Cellular mechanisms involved in CO2 and acid signaling in chemosensitive neurons

American Journal of Physiology - Cell Physiology

Volumn 287, Issue 6 56-6, 2004, Pages

  Putnam, Robert W ^a   Filosa, Jessica A ^a,b   Ritucci, Nicola A ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

Brain stem; Calcium; Carbonic anhydrase; Channel; Gap junction; Glia; Glomus; Hypercapnia; Nociception; Peripheral chemoreceptor; Potassium; Taste receptor; Ventilation

Indexed keywords

BICARBONATE; CALCIUM CHANNEL; CARBON DIOXIDE; NEUROTRANSMITTER; POTASSIUM CHANNEL;

BRAIN NERVE CELL; BRAIN STEM; CALCIUM CELL LEVEL; CAROTID BODY CHEMORECEPTOR; CELL MEMBRANE DEPOLARIZATION; CHEMOSENSITIVITY; GAP JUNCTION; GLIA CELL; NONHUMAN; OXIDATIVE STRESS; PAIN RECEPTOR; PH; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TASTE BUD;

AVES; GLOMUS; INVERTEBRATA;

EID: 8644248306     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00282.2004     Document Type: Review

References (414)

1. 2+ channel: perspectives for new pharmacological targets. J Pharmacol Exp Ther 300: 724-728, 2002.
2. Aghajanian GK, Vandermaelen CP, and Andrade R. Intracellular studies on the role of calcium in regulating the activity and reactivity of locus coeruleus neurons in vivo. Brain Res 273: 237-243, 1983.
3. Ahmad HR and Loeschcke HH. Fast bicarbonate-chloride exchange between brain cells and brain extracellular fluid in respiratory acidosis. Pflügers Arch 395: 293-299, 1982.
4. 2. Pflügers Arch 395: 300-305, 1982.
5. 2. Pflügers Arch 395: 285-292, 1982.
6. Alvarez-Maubecin V, Garcia-Hernández F, Williams JT, and Van Bockstaele E. Functional coupling between neurons and glia. J Neurosci 20: 4091-4098, 2000.
7. Andreatta-Van Leyen S, Averill DB, and Guertzenstein PG. Cardiorespiratory effects induced by acetazolamide on the ventromedullary surface of the cat. J Physiol 421: 171-184, 1990.
8. Andrzejewski M, Mückenhoff K, Scheid P, and Ballantyne D. Synchronized rhythms in chemosensitive neurons of the locus coeruleus in the absence of chemical synaptic transmission. Respir Physiol 129: 123-140, 2001.
9. Aston-Jones G. Behavioral function of locus coeruleus derived from cellular attributes. Physiol Psychol 13: 118-126, 1985.
10. Baker RE, Ballantyne D, Bingmann D, Jones D, and Widman G. Rhythm generation in organotypic medullary cultures of newborn rats. Int J Dev Neurosci 13: 799-809, 1995.
11. Balaban CD. Neural substrates linking balance control and anxiety. Physiol Behav 77: 469-475, 2002.
12. Ballantyne D and Scheid P. Central chemosensitivity of respiration: a brief overview. Respir Physiol 129: 5-12, 2001.
13. Ballantyne D and Scheid P. Mammalian brainstem chemosensitive neurones: linking them to respiration in vitro. J Physiol 525: 567-577, 2000.
14. Ballanyi K, Mückenhoff K, Bellingham MC, Okada Y, Scheid P, and Richter DW. Activity-related pH changes in respiratory neurones and glial cells of cats. Neuroreport 6: 33-36, 1994.
15. Ballanyi K, Volker A, and Richter DW. Anoxia induced functional inactivation of neonatal respiratory neurones in vitro. Neuroreport 6: 165-168, 1994.
16. + channel expressed in brain stem respiratory neurons. Respir Physiol 129: 159-174, 2001.
17. Beatty RM and Cragg LH. The sourness of acids. J Am Chem Soc 57: 2347-2351, 1935.
18. 2 sensitivity of avian intrapulmonary chemoreceptors. Am J Physiol Regul Integr Comp Physiol 276: R317-R322, 1999.
19. Becker H, Polo O, McNamara SG, Berthon-Jones M, and Sullivan CE. Effect of different levels of hyperoxia on breathing in healthy subjects. J Appl Physiol 81: 1683-1690, 1996.
20. Bellingham MC and Ireland MF. Contribution of cholinergic systems to state-dependent modulation of respiratory control. Respir Physiol Neurobiol 131: 135-144, 2002.
21. v channels in coronary and pulmonary vascular muscle. Am J Physiol Heart Circ Physiol 275: H1351-H1359, 1998.
22. Bernard DG. Cardiorespiratory responses to glutamate microinjected into the medullary raphé. Respir Physiol 113: 11-21, 1998.
23. Bernard DG, Li A, and Nattie EE. Evidence for central chemoreception in the midline raphé. J Appl Physiol 80: 108-115, 1996.
24. 2-free gas mixtures with low, normal, or high oxygen concentrations. Respir Physiol 1: 390-397, 1966.
25. Bianchi L and Driscoll M. Protons at the gate: DEG/ENaC ion channels help us feel and remember. Neuron 34: 337-340, 2002.
26. Bickler PE, Litt L, Banville DL, and Severinghaus JW. Effects of acetazolamide on cerebral acid-base balance. J Appl Physiol 65: 422-427, 1988.
27. Bingmann D, Baker RE, and Ballantyne D. Rhythm generation in brainstem cultures grown in a serum-free medium. Neurosci Lett 132: 167-170, 1991.
28. Bledsoe SW, Berger AJ, and Hornbein TF. Limitations of ventriculocisternal perfusion for determining brain interstitial fluid composition. J Appl Physiol 54: 1505-1510, 1983.
29. Bond CT, Maylie J, and Adelman JP. Small-conductance calcium-activated potassium channels. Ann NY Acad Sci 868: 370-378, 1999.
30. + channel subunit, SK3. Science 289: 1942-1946, 2000.
31. 2 on depth and rate of breathing in decerebrate cats. Respir Physiol 30: 311-325, 1977.
32. T in chemodenervated decerebrate cats. Comput Biomed Res 13: 458-472, 1980.
33. 3, and metabolic inhibitors. J Gen Physiol 67: 91-112, 1976.
34. Bou-Flores C and Berger AJ. Gap junctions and inhibitory synapses modulate inspiratory motoneuron synchronization. J Neurophysiol 85: 1543-1551, 2001.
35. Bouvier M, Szatkowski M, Amato A, and Attwell D. The glial cell glutamate uptake carrier countertransports pH-changing anions. Nature 360: 471-474, 1992.
36. Bouyer PG, Bradley SR, Zhao J, Wang W, Richerson GB, and Boron WF. Effect of extracellular acid-base disturbances on the intracellular pH of neurones cultured from rat medullary raphé or hippocampus. J Physiol 559: 85-101, 2004.
37. +/nigericin for calibrating BCECF. I. Estimating steady-state intracellular pH. Am J Physiol Cell Physiol 271: C1131-C1145, 1996.
38. Bradley PMJ, Paton JFR, Murphy D, and Kasparov S. Optical recording of calcium transients from respiratory rhythmic neurones in situ (Abstract). FASEB J 17: A396, 2003.
39. Bredt DS, Wang TL, Cohen NA, Guggino WB, and Snyder SH. Cloning and expression of two brain-specific inwardly rectifying potassium channels. Proc Natl Acad Sci USA 92: 6753-6757, 1995.
40. Brewer GJ and Cotman CW. Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen. Brain Res 494: 65-74, 1989.
41. 2+ and pH and activated by protein kinase A. Glia 19: 311-323, 1997.
42. Bruehl C and Witte OW. Relation between bicarbonate concentration and voltage dependence of sodium currents in freshly isolated CA1 neurons of the rat. J Neurophysiol 89: 2489-2498, 2003.
43. Buckler KJ and Vaughan-Jones RD. Effects of hypercapnia on membrane potential and intracellular calcium in rat carotid body type I cells. J Physiol 418: 157-171, 1994.
44. i in acid chemoreception in type-I cells of the carotid body. In: Arterial Chemoreceptors: Cell to System, edited by O'Regan RG, Nolan P, McQueen DS, and Paterson DJ. New York: Plenum, 1994, p. 41-55.
45. - on intracellular pH in isolated type-I cells of the neonatal rat carotid body. J Physiol 444: 703-721, 1991.
46. Buckler KJ, Vaughan-Jones RD, Peers C, and Nye PCG. Intracellular pH and its regulation in isolated type I carotid body cells of the neonatal rat. J Physiol 436: 107-129, 1991.
47. Buckler KJ, Williams BA, and Honore E. An oxygen-, acid- and anaesthetic-sensitive TASK-like background potassium channel in rat arterial chemoreceptor cells. J Physiol 525: 135-142, 2000.
