Muscimol dialysis in the retrotrapezoid nucleus region inhibits breathing in the awake rat

Journal of Applied Physiology

Volumn 89, Issue 1, 2000, Pages 153-162

  Nattie, Eugene ^a   Li, Aihua ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Central chemoreceptors; Control of breathing; GABA(A) receptors; Hypoventilation; Rostral ventrolateral medulla

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CARBON DIOXIDE; MUSCIMOL; OXYGEN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; BREATHING; DIALYSIS; HYPERCAPNIA; NEUROMODULATION; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; RESPIRATION CENTER; TIDAL VOLUME; WAKEFULNESS;

EID: 0033929694     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.89.1.153     Document Type: Article

References (29)

1. Akilesh MR, Kamper M, Li A, and Nattie EE. Effects of unilateral lesions of retrotrapezoid nucleus on breathing in awake rats. J Appl Physiol 82: 469-479, 1997.
2. Alessandri B, Landolt H, Langemann H, Gregorin J, Hall J, and Gratzl O. Application of glutamate in the cortex of rats: a microdialysis study. Acta Neurochir 67, Suppl: 6-12, 1996.
3. Bernard DG, Li A, and Nattie EE. Evidence for chemoreception in the medullary raphe. J Appl Physiol 80: 108-115, 1996.
4. Bruce EN and Cherniack NS. Central chemoreceptors. J Appl Physiol 62: 389-402, 1987.
5. Budzinska K, von Euler C, Kao FF, Panteleo T, and Yamamoto Y. Effects of graded focal cold block in the rostral areas of the medulla. Acta Physiol Scand 124: 329-340, 1985.
6. Coates EL, Li A, and Nattie EE. Widespread sites of brainstem ventilatory chemoreceptors. J Appl Physiol 75: 5-14, 1993.
7. Cream CL, Nattie E, and Li A. TRH microdialysis into the RTN of the conscious rat increases breathing, metabolism, and temperature. J Appl Physiol 87: 673-682, 1999.
8. De Lange E, Bouw M, Mandema J, Danhof M, de Bour A, and Breimer D. Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat brain. Br J Pharmacol 116: 2538-2544, 1995.
9. Fencl V, Miller TB, and Pappenheimer JR. Studies on the respiratory response to disturbances of acid-base balance, with deductions concerning the ionic composition of cerebral interstitial fluid. Am J Physiol 210: 459-472, 1966.
10. Forster HV, Ohtake PJ, Pan LG, and Lowry TF. Effect on breathing of surface ventrolateral medullary cooling in awake, anesthetized and asleep goats. Respir Physiol 110: 187-197, 1997.
11. Gatti PJ, DaSilva AMT, and Gillis RA. Cardiorespiratory effects produced by injecting drugs that affect GABA receptors into nuclei associated with the ventral surface of the medulla. Neuropharmacology 26: 423-431, 1987.
12. Haxhiu MA, Mitra J, Van Lunteren E, Prabhakar N, Bruce EN, and Cherniack NS. Responses of hypoglossal and phrenic nerves to decreased respiratory drive in cats. Respiration 50: 130-138, 1986.
13. Kneussl MP, Pappagianopoulos P, Hoop B, and Kazemi H. Reversible depression of ventilation and cardiovascular function by ventriculocisternal perfusion with gamma-aminobutyric acid in dogs. Am Rev Respir Dis 133: 1024-1028, 1986.
14. King KA and Holtman JR Jr. Gamma-aminobutyric acid receptors at the ventral surface of the medulla inhibit respiratory motor outflow to the laryngeal musculature. Neuropharmacology 28: 255-263, 1989.
15. 2 diffusion pipette in vivo. J Appl Physiol 83: 420-428, 1997.
16. 2 microdialysis in the retrotrapezoid nucleus of the rat increases breathing in wakefulness but not in sleep. J Appl Physiol 87: 910-919, 1999.
17. Nattie EE. Central chemoreceptors, pH, and respiratory control. In: PH and Brain Function, edited by Kaila K and Ransom BR. New York: Wiley, 1998, p. 535-560.
18. 2, brainstem chemoreceptors, and breathing. Prog Neurobiol 59: 299-331, 1999.
19. 2 sensitivity in rats. Respir Physiol 97: 63-77, 1994.
20. Nattie EE and Li A. Central chemoreception in the region of the ventral respiratory group of the rat. J Appl Physiol 81: 1987-1995, 1996.
21. Nattie EE, Li A, and St John WM. Lesions in retrotrapezoid nucleus decrease ventilatory output in anesthetized or decerebrate cats. J Appl Physiol 71: 1364-1375, 1991.
22. Ohtake PJ, Forster HV, Pan LG, Lowry TF, Korducki MJ, Aaron EA, and Weiss EM. Ventilatory responses to cooling the ventrolateral medullary surface of awake and anesthetized goats. J Appl Physiol 78: 247-257, 1995.
23. Pappenheimer JR. Sleep and respiration of rats during hypoxia. J Physiol (Lond) 266: 191-207, 1977.
24. Paxinos G and Watson C. The Rat Brain in Stereotaxic Coordinates. New York: Academic, 1986.
25. Schlöfke ME. Elimination of central chemosensitivity by coagulation of a bilateral area on the ventral medullary surface in awake cats. Pflügers Arch 379: 231-241, 1979.
26. Smith JC, Morrison DE, Ellenberger HH, Otto MR, and Feldman J. Brainstem projections to the major respiratory neuron populations in the medulla of the cat. J Comp Neurol 281: 69-96, 1989.
27. Yamada KA, Hamosh P, and Gillis R. Respiratory depression produced by activation of GABA receptors in hindbrain of cat. J Appl Physiol 51: 1278-1286, 1981.
28. Yamada KA, Norman WP, Hamosh P, and Gillis R. Medullary ventral surface GABA receptors affect respiratory and cardiovascular function. Brain Res 248: 71-78, 1982.
29. A receptors in rat brainstem and rostral brain regions. Neuroscience 49: 973-989, 1992.