The pulmonary neuroendocrine system: The past decade

Archives of Histology and Cytology

Volumn 62, Issue 1, 1999, Pages 1-16

  Van Lommel, A ^a   Bolle T ^a   Fannes, W ^a   Lauweryns, J M ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CELL FUNCTION; CELL HYPOXIA; CHEMORECEPTOR; IMMUNOMODULATION; NEUROENDOCRINE SYSTEM; NEUROSECRETORY CELL; NONHUMAN; ONTOGENY; PHYLOGENY; PROTEIN DETERMINATION; RESPIRATORY SYSTEM; REVIEW;

ADJUVANTS, IMMUNOLOGIC; AMINES; ANIMALS; ANOXIA; LUNG; NEUROSECRETORY SYSTEMS; PEPTIDES; PHYLOGENY; RABBITS; RATS;

EID: 0032946533     PISSN: 09149465     EISSN: None     Source Type: Journal    
DOI: 10.1679/aohc.62.1     Document Type: Review

References (115)

1. ADRIAENSEN, D. and D. W. SCHEUERMANN: Neuroendocrine cells and nerves of the lung. Anat. Rec. 236: 70-85 (1993).
2. ADRIAENSEN, D., D. W. SCHEUERMANN, T. GOMI, A. KIMURA, J. P. TIMMERMANS and M. H. A. DE GROODT-LASSEEL: The pulmonary neuroepithelial endocrine system in the quail Coturnix coturnix. Light- and electron-microscopical immunocytochemistry and morphology. Anat. Rec. 239: 65-74 (1994).
3. ADRIAENSEN, D., D. W. SCHEUERMANN, J. P. TIMMERMANS and M. H. A. DE GROODT-LASSEEL: Neuroepithelial endocrine cells in the lung of the lungfish Protopterus aethiopicus. Acta Anat. 139: 70-77 (1990).
4. ADRIAENSEN, D., J. P. TIMMERMANS, I. BROUNS, H. R. BERTHOUD, W. L. NEUHUBER and D. W. SCHEUERMANN: Pulmonary intraepithelial vagal nodose afferent nerve terminals are confined to neuroepithelial bodies: an anterograde tracing and confocal microscopic study in adult rats. Cell Tiss. Res. 293: 395-405 (1998).
5. AGUAYO, S. M., M. A. KANE, T. E. KING, M. I. SCHWARZ, L. GRAUER and Y. E. MILLER: Increased levels of bombesin-like peptides in the lower respiratory tract of asymptomatic sigarette smokers. J. Clin. Invest. 84: 1105-1113 (1989).
6. AGUAYO, S. M., T. E. KING, J. A. WALDRON, K. M. SHERRITT, M. A. KANE and Y. E. MILLER: Increased pulmonary neuroendocrine cells with bombesin-like immunoreactivity in adult patients with eosinophilic granuloma. J. Clin. Invest. 86: 838-844 (1990).
7. AVADHANAM, K. P., C. G. PLOPPER and K. E. PINKERTON: Mapping the distribution of neuroepithelial bodies of the rat lung. A whole-mount immunohistochemical approach. Amer. J. Pathol. 150: 851-859 (1997).
8. BALAGUER, L. and J. ROMANO: Solitary neuroendocrine cells and neuroepithelial bodies in the lower airways of embryonic, fetal, and postnatal sheep. Anat. Rec. 231: 333-338 (1991).
9. BALAGUER, L., J. ROMANO and P. RUIZ-PESINI: Coexistence of serotonin and cholecystokinin in paraneurons of the foetal sheep lung. Histol. Histopathol. 9: 49-51 (1994).
10. BEORLEGUI, C., P. SESMA and A. MARTINEZ: Colocalization of immunoreactivities to serotonin, calcitonin and CGRP in endocrine pulmonary cells of the Iberian lizard Podarcis hispanica (Reptilia). Tiss. Cell 26: 817-825 (1994).
