In situ labeling of dying cortical neurons in normal aging and in Alzheimer's disease: Correlations with senile plaques and disease progression

Journal of Neuropathology and Experimental Neurology

Volumn 55, Issue 11, 1996, Pages 1134-1142

  Troncoso, Juan C ^a   Sukhov, Renat R ^a   Kawas, Claudia H ^a   Koliatsos, Vassilis E ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amyloid; Cell death; Neocortex; NFT; Senile plaques; TUNEL

Indexed keywords

ADULT; AGED; AGING; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DETERIORATION; DNA STRAND BREAKAGE; FEMALE; HUMAN; HUMAN TISSUE; MALE; NERVE CELL DEGENERATION; PRIORITY JOURNAL; SENILE PLAQUE;

EID: 0029852587     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199611000-00004     Document Type: Article

References (55)

1. Evans DA, Funkenstein HH, Albert MS, et al. Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. JAMA 1989;262:2551-56
2. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-44
3. Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991;82:239-59
4. McKee AC, Kosik KS, Kowall NW. Neuritic pathology and dementia in Alzheimer's disease. Ann Neurol 1991;30:156-65
5. Terry RD, Masliah E, Salmon DP, et al. Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Ann Neurol 1991;30:572-80
6. Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 1992;42:631-39
7. Whitehouse PJ, Price DL, Struble RG, Clark AW, Coyle JT, DeLong MR. Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain. Science 1982;215:1237-39
8. Tomlinson BE, Irving D, Blessed G. Cell loss in locus coeruleus in senile dementia of Alzheimer type. J Neurol Sci 1981;49:419-28
9. German DC, Manaye KF, White CL, III, et al. Disease-specific patterns of locus coeruleus cell loss. Ann Neurol 1992;32:667-76
10. Ball MJ. Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. A qualitative study. Acta Neuropathol (Berl) 1977;37:111-18
11. Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL. Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation. Science 1984;225:1168-70
12. West MJ, Coleman PD, Flood DG, Troncoso JC. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 1994;344:769-72
13. Hyman BT, Van Hoesen GW, Kromer LJ, Damasio AR. Perforant pathway changes and the memory impairment of Alzheimer's disease. Ann Neurol 1986:20:472-81
14. Terry RD, Peck A, DeTeresa R, Schlechter R, Horoupian DS. Some morphometric aspects of the brain in senile dementia of the Alzheimer type. Ann Neurol 1981;10:184-92
15. Mountjoy CQ, Roth M, Evans NJR, Evans HM. Cortical neuronal counts in normal elderly controls and demented patients. Neurobiol Aging 1983;4:1-11
16. Mann DMA, Yates PO, Marcyniuk B. Some morphometric observations on the cerebral cortex and hippocampus in presenile Alzheimer's disease, senile dementia of Alzheimer type and Down's syndrome in middle age. J Neurol Sci 1985;69:139-59
17. Arnold SE, Hyman BT, Flory J, Damasio AR, Van Hoesen GW. The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease. Cereb Cortex 1991;1:103-16
18. Graeber MB, Streit WJ, Kiefer R, Schoen SW, Kreutzberg GW. New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury. J Neuroimmunol 1990;27:121-32
19. Migheli A, Cavalla P, Marino S, Schiffer D. A study of apoptosis in normal and pathologic nervous tissue after in situ end-labeling of DNA strand breaks. J Neuropathol Exp Neurol 1994;53:606-16
20. Gorzyca W, et al. DNA strand breaks occurring during apoptosis - their early in situ detection by terminal deoxynucleotidyl transferase and nick translation assays and prevention by serine protease inhibitors. Int J Oncol 1992;1:639-48
21. Wijsman JH, Jonker RR, Keijzer R, Van de Velde CJH, Cornelisse CJ, Van Dierendonck JH. A new method to detect apoptosis in paraffin sections: In situ end-labeling of fragmented DNA. J Histochem Cytochem 1993;41:7-12
22. Chang G-Q, Hao Y, Wong F Apoptosis: Final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. Neuron 1993;11:595-605
23. Veis DJ, Sorenson CM, Shutter JR, Korsmeyer SJ. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis polycystic kidneys and hypopigmented hair. Cell 1993;75:229-40
24. Portera-Cailliau C, Sung C-H, Nathans J, Adler R. Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. Proc Natl Acad Sci USA 1994;91:974-78
