Dixit. 1997b. The receptor for the cytotoxic ligand TRAIL. Science 276: 111-113.
158. L, and Apaf-1 form a ternary complex. J. Biol. Chem. 273: 5841-5845.
159. Piedrafita, F.J. and M. Pfahl. 1997. Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation. Mol. Cell. Biol. 17: 6348-6358.
160. Quan, L.T., M. Tewari, K. O'Rourke, V. Dixit, S.J. Snipas, G.G. Poirier, C. Ray, D.J. Pickup, and G.S. Salvesen. 1996. Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B. Proc. Natl. Acad. Sci. 93: 1972-1976.
161. Rao, L., D. Perez, and E. White. 1996. Lamin proteolysis facilitates nuclear events during apoptosis. J. Cell Biol. 135: 1441-1455.
162. Ray, C.A., R.A. Black, S.R. Kronheim, T.A. Greenstreet, P.R. Sleath, G.S.
163. Reed, J.C. 1995. Regulation of apoptosis by Bcl-2 family proteins and its role in cancer and chemoresistance. Curr. Opin. Oncol. 7: 541-546.
164. Rhéaume, E., L.Y. Cohen, F. Uhlmann, C. Lazure, A. Alam, J. Hurwitz, R.-P. Sékaly, and F. Denis. 1997. The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis. EMBO J. 16: 6346-6354.
165. Rossé, T., R. Olivier, L. Monney, M. Rager, S. Conus, I. Fellay, B. Jansen, and C. Borner. 1998. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature 391: 496-499.
166. Rothe, M., M.G. Pan, W.J. Henzel, T.M. Ayres, and D.V. Goeddel. 1995. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 83: 1243-1252.
167. Rotonda, J., D.W. Nicholson, K.M. Fazil, M. Gallant, Y. Gareau, M. Labelle, E.P. Peterson, D.M. Rasper, R. Ruel, J.P. Vaillancourt, N.A. Thornberry, and J.W. Becker. 1996. The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis. Nature Struct. Biol. 3: 619-625.
168. Roy, N., M.S. Mahadevan, M. McLean, G. Shutler, Z. Yaraghi, R. Farahani, S. Baird, A. Besner-Johnston, C. Lefebvre, X. Kang, M. Salih, H. Aubry, K. Tamai, X. Guan, P. Ioannou, T.O. Crawford, P.J. de Jong, L. Surh, J.-E. Ikeda, R.G. Korneluk, and A. MacKenzie. 1995. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Cell 80: 167-178.
169. Roy, N., Q. Deveraux, R. Takahashi, G. Salvesen, and J. Reed. 1997. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. 16: 6914-6925.
170. Rudel, T. and G. Bokoch. 1997. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science 276: 1571-1574.
171. Sakahira, H., M. Enari, and S. Nagata. 1998. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 391: 96-99.
172. Salvesen, G.S. and V.M. Dixit. 1997. Caspases: Intracellular signaling by proteolysis. Cell 91: 443-446.
173. Schendel, S.L., Z. Xie, M.O. Montal, S. Matsuyama, M. Montal, and J.C. Reed. 1997. Channel formation by antiapoptotic protein Bcl-2. Proc. Natl. Acad. Sci. 94: 5113-5118.
174. Schievella, A.R., J.H. Chen, J.R. Graham, and L.-L. Lin. 1997. MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase. J. Biol. Chem. 272: 12069-12075.
175. Schneider, P., J. Bodmer, M. Thome, K. Hofmann, N. Holler, and J. Tschopp. 1997a. Characterization of two receptors for TRAIL. FEBS Lett. 416: 329-334.
176. Schneider, P., M. Thome, K. Burns, J.-L. Bodmer, K. Hofmann, T. Kataoka, N. Holler, and J. Tschopp. 1997b. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-κB. Immunity 7: 831-836.
177. Seshagiri, S. and L.K. Miller. 1997a. Baculovirus inhibitors of apoptosis (IAPs) block activation of Sf-caspase-1. Proc. Natl. Acad. Sci. 94: 13606-13611.
178. _. 1997b. Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced apoptosis. Curr. Biol. 7: 455-460.
179. Shaham, S. and H. Horvitz. 1996. Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities. Genes & Dev. 10: 578-591.
180. Sheridan, J.P., S.A. Marsters, R.M. Pitti, A. Gurney, M. Skubatch, D. Baldwin, L. Ramakrishnan, C.L. Gray, K. Baker, W.I. Wood, A.D. Goddard, P. Godowski, and A. Ashkenazi. 1997. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 277: 818-821.
