Acetazolamide and respiratory chemosensitivity to CO2 in the neonatal rat transverse medullary slice

Respiratory Physiology and Neurobiology

Volumn 132, Issue 3, 2002, Pages 279-287

  Necakov, Aleksandar ^a   Peever, John H ^a,c   Shen, Linlin ^a   Duffin, James ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Carbon dioxide, central chemosensitivity, carbonic anhydrase; Control of breathing central chemosensitivity; Enzyme, carbonic anhydrase; Mammals, rat; Nerve, hypoglossal; Pharmacological agent, acetazolamide

Indexed keywords

ACETAZOLAMIDE; CARBON DIOXIDE; CARBONATE DEHYDRATASE; DIMETHYL SULFOXIDE;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; BREATHING RATE; CHEMORECEPTOR; CHEMOSENSITIVITY; CONTROLLED STUDY; HYPOGLOSSAL NERVE; HYPOTHESIS; MEDULLA OBLONGATA; NERVE ROOT; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATORY BURST;

ACETAZOLAMIDE; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BRAIN STEM; CARBON DIOXIDE; CARBONIC ANHYDRASE INHIBITORS; CHEMORECEPTORS; ELECTROPHYSIOLOGY; HYDROGEN-ION CONCENTRATION; HYPOGLOSSAL NERVE; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATION;

EID: 0037019774     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1569-9048(02)00117-9     Document Type: Article

References (35)

1. 2. Brain Res. 519:1990;23-28
2. 2 chemoreceptors. Respir. Physiol. 129:2001;219-229
3. 2. J. Physiol. London. 441:1991;433-451
4. Fung M.L., Wang W., St. John W.M. Medullary loci critical for expression of gasping in adult rats. J. Physiol. London. 480:1994;597-611
5. Hanson M.A., Nye P.C., Torrance R.W. The location of carbonic anhydrase in relation to the blood-brain barrier at the medullary chemoreceptors of the cat. J. Physiol. London. 320:1981;113-125
6. Iturriaga R., Lahiri S., Mokashi A. Carbonic anhydrase and chemoreception in the cat carotid body. Am. J. Physiol. Cell Physiol. 261:1991;C565-C573
7. Johnson S.M., Koizumi H., Trouth C.O., Smith J.C. Chemosensory responses of the isolated respiratory network in medullary slices in vitro. Society for Neuroscience. 23: 1997;1252
8. Johnson S.M., Trouth C.O., Smith J.C. Chemosensitivity of respiratory pacemaker neurons in the pre-Bötzinger complex in vitro. Society of Neuroscience. 24: 1998;875
9. Koshiya N., Smith J.C. Neuronal pacemaker for breathing visualized in vitro. Nature. 400:1999;360-363
10. Mortola J.P., Lanthier C. The ventilatory and metabolic response to hypercapnia in newborn mammalian species. Respir. Physiol. 103:1996;263-270
11. 2, brainstem chemoreceptors and breathing. Prog. Neurobiol. 39:1999;299-331
12. Nattie E.E., Li A. Central chemoreception in the region of the ventral respiratory group in the rat. J. Appl. Physiol. 81:1996;1987-1995
13. Neubauer J. Carbonic anhydrase and sensory function in the central nervous system. Dodgson S. Gros G. Carter N. The Carbonic Anhydrases: Cellular Physiology and Molecular Genetics. 1991;319-324 Plenum Press New York
14. Neubauer J.A. Cellular mechanisms of central chemosensitivity. Speck D.F. Dekin M.S. Revelette W.R. Frazier D.T. Respiratory Control: Central and Peripheral Mechanisms. 1993;152-156 The University Press of Kentucky Lexington, KY
15. Okada Y., Chen Z., Kuwana S. Cytoarchitecture of central chemoreceptors in the mammalian ventral medulla. Respir. Physiol. 129:2001a;13-23
16. Okada Y., Chen Z., Yoshida H., Kuwana S., Jiang W., Maruiwa H. Optical recording of the neuronal activity in the brainstem-spinal cord: application of a voltage-sensitive dye. Adv. Exp. Med. Biol. 499:2001b;113-118
17. Onimaru H., Homma I. Whole cell recordings from respiratory neurons in the medulla of brainstem-spinal cord preparations isolated from newborn rats. Pflugers Arch. 420:1992;399-406
18. Onimaru H., Homma I., Iwatsuki K. Excitation of inspiratory neurons by preinspiratory neurons in rat medulla in vitro. Brain Res. Bull. 29:1992;879-882
19. Peever J.H., Tian G.F., Duffin J. Temperature and pH affect respiratory rhythm of in vitro preparations from neonatal rats. Respir. Physiol. 117:1999;97-107
20. Peever J.H., Necakov A., Duffin J. Nucleus raphé obscurus modulates hypoglossal output of neonatal rat in vitro transverse brain stem slices. J. Appl. Physiol. 90:2001;269-279
21. Putnam R.W. Intracellular pH regulation of neurons in chemosensitive and nonchemosensitive areas of brain slices. Respir. Physiol. 129:2001;37-56
22. Ramirez J.M., Quellmalz U.J., Richter D.W. Postnatal changes in the mammalian respiratory network as revealed by the transverse brainstem slice of mice. J. Physiol. London. 491:1996;799-812
23. 2 of neurons in the rostral ventral medulla in vitro. J. Neurophysiol. 73:1995;933-944
24. Richerson G., Wang W., Tiwari J., Bradley S. Chemo sensitivity of serotonergic neurons in the rostral ventral medulla. Respir. Physiol. 129:2001;175-189
25. Ridderstråle Y., Hanson M. Histochemical study of the distribution of carbonic anhydrase in the cat brain. Acta Physiol. Scand. 124:1985;557-564
26. Scheid P., Kuhlmann W.D., Fedde M.R. Intrapulmonary receptors in the Tegu lizard: II. Functional characteristics and localization. Respir. Physiol. 29:1977;49-62
27. Smith J.C., Greer J.J., Liu G.S., Feldman J.L. Neural mechanisms generating respiratory pattern in mammalian brain stem-spinal cord in vitro. J. Neurophysiol. 64:1990;1149-1169
28. Smith J.C., Ellenberger H.H., Ballanyi K., Richter D.W., Feldman J.L. Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science. 254:1991;726-729
29. St. John W.M. Neurogenesis of patterns of automatic ventilatory activity. Prog. Neurobiol. 56:1998;97-117
30. St. John W.M., Paton J.F. Characterizations of eupnea, apneusis and gasping in a perfused rat preparation. Respir. Physiol. 123:2000;201-213
31. Suzue T. Respiratory rhythm generation in the in vitro brain stem-spinal cord preparation of the neonatal rat. J. Physiol. London. 354:1984;173-183
32. Telgkamp P., Ramirez J.M. Differential responses of respiratory nuclei to anoxia in rhythmic brain stem slices of mice. J. Neurophysiol. 82:1999;2163-2170
33. 2 after carbonic anhydrase inhibition with acetazolamide administration in the anesthetized rat. Jpn. J. Physiol. 38:1988;55-65
34. Torrance R.W. Carbonic anhydrase near central chemoreceptors. Adv. Exp. Med. Biol. 337:1993;235-239
35. Torrance R.W. Prolegomena. Chemoreception upstream of transmitters. Adv. Exp. Med. Biol. 410:1996;13-38