25. Rabacchi SA, Bonfanti L, Liu X-H, Maffei L. Apoptotic cell death induced by optic nerve lesion in the neonatal rat. J Neurosci 1994;14:5292-5301
26. Surh CD, Sprent J. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 1994;372:100-103
27. Wilcox BJ, Applegate MD, Portera-Cailliau C, Koliatsos VE. Nerve growth factor prevents apoptotic cell death in injured central cholinergic neurons. J Comp Neurol 1995;359:573-85
28. Petito CK, Roberts B. Evidence of apoptotic cell death in HIV encephalitis. Am J Pathol 1995;146:1121-30
29. Portera-Cailliau C, Hedreen JC, Price DL, Koliatsos VE. Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models. J Neurosci 1995;15:3775-87
30. Su JH, Anderson AJ, Cummings BJ, Cotman CW. Immunohistochemical evidence for apoptosis in Alzheimer's disease. Neuroreport 1994;5:2529-33
31. Lassmann H, Bancher C, Breitschopf H, et al. Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ. Acta Neuropathol 1995;89:35-41
32. Smale G, Nichols NR, Brady DR, Finch CE, Horton WE Jr. Evidence for apoptotic cell death in Alzheimer's disease. Exp Neurol 1995;133:225-30
33. Anderson AJ, Su JH, Cotman CW. DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay. J Neurosci 1996;16:1710-19
34. Mirra SS, Heyman A, McKeel D, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991;41:479-86
35. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state." A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-98
36. Yamamoto T, Hirano A. A comparative study of modified Bielschowsky, Bodian and thioflavin S stains on Alzheimer's neurofibrillary tangles. Neuropathol Appl Neurobiol 1986;12:3-9
37. Martin LJ, Sisodia SS, Koo EH, et al. Amyloid precursor protein in aged nonhuman primates. Proc Natl Acad Sci USA 1991;88:1461-65
38. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA framentation. J Cell Biol 1992;119:493-501
39. Amaral DG, Insausti R. Hippocampal formation. In: Paxinos G, ed. The human nervous system. San Diego: Academic Press, Inc. 1990: 711-55
40. Braak H. Architectonics of the human telencephalic vortex. Berlin: Springer-Verlag, 1980:25-48
41. Kerr JFR, Harmon BV. Definition and incidence of apoptosis: An historical perspective. In: Tomei LD, Cope FO, eds. Apoptosis. New York: Cold Spring Harbor Laboratory, 1991:5-29
42. Tominaga T, Kure S, Narisawa K, Yoshimoto T. Endonuclease activation following focal ischemic injury in the rat brain. Brain Res 1993;608:21-6
43. Schwartz LM, Osborne BA. Programmed cell death, apoptosis and killer genes. Immunol Today 1993;14:582-90
44. Sträter J, Günthert AR, Brüderlein S, Möller P. Microwave irradiation of paraffin-embedded tissue sensitizes the TUNEL method for in situ detection of apoptotic cells. Histochemistry 1995;103:157-60
45. Hyman BT, Gomez-Isla T. Alzheimer's disease is a laminar, regional, and neural system specific disease, not a global brain disease. Neurobiol Aging 1994;15:353-54
46. Mountcastle V. The evolution of ideas concerning the function of the neocortex. Cereb Cortex 1995;5:289-95
47. Katzman R, Terry R, DeTeresa R, et al. Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol 1988;23:138-44
48. Crystal H, Dickson D, Fuld P, et al. Clinico-pathologic studies in dementia: Nondemented subjects with pathologically confirmed Alzheimer's disease. Neurology 1988;38:1682-87
49. Dickson DW, Crystal HA, Mattiace LA, et al. Identification of normal and pathological aging in prospectively studied nondemented elderly humans. Neurobiol Aging 1991;13:179-89
50. Berg L, McKeel DW Jr., Miller JP, Baty J, Morris JC. Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older. Arch Neurol 1993;50:349-58
51. Troncoso JC, Martin LJ, Dal Forno G, Kawas CH. Neuropathology in controls and demented subjects from the Baltimore Longitudinal Study of Aging. Neurobiol Aging 1996;17:365-71
52. Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry 1968;114: 797-811
53. Hengartner MO, Horvitz HR. Programmed cell death in Caenorhabditis elegans. Curr Opin Genet Dev 1994;4:581-86
54. Korsmeyer SJ. Regulators of cell death. Trends Genet 1995;11:101-5
55. Johnson EM Jr. Possible role of neuronal apoptosis in Alzheimer's disease. Neurobiol Aging 1994;15:s187-89