11. BOERS, J., J. L. M. DEN BROK, J. KOUDSTAAL, J. W. ARENDS and B. J. M. THUNNISSEN: Number and proliferation of neuroendocrine cells in normal human airway epithelium. Amer. J. Respir. Crit. Care Med. 154: 758-763 (1996).
12. BORGES, M., R. I. LINNOILA, H. J. K. VAN DE VELDE, H. CHEN, B. D. NELKIN, M. MABRY, S. B. BAYLIN and D. W. BALL: An achaete-scute homologue essential for neuroendocrine defferentiation in the lung. Nature 386: 852-855 (1997).
13. BOUSBAA, H. and J. FLEURY-FEITH: Effects of a longstanding challenge on pulmonary neuroendocrine cells of actively sensitized Guinea pigs. Amer. Rev. Respir. Dis. 144: 714-717 (1991).
14. BOUSBAA, H., F,. PORON and J. FLEURY-FEITH: Changes in chromogranin A-immunoreactive Guinea-pig pulmonary neuroendocrine cells after sensitization and challenge with ovalbumin. Cell Tiss. Res. 275: 195-199 (1994).
15. CHO, T., W. CHAN and E. CUTZ: Distribution and frequency of neuro-epithelial bodies in postnatal rabbit lung: quantitative study with monoclonal antibody against serotonin. Cell Tiss. Res. 255: 353-362 (1989).
16. CUTZ, E., J. E. GILLAN and D. G. PERRIN: Pulmonary neuroendocrine cell system: an overview of cell biology and pathology with emphasis on pediatric lung disease. Perspect. Pediatr. Pathol. 18: 32-70 (1995).
17. CUTZ, E., T. K. F. MA, D. G. PERRIN, A. M. MOORE and L. E. BECKER: Peripheral chemoreceptors in congenital central hypoventilation syndrome. Amer. J. Respir. Crit. Care Med. 155: 358-363 (1997).
18. 2+ ionophore on serotonin content and exocytosis of dense core vesicles. Anat. Rec. 236: 41-51 (1993).
19. DURBIN, J., P. THOMAS, C. LANGSTON, S. GOSWAMI and M. A. GRECO: Gastrin-releasing peptide in hypoplasmic lungs. Pediatr. Pathol. Lab. Med. 16: 927-934 (1996).
20. EBINA, M., R. F. HOYT, N. A. MCNELLY, S. P. SOROKIN and R. I. LINNOILA: Effects of hydrogen and bicarbonate ions on endocrine cells in fetal rat lung organ cultures. Amer. J. Physiol. Lung Cell. Mol. Physiol. 272: L178-L186 (1997).
21. EBINA, M., R. F. HOYT, S. P. SOROKIN and N. A. MCNELLY: Calcium and ionophore A23187 lower calcitonin gene-related peptide-like immunoreactivity in endocrine cells of organ cultured fetal rat lungs. Anat. Rec. 236: 226-230 (1993).
22. FISCHER, A., W. KUMMER, J. Y. COURAUD, D. ADLER, D. BRANSCHEID and C. HEYM: Immunohistochemical localization of receptors for vasoactive intestinal peptide and substance P in human trachea. Lab. Invest. 67: 387-393 (1992).
23. FLEETWOOD, J. N. and J. F. MUNNELL: Morphology of the airways and lung parenchyma in hatchlings of the loggerhead sea turtle, Caretta caretta. J. Morphol. 227: 289-304 (1996).
24. FREITAG, A., I. WESSLER and K. RACKE: Characterization of 5-hydroxytryptamine release from isolated rabbit and rat trachea: the role of neuroendocrine epithelial cells and mast cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 353: 55-63 (1995).
25. _ _ _: Adrenoceptor- and cholinoceptor-mediated mechanisms in the regulation of 5-hydroxytryptamine release from isolated tracheae of newborn rabbits. Brit. J. Pharmacol. 119: 91-98 (1996).