48. Bülow K. Respiration and wakefulness in man. Acta Physiol Scand 59, Suppl 209: 1-110, 1963.
49. Burton MB and Kazemi H. Neurotransmitters in central respiratory control. Respir Physiol 122: 111-121, 2000.
50. Burton MD, Nouri K, Baichoo S, Samuels-Toyloy N, and Kazemi H. Ventilatory output and acetylcholine: perturbations in release and muscarinic receptor activation. J Appl Physiol 77: 2275-2284, 1994.
51. Carpenter DO, Hubbard JH, Humphrey DR, Thompson HK, and Marshall WH. Carbon dioxide effects on nerve cell function. In: Carbon Dioxide and Metabolic Regulation, edited by Nahas G and Schaefer KE. New York: Springer, 1974, p. 49-62.
52. 2 in the awake lamb: role of the carotid chemoreceptors. J Appl Physiol 71: 2198-2205, 1991.
53. 2+ channels. Annu Rev Cell Dev Biol 16: 521-555, 2000.
54. Chambers-Kersh L, Ritucci NA, Dean JB, and Putnam RW. Response of intracellular pH to acute anoxia in individual neurons from chemosensitive and nonchemosensitive regions of the medulla. In: Oxygen Sensing: Molecule to Man, edited by Lahiri S, Prabhakar N, and Forster RE II. New York: Kluwer Academic/Plenum, 2000, p. 453-464.
55. Chen N, Luo T, and Raymond LA. Subtype-dependence of NMDA receptor channel open probability. J Neurosci 19: 6844-6854, 1999.
56. 2 chemosensitivity in Helix aspersa (Abstract). FASEB J 17: A584, 2003.
57. Chesler M. The regulation and modulation of pH in the brain. Physiol Rev 83: 1183-1221, 2003.
58. Chesler M and Chen JCT. Alkaline extracellular pH shifts generated by two transmitter-dependent mechanisms. Can J Physiol Pharmacol 70: S286-S292, 1992.
59. Chesler M and Kaika K. Modulation of pH by neuronal activity. Trends Neurosci 15: 396-402, 1992.
60. Choe H, Zhou H, Palmer LG, and Sackin HA. A conserved cytoplasmic region of ROMK modulates pH sensitivity, conductance, and gating. Am J Physiol Renal Physiol 273: F516-F529, 1997.
61. 2+, pH and membrane potential. Pflügers Arch 408: 249-259, 1987.
62. Christie MJ and Jelinek HF. Dye coupling among neurons of the rat locus coeruleus during postnatal development. Neuroscience 56: 129-137, 1993.
63. Christie MJ, Williams JT, and North RA. Electrical coupling synchronizes subthreshold activity in locus coeruleus neurons in vitro from neonatal rats. J Neurosci 9: 3584-3589, 1989.
64. Church J. Effects of pH changes on calcium-mediated potentials in rat hippocampal neurons in vitro. Neuroscience 89: 731-742, 1999.
65. + channel in cultured rat hippocampal neurones. J Physiol 511.1: 119-132, 1998.
66. + channel Kv1.4 by acidosis: protonation of an extracellular histidine slows the recovery from N-type inactivation. J Physiol 526: 253-264, 2000.
67. 2. J Physiol 441: 433-451, 1991.
68. Coates EL, Li A, and Nattie E. Widespread sites of brain stem ventilatory chemoreceptors. J Appl Physiol 75: 5-14, 1993.
69. 3 ion and of morphine on the respiratory centre. J Physiol 54: 58-61, 1921.
70. Conrad SC, Mulkey DK, Ritucci NA, Dean JB, and Putnam RW. Development of chemosensitive neurons in the NTS (Abstract). FASEB J 18: A337, 2004.
71. + channels in pancreatic B-cells. Nature 311: 269-271, 1984.
72. Coulter KL, Perier F, Radeke CM, and Vandenberg CA. Identification and molecular localization of a pH-sensing domain for the inward rectifier potassium channel HIR. Neuron 15: 1157-1168, 1995.
73. Cowan IA and Martin RL. Simultaneous measurement of pH and membrane potential in rat dorsal vagal motoneurons during normoxia and hypoxia: a comparison in bicarbonate and HEPES buffer. J Neurophysiol 74: 2713-2721, 1995.
74. Cragg P, Drysdale DB, and Hamilton JH. Ventilation in intact and glossopharyngeal nerve sectioned anaesthetized rats exposed to oxygen at high pressure. J Physiol 370: 489-499, 1986.
75. Cragg P, Patterson L, and Purves MJ. The pH of brain extracellular fluid in the cat. J Physiol 272: 137-166, 1977.
76. 2 at physiological levels. J Cell Physiol 189: 229-236, 2001.
77. 2 and in arterial pH. In: Handbook of Physiology. The Respiratory System. Control of Breathing. Bethesda, MD: Am. Physiol. Soc., 1986, sect. 3, vol. II, pt. 2, chapt. 15, p. 475-528.
78. 2 response in decerebrate piglets. Respir Physiol 123: 23-37, 2000.
79. + channels. Cell Signal 9: 551-573, 1997.
80. Dasso LLT, Buckler KJ, and Vaughan-Jones RD. Interactions between hypoxia and hypercapnic acidosis on calcium signaling in carotid body type I cells. Am J Physiol Lung Cell Mol Physiol 279: L36-L42, 2000.
81. 2 chemoreception and respiratory control. Am J Physiol Lung Cell Mol Physiol 283: L665-L670, 2002.
82. Dean JB, Bayliss DA, Erickson JT, Lawing WL, and Millhorn DE. Depolarization and stimulation of neurons in nucleus tractus solitarii by carbon dioxide does not require chemical synaptic input. Neuroscience 36: 207-216, 1990.
83. 2-sensitive neurons in the dorsal vagal complex studied in vitro (Abstract). Soc Neurosci Abstr 16: 1235, 1990.
84. Dean JB, Huang RQ, Erlichman JS, Southard TL, and Hellard DT. Cell-cell coupling occurs in dorsal medullary neurons after minimizing anatomical-coupling artifacts. Neuroscience 80: 21-40, 1997.
85. +-excited neurons in brainstem slices. Respir Physiol 129: 83-100, 2001.
86. 2 decreases membrane conductance and depolarizes neurons in the nucleus tractus solitarii. Exp Brain Res 76: 656-661, 1989.
87. Dean JB, Mulkey DK, Garcia AJ, Putnam RW, and Henderson RA. Neuronal sensitivity to hyperoxia, hypercapnia, and inert gases at hyperbaric pressures. J Appl Physiol 95: 883-909, 2003.
88. + chemosensitivity in brainstem neurons. In: Ventral Brainstem Mechanisms and Control of Respiration and Blood Pressure, edited by Trouth CO and Millis RM, Kiwull-Schone HF, and Schläfke ME. New York: Dekker, 1995, p. 453-461.
89. Deitmer JW. Strategies for metabolic exchange between glial cells and neurons. Respir Physiol 129: 71-81, 2001.
90. Deitmer JW and Rose CR. pH regulation and proton signalling by glial cells. Prog Neurobiol 48: 73-103, 1996.
91. Dejours P. Control of respiration by arterial chemoreceptors. Ann NY Acad Sci 109: 682-695, 1963.
92. Denavit-Saubié M, Schafer T, Boudinot E, Kato F, and Morin-Surun MP. Perfused isolated adult brainstem. A novel approach to study central chemosensitivity. In: Ventral Brainstem Mechanisms and Control of Respiration and Blood Pressure, edited by Trouth CO, Millis RM, Kiwull-Schone HF, and Schläfke ME. New York: Dekker, 1995, p. 785-795.
93. + chemosensitivity in Helix aspersa neurons (Abstract). FASEB J 15: A152, 2001.
94. + chemoreceptor region in Helix aspersa (Abstract). Soc Neurosci Abstr 26: 1549, 2000.
95. Dev NB and Loeschcke HH. A cholinergic mechanism involved in the respiratory chemosensitivity of the medulla oblongata in the cat. Pflügers Arch 379: 29-36, 1979.
96. Dev NB and Loeschcke HH. Topography of the respiratory and circulatory responses to acetylcholine and nicotine on the ventral surface of the medulla oblongata. Pflügers Arch 379: 19-27, 1979.
97. + and intracellular pH allosterically regulate renal Kir1.1 channels. J Biol Chem 271: 17261-17266, 1996.
98. Downen M, Belkowski S, Knowles H, Cardillo M, and Prystowsky MB. Developmental expression of voltage-gated potassium channel β subunits. Dev Brain Res 117: 71-80, 1999.
99. + channel to sense external pH variations near physiological pH. EMBO J 16: 5464-5471, 1997.
