Mechanisms of cell death in Alzheimer disease - Immunopathology

Journal of Neural Transmission, Supplement

Volumn , Issue 54, 1998, Pages 159-166

  McGeer, P L ^a   McGeer, E G ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE PHASE PROTEIN; AMYLOID BETA PROTEIN; BLOOD CLOTTING FACTOR 12; C REACTIVE PROTEIN; COMPLEMENT; CYTOKINE; GLUTAMIC ACID; HEAT SHOCK PROTEIN; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; OXYGEN RADICAL; PROTEINASE; PROTEINASE INHIBITOR;

ALZHEIMER DISEASE; ASTROCYTE; CLINICAL TRIAL; COMPLEMENT ACTIVATION; HUMAN; IMMUNOPATHOLOGY; INFLAMMATION; MICROGLIA; NERVE CELL NECROSIS; PRIORITY JOURNAL; REVIEW; BIOLOGICAL MODEL; BRAIN; IMMUNOLOGY; NERVE CELL; PARKINSON DISEASE; PATHOLOGY;

ALZHEIMER DISEASE; ASTROCYTES; BRAIN; HUMANS; INFLAMMATION; MICROGLIA; MODELS, IMMUNOLOGICAL; MODELS, NEUROLOGICAL; NEURONS; PARKINSON DISEASE;

EID: 0031593604     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-7508-8_15     Document Type: Review

References (22)

1. Akiyama H, Tooyama I, Kondo H, Ikeda K, Kimura H, McGeer EG, McGeer PL (1994) Early response of brain resident microglia to kainic acid-induced hippocampal lesions. Brain Res 635: 257-268
2. Breitner JCS, Gau BA, Welsh KA, Plassman BL, McDonald WM, Helmas MJ, Anthony JC (1994) Inverse association of anti-inflammatory treatments and Alzheimer's disease. Neurology 44: 227-232
3. Breitner JCS, Welsh KA, Helms MJ, Gaskell PC, Gau BA, Roses AD, Pericak-Vance MA, Saunders AM (1995) Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs. Neurobiol Aging 16: 523-530
4. Doraiswamy PM, Krishen A, Stallone F, Martin WL, Potts NLS, Metz A, DeVeaugh-Geiss J (1996) NSAIDs and cognition in Alzheimer's disease. Neurology 46: 1994
5. Graham DY, Agrawal NM, Roth SH (1988) Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial. Lancet ii: 1277-1280
6. Klegeris A, McGeer PL (1994) Rat brain microglia and peritoneal macrophages show similar responses to respiratory burst stimulants. J Neuroimmunol 53: 83-90
7. Klegeris A, McGeer PL (1997) β-Amyloid protein and glutamine enhance macrophage production of oxygen free radicals and glutamate. J Neurosci Res 49: 229-235
8. Laskin DL, Pendino KJ (1995) Macrophages and inflammatory mediators in tissue injury. Ann Rev Pharmacol Toxicol 35: 655-677
9. McGeer PL, Rogers J (1992) Anti-inflammatory agents as a therapeutic approach to Alzheimer's disease. Neurology 42: 447-449
10. McGeer PL, McGeer EG (1995) The inflammatory system of brain: implications for therapy of Alzheimer and other neurodegenerative disorders. Brain Res Rev 21: 195-218
11. McGeer EG, McGeer PL (1997) Inflammatory cytokines in the CNS. CNS Drugs 7: 214-228
12. McGeer PL, Schulzer M, McGeer EG (1996) Arthritis and antiinflammatory agents as negative risk factors for Alzheimer disease: a review of seventeen epidemiological studies. Neurology 47: 425-432
13. Ostbye T, Crosse E (1994) Net economic costs of dementia in Canada. Can Med Assoc J 151: 1457-1464
14. Pasinetti GM, Johnson SA, Rozovsky I, Lampert-Etchells M, Morgan DG, Gordon MN, Morgan TE, Willoughby D, Finch CE (1992) Complement C1qB and C4 mRNAs responses to lesioning in rat brain. Exp Neurol 118: 117-125
15. Rich JB, Rasmusson DX, Folstein MF, Carson KA, Kawas C, Brandt J (1995) Nonsteroidal anti-inflammatory drugs in Alzheimer's disease. Neurology 45: 51-55
16. Rogers J, Kirby LC, Hempelman SR, Berry DL, McGeer PL, Kaszniak AW, Zalinski J, Cofield M, Mansukhani L, Willson P, Kogan F (1993) Clinical trial of indomethacin in Alzheimer's disease. Neurology 43: 1609-1611
17. Roses AD (1996) Apolipoprotein E alleles as risk factors in Alzheimer's disease. Ann Rev Med 47: 387-400
18. Shen Y, Li R, McGeer EG, McGeer PL (1997) Neuronal expression of mRNAs for complement proteins of the classical pathway in Alzheimer brain. Brain Res 769: 391-395
19. Stewart WF, Kawas C, Corrada M, Metter EJ (1997) Risk of Alzheimer's disease and duration of NSAID use. Neurology 48: 626-632
20. Taupenot L, Ciesielski-Traska J, Ulrich G, Chasserot-Golaz S, Aunis D, Bader MF (1996) Chromogranin A triggers a phenotypic transformation and the generation of nitric oxide in brain microglial cells. Neuroscience 72: 377-389
21. Terai K, Matsuo A, McGeer PL (1996) Enhancement of immunoreactivity for NF-κB in the hippocampal formation and cerebral cortex of Alzheimer's disease. Brain Res 735: 159-168
22. Walker DG, Kim SU, McGeer PL (1995) Complement and cytokine gene expression in cultured microglia derived from postmortem human brains. J Neurosci Res 40: 478-493