26. _ _ _: Nitric oxide, via activation of guanyl cyclase, suppresses α2-adrenoceptor-mediated 5-hydroxytryptamine release from neuroendocrine cells of rabbit tracheae. Naunyn-Schmiedeberg's Arch. Pharmacol. 356: 856-859 (1997).
27. GALLEGO, R., T. GARCIA-CABALLERO, M. FRAGA and A. BEIRAS: S-100 immunoreactivity in pulmonary neuroendocrine cells of newborn infants. Eur. J. Histochem. 40: 119-124 (1996).
28. GIAID, A., J. POLAK, V. GAITONDE, Q. HAMID, G. MOSOSO, S. LEGON, D. UWANOGHO, M. RONCALLI, O. SHINMI, T. SAWAMURA, S. KIMURA, M. YANAGISAWA, T. MASAKI and D. SPRINGALL: Distribution of endothelin-like immunoreactivity and mRNA in the developing and adult human lung. Amer. J. Respir. Cell Mol. Biol. 4: 50-58 (1991).
29. GILLAN, J. E. and E. CUTZ: Abnormal pulmonary bombesin immunoreactive cells in Wilson-Mikity syndrome (pulmonary dysmaturity) and bronchopulmonary dysplasia. Pediatr. Pathol. 13: 165-180 (1993).
30. GOMI, T., Y. KIKUCHI, D. ADRIAENSEN, J. P. TIMMERMANS, M. H. A. DE GROODT-LASSEEL, A. KIMURA, H. NARUSE, Y. ISHIKAWA, K. KISHI and D. W. SCHEUERMANN: Immunocytochemical survey of the neuroepithelial endocrine system in the respiratory tract of the Tokyo salamander, Hynobius nebulosus tokyoensis Tago. Histochemistry 102: 425-431 (1994).
31. GONIAKOWSKA-WITALINSKA, L.: Neuroepithelial bodies and solitary neuroendocrine cells in the lungs of amphibia. Microsc. Res. Tech. 37: 13-30 (1997).
32. GONIAKOWSKA-WITALINSKA, L., J. M. LAUWERYNS, G. ZACCONE, S. FASULO and G. TAGLIAFIERRO: Ultrastructure and immunocytochemistry of the neuroepithelial bodies in the lung of the tiger salamander, Ambystoma tigrinum (Urodela, Amphibia). Anat. Rec. 234: 419-431 (1992).
33. GOSNEY, J. R.: Pulmonary endocrine cells in native Peruvian Guinea pigs at low and high altitude. J. Comp. Pathol. 102: 7-12 (1990).
34. _: Neuroendocrine cell populations in postnatal human lungs: minimal variation from childhood to old age. Anat. Rec. 236: 177-180 (1993).
35. GOSNEY, J. R., J. PEERS, C. BEESLEY and E. GRADWELL: Pulmonary endocrine cells in anthracosilicotic lungs. Eur. Respir. J. 10: 388-391 (1997).
36. GOSNEY, J. R., M. C. J. SISSONS, R. O. ALLIBONE and A. F. BLAKEY: Pulmonary endocrine cells in chronic bronchitis and emphysema. J. Pathol. 157: 127-133 (1989).
37. GUBBELMANS, H. L. L., B. L. P. MAESEN, J. KOUDSTAAL and F. B. J. M. THUNISSEN: Neuroendocrine cells in anthracosilicotic lungs. Eur. Respir. J. 4: 824-828 (1991).
38. HALLER, C. J.: Evidence for the coexistence of serotonin and calcitonin gene-related peptide at the subcellular level in neuro-epithelial bodies in the lung of a marsupial, Isoodon macrourus. Cell Tiss. Res. 270: 199-203 (1992).
39. HALLER, C. J.: A scanning and transmission electron microscopic study of the development of the surface structure of neuroepithelial bodies in the mouse lung. Micron 25: 527-538 (1994).