100. Dutschmann M and Paton JFR. Whole cell patch clamp (wcp) recording from the intact respiratory network of the neonatal rat in situ: a lateral approach (Abstract). FASEB J 17: A396, 2003.
101. Dutschmann M, Wilson RJ, and Paton JFR. Respiratory activity in neonatal rats. Auton Neurosci 84: 19-29, 2000.
102. 2 sensors or relay neurons? (Abstract). FASEB J 15: A150, 2001.
103. 2 sensing. Physiologist 45: 356, 2002.
104. Eglen RM, Hunter JC, and Dray A. Ions in the fire: recent ion-channel research and approaches to pain therapy. Trends Pharmacol Sci 20: 337-342, 1999.
105. Eisner DA, Kenning NA, O'Neill SC, Pocock G, Richards CD, and Valdeolmillos M. A novel method for absolute calibration of intracellular pH indicators. Pflügers Arch 413: 553-558, 1989.
106. Eldridge FL, Kiley JP, and Millhorn DE. Respiratory responses to medullary hydrogen ion changes in cats: different effects of respiratory and metabolic acidosis. J Physiol 358: 285-297, 1985.
107. Erlichman JS and Leiter JC. Central chemoreceptor stimulus in the terrestrial, pulmonate snail, Helix aspersa. Respir Physiol 95: 209-226, 1994.
108. 2 chemoreception. Respir Physiol 110: 177-185, 1997.
109. 2 chemoreceptors in Helix pomatia. Am Zool 37: 54-64, 1997.
110. Erlichman JS, Li A, and Nattie EE. Ventilatory effects of glial dysfunction in a rat brain stem chemoreceptor region. J Appl Physiol 85: 1599-1604, 1998.
111. Eyzaguirre C. Carotid body gap junctions: secretion of transmitters and possible electric coupling between glomus cells and nerve terminals. In: Oxygen Sensing: Molecule to Man, edited by Lahiri S, Prabhakar N, and Forster RE II. New York: Kluwer Academic/Plenum, 2000, p. 349-357.
112. Eyzaguirre C and Abudara V. Possible role of coupling between glomus cells in carotid body chemoreception. Biol Signals 4: 263-270, 1995.
113. + channels from subunits of different subfamilies: Kir2.1 (IRK1) and Kir41 (BIR10). Pflügers Arch 433: 77-83, 1996.
114. Fencl V, Miller TB, and Pappenheimer JR. Studies on the respiratory response to disturbances of acid-base balance, with deductions concerning the ionic composition of cerebral interstitial fluid. Am J Physiol 210: 459-472, 1966.
115. Fidone SJ and Gonzalez C. Initiation and control of chemoreceptor activity in the carotid body. In: Handbook of Physiology. The Respiratory System. Control of Breathing. Bethesda, MD: Am. Physiol. Soc., 1986, sect. 3, vol. II, pt. 1, chapt. 9, p. 247-312.
116. Filosa JA, Dean JB, and Putnam RW. Role of intracellular and extracellular pH in the chemosensitive response of rat locus coeruleus neurones. J Physiol 541: 493-509, 2002.
117. 2+ channels. Am J Physiol Cell Physiol 284: C145-C155, 2003.
118. + channel. EMBO J 15: 6854-6862, 1996.
119. Fitzgerald SC, Willis MA, Yu C, and Rigatto H. In search of the central respiratory neurons. I. Dissociated cell cultures of respiratory areas from the upper medulla. J Neurosci Res 33: 579-589, 1992.
120. -] on neurons in the rat medullary chemosensitive areas in vitro. Pflügers Arch 398: 324-330, 1983.
121. Fukuda Y and Honda Y. pH sensitivity of cells located at the ventro-lateral surface of the cat medulla oblongata in vitro. Pflügers Arch 364: 243-247, 1976.
122. Fukuda Y and Honda Y. pH-sensitive cells at ventro-lateral surface of rat medulla oblongata. Nature 256: 317-318, 1975.
123. + on the membrane potential of silent cells in the ventral and dorsal surface layers of the rat medulla in vitro. Pflügers Arch 376: 229-235, 1978.
124. + in the respiratory chemosensitive structures of the ventral medulla oblongata of rats in vitro. Pflügers Arch 379: 125-135, 1979.
125. + on spontaneous neuronal activity in the surface layer of the rat medulla oblongata in vitro. Pflügers Arch 371: 125-134, 1977.
126. +-sensitivity and pattern of discharge of neurons in the chemosensitive areas of the ventral medulla oblongata of rats in vitro. Pflügers Arch 388: 53-61, 1980.
127. Gautier H, Bonora M, and Gaudy JH. Ventilatory response of the conscious or anesthetized cat to oxygen breathing. Respir Physiol 65: 181-196, 1986.
128. Gesell R and Hertzman AB. Regulation of respiration. III. Continuous method of recording changes in acidity applied to circulating blood and other body fluids. Am J Physiol 78: 206-223, 1926.
129. Gesell R and Hertzman AB. Regulation of respiration. IV. Tissue acidity, blood acidity and pulmonary ventilation: study of effects of semipermeability of membranes and buffering action of tissues with continuous method of recording changes in acidity. Am J Physiol 78: 610-629, 1926.
130. Gilbertson TA, Avenet P, Kinnamon SC, and Roper SD. Proton currents through amiloride-sensitive Na channels in hamster taste cells: role in acid transduction. J Gen Physiol 100: 803-824, 1992.
131. Goldstein JI, Mok JM, Simon CM, and Leiter JC. Intracellular pH regulation in neurons from chemosensitive and nonchemosensitive regions of Helix aspersa. Am J Physiol Regul Integr Comp Physiol 279: R414-R423, 2000.
132. González C, Almaraz A, Obeso A, and Rigual R. Oxygen and acid chemoreception in the carotid body chemoreceptors. Trends Neurosci 15: 146-153, 1992.
133. Gray JS. The multiple factor theory of the control of respiratory ventilation. Science 103: 739-744, 1946.
134. Gray JS. Pulmonary Ventilation and its Physiological Regulation. Springfield, IL: Charles C. Thomas, 1950.
135. Gray PA, Janczewski WA, Mellen N, McCrimmon DR, and Feldman JL. Normal breathing requires preBötzinger complex neurokinin-1 receptor-expressing neurons. Nat Neurosci 4: 927-930, 2001.
136. Gray PA, Rekling JC, Bocchiaro CM, and Feldman JL. Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBötzinger complex. Science 286: 1566-1568, 1999.
137. Green CR. The role of gap junctions during development and patterning. In: Fundamentals of Medical Cell Biology, Developmental Biology, edited by Edward E. Greenwich, CT: JAI, 1992, p. 133-149.
138. Grinstein S, Romanek R, and Rotstein OD. Method for manipulation of cytosolic pH in cells clamped in the whole cell or perforated-patch configurations. Am J Physiol Cell Physiol 267: C1152-C1159, 1994.
139. Grönroos M and Pertovaara A. A selective suppression of human pain sensitivity by carbon dioxide: central mechanisms implicated. Eur J Appl Physiol 68: 74-79, 1994.
140. Gurney AM, Osipenko ON, MacMillan D, and Kempsill FEJ. Potassium channels underlying the resting potential of pulmonary artery smooth muscle cells. Clin Exp Pharmacol Physiol 29: 330-333, 2002.
141. 2 deprivation induces a major depolarization in brain stem neurons in the adult but not in the neonatal rat. J Physiol 429: 411-428, 1990.
142. 2 deprivation in the central nervous system: on mechanisms of neuronal response, differential sensitivity and injury. Prog Neurobiol 40: 277-318, 1993.
143. Hanson MA, Nye PCG, and Torrance RW. The exodus of an extracellular bicarbonate theory of chemoreception and the genesis of an intracellular one. In: Arterial Chemoreception, edited by Belmonte C, Pallot DJ, Acker H, and Fidone S. Leicester, UK: Leicester University Press, 1971, p. 403-416.
144. Harada Y, Kuno M, and Wang YZ. Differential effects of carbon dioxide and pH on central chemoreceptors in the rat in vitro. J Physiol 368: 679-693, 1985.
145. + channel. J Biol Chem 276: 26499-26508, 2001.
146. Hatton GI. Glial-neuronal interactions in the mammalian brain. Adv Physiol Educ 26: 225-237, 2002.
147. Hayashida Y and Hirakawa H. Electrical properties of chemoreceptor elements in the carotid body. Microsc Res Tech 59: 243-248, 2002.
148. Haydon PG. Glia: listening and talking to the synapse. Nat Rev Neurosci 2: 185-193, 2001.
149. + exchange. Am J Physiol Regul Integr Comp Physiol 284: R1551-R1559, 2003.
150. 2 (Abstract). FASEB J 16: A813, 2002.
151. 2 chemotransduction in avian intrapulmonary chemoreceptors (Abstract). FASEB J 11: A133, 1997.
