GABA- and glycine-mediated fall of intracellular pH in rat medullary neurons in situ

Journal of Neurophysiology

Volumn 77, Issue 4, 1997, Pages 1844-1852

  Lückermann, Mark ^a   Trapp, Stefan ^a   Ballanyi, Klaus ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; 4 AMINOBUTYRIC ACID; BICARBONATE; BICUCULLINE; CARBON DIOXIDE; CARBONATE DEHYDRATASE; CARBOXYFLUORESCEIN; CHLORIDE CHANNEL; GLYCINE; STRYCHNINE;

ACIDOSIS; ANIMAL CELL; ARTICLE; BRAIN STEM; CELL PH; CONTROLLED STUDY; FEMALE; MALE; MEDULLA OBLONGATA; MEMBRANE CURRENT; NERVE CELL MEMBRANE POTENTIAL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0345632915     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1997.77.4.1844     Document Type: Article

References (44)

1. ARATA, A., ONIMARU, H., AND HOMMA, I. Respiration-related neurons in the ventral medulla of newborn rats in vitro. Brain Res. Bull. 24: 599-604, 1990.
2. BALLANTYNE, D. AND RICHTER, D. W. The non-uniform character of expiratory synaptic activity in expiratory bulbospinal neurones of the cat. J. Physiol. Lond. 370: 433-456, 1986.
3. BALLANYI, K. AND GRAFE, P. An intracellular analysis of γ-aminobutyric-acid-associated ion movements in rat sympathetic neurones. J. Physiol. Lond. 365: 41-58, 1985.
4. BALLANYI, K., MÜCKENHOFF, K., BELLINGHAM, M. C., OKADA, Y., SCHEID, P., AND RICHTER, D. W. Activity-related pH changes in respiratory neurones and glial cells of cats. Neuroreport 6: 33-36, 1994a.
5. BALLANYI, K., VÖLKER, A., AND RICHTER, D. W. Anoxia induced functional inactivation of neonatal respiratory neurons in vitro. Neuroreport 6: 165-168, 1994b.
6. BORMANN, J., HAMILL, O. P., AND SAKMANN, B. Mechanism of anion permeation through channels gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neurones. J. Physiol. Lond. 385: 243-286, 1987.
7. --mediated inhibition in respiratory neurons of neonatal rats in vitro. In: Proceedings of the Neurowissenschaftliche Gesellschaft, Neuroforum, Heidelberg, Germany: Spektrum, 1995, p. 219.
8. BROWN, D. A. Extrasynaptic GABA systems. Trends Neurosci. 2: 271-272, 1979.
9. CHEN, J.C.T. AND CHESLER, M. Extracellular alkalinization evoked by GABA and its relationship to activity-dependent pH shifts in turtle cerebellum. J. Physiol. Lond. 442: 431-446, 1991.
10. CHEN, J.C.T. AND CHESLER, M. Modulation of extracellular pH by glutamate and GABA in rat hippocampal slices. J. Neurophysiol. 67: 29-36, 1992.
11. CHESLER, M. The regulation and modulation of pH in the nervous system. Prog. Neurobiol. 34: 401-427, 1990.
12. CHESLER, M. AND KAILA, K. Modulation of pH by neuronal activity. Trends Neurosci. 15: 396-402, 1992.
13. FELDMAN, J. L. AND SMITH, J. C. Cellular mechanisms underlying modulation of breathing pattern in mammals. Ann. NY Acad. Sci. 563: 114-130, 1989.
14. A receptor channel function in the nervous system. Prog. Neurobiol. 42: 489-537, 1994.
15. A receptors in rat hippocampal slices. Neuroreport 3: 105-108, 1992a.
16. A receptors in cultured rat astrocytes. Neurosci. Lett. 126: 9-12, 1991.
17. KAILA, K., RYDQVIST, B., PASTERNACK, M., AND VOIPIO, J. Inward current caused by sodium-dependent uptake of GABA in the crayfish stretch receptor neurone. J. Physiol. Lond. 453: 627-645, 1992b.
18. KAILA, K. AND VOIPIO, J. Postsynaptic fall in intracellular pH induced by GABA-activated bicarbonate conductance. Nature Lond. 330: 163-165, 1987.
19. A receptor-mediated IPSPs of rat neocortical neurones. J. Physiol. Lond. 464: 273-289, 1993.
20. KHAZIPOV, R., BREGESTOVSKI, P., AND BEN-ARI, Y. Hippocampal inhibitory interneurons are functionally disconnected from excitatory inputs by anoxia. J. Neurophysiol. 70: 2251-2259, 1993.
21. LÜCKERMANN, M., TRAPP, S., BROOKS, P. A., AND BALLANYI, K. Simultaneous measurements of intracellular pH and membrane currents of rat brainstem neurons in vitro. In: Proceedings of the 23rd Göttingen Neurobiology Conference, edited by N. Elsner and R. Menzel. 1995, vol. II, p. 632.
22. A-receptor subtypes really occur in the brain? Trends Neurosci. 19: 139-143, 1996.
