In vitro study of H+-sensitive neurons in the ventral medullary surface of neonate rats

Brain Research

Volumn 777, Issue 1-2, 1997, Pages 95-102

  Sugama, Shuei ^a   Shimokawa, Noriaki ^a   Okada, Junichi ^a   Miura, Mitsuhiko ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

Aminobutyric acid (GABA); BCECF; Central chemoreceptor; Control of breathing; Dissociated cell culture; Glutamate; Respiration

Indexed keywords

4 AMINOBUTYRIC ACID; CARBOXYFLUORESCEIN; GLUTAMIC ACID; PROTON;

ANIMAL CELL; ARTICLE; CELL LABELING; CELL PH; CHEMORECEPTOR; IMMUNOHISTOCHEMISTRY; MEDULLA OBLONGATA; NERVE CELL CULTURE; NEUROTRANSMISSION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATION CONTROL; SOLITARY TRACT NUCLEUS;

ANIMALS; ANIMALS, NEWBORN; CELL SIZE; CELLS, CULTURED; CHEMORECEPTORS; FLUORESCEINS; FLUORESCENT DYES; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; HYDROGEN-ION CONCENTRATION; MICROSCOPY, FLUORESCENCE; NEURONS, AFFERENT; PROTONS; RATS; RATS, WISTAR; RESPIRATION; SOLITARY NUCLEUS;

EID: 0031589729     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01044-5     Document Type: Article

References (38)