181. Shi, L., G. Chen, G. MacDonald, L. Bergeron, H. Li, M. Miura, R.J. Rotello, D.K. Miller, P. Li, T. Seshadri, J. Yuan, and A. Greenberg. 1996. Activation of an interleukin 1 converting enzyme-dependent apoptosis pathway by granzyme B. Proc. Natl. Acad. Sci. 93: 11002-11007.
182. Shimizu, S., Y. Eguchi, W. Kamiike, H. Matsuda, and Y. Tsujimoto. 1996. Bcl-2 expression prevents activation of the ICE protease cascade. Oncogene 12: 2251-2257.
183. Shu, H.-B., M. Takeuchi, and D.V. Goeddel. 1996. The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. Proc. Natl. Acad. Sci. 93: 13973-13978.
184. Song, Q., S.P. Lees-Miller, S. Kumar, Z. Zhang, D.W. Chan, G.C. Smith, S.P. Jackson, E.S. Alnemri, G. Litwack, K.K. Khanna, and M.F. Lavin. 1996. DNA-dependent protein kinase catalytic subunit: A target for an ICE-like protease in apoptosis. EMBO J. 15: 3238-3246.
185. Song, Z., K. McCall, and H. Steller. 1997. DCP-1, a Drosophila cell death protease essential for development. Science 275: 536-540.
186. Spector, M., S. Desnoyers, D. Hoeppner, and M. Hengartner. 1997. Interaction between the C. elegans cell-death regulators CED-9 and CED-4. Nature 385: 653-656.
187. L functions downstream of caspase-8 to inhibit Fas-and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells. J. Biol. Chem. 273: 4523-4529.
188. Srinivasula, S.M., M. Ahmad, T. Fernandes-Alnemri, G. Litwack, and E.S. Alnemri. 1996. Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ ICE-like cysteine proteases. Proc. Natl. Acad. Sci. 93: 14486-14491.
189. Srinivasula, S.M., M. Ahmad, S. Ottilie, F. Bullrich, S. Banks, Y. Wang, T. Fernandes-Alnemri, C.M. Croce, G. Litwack, K.J. Tomaselli, R.C. Armstrong, and E.S. Elnemri. 1997. FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. J. Biol. Chem. 272: 18542-18545.
190. Stamler, J.S. 1994. Redox signaling: Nitrosylation and related target interactions of nitric oxide. Cell 78: 931-936.
191. Stanger, B.Z., P. Leder, T.-H. Lee, E. Kim, and B. Seed. 1995. RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 81: 513-523.
192. Susin, S.A., N. Zamzami, M. Castedo, E. Daugas, H.-G. Wang, S. Geley, F. Fassy, J.C. Reed, and G. Kroemer. 1997. The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95-and ceramide-induced apoptosis. J. Exp. Med. 186: 25-37.
193. Takahashi, A., E.S. Alnemri, Y.A. Lazebnik, T. Fernandes-Alnemri, G. Litwack, R.D. Moir, R.D. Goldman, G.G. Poirier, S.H. Kaufmann, and W.C. Earnshaw. 1996. Cleavage of lamin A by Mch2α but not CPP32: Multiple interleukin 1β-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proc. Natl. Acad. Sci. 93: 8395-8400.
194. Talanian, R.V., C. Quinlan, S. Trautz, M.C. Hackett, J.A. Mankovich, D. Banach, T. Ghayur, K.D. Brady, and W.W. Wong. 1997. Substrate specificities of caspase family proteases. J. Biol. Chem. 272: 9677-9682.
195. Tan, X., S. Martin, D. Green, and J. Wang. 1997. Degradation of retinoblastoma protein in tumor necrosis factor-and CD95-induced cell death. J. Biol. Chem. 272: 9613-9616.
196. Tenneti, L., D.M. D'Emilia, and S.A. Lipton. 1997. Suppression of neuronal apoptosis by S-nitrosylation of caspases. Neurosci. Lett. 236: 139-142.
197. Teo, M., E. Manser, and L. Lim. 1995. Identification and molecular cloning of a p21cdc42/rac1-activated serine/threonine kinase that is rapidly activated by thrombin in platelets. J. Biol. Chem. 270: 26990-26997.
198. Tewari, M. and V.M. Dixit. 1995. Fas-and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J. Biol. Chem. 270: 3255-3260.