40. HEATH, D., P. HARRIS, G. J. SUI, Y. H. LIU, J. GOSNEY, E. HARRIS and I. S. ANAND: Pulmonary blood vessels and endocrine cells in subacute infantile mountain sickness. Resp. Med. 83: 77-81 (1989).
41. HEATH, D., B. MADDEN and M. YACOUB: Pulmonary endocrine cells in plexogenic pulmonary arteriopathy. Physiol. Bohemoslav. 39: 309-313 (1990a).
42. HEATH, D., M. YACOUB, J. R. GOSNEY, B. MADDEN, A. W. CASLIN and P. SMITH: Pulmonary endocrine cells in hypertensive pulmonary vascular disease. Histopathology 16: 21-28 (1990b).
43. 3H-thymidine labeling in vivo. Anat. Rec. 227: 340-350 (1990).
44. HOYT, R. F., S. P. SOROKIN, E. M. MCDOWELL and N. A. MCNELLY: Neuroepithelial bodies and growth of the airway epithelium in developing hamster lung. Anat. Rec. 236: 15-22 (1993).
45. HUNTRAKOON, M., C. D. MENON and K. S. HUNG: Diethylnitrosamine-induced pulmonary endocrine cell hyperplasia and its association with adenomatosis and adenocarcinoma in rabbits. Amer. J. Pathol. 135: 119-1128 (1989).
46. INOUE, S., M. FUYIMIA, T. MAEDA and A. MORI: Change in distribution and density of CGRP, PGP 9.5, serotonin and chromogranin A reactivity in the perinatal rat respiratory tract. Acta Histochem. Cytochem. 30: 363-370 (1997).
47. ITO, T., A. NOZAWA, Y. USUDA, H. KITAMURA and M. KANISAWA: Hamster pulmonary endocrine cells with neural cell adhesion molecule (NCAM) immunostaining. Histochem. Cell Biol. 104: 357-362 (1995).
48. ITO, T., H. NOGAWA, N. UDAKA, H. KITAMURA and M. KANISAWA: Development of pulmonary neuroendocrine cells of fetal hamster in explant culture. Lab. Invest. 77: 449-457 (1997a).
49. ITO, T., K. I. OHYAMA, T. KUSANO, Y. USUDA, A. NOZAWA, H. HAYASHI, H. OHJI, H. KITAMURA and M. KANISAWA: Pulmonary endocrine cell hyperplasia and papilloma in rats induced by intratracheal injections of extract from particulate air pollutants. Exp. Toxic Pathol. 49: 65-70 (1997b).
50. ITO, T., N. UDAKA, Y. INAYAMA, H. KITAMURA and M. KANISAWA: Hamster pulmonary endocrine cells with positive immunostaining for calbindin-D28K. Histochem. Cell Biol. 109: 67-73 (1998).
51. JOHNSON, D. E., W. R. ANDERSON and B. A. BURKE: Pulmonary neuroendocrine cells in pediatric lung disease: alterations in airway structure in infants with bronchopulmonary dysplasia. Anat. Rec. 236: 115-119 (1993).
52. KASUYA, K. and T. FUJITA: Perinatal changes in bovine SEGI's caps with special reference to their endocrine cells migrating into the lamina propria. Arch. Histol. Cytol. 59: 169-187 (1996).
53. KEITH, I. M. and R. EKMAN: PYY-like material and its spatial relationship with NPY, CGRP and 5-HT in the lung of the Syrian golden hamster. Cell Tiss. Res. 262: 543-550 (1990).
54. KEITH, I. M., M. PELTO-HUIKKO, M. SCHALLING and T. HÖKFELT: Calcitonin gene-related peptide and its mRNA in pulmonary neuroendocrine cells and ganglia. Histochemistry 96: 311-315 (1991).
55. KHOOR, A., M. E. GRAY, G. SINGH and M. T. STAHLMAN: Ontogeny of Clara cell-specific protein and its mRNA: their association with neuroepithelial bodies in human fetal lung and in bronchopulmonary dysplasia. J. Histochem. Cytochem. 44: 1429-1438 (1996).