152. Hempleman SC, Rodriguez TA, Bhagat YA, and Begay RS. Benzolamide, acetazolamide, and signal transduction in avian intrapulmonary chemoreceptors. Am J Physiol Regul Integr Comp Physiol 279: R1988-R1995, 2000.
153. Heymans JF and Heymans C. Sur les modifications directes et sur la regulation reflexe de l'activite du centre respiratoire de lat tete isolee du chien. Arch Int Pharmacodyn Ther 33: 273-372, 1927.
154. Hobson JA, McCarley RW, and Wyzinski PW. Sleep cycle oscillation: reciprocal discharge by two brainstem neuronal groups. Science 189: 55-58, 1975.
155. Hoeger-Bement MK and Sluka KA. Phosphorylation of CREB and mechanical hyperalgesia is reversed by blockade of the cAMP pathway in a time-dependent manner after repeated intramuscular acid injections. J Neurosci 23: 5437-5445, 2003.
156. Holleran J, Babbie M, and Erlichman JS. Ventilatory effects of impaired glial function in a brain stem chemoreceptor region in the conscious rat. J Appl Physiol 90: 1539-1547, 2001.
157. + channel TREK-1. EMBO J 21: 2968-2976, 2002.
158. Horn EM and Waldrop TG. Modulation of the respiratory responses to hypoxia and hypercapnia by synaptic input onto caudal hypothalamic neurons. Brain Res 664: 25-33, 1994.
159. 2-excited neurons in the dorsal medulla oblongata. Neuroscience 80: 41-57, 1997.
160. Ishii K, Nunoki K, Yamagishi T, Okada H, and Taira N. Differential sensitivity of Kv1.4, Kv1.2, and their tandem channel to acidic pH: involvement of a histidine residue in high sensitivity to acidic pH. J Pharmacol Exp Ther 296: 405-411, 2001.
161. Ishimatsu M and Williams JT. Synchronous activity in locus coeruleus results from dendritic interactions in pericoerulear regions. J Neurosci 16: 5196-5204, 1996.
162. Isomoto S, Kondo C, and Kurachi Y. Inwardly rectifying potassium channels: their molecular heterogeneity and function. Jpn J Physiol 47: 11-39, 1997.
163. -. Adv Exp Med Biol 410: 211-216, 1996.
164. Iturriaga R, Lahiri S, and Mokashi A. Carbonic anhydrase and chemoreception in the cat carotid body. Am J Physiol Cell Physiol 261: C565-C573, 1991.
165. Iturriaga R, Mokashi A, and Lahiri S. Anion exchanger and chloride channel in cat carotid body chemotransduction. J Auton Nerv Syst 70: 23-31, 1998.
166. Jacobs M. The influence of ammonium salts on cell reaction. J Gen Physiol 2: 181-187, 1922.
167. Jan LY and Jan YN. Voltage-gated and inwardly rectifying potassium channels. J Physiol 505: 267-282, 1997.
168. Jarolimek W, Misgeld U, and Lux HD. Neurons sensitive to pH in slices of the rat ventral medulla oblongata. Pflügers Arch 416: 247-253, 1990.
169. Jean-Charles V and Gérard H. Noradrenergic receptors and in vitro respiratory rhythm: possible interspecies differences between mouse and rat neonates. Neurosci Lett 294: 149-153, 2002.
170. 31P-NMR study. Acta Physiol Scand 134: 295-298, 1988.
171. Judd MG, Tavarekere N, Nagaraja TN, and Brookes N. Potassium-induced stimulation of glutamate uptake in mouse cerebral astrocytes: the role of intracellular pH. J Neurochem 66: 169-176, 1996.
172. Kaila K and Voipio J. Postsynaptic fall in intracellular pH induced by GABA-activated bicarbonate conductance. Nature 330: 163-165, 1987.
173. A receptor-mediated IPSPs of rat neocortical neurones. J Physiol 464: 273-289, 1993.
174. +-sensitive area in the ventral medullary surface assessed by the effects of chemical stimulation on respiration. J Auton Nerv Syst 72: 24-33, 1998.
175. Kanner BI and Borre L. The dual-function glutamate transporters: structure and molecular characterisation of the substrate-binding sites. Biochim Biophys Acta 1555: 92-95, 2002.
176. Kaplan FS, Brighton CT, Boytim MJ, Selzer ME, Lee V, Spindler K, Silberberg D, and Black J. Enhanced survival of rat neonatal cerebral cortical neurons at subatmospheric oxygen tensions in vitro. Brain Res 384: 199-203, 1986.
177. Katsura K, Kristián T, Nair R, and Siesjö BK. Regulation of intra- and extracellular pH in the rat brain in acute hypercapnia: a re-appraisal. Brain Res 651: 47-56, 1994.
178. Katsura K, Kristián T, Smith ML, and Siesjö BK. Acidosis induced by hypercapnia exaggerates ischemic brain damage. J Cereb Blood Flow Metab 14: 243-250, 1994.
179. Katzman MA, Struzik L, Vijay N, Coonerty-Femiano A, Mahamed S, and Duffin J. Central and peripheral chemoreflexes in panic disorder. Psychiatry Res 113: 181-192, 2002.
180. Kawai A, Ballantyne D, Mückenhoff K, and Scheid P. Chemosensitive medullary neurones in the brainstem-spinal cord preparation of the neonatal rat. J Physiol 492: 277-292, 1996.
181. Kazemi H and Hoop B. Glutamic acid and γ-aminobutyric acid neurotransmittiers in central control of breathing. J Appl Physiol 70: 1-7, 1991.
182. Kemp PJ, Lewis A, Hartness ME, Searle GJ, Miller P, O'Kelly I, and Peers C. Airway chemotransduction. From oxygen sensor to cellular effector. Am J Respir Crit Care Med 166: S17-S24, 2002.
183. + channel (cTBAK-1). Circ Res 82: 513-518, 1998.
184. + channel family. J Biol Chem 275: 9340-9347, 2000.
185. King BF, Ziganshina LE, Pinto J, and Burnstock G. Full sensitivity of P2X2 purinoceptor to ATP revealed by changing extracellular pH. Br J Pharmacol 117: 1371-1373, 1996.
186. Kinney HC, Filiano JJ, Sleeper LA, Mandell F, Valdes-Dapena M, and Frost White W. Decreased muscarinic receptor binding in the arcuate nucleus in sudden infant death syndrome. Science 269: 1446-1450, 1995.
187. 2+ channels by intracellular pH in chick sensory neurons. J Neurophysiol 81: 1839-1847, 1999.
188. Kiwull-Schöne HF. The "Reaction Theory" of Hans Winterstein (1879-1963) in the light of today's research on the ventrolateral medulla. In: Ventral Brainstem Mechanisms and Control of Respiration and Blood Pressure, edited by Trouth CO, Millis RM, Kiwull-Schone HF, and Schläfke ME. New York: Dekker, 1995, p. 1-39.
189. Kiwull-Schöne HF and Kiwull P. Hypoxia and the "reaction theory" of central respiratory chemosensitivity. Adv Exp Med Biol 316: 347-357, 1992.
190. Kiwull-Schöne HF and Kiwull P. Hypoxic modulation of central chemosensitivity. In: Central Neuroenvironment and the Control Systems of Breathing and Circulation, edited by Schläfke ME, Koepchen HP, and See WR. New York: Springer, 1983, p. 88-95.
191. 2+ channels. J Gen Physiol 103: 647-663, 1994.
192. Kondo T, Kumagai M, Ohta Y, and Bishop B. Ventilatory responses to hypercapnia and hypoxia following chronic hypercapnia in the rat. Respir Physiol 122: 35-43, 2000.
193. + channel activities in the rat locus coeruleus neurons during metabolic inhibition. Brain Res 828: 189-192, 1999.
194. A receptor is associated with the receptor subunit composition. J Physiol 492.2: 431-443, 1996.
195. 2 chemosensitivity. Functional, cellular and molecular studies. In: Oxygen Sensing: Molecule to Man, edited by Lahiri S, Prabhakar N, and Forster RE II. New York: Kluwer Academic/Plenum, 2000, p. 405-410.
196. Kume H, Takagi K, Satake T, Tokuno H, and Tomita T. Effects of intracellular pH on calcium-activated potassium channels in rabbit tracheal smooth muscle. J Physiol 424: 445-457, 1990.
197. Kuwana SI, Okada Y, and Natsui T. Effects of extracellular calcium and magnesium on central respiratory control in the brainstem-spinal cord of neonatal rat. Brain Res 786: 194-204, 1998.
198. Lahiri S, Iturriaga R, Mokashi A, Botré F, Chugh D, and Osanai S. Adaptation to hypercapnia vs. intracellular pH in cat carotid body: responses in vitro. J Appl Physiol 80: 1090-1099, 1996.