199. Thome, M., P. Schneider, K. Hofmann, H. Fickenscher, E. Meinl, F. Neipel, C. Mattmann, K. Burns, J. Bodmer, M. Schroter, C. Scaffidi, P. Krammer, M. Peter, and J. Tschopp. 1997. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 386: 517-521.
200. Thompson, C.B. 1995. Apoptosis in the pathogenesis and treatment of disease. Science 267: 1456-1462.
201. Thornberry, N., T. Rano, E. Peterson, D. Rasper, T. Timkey, M. Garcia-Calvo, V. Houtzager, P. Nordstrom, S. Roy, J. Vaillancourt, K. Chapman, and D. Nicholson. 1997. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J. Biol. Chem. 272: 17907-17911.
202. Thornberry, N.A., H.G. Bull, J.R. Calaycay, K.T. Chapman, A.D. Howard, M.J. Kostura, D.K. Miller, S.M. Molineaux, J.R. Weidner, J. Aunins, K.O. Elliston, J.M. Ayala, F.J. Casano, J. Chin, G.J.-F. Ding, L.A. Egger, E.P. Gaffney, G. Limjuco, O.C. Palyha, S.M. Raju, A.M. Rolando, J.P. Salley, T.-T. Yamin, T.D. Lee, J.E. Shively, M. MacCross, R.A. Mumford, J.A. Schmidt, and M.J. Tocci. 1992. A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes. Nature 356: 768-774.
203. Ubeda, M. and J.F. Habener. 1997. The large subunit of the DNA replication complex C (DSEB/RF-C140) cleaved and inactivated by caspase-3 (CPP32/YAMA) during Fas-induced apoptosis. J. Biol. Chem. 272: 19562-19568.
204. Uren, A.C., M. Pakusch, C.J. Hawkins, K.L. Puls, and D.L. Vaux. 1996. Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. Proc. Natl. Acad. Sci. 93: 4974-4978.
205. Vanags, D.M., M.I. Porn-Ares, S. Coppola, D.H. Burgess, and S. Orrenius. 1996. Protease involvement in fodrin cleavage and phosphatidylserine exposure in apoptosis. J. Biol. Chem. 271: 31075-31085.
206. L regulates the membrane potential and volume of homeostasis of mitochondria. Cells 91: 627-637.
207. Vaux, D. 1997. CED-4-The third horseman of apoptosis. Cell 90: 389-390.
208. Vaux, D.L., S. Cory, and J.M. Adams. 1988. Bcl-2 oncogene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335: 440-442.
209. Vaux, D.L., I.L. Weissman, and S.K. Kim. 1992. Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2. Science 258: 1955-1957.
210. Verheij, M., R. Bose, X.H. Lin, B. Yao, W.D. Jarvis, S. Grant, M.J. Birrer, E. Szabo, L.I. Zon, J.M. Kyriakis, A. Haimovitz-Friedman, Z. Fuks, and R.N. Kolesnick. 1996. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380: 75-79.
211. Villa, P., S.H. Kaufmann, and W.C. Earnshaw. 1997. Caspases and caspase inhibitors. Trends Biochem. Sci. 22: 388-393.
212. Vincenz, C. and V.M. Dixit. 1997. Fas-associated death domain protein interleukin-1β-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95-and p55-mediated death signaling. J. Biol. Chem. 272: 6578-6583.
213. Vito, P., T. Ghayur, and L. D'Adamio. 1997. Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage. J. Biol. Chem. 272: 28315-28320.
214. Wajant, H., F.-J. Johannes, E. Haas, K. Siemienski, R. Schwenzer, G. Schubert, T. Weiss, M. Grell, and P. Scheurich. 1997. Dominant negative FADD inhibits TNFR60-, Fas/Apo1-and TRAIL-R/Apo2-mediated cell death. Curr. Biol. 8: 113-116.
215. Walczak, H., M.A. Degli-Esposti, R.S. Johnson, P.J. Smolak, J.Y. Waugh, N. Boiani, M.S. Timour, M.J. Gerhart, K.A. Schooley, C.A. Smith, R.G. Goodwin, and C.T. Rauch. 1997. TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J. 16: 5386-5397.
216. Walker, N.P.C., R.V. Talanian, K.D. Brady, L.C. Dang, N.J. Bump, C.R. Ferenz, S. Franklin, T. Ghayur, M.C. Hackett, L.D. Hammill, L. Herzog, M. Hugunin, W. Houy, J.A. Mankovich, L. McGuiness, E. Orlewicz, M. Paskind, C.A. Pratt, P. Reis, A. Summani, M. Terranova, J.P. Welch, L. Xiong, A. Möller, D.E. Tracey, R. Kamen, and W.W. Wong. 1994. Crystal structure of the cysteine protease interleukin-1β-converting enzyme: a (p20/p10)2 homodimer. Cell 78: 343-352.
