Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor

Nature

Volumn 390, Issue 6657, 1997, Pages 305-308

  Xue, Ding ^a,b   Horvitz, H Robert ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACULOVIRUS; CAENORHABDITIS ELEGANS; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CELL SURVIVAL; MAMMAL; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BINDING SITES; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CASPASES; CYSTEINE ENDOPEPTIDASES; HELMINTH PROTEINS; HUMANS; MUTAGENESIS; PROTO-ONCOGENE PROTEINS;

CAENORHABDITIS ELEGANS; MAMMALIA; UNIDENTIFIED BACULOVIRUS;

EID: 0030776157     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/36889     Document Type: Article

References (30)

1. Hengartner, M. O., Ellis, R. E. & Horvitz, H. R. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature 356, 494-499 (1992).
2. Hengartner, M. O. & Horvitz, H. R. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 76, 665-676 (1994).
3. Cleary, M. L., Smith, S. D. & Sklar, J. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14; 18) translocation. Cell 47, 19-28 (1986).
4. Tsujimoto, Y. & Croce, C. M. Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc. Natl Acad. Sci. USA 83, 5214-5218 (1986).
5. Vaux, D. L., Cory, S. & Adams, J. M. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335, 440-442 (1988).
6. Hockenbery, D., Nunez, G., Milliman, C., Schreiber, R. D. & Korsmeyer, S. J. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348, 334-336 (1990).
7. Nunez, G. et al. Deregulated Bcl-2 gene expresison selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J. Immunol. 144, 3602-3610 (1990).
8. Yuan, J., Shaham, S., Ledoux, S., Ellis, H. M. & Horvitz, H. R. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell 75, 641-652 (1993).
9. Xue, D. & Horvitz, H. R. Inhibition of the Caenorhabditis elegant cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature 377, 248-251 (1995).
10. Thornberry, N. A. et al. A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes. Nature 356, 768-774 (1992).
11. Cerretti, D. P. et al. Molecular cloning of the interleukin-1β converting enzyme. Science 256, 97-100 (1992).
12. Alnemri, E. S. et al. Human ICE/CED-3 protease nomenclature. Cell 87, 171 (1996).
13. Clem, R. J., Fechheimer, M. & Miller, L. K. Prevention of apoptosis by a baculovirus gene during infection of insect cells. Science 254, 1388-1390 (1991).
14. Rabizadeh, S., LaCount, D. J., Friesen, P. D. & Bredesen, D. E. Expression of the baculovirus p35 gene inhibits mammalian neural cell death. J. Neurochem. 61, 2318-2321 (1993).
15. Sugimoto, A., Friesen, P. D. & Rothman, J. H. Baculovirus p35 prevents developmentally programmed cell death and rescues a ced-9 mutant in the nematode Caenorhabditis elegans. EMBO J. 13, 2023-2028 (1994).
16. Hay, B. A., Wolff, T. & Rubin, G. M. Expression of baculovirus P35 prevents cell death in Drosophila. Development 120, 2121-2129 (1994).
17. Bump, N. J. et al. Inhibition of ICE family proteases by baculovirus anti-aptptotic protein p35. Science 269, 1885-1888 (1995).
18. Xue, D., Shaham, S. & Horvitz, H. R. The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease. Genes Dev. 10, 1073-1083 (1996).
19. Nicholson, D. W. ICE/CED-3-like proteases as therapeutic targets for the control of inappropriate apoptosis. Nature Biotechnol. 14, 297-301 (1996).
20. Vaux, D. L., Weissman, I. L. & Kim, S. K. Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2. Science 258, 1955-1957 (1992).
21. Yin, X. M., Oltvai, Z. N. & Korsmeyer, S. J. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 369, 321-323 (1994).
22. Hengartner, M. O. & Horvitz, H. R. Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in Bcl-2. Nature 369, 318-320 (1994).
23. Shaham, S. & Horvitz, H. R. Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities. Genes Dev. 10, 578-591 (1996).
24. Ellis, H. M. & Horvitz, H. R. Genetic control of programmed cell death in the nematode C. elegans. Cell 44, 817-829 (1986).
25. Yuan, J. & Horvitz, H. R. The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death. Development 116, 309-320 (1992).
26. Chinnaiyan, A. M., O'Rourke, K., Lane, B. R. & Dixit, V. M. Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death. Science 275, 1122-1126 (1997).
27. Spector, M. S., Desnoyers, S., Hoeppner, D. J. & Hengartner, M. O. Interaction between the C. elegans cell-death regulators CED-9 and CED-4. Nature 385, 653-656 (1997).
28. Wu, D., Wallen, H. D. & Nunez, G. Interaction and regulation of subcellular localization of CED-4 by CED-9. Science 275, 1126-1129 (1997).
29. Sambrook, J., Fritsch, E. F. & Maniatis, T. Molecular Cloning: A Laboratory Manual 2nd edn (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1989).
30. Reed, J. C. Double identity for proteins of the Bcl-2 family. Nature 387, 773-776 (1997).