199. Lassen NA. Is central chemoreceptor sensitive to intracellular rather than extracellular pH? Clin Physiol 10: 311-319, 1990.
200. + channel from rat skeletal muscle incorporated into planar bilayers. J Gen Physiol 98: 1025-1042, 1991.
201. + channel present in rat cortical neurones. J Physiol 488.2: 319-337, 1995.
202. Lehmenkühler A, Bingmann D, and Speckmann EJ. Neuronal and glial responses to hypoxia and hypercapnia. Biomed Biochim Acta 48: S155-S160, 1989.
203. Leiter JC, Smith A, Wages P, Parisian K, and Erlichman JS. Evidence for sodium-bicarbonate cotransport in medullary glial cells in the dorsal and ventral medulla (Abstract). FASEB J 17: A813, 2002.
204. Leonoudakis D, Gray AT, Winegar BD, Kindler CH, Harada M, Taylor DM, Chavez RA, Forsayeth JR, and Yost CS. An open rectifier potassium channel with two pore domains in tandem cloned from rat cerebellum. J Neurosci 18: 868-877, 1998.
205. + channel with a novel structure. EMBO J 15: 1004-1011, 1996.
206. + channel. FEBS Lett 402: 28-32, 1997.
207. Li A and Nattie EE. Prolonged stimulation of respiration by brain stem metabotropic glutamate receptors. J Appl Physiol 79: 1650-1656, 1995.
208. 2 microdialysis in the retrotrapezoid nucleus of the rat increases breathing in wakefulness but not in sleep. J Appl Physiol 87: 910-919, 1999.
209. +: evidence for transmembrane communication. Am J Physiol Heart Circ Physiol 284: H71-H80, 2003.
210. + channels via cytosolic factors in mice neocortical neurons. J Clin Invest 104: 577-588, 1999.
211. Loeschcke HH. Central chemosensitivity and the reaction theory. J Physiol 332: 1-24, 1982.
212. Lopez-Barneo J. Oxygen and glucose sensing by carotid body glomus cells. Curr Opin Neurobiol 13: 493-499, 2003.
213. Low CM, Lyuboslavsky P, French A, Le P, Wyatte K, Thiel WH, Marchan EM, Igarashi K, Kashiwagi K, Gernert K, Williams K, Traynelis SF, and Zheng F. Molecular determinants of proton-sensitive N-methyl-D-aspartate receptor gating. Mol Pharmacol 63: 1212-1222, 2003.
214. 2 chemosensitivity in Helix aspersa. Respir Physiol 111: 65-78, 1998.
215. Lückermann M, Trapp S, and Ballanyi K. GABA- and glycine-mediated fall of intracellular pH in rat medullary neurons in situ. J Neurophysiol 77: 1844-1852, 1997.
216. Lühring H. pH-sensitive gating kinetics of the maxi-K channel in the tonoplast of Chara australis. J Membr Biol 168: 47-61, 1999.
217. Lyall V, Alam RI, Phan DQ, Ereso GL, Phan THT, Malik SA, Montrose MH, Chu S, Heck GL, Feldman GM, and DeSimone JA. Decrease in rat taste receptor cell intracellular pH is the proximate stimulus in sour taste transduction. Am J Physiol Cell Physiol 281: C1005-C1013, 2001.
218. 2+. J Neurophysiol 87: 399-408, 2002.
219. + activity in polarized taste receptor cells by pH. J Gen Physiol 120: 793-815, 2002.
220. - on intracellular pH in isolated rat taste buds. Am J Physiol Cell Physiol 273: C1008-C1019, 1997.
221. MacGregor DG, Chesler M, and Rice ME. HEPES prevents edema in rat brain slices. Neurosci Lett 303: 141-144, 2001.
222. Maingret F, Patel AJ, Lesage F, Lazdunski M, and Honoré E. Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel. J Biol Chem 274: 26691-26696, 1999.
223. Mallios VJ, Lydic R, and Baghdoyan HA. Muscarinic receptor subtypes are differentially distributed across brain stem respiratory nuclei. Am J Physiol Lung Cell Mol Physiol 268: L941-L949, 1995.
224. 2. J Appl Physiol 58: 549-557, 1985.
225. Mathie A, Wooltorton JR, and Watkins CS. Voltage-activated potassium channels in mammalian neurons and their block by novel pharmacological agents. Gen Pharmacol 30: 13-24, 1998.
226. McCleskey EW and Gold MS. Ion channels of nociception. Annu Rev Physiol 61: 835-856, 1999.
227. McDonald DM. Peripheral chemoreceptors: structure-function relationships of the carotid body. In: Regulation of Breathing, Part I, edited by Hornbein TF. New York: Dekker, 1981, p. 105-309.
228. + channel, ROMK. Am J Physiol Renal Physiol 275: F972-F981, 1998.
229. 2 response and alters sleep in newborn piglets. Respir Physiol Neurobiol 133: 197-214, 2002.
230. 2 in hypoxia and in high oxygen. Respir Physiol 20: 17-31, 1974.
231. Miller MJ and Tenney SM. Hyperoxic hyperventilation in carotid-deafferented cats. Respir Physiol 23: 23-30, 1975.
232. Miller P, Peers C, and Kemp PJ. Polymodal regulation of hTREK1 by pH, arachidonic acid, and hypoxia: physiological impact in acidosis and alkalosis. Am J Physiol Cell Physiol 286: C272-C282, 2004.
233. Monteau R, Morin D, and Hilaire G. Acetylcholine and central chemosensitivity: in vitro study in the newborn rat. Respir Physiol 81: 241-254, 1990.
234. Morin-Surun MP, Boudinot E, Schäfer T, and Denavit-Saubié M. Localization of chemosensitive structures in the isolated brainstem of adult guinea-pig. J Physiol 485: 203-212, 1995.
235. Morrell MJ, Heywood P, Moosavi SH, Stevens J, and Guz A. Central chemosensitivity and breathing asleep in unilateral medullary lesion patients: comparisons to animal data. Respir Physiol 129: 269-277, 2001.
236. + channels TASK-1 and -2. Pflügers Arch 445: 577-583, 2003.
237. Mulkey DK, Henderson RA, Olson JE, Putnam RW, and Dean JB. Oxygen measurements in brain stem slices exposed to normobaric hyperoxia and hyperbaric oxygen. J Appl Physiol 90: 1887-1899, 2001.
238. +-sensitive neurons in rat brain stem slices. J Appl Physiol 95: 910-921, 2003.
239. Nattie EE. Central chemoreceptors, pH, and respiratory control. In: pH and Brain Function, edited by Kaika K and Ransom BR. New York: Wiley-Liss, 1998, p. 535-560.
240. Nattie EE. Central chemosensitivity, sleep, and wakefulness. Respir Physiol 129: 257-268, 2001.
241. 2, brainstem chemoreceptors and breathing. Prog Neurobiol 59: 299-331, 1999.
242. + sensitivity. J Appl Physiol 64: 1600-1609, 1988.
243. Nattie E. Invited Editorial on "Adaptation to hypercapnia vs. intracellular pH in cat carotid body: response in vitro". J Appl Physiol 80: 1088-1089, 1996.
244. 2-sensitive phrenic and sympathetic output. J Appl Physiol 74: 2958-2968, 1993.
245. Nattie EE and Li A. Central chemoreception in the region of the ventral respiratory group of the rat. J Appl Physiol 81: 1987-1995, 1996.
246. 2 dialysis in the medullary raphe of the rat increases ventilation in sleep. J Appl Physiol 90: 1247-1257, 2001.
247. Nattie EE and Li A. Muscimol dialysis in the retrotrapezoid nucleus region inhibits breathing in the awake rat. J Appl Physiol 89: 153-162, 2000.
248. 2 in the neonatal rat transverse medullary slice. Respir Physiol Neurobiol 132: 279-287, 2002.
249. Nedvetsky PI, Kleinschnitz C, and Schmidt HHHW. Regional distribution of protein and activity of the nitric oxide receptor, soluble guanylyl cyclase, in rat brain suggests multiple mechanisms of regulation. Brain Res 950: 148-154, 2002.
250. Neubauer JA, Gonsalves SF, Chou W, Geller HM, and Edelman NH. Chemosensitivity of medullary neurons in explant tissue cultures. Neuroscience 45: 701-708, 1991.
251. Newman EA. Glial cell inhibition of neurons by release of ATP. J Neurosci 23: 1659-1666, 2003.
252. Nichols CG and Lopatin AN. Inward rectifier potassium channels. Annu Rev Physiol 59: 171-191, 1997.
253. Nielsen M and Smith H. Studies on the regulation of respiration in acute hypoxia. Acta Physiol Scand 24: 293-313, 1951.
254. + channel TASK-2 (KCNK5) by changes in cell volume. J Biol Chem 276: 43166-43174, 2001.