56. LAUWERYNS, J. M. and J. C. PEUSKENS: Argyrophil (kinin and amine producing?) cells in human infant airway epithelium. Life Sci. 8: 577-585 (1969).
57. _ _: Neuro-epithelial bodies (neuroreceptor or secretory organs?) in human infant bronchial and bronchiolar epithelium. Anat. Rec. 172: 471-482 (1972).
58. LAUWERYNS, J. M., J. C. PEUSKENS and M. COKELAERE: Argyrophil, fluorescent and granulated (peptide and amine producing?) AFG cells in human infant bronchial epithelium. Light and electron microscopic studies. Life Sci. 9: 1417-1429 (1970).
59. LUTS, A., R. UDDMAN, A. ABSOOD, R. HAKANSON and F. SUNDLER: Chemical coding of endocrine cells of the airways: presence of helodermin-like peptides. Cell Tiss. Res. 265: 425-433 (1991).
60. MCBRIDE, J. T., D. R. SPRINGALL, R. J. D. WINTER and J. M. POLAK: Quantitative immunocytochemistry shows calcitonin gene-related peptide-like immunoreactivity in lung neuroendocrine cells is increased by chronic hypoxia in the rat. Amer. J. Respir. Cell Mol. Biol. 3: 587-593 (1990).
61. MCDOWELL, E. M., S. SOROKIN and R. F. HOYT: Ontogeny of endocrine cells in the respiratory system of Syrian golden hamsters. I. Larynx and trachea. Cell Tiss. Res. 275: 143-156 (1994a).
62. MCDOWELL, E. M., R. F. HOYT and S. P. SOROKIN: Ontogeny of endocrine cells in the respiratory system of Syrian golden hamsters. II. Intrapulmonary airways and alveoli. Cell Tiss. Res. 275: 157-167 (1994b).
63. 2/CO concentration. Int. J. Oncol. 8: 423-429 (1996).
64. MONTUENGA, L. M., D. R. SPRINGALL, J. GAER, R. J. D. WINTER, L. ZHAO, J. T. MCBRIDE, K. M. TAYLOR, G. BARER and J. M. POLAK: CGRP-immunoreactive endocrine cell proliferation in normal and hypoxic rat lung studied by immunocytochemical detection of incorporation of 5'-bromodeoxyuridine. Cell Tiss. Res. 268: 9-15 (1992).
65. NAKATANI, T.: Pulmonary endocrine cells in infancy and childhood. Pediatr. Pathol. 11: 31-48 (1991).
66. NYLEN, E. and K. L. BECKER: Chronic hyperoxia and hamster pulmonary neuroendocrine cell bombesin and calcitonin. Anat. Rec. 236: 248-252 (1993).
67. NYLEN, E., K. L. BECKER, P. A. JOSHI, R. H. SNIDER and H. M. SCHULLER: Pulmonary bombesin and calcitonin in hamsters during exposure to hyperoxia and diethylnitrosamine. Amer. J. Respir. Cell Mol. Biol. 2: 25-31 (1990).
68. NYLEN, E. S., K. L. BECKER, R. H. SNIDER, A. R. TABASSIAN, M. M. CASSIDY and I. LINNOILA: Cholinergic-nicotinic control of growth and secretion of cultured pulmonary neuroendocrine cells. Anat. Rec. 236: 129-135 (1993).
69. O'NEILL, D., R. FERRARI, C. CECONI, A. RODELLA, P. SMITH, P. HARRIS and D. HEATH: Pulmonary peptides, norepinephrine and endocrine cells in monocrotaline pulmonary hypertension. Cardioscience 2: 27-33 (1991).
70. PASTOR, L. M.: A morphological study of the tracheal epithelium of the snake Natrix maura. J Anat. 172: 47-57 (1990).