217. Wang, L., M. Miura, L. Bergeron, H. Zhu, and J. Yuan. 1994. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78: 739-750.
218. Wang, S., M. Miuyra, Y.-k. Jung, H. Zhu, E. Li, and J. Yuan. 1998. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell 92: 501-509.
219. Wang, X., N.G. Zelenski, J. Yang, J. Sakai, M.S. Brown, and J.L. Goldstein. 1996. Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. EMBO J. 15: 1012-1020.
220. Waterhouse, N., S. Kumar, Q. Song, P. Strike, L. Sparrow, G. Dreyfuss, E.S. Alnemri, G. Litwack, M. Lavin, and D. Watters. 1996. Heteronuclear ribonucleoproteins C1 and C2, components of the spliceosome, are specific targets of interleukin 1β-converting enzyme-like proteases in apoptosis. J. Biol. Chem. 271: 29335-29341.
221. Wen, L.-P., J. Fahrni, S. Troie, J.-L. Guan, K. Orth, and G. Rosen. 1997. Cleavage of focal adhesion kinase by caspases during apoptosis. J. Biol. Chem. 272: 26056-26061.
222. Wilson, K.P., J.-A.F. Black, J.A. Thomson, E.E. Kim, J.P. Griffith, M.A. Navia, M.A. Murcko, S.P. Chambers, R.A. Aldape, S.A. Raybuck, and D.J. Livingston. 1994. Structure and mechanism of interleukin-1β converting enzyme. Nature 370: 270-275.
223. Wissing, D., H. Mouritzen, M. Egeblad, G.G. Poirier, and M. Jaattela. 1997. Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor-induced apoptosis. Proc. Natl. Acad. Sci. 94: 5073-5077.
224. Wu, D., H.D. Wallen, and G. Nuñez. 1997. Interaction and regulation of subcellular localization of CED-4 by CED-9. Science 275: 1126-1129.
225. Wyllie, A.H., R.G. Morris, A.L. Smith, and D. Dunlop. 1984. Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macro-molecular synthesis. J. Pathol. 142: 66-77.
226. Xia, Z., M. Dickens, J. Raingeaud, R.J. Davis, and M.E. Greenberg. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331.
227. Xiang, J., D.T. Chao, and S.J. Korsmeyer. 1996. BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases. Proc. Natl Acad. Sci. 93: 14559-14563.
228. Xue, D. and H.R. Horvitz. 1995. Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature 377: 248-251.
229. _. 1997. Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor. Nature 390: 305-308.
230. Yang, J., X. Liu, K. Bhalla, C.N. Kim, A.M. Ibrado, J. Cai, T.-I. Peng, D.P. Jones, and X. Wang. 1997. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275: 1129-1132.
231. Yaoita, H., K. Ogawa, K. Maehara, and Y. Maruyama. 1998. Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor. Circulation 97: 276-281.
232. Yuan, J. and H.R. Horvitz. 1992. The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death. Development 116: 309-320.
233. Yuan, J., S. Shaham, S. Ledoux, H.M. Ellis, and H.R. Horvitz. 1993. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell 75: 641-652.
234. Zamzami, N., P. Marchetti, M. Castedo, D. Decaudin, A. Macho, T. Hirsch, S.A. Susin, P.X. Petit, B. Mignotte, and G. Kroemer. 1995. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J. Exp. Med. 182: 367-377.
235. Zamzami, N., P. Marchetti, M. Castedo, T. Hirsch, S.A. Susin, B. Masse, and G. Kroemer. 1996a. Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis. FEBS Lett. 384: 53-57.
236. Zamzami, N., S.A. Susin, P. Marchetti, T. Hirsch, I. Gómez-Monterrey, M. Castedo, and G. Kroemer. 1996b. Mitochondrial control of nuclear apoptosis. J. Exp. Med. 183: 1533-1544.
237. Zhivotovsky, B., S. Orrenius, O.T. Brustugun, and S.O. Døskeland. 1998. Injected cytochrome c induces apoptosis. Nature 391: 449-450.
238. Zou, H., W. Henzel, X. Liu, A. Lutschg, and X. Wang. 1997. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90: 405-413.