255. Nottingham S, Leiter JC, Wages P, Buhay S, and Erlichman JS. Developmental changes in intracellular pH regulation in medullary neurons of the rat. Am J Physiol Regul Integr Comp Physiol 281: R1940-R1951, 2001.
256. Nurse CA. Carbonic anhydrase and neuronal enzymes in cultured glomus cells of the carotid body of the rat. Cell Tissue Res 261: 65-71, 1990.
257. Okada Y, Chen Z, Jiang W, Kuwana SI, and Eldridge FL. Anatomical arrangement of hypercapnia-activated cells in the superficial ventral medulla of rats. J Appl Physiol 93: 427-439, 2002.
258. O'Regan RG and Majcherczyk S. Role of peripheral chemoreceptors and central chemosensitivity in the regulation of respiration and circulation. J Exp Biol 100: 23-40, 1982.
259. Osanai S, Buerk DG, Mokashi A, Chugh D, and Lahiri S. Cat carotid body chemosensory discharge (in vitro) is insensitive to charybdotoxin. Brain Res 747: 324-327, 1997.
260. Osmanović SS and Shefner SA. Calcium-activated hyperpolarizations in rat locus coeruleus neurons in vitro. J Physiol 469: 89-109, 1993.
261. Oyamada Y, Andrzejewski M, Mückenhoff K, Scheid P, and Ballantyne D. Locus coeruleus neurones in vitro: pH-sensitive oscillations of membrane potential in an electrically coupled network. Respir Physiol 118: 131-147, 1999.
262. Oyamada Y, Ballantyne D, Mückenhoff K, and Scheid P. Respiration-modulated membrane potential and chemosensitivity of locus coeruleus neurones in the in vitro brainstem-spinal cord of the neonatal rat. J Physiol 513: 381-398, 1998.
263. Padanilam BJ, Lu T, Hoshi T, Padanilam BA, Shibata EF, and Lee HC. Molecular determinants of intracellular pH modulation of human Kv1.4 N-type inactivation. Mol Pharmacol 62: 127-134, 2002.
264. Pan Y, Nauss K, Bernard DG, Douglas RM, and Trouth CO. Carbonic anhydrase in brainstem respiratory chemosensitive regions (Abstract). Soc Neurosci Abstr 17: 201, 1991.
265. + channels examined by scanning mutagenesis. J Gen Physiol 117: 345-360, 2001.
266. + channels. Trends Neurosci 24: 339-346, 2001.
267. Paton JFR. A working heart-brainstem preparation of the mouse. J Neurosci Methods 65: 63-68, 1996.
268. Paton JFR and Butcher JW. Cardiorespiratory reflexes in mice. J Auton Nerv Syst 68: 115-124, 1998.
269. Peano CA, Shonis CA, Dillon GH, and Waldrop TG. Hypothalamic GABAergic mechanism involved in respiratory response to hypercapnia. Brain Res Bull 28: 107-113, 1991.
270. + channel function in rat dorsal vagal neurones. J Physiol 527.2: 283-290, 2000.
271. Peers C and Buckler KJ. Transduction of chemostimuli by type I carotid body cell. J Membr Biol 144: 1-9, 1995.
272. + currents by intracellular acidosis in isolated type I cells of the neonatal rat carotid body. J Physiol 437: 589-602, 1991.
273. Pessia M, Imbrici P, D'Adamo MC, Salvatore L, and Tucker SJ. Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1. J Physiol 532: 359-367, 2001.
274. Petheo GL, Molnár Z, Róka A, Makara JK, and Spät A. A pH-sensitive chloride current in the chemoreceptor cell of rat carotid body. J Physiol 535: 95-106, 2001.
275. Pfeiffer JR and Leiter JC. Intracellular pH regulation during hypercapnia of neurons from Helix aspersa (Abstract). FASEB J 16: A813, 2002.
276. Pineda J and Aghajanian GK. Carbon dioxide regulates the tonic activity of locus coeruleus neurons by modulating a proton- and polyamine-sensitive inward rectifier potassium current. Neuroscience 77: 723-743, 1997.
277. 2 in hyperoxia and hypoxia in older aged humans. J Appl Physiol 75: 2209-2216, 1993.
278. Prasad M, Fearon IM, Zhang M, Laing M, Vollmer C, and Nurse CA. Expression of P2X2 and P2X3 receptor subunits in rat carotid body afferent neurones: role in chemosensory signalling. J Physiol 537.3: 667-677, 2001.
279. Putnam RW. Intracellular pH regulation of neurons in chemosensitive and nonchemosensitive areas of brain slices. Respir Physiol 129: 37-56, 2001.
280. Putnam RW, Ritucci NA, and Dean JB. Intracellular pH and firing rate responses of locus coeruleus neurons to various levels of hypercapnia (Abstract). Soc Neurosci Abstr Prog. No. 826.19, 2003.
281. Putnam RW and Roos A. Intracellular pH. In: Handbook of Physiology. Cell Physiology. Bethesda, MD: Am. Physiol. Soc., 1997, sect. 14, chapt. 9, p. 389-440.
282. + channels by proton-mediated interactions of N- and C-terminal domains. J Biol Chem 275: 31573-31580, 2000.
283. Qu Z, Zhu G, Yang Z, Cui N, Li Y, Chanchevalap S, Sulaiman S, Haynie H, and Jiang C. Identification of a critical motif responsible for gating of Kir2.3 channel by intracellular protons. J Biol Chem 274: 13783-13789, 1999.
284. + channel. An extracellular histidine as pH sensor. J Biol Chem 275: 16650-16657, 2000.
285. - exchange function differs in adult and fetal rat hippocampal neurons. Brain Res 614: 308-314, 1993.
286. Ramirez JM, Quellmalz UJA, and Richter DW. Postnatal changes in the mammalian respiratory network as revealed by the transverse brainstem slice of mice. J Physiol 491: 799-812, 1996.
287. Ramirez JM, Quellmalz UJA, Wilken B, and Richter DW. The hypoxic response of neurones within the in vitro mammalian respiratory network. J Physiol 507: 571-582, 1998.
288. 2. J Cereb Blood Flow Metab 9: 65-70, 1989.
289. Rekling JC, Shao XM, and Feldman JL. Electrical coupling and excitatory synaptic transmission between rhythmogenic respiratory neurons in the preBötzinger complex. J Neurosci 20: RC113, 2000.
290. Ren X and Robbins PA. Ventilatory responses to hypercapnia and hypoxia after 6 h passive hyperventilation in humans. J Physiol 514: 885-894, 1999.
291. Rentero N, Bruandet N, Milne B, and Quintin L. Catechol activation in rat rostral ventrolateral medulla after systemic isocapnic metabolic acidosis. Am J Physiol Regul Integr Comp Physiol 275: R350-R356, 1998.
292. Rice ME. Use of ascorbate in the preparation and maintenance of brain slices. Methods 18: 144-149, 1999.
293. Rice ME, Pérez-Pinzón MA, and Lee EJ. Ascorbic acid, but not glutathione, is taken up by brain slices and preserves cell morphology. J Neurophysiol 71: 1591-1596, 1994.
294. Richerson GB. Cellular mechanisms of sensitivity to pH in the mammalian respiratory system. In: pH and Brain Function, edited by Kaila K and Ransom BR. New York: Wiley-Liss, 1998, p. 509-533.
295. 2 of neurons in the rostral ventral medulla in vitro. J Neurophysiol 73: 933-944, 1995.
296. Richerson GB. Sudden infant death syndrome: the role of central chemosensitivity. Neuroscientist 73: 3-7, 1997.
297. Richerson GB and Messer C. Effect of composition of experimental solutions on neuronal survival during rat brain slicing. Exp Neurol 131: 133-143, 1995.
298. Richerson GB, Wang W, Tiwari JK, and Bradley SR. Chemosensitivity of serotonergic neurons in the rostral ventral medulla. Respir Physiol 129: 175-189, 2001.
299. Ridderstråle Y and Hanson M. Histochemical study of the distribution of carbonic anhydrase in the cat brain. Acta Physiol Scand 124: 557-564, 1985.
300. Ridderstråle Y and Wistrand PJ. Carbonic anhydrase isoforms in the mammalian nervous system. In: pH and Brain Function, edited by Kaila K and Ransom BR. New York: Wiley-Liss, 1998, p. 21-43.
301. Ridderstråle Y and Wistrand PJ. Membrane-associated carbonic anhydrase activity in the brain of CA II-deficient mice. J Neurocytol 29: 263-269, 2000.
302. 2 and low pH. J Neurosci Res 33: 590-597, 1992.
303. 2 and low pH. Biol Neonate 65: 149-155, 1994.
304. Ritucci NA, Chambers-Kersh L, Dean JB, and Putnam RW. Intracellular pH regulation in neurons from chemosensitive and nonchemosensitive areas of the medulla. Am J Physiol Regul Integr Comp Physiol 275: R1152-R1163, 1998.