1. 2. In H.H. Loeschcke (ed.), Acid Base Homeostasis of the Brain Extracellular Fluid and the Respiratory Control System, Thieme Verlag, Stuttgart, 1976, pp. 19-27.
2. [2] N. Akaike, O.A. Krishtal, T. Maruyama, Proton-induced sodium current in frog isolated dorsal root ganglion cells, J. Neurophysiol. 63 (1990) 805-813.
3. [3] L. Best, C. Ammala, P. Rorsman, S. Tomlinson, Intracellular pH, cytosolic calcium concentration and electrical activity in RINm5F insulinoma cells, Biochem. Biophys. Acta 1192 (1994) 107-111.
4. [4] S. Bevan, P. Geppetti, Protons: small stimulants of capsaicin-sensitive sensory nerves, Trends Neurosci. 17 (1994) 509-512.
5. [5] E.L. Coates, A. Li, E.F. Nattie, Widespread sites of brain stem ventilatory chemoreceptors, J. Appl. Physiol. 75 (1993) 5-14.
6. [6] P. Cragg, L. Patterson, M.J. Purves, The pH of brain extracellular fluid in the cat, J. Physiol. (London) 272 (1977) 137-166.
7. [7] J.B. Dean, D.A. Bayliss, J.T. Erickson, W.L. Lawing, D.E. Millhorn, Depolarization and stimulation of neurons in nucleus tractus solitarii by carbon dioxide does not require chemical synaptic input, Neuroscience 36 (1990) 207-216.
8. [8] M. Elam, T. Yao, P. Thoren, T.H. Svensson, Hypercapnia and hypoxia: chemoreceptor-mediated control of locus coeruleus neurons and splanchnic, sympathetic nerves, Brain Res. 222 (1981) 373-381.
9. [9] Y. Fukuda, Y. Honda, pH-sensitive cells at ventro-lateral surface of rat medulla oblongata, Nature 256 (1975) 317-318.
10. [10] Y. Fukuda, Y. Honda, pH sensitivity of cells located at the ventrolateral surface of the cat medulla obolongata in vitro, Pfluegers Arch. 364 (1976) 243-247.
11. + on spontaneous neuronal activity in the superficial layer of the rat medulla oblongata in vitro, Pfluegers Arch. 371 (1977) 125-134.
12. + in the respiratory chemosensitive structures of the ventral medulla oblongata of rats in vitro, Pfluegers Arch. 379 (1979) 125-135.
13. [13] T. Hori, G.I. Roth, S. Yamamoto, Respiratory sensitivity of rat brain-stem surface to chemical stimuli, J. Appl. Physiol. 28 (1970) 721-724.
14. [14] M. Inoue, M. Hara, X.-T. Zeng, T. Hirose, S. Ohnishi, T. Yasukura, T. Uriu, K. Omori, A. Minato, C. Inagaki, An ATP-driven Cl-pump regulates Cl-concentrations in rat hippocampal neurons, Neurosci. Lett. 134 (1991) 75-78.
15. 2, J. Appl. Physiol. 72 (1992) 439-446.
16. [16] A. Kawai, D. Ballantyne, K. Mueckenhoff, P. Scheid, Chemosensitive medullary neurones in the brainstem-spinal cord preparation of the neonatal rat, J. Physiol. (London) 492 (1996) 277-292.
17. [17] J.P. Kiley, F.L. Eldridge, D.E. Millhorn, The roles of medullary extracellular and cerebrospinal fluid pH in control of respiration, Respir. Physiol. 59 (1985) 117-130.
18. + sensitive neurons, J. Appl. Physiol. 69 (1990) 1408-1412.
19. [19] O.A. Krishtal, V.I. Pidoplichko, A receptor for protons in the membrane of sensory neurons may participate in nociception, Neuroscience 6 (1981) 2599-2601.
20. [20] H.H. Loeschcke, L. De Lattre, M.E. Schlaefke, C.O. Trouth, Effects on respiration and circulation of electrically stimulating the ventral surface of the medulla oblongata, Respir. Physiol. 10 (1970) 184-197.
21. [21] R.A. Mitchell, H. Loeschcke, W.H. Massion, J.W. Severinghaus, Respiratory response mediated through superficial chemosensitive areas on the medulla, J. Appl. Physiol. 18 (1963) 523-533.
22. [22] M. Miura, J. Okada, K. Takayama, T. Suzuki, Neuronal expression of Fos and Jun protein in the rat medulla and spinal cord after anoxic and hypercapnic stimulations, Neurosci. Lett. 178 (1994) 227-230.
23. [23] M. Miura, J. Okada, K. Takayama, Parapyramidal rostroventromedial medulla as a respiratory rhythm modulator, Neurosci. Lett. 203 (1996) 41-44.
24. +-sensitive neurons in the ventral medullary surface, Abstracts of XXXIII International Congress of Physiological Sciences IUPS, St.Petersburg, Russia, 1997, PO30.35.
25. [25] R. Monteau, D. Morin, G. Hilaire, Acetylcholine and central chemosensitivity: in vitro study in the newborn rat, Respir. Physiol. 81 (1990) 241-253.
26. + exchange in gastric glands as measured with a cytoplasmic-trapped, fluorescent pH indicator, Proc. Natl. Acad. Sci. USA 81 (1984) 7436-7443.
27. 2 and low pH, J. Neurosci. Res. 33 (1992) 590-597.
28. 2 and low pH, Biol. Neonate 65 (1994) 149-155.
29. [29] M. Saji, M. Miura, Transmitter sensitivities among various types of cultured brain stem neurons, Brain Res. 233 (1982) 83-96.
30. [30] M.E. Schlaefke, H.H. Loeschcke, Lokalisation eines an der Regulation von Atmung und Kreislauf beteiligen Gebietes an der ventralen Oberfläche der Medulla oblongata durch Kälteblockade, Pfluegers Arch. 297 (1967) 201-220.
31. + ion concentration in small area of the ventral medullary surface, Respir. Physiol. 10 (1970) 198-212.
32. [32] M.E. Schlaefke, M. Pokorski, W.R. See, R.K. Prill, H.H. Loeschcke, Chemosensitive neurons on the ventral medullary surface, Bull. Physiopathol. Respir. 11 (1975) 277-284.
33. +-activity in the extracellular fluid of the brain in respiratory or metabolic acidosis, Pfluegers Arch. 312 (1981) R55.
34. [34] N. Takei, J. Kondo, K. Nagaike, K. Ohsawa, K. Kato, S. Kohsaka, Neuronal survival factor from bovine brain is identical to neuronspecific enolase, J. Neurochem. 57 (1991) 1178-1184.
35. [35] L. Tanasugarn, P. McNeil, G. Reynolds, D.L. Taylor, Microspectrofluorometry by digital image processing: measurement of cytoplasmic pH, J. Cell Biol. 98 (1984) 717-724.
36. [36] J.A. Thomas, R.N. Buchsbaum, A. Zimniak, E. Racker, Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ, Biochemistry 18 (1979) 2210-2218.
37. [37] C.O. Trouth, H.H. Loeschcke, J. Berndt, Histological structures in the chemosensitive regions on the ventral surface of the cat's medulla oblongata, Pfluegers Arch. 339 (1973) 171-183.
38. [38] R. Waldmann, G. Champigny, F. Bassilana, C. Heurteaux, M. Lazdunski, A proton-gated cation channel involved in acid-sensing, Nature 386 (1997) 173-177.