71. PERRIN, G., T. J. MCDONALD and E. CUTZ: Hyperplasia of bombesin-immunoreactive pulmonary neuroendocrine cells and neuroepithelial bodies in sudden infant death syndrome. Pediatr. Pathol. 11: 431-447 (1991).
72. RODRIGUEZ, A., L. PENA, J. M. FLORES, M. GONZALEZ and M. CASTANO: Immunocytochemical study of the diffuse neuroendocrine system cells in equine lungs. Anat. Histol. Embryol. 21: 136-145 (1992).
73. ROGERS, D. C.: Phylogenetic aspects of the neuroepithelial bodies. Arch. Histol. Cytol. 52, Suppl.: 397-402 (1989).
74. RONCALLI, M., D. R. SPRINGALL, M. MAGGIONI, A. MORADOGLI-HAFTVANI, R. J. D. WINTER, L. ZHAO, G. COGGI and J. M. POLAK: Early changes in the calcitonin gene-related peptide (CGRP) content of pulmonary endocrine cells concomitant with vascular remodelling in the hypoxic rat. Amer. J. Respir. Cell Mol. Biol. 9: 467-474 (1993).
75. SCHEUERMANN, D. W.: Comparative histology of pulmonary neuroendocrine cell system in mammalian lungs. Microsc. Res. Tech. 37: 31-42 (1997).
76. SCHEUERMANN, D. W., D. ADRIAENSEN, J. TIMMERMANS and M. H. A. DE GROODT-LASSEEL: Neuroepithelial endocrine cells in the lung of Ambystoma mexicanum. Anat. Rec. 225: 139-149 (1989).
77. SCHEUERMANN, D. W., D. ADRIAENSEN, J. P. TIMMERMANS and M. H. A. DE GROODT-LASSEEL: Comparative histological overview of the chemical coding of the pulmonary neuroepithelial endocrine system in health and disease. Eur. J. Morphol. 30: 101-112 (1992).
78. SCHULLER, H.: Carbon dioxide potentiates the mitogenic effects of nicotine and its carcinogenic derivative, NKK, in normal and neoplastic neuroendocrine lung cells via stimulation of autocrine and protein kinase C-dependent mitogenic pathways. Neurotoxicology 15: 877-886 (1994).
79. SHENBERGER, J. S., R. L. SHEW and D. E. JOHNSON: Hyperoxia-induced airway remodeling and pulmonary neuroendocrine cell hyperplasia in the weanling rat. Pediatr. Res. 42: 539-544 (1997).
80. SHIMOSEGAWA, T. and S. I. SAID: Pulmonary calcitonin gene-related peptide immunoreactivity: nerve-endocrine cell interrelationships. Amer. J. Respir. Cell Mol. Biol. 4: 126-134 (1991).
81. SOROKIN, S. P., M. EBINA and R. HOYT: Development of PGP 9.5- and calcitonin gene-related peptide-like immunoreactivity in organ cultured fetal rat lungs. Anat. Rec. 236: 213-225 (1993).
82. SOROKIN, S. P., K. HOYT and M. J. SHAFFER: Ontogeny of neuroepithelial bodies: correlations with mitogenesis and innervation. Microsc. Res. Tech. 37: 43-61 (1997).
83. SPEIRS, V., Y. WANG, H. YEGER and E. CUTZ: Isolation and culture of neuroendocrine cells from fetal rabbit lung using immunomagnetic techniques. Amer. J. Respir. Cell Mol. Biol. 6: 63-67 (1992).
84. STAHLMAN, M. E. and M. T. GRAY: Immunogold EM localization of neurochemicals in human pulmonary neuroendocrine cells. Microsc. Res. Tech. 37: 77-91 (1997).
85. STEVENS, T. P., J. T. MCBRIDE, J. L. PEAKE, K. E. PINKERTON and B. R. STRIPP: Cell proliferation contributes to PNEC hyperplasia after acute airway injury. Amer. J. Physiol. Lung Cell. Mol. Physiol. 272: L486