305. Ritucci NA, Dean JB, and Putnam RW. Intracellular pH response to hypercapnia in neurons from chemosensitive areas of the medulla. Am J Physiol Regul Integr Comp Physiol 273: R433-R441, 1997.
306. Ritucci NA, Erlichman JS, Dean JB, and Putnam RW. A fluorescence technique to measure intracellular pH of single neurons in brainstem slices. J Neurosci Methods 68: 149-163, 1996.
307. i) in neurons and glia from the retrotrapezoid nucleus (RTN) (Abstract). FASEB J 18: A1062, 2004.
308. Ritucci NA, Putnam RW, and Dean JB. Simultaneous measurement of intracellular pH and membrane potential in locus coeruleus neurons during hypercapnia (Abstract). FASEB J 13: A163, 1999.
309. Roberts EL Jr, He J, and Chih CP. Rat hippocampal slices need bicarbonate for the recovery of synaptic transmission after anoxia. Brain Res 875: 171-174, 2000.
310. Rodman JR, Curran AK, Henderson KS, Dempsey JA, and Smith CA. Carotid body denervation in dogs: eupnea and the ventilatory response to hyperoxic hypercapnia. J Appl Physiol 91: 328-335, 2001.
311. Romijn HJ, De Jong BM, and Ruijter JM. A procedure for culturing rat neocortex explants in a serum free nutrient medium. J Neurosci Methods 23: 75-83, 1988.
312. Roos A. Intracellular pH and buffering power of rat brain. Am J Physiol 221: 176-181, 1971.
313. Roos A. Intracellular pH and intracellular buffering power of the cat brain. Am J Physiol 209: 1233-1246, 1965.
314. 2+ channels. Brain Res 769: 396-399, 1997.
315. + channels. Pflügers Arch 441: 1-11, 2000.
316. 2+ to hypercapnic acidosis in cultured glomus cells of the adult rabbit carotid body. Brain Res 662: 251-254, 1994.
317. Ca channel of rat small artery smooth muscle cells. J Vasc Res 38: 30-38, 2001.
318. + channels by intracellular pH. Eur J Biochem 267: 5837-5841, 2000.
319. Schultz JH, Czachurski J, Volk T, Ehmke H, and Seller H. Central sympathetic chemosensitivity and Kir1 potassium channels in the cat. Brain Res 963: 113-120, 2003.
320. Severinghaus JW, Hamilton FN, and Cotev S. Carbonic acid production and the role of carbonic anhydrase in decarboxylation in brain. Biochem J 114: 703-705, 1969.
321. Shah MJ, Meis S, Munsch T, and Pape HC. Modulation by extracellular pH of low- and high-voltage-activated calcium currents of rat thalamic relay neurons. J Neurophysiol 85: 1051-1058, 2001.
322. + as central stimuli of respiration in the cat. J Appl Physiol 58: 357-364, 1985.
323. Shoemaker JM and Hempleman SC. Avian intrapulmonary chemoreceptor discharge rate is increased by anion exchange blocker 'DIDS'. Respir Physiol 128: 195-204, 2001.
324. Simon RP, Niro M, and Gwinn R. Brain acidosis induced by hypercarbic ventilation attenuates focal ischemic injury. J Pharmacol Exp Ther 267: 1428-1431, 1993.
325. Simon SA. Interactions between salt and acid stimuli: a lesson in gustation from simultaneous epithelial and neural recordings. J Gen Physiol 120: 787-791, 2002.
326. Sinha SS, Coplan JD, Pine DS, Martinez JA, Klein DF, and Gorman JM. Panic induced by carbon dioxide inhalation and lack of hypothalamic-pituitary-adrenal axis activation. Psychiatry Res 86: 93-98, 1999.
327. + channel is a molecular substrate for neuronal effects of inhalation anesthetics. J Neurosci 20: 6347-6354, 2000.
328. Smith JC, Ellenberger HH, Ballanyi K, Richter DW, and Feldman JL. Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science 254: 726-729, 1991.
329. 2- chemosensitive brainstem regions in the rat. Respir Physiol Neurobiol 139: 1-20, 2003.
330. Solomon IC, Chon KH, and Rodriguez MN. Blockade of brain stem gap junctions increases phrenic burst frequency and reduces phrenic burst synchronization in adult rat. J Neurophysiol 89: 135-149, 2003.
331. 2-chemoreception and respiratory control. Respir Physiol Neurobiol 131: 155-173, 2002.
332. + chemoreception in the cat pre-Bötzinger complex in vivo. J Appl Physiol 88: 1996-2007, 2000.
333. 2-chemosensitive brainstem regions in rat. Respir Physiol 129: 101-121, 2001.
334. Spengler CM, Gozal D, and Shea SA. Chemoreceptive mechanisms elucidated by studies of congenital central hypoventilation syndrome. Respir Physiol 129: 247-255, 2001.
335. Spyer KM, St. Lambert JH, and Thomas T. Central nervous system control of cardiovascular function: neural mechanisms and novel modulators. Clin Exp Pharmacol Physiol 24: 743-747, 1997.
336. 2 levels: a role for medullary P2X receptors. J Auton Nerv Syst 81: 228-235, 2000.
337. Stea A and Nurse CA. Chloride channels in cultured glomus cells of the rat carotid body. Am J Physiol Cell Physiol 257: C174-C181, 1989.
338. Steidl JV and Yool AJ. Differential sensitivity of voltage-gated potassium channels Kv1.5 and Kv1.2 to acidic pH and molecular identification of pH sensor. Mol Pharmacol 55: 812-820, 1999.
339. Stewart RE, DeSimone JA, and Hill DL. New perspectives in gustatory physiology: transduction, development, and plasticity. Am J Physiol Cell Physiol 272: C1-C26, 1997.
340. Stewart RE, Lyall V, Feldman GM, Heck GL, and DeSimone JA. Acid-induced responses in hamster chorda tympani and intracellular pH tracking by taste receptor cells. Am J Physiol Cell Physiol 275: C227-C238, 1998.
341. + channel subunits, SK1, SK2, and SK3, in the adult rat central nervous system. Mol Cell Neurosci 15: 476-493, 2000.
342. Stunden CE, Filosa JA, Garcia AJ, Dean JB, and Putnam RW. Development of in vivo ventilatory and single chemosensitive neuron responses to hypercapnia in rats. Respir Physiol 127: 135-155, 2001.
343. +-sensitive neurons in the ventral medullary surface of neonate rats. Brain Res 777: 95-102, 1997.
344. Summers BA, Overholt JL, and Prabhakar N. Augmentation of calcium current by hypoxia in carotid body glomus cells. Adv Exp Med Biol 475: 589-599, 2000.
345. Summers BA, Overholt JL, and Prabhakar N. Augmentation of L-type calcium current by hypoxia in rabbit carotid body glomus cells: evidence for a PKC-sensitive pathway. J Neurophysiol 84: 1636-1644, 2000.
346. 2+ current in rabbit carotid body glomus cells. J Neurophysiol 88: 604-612, 2002.
347. Suzue T. Respiratory rhythm generation in the in vitro brain stem-spinal cord preparation of the neonatal rat. J Physiol 354: 173-183, 1984.
348. Suzue T, Murakoshi T, and Tamai S. Electrophysiology of reflexes in an isolated brainstem-spinal cord preparation of the newborn rat. Biomed Res (Tokyo) 4: 611-614, 1983.
349. i induced by a weak acid and base. Pflügers Arch 407: 59-63, 1986.
350. Takahashi KI and Copenhagen DR. Modulation of neuronal function by intracellular pH. Neurosci Res 24: 109-116, 1996.
351. + channel, is modulated by multiple neurotransmitters in motoneurons. Neuron 25: 399-410, 2000.
352. + channel by heteromeric subunit assembly of Kir5.1 with Kir4.1. J Physiol 525: 587-592, 2000.
353. Teppema LJ, Barts PWJA, Folgering HT, and Evers JAM. Effects of respiratory and (isocapnic) metabolic arterial acid-base disturbances on medullary extracellular fluid pH and ventilation in cats. Respir Physiol 53: 379-395, 1983.
354. 2 forcing. Respir Physiol 50: 359-380, 1982.
355. Thomas T, Ralevic V, Bardini M, Burnstock G, and Spyer KM. Evidence for the involvement of purinergic signalling in the control of respiration. Neuroscience 107: 481-490, 2001.
356. 2 chemoreception: a mechanism involving P2 purinoceptors localized in the ventrolateral medulla of the anaesthetized rat. J Physiol 517: 899-905, 1999.
357. 2 chemoreception. J Physiol 523: 441-447, 2000.