23. ONIMARU, H., ARATA, A., AND HOMMA, I. Inhibitory synaptic inputs to the respiratory rhythm generator in the medulla isolated from newborn rats. Pfluegers Arch. 417: 425-432, 1990.
24. ONIMARU, H., BALLANYI, K., AND RICHTER, D. W. Calcium-dependent responses in neurons of the isolated respiratory network of newborn rats. J. Physiol. Lond. 491: 677-695, 1996.
25. ONIMARU, H. AND HOMMA, I. Whole cell recordings from respiratory neurons in the medulla of brainstem-spinal cord preparations isolated from newborn rats. Pfluegers Arch. 420: 399-406, 1992.
26. PAALASMAA, P. AND KAILA, K. Role of voltage-gated calcium channels in the generation of activity-induced extracellular pH transients in the rat hippocampal slices. J. Neurophysiol. 75: 2354-2360, 1996.
27. PASTERNACK, M., VOIPIO, J., AND KAILA, K. Intracellular carbonic anhydrase activity and its role in GABA-induced acidosis in isolated rat hippocampal pyramidal neurones. Acta Physiol. Scand. 148: 229-231, 1993.
28. PATON, J.F.R AND RICHTER, D. W. Role of fast inhibitory synaptic mechanisms in respiratory rhythm generation in the maturing mouse. J. Physiol. Lond. 484: 505-521, 1995.
29. PATON, J.F.R., RAMIREZ, J.-M., AND RICHTER, D. W. Mechanisms of respiratory rhythm generation change profoundly during early life in mice and rats. Neurosci. Lett. 170: 167-170, 1994.
30. RAMIREZ, J. M., QUELLMALZ, U., AND RICHTER, D. W. Postnatal changes in the mammalian respiratory network as revealed by the transverse brainstem slice of mice. J. Physiol. Lond. 491: 799-812, 1996.
31. RICHTER, D. W. Neural regulation of respiration: rhythmogenesis and afferent control. In: Comprehensive Human Physiology, edited by R. Greger and U. Windhorst. Berlin: Springer-Verlag, 1996, vol. 2, p. 2079-2095.
32. RICHTER, D. W., BALLANYI, K., AND SCHWARZACHER, S. Mechanisms of respiratory rhythm generation. Curr. Opin. Neurobiol. 2: 788-793, 1992.
33. RICHTER, D. W., RAMIREZ, J. M., AND BALLANYI, K. Respiratory rhythm generation. In: Neural Control of the Respiratory Muscles, edited by A. Miller, B. Bishop, and A. L. Bianchi. Boca Raton, FL: CRC, 1997, p. 119-131.
34. SCHWIENTNG, C. J., KENNEDY, H. J., AND THOMAS, R. C. Calcium-hydrogen exchange by the plasma membrane Ca-ATPase of voltage-clamped snail neurons. Proc. R. Soc. Lond. B Biol. Sci. 253: 285-289, 1993.
35. SMITH, J. C., BALLANYI, K., AND RICHTER, D. W. Whole-cell patch-clamp recordings from respiratory neurons in neonatal rat brainstem in vitro. Neurosci. Lett. 134: 153-156, 1992.
36. SMITH, J. C., ELLENBERGER, H. H., BALLANYI, K., RICHTER, D. W., AND FELDMAN, J. L. Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science Wash. DC 254: 726-729, 1991.
37. TAIRA, T., PAALASMAA, P., VOIPIO, J., AND KAILA, K. Relative contributions of excitatory and inhibitory neuronal activity to alkaline transients evoked by stimulation of Schaffer collaterals in the rat hippocampal slice J. Neurophysiol. 74: 643-649, 1995.
38. TAKAHASHI, K.-I. AND COPENHAGEN, D. R. Modulation of neuronal function by intracellular pH. Neurosci. Res. 24: 109-116, 1996.
39. THOMAS, J. A., BUCHSBAUM, R. N., ZIMNIAK, A., AND RACKER, E. Intracellular pH measurements in Ehrlich Ascites Tumor Cells utilizing spectroscopic probes generated in situ. Biochemistry 18: 2210-2218, 1979.
40. THOMAS, R. C. Experimental displacement of intracellular pH and the mechanism of its subsequent recovery. J. Physiol. Lond. 354: 3-22, 1984.
41. TRAPP, S., LÜCKERMANN, M., AND BALLANYI, K. GABA and glycine decrease intracellular pH in medullary neurons of thin slices of neonatal rats. In: 4th IBRO World Congress of Neuroscience. Oxford, UK: Rapid Communications of Oxford, 1995, p. 22.
42. TRAPP, S., LÜCKERMANN, M., BROOKS, P. A., AND BALLANYI, K. Acidosis of rat dorsal vagal neurons in situ during spontaneous and evoked activity. J. Physiol. Lond. 496: 695-710, 1996a.
43. + pump. Neuroreport 7: 2000-2004, 1996b.
44. VOIPIO, J., PASTERNACK, M., RYDQUIST, B., AND KAILA, K. Effect of γ-aminobutyric acid on intracellular pH in the crayfish stretch-receptor neurone. J. Exp. Biol. 156: 349-361, 1991.