358. Tiwari JK, Zaykin AV, Ua Cruadhlaoich MI, Wang W, and Richerson GB. A novel pH sensitive cation current is present in putative central chemoreceptors of the medullary raphe (Abstract). Soc Neurosci Abstr 26: 423, 2000.
359. 2 and hypoxia in humans. Jpn J Physiol 36: 511-521, 1986.
360. Tojima H, Kuriyama T, and Fukuda Y. Delayed ventilatory response to
361. 2+ dynamics in dendrites of CA1 interneurons. J Neurophysiol 80: 1702-1712, 1998.
362. Tombaugh GC and Sapolsky RM. Evolving concepts about the role of acidosis in ischemic neuropathology. J Neurochem 61: 793-803, 1993.
363. 2+ currents in isolated rat CA1 neurons. J Neurophysiol 77: 639-653, 1997.
364. Tong CK, Cammer W, and Chesler M. Activity-dependent pH shifts in hippocampal slices from normal and carbonic anhydrase II-deficient mice. Glia 31: 125-130, 2000.
365. Trapani JG and Korn SJ. Effect of external pH on activation of the Kv1.5 potassium channel. Biophys J 84: 195-204, 2003.
366. Trapp S, Lückermann M, Brooks PA, and Ballanyi K. Acidosis of rat dorsal vagal neurons in situ during spontaneous and evoked activity. J Physiol 496: 695-710, 1996.
367. + sensitivity of excitatory amino acid receptor channels in rat cerebellar granule neurones. J Physiol 433: 727-763, 1991.
368. Traynelis SF and Cull-Candy SG. Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons. Nature 345: 347-350, 1990.
369. Trivagli RA, Dunwiddie TV, and Williams JT. Opioid inhibition of locus coeruleus. J Neurophysiol 74: 519-528, 1995.
370. + channel expressed in Xenopus oocytes. Am J Physiol Cell Physiol 268: C1173-C1178, 1995.
371. Tucker SJ, Imbrici P, Salvatore L, D'Adamo MC, and Pessia M. pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia. J Biol Chem 275: 16404-16407, 2000.
372. 2 pressure changes. Respir Physiol Neurobiol 130: 99-110, 2002.
373. 2 in cats. Respir Physiol 51: 379-390, 1983.
374. Van Lommel A, Bolle T, Fannes W, and Lauweryns JM. The pulmonary neuroendocrine system: the past decade. Arch Histol Cytol 62: 1-16, 1999.
375. Van Lommel A and Lauweryns JM. Postnatal development of the pulmonary neuroepithelial bodies in various animal species. J Auton Nerv Syst 65: 17-24, 1997.
376. i and their role as chemostimulants in the isolated respiratory network of neonatal rats. J Physiol 499: 527-542, 1997.
377. Von Euler US, Liljestrand G, and Zotterman Y. The excitation mechanism of the chemoreceptors of the carotid body. Skand Arch Physiol 83: 132-152, 1939.
378. 31P NMR study. J Cereb Blood Flow Metab 9: 417-421, 1989.
379. + channel specific for sensory neurons. J Biol Chem 272: 20975-20978, 1997.
380. Waldmann R, Champigny G, Bassllana F, Heurteaux C, and Lazdunski M. A proton-gated cation channel involved in acid-sensing. Nature 386: 173-177, 1997.
381. Walker BR, Adams EM, and Voelkel NF. Ventilatory responses of hamsters and rats to hypoxia and hypercapnia. J Appl Physiol 59: 1955-1960, 1985.
382. 2. J Physiol 540: 951-970, 2002.
383. Wang W, Pizzonia JJ, and Richerson GB. Chemosensitivity of rat medullary raphe neurones in primary tissue culture. J Physiol 511: 433-450, 1998.
384. Wang W and Richerson GB. Chemosensitivity of non-respiratory rat CNS neurons in tissue culture. Brain Res 860: 119-129, 2000.
385. Wang W and Richerson GB. Development of chemosensitivity of rat medullary raphe neurons. Neuroscience 90: 1001-1011, 1999.
386. Wang W, Tiwari JK, Bradley SR, Zaykin AV, and Richerson GB. Acidosis-stimulated neurons of the medullary raphe are serotonergic. J Neurophysiol 85: 2224-2235, 2001.
387. Wegelius K, Reeben M, Rivera C, Kaila K, Saarma M, and Pasternack M. The rho 1 GABA receptor cloned from rat retina is down-modulated by protons. Neuroreport 7: 2005-2009, 1996.
388. Wegner H, Reeh PW, Brehm S, Kreysel HW, and Steen KH. Diltiazem blocks the pH-induced excitation of rat nociceptors together with their mechanical and electrical excitability in vitro. J Neurophysiol 75: 1-10, 1996.
389. 2-sensitive neurons in organotypic cultures of the fetal rat medulla. Respir Physiol 111: 137-151, 1998.
390. + channels to central chemosensitivity in cultivated neurons of fetal rat medulla. J Neurophysiol 79: 2885-2894, 1998.
391. + channels. J Biol Chem 277: 2369-2372, 2002.
392. Wemmie JA, Askwith CC, Lamani E, Cassell MD, Freeman JH, and Welsh MJ. Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning. J Neurosci 23: 5496-5502, 2003.
393. Wiemann M and Bingmann D. Ventrolateral neurons of medullary organotypic cultures: intracellular pH regulation and bioelectric activity. Respir Physiol 129: 57-70, 2001.
394. +-sensitive medullary neurones. Pflügers Arch 438: 255-262, 1999.
395. Williams JT and Marshall KC. Membrane properties and adrenergic responses in locus coeruleus neurons of young rats. J Neurosci 7: 3687-3694, 1987.
396. Williams JT and North RA. Catecholamine inhibition of calcium action potentials in rat locus coeruleus neurones. Neuroscience 14: 103-109, 1985.
397. Williams JT, North RA, Shefner SA, Nishi S, and Egan TM. Membrane properties of rat locus coeruleus neurones. Neuroscience 13: 137-156, 1984.
398. Willoughby D and Schwiening CJ. Electrically evoked dendritic pH transients in rat cerebellar Purkinje cells. J Physiol 544.2: 487-499, 2002.
399. Winterstein H. Chemical control of pulmonary ventilation. III. The "reaction theory" of respiratory control. N Engl J Med 255: 331-337, 1956.
400. Winterstein H. Die Regulierung der Atmung durch das Blut. Pflügers Arch 138: 167-184, 1911.
401. Xu F, Sato M, Spellman MJ, Mitchell RA, and Severinghaus JW. Topography of cat medullary ventral surface hypoxic acidification. J Appl Physiol 73: 2631-2637, 1992.
402. Xu F, Zhang Z, and Frazier DT. Microinjection of acetazolamide into the fastigial nucleus augments respiratory output in the rat. J Appl Physiol 91: 2342-2350, 2001.
403. Xu FD, Spellman MJ, Sato M, Baumgartner JE, Ciricillo SF, and Severinghaus JW. Anomalous hypoxic acidification of medullary ventral surface. J Appl Physiol 71: 2211-2217, 1991.
404. Xu H, Cui N, Yang Z, Qu Z, and Jiang C. Modulation of Kir4.1 and Kir5.1 by hypercapnia and intracellular acidosis. J Physiol 524: 725-735, 2000.
405. Xu H, Yang Z, Cui N, Chanchevalap S, Valesky WW, and Jiang C. A single residue responsible for the difference of Kir4.1 channel from Kir1.1 in pH-sensitivity, rectification and single channel conductance. J Physiol 528: 267-277, 2000.
406. 2+ channels in porcine tracheal smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 268: L642-L646, 1995.
407. Yang Z and Jiang C. Opposite effects of pH on open-state probability and single channel conductance of kir4.1 channels. J Physiol 520: 921-927, 1999.
408. 2 and pH. J Gen Physiol 116: 33-45, 2000.
409. Yiangou Y, Facer P, Smith JAM, Sangameswaran L, Eglen R, Birch R, Knowles C, Williams N, and Anand P. Increased acid-sensing ion channel ASIC-3 in inflamed human intestine. Eur J Gastroenterol Hepatol 13: 891-896, 2001.
410. Youn H, Kerby RL, Conrad M, and Roberts GP. Functionally critical elements of CooA-related CO sensors. J Bacteriol 186: 1320-1329, 2004.
411. Zerangue N and Kavanaugh MP. Flux coupling in a neuronal glutamate transporter. Nature 383: 634-637, 1996.
412. - reabsorption by rabbit S2 proximal tubule. Am J Physiol Renal Physiol 285: F359-F369, 2003.
413. Zhu G, Chanchevalap S, Cui N, and Jiang C. Effects of intra and extracellular acidification on single channel Kir2.3 currents. J Physiol 516: 699-710, 1999.
414. --responsive soluble adenylyl cyclase as a putative metabolic sensor. Trends Endocrinol Metab 12: 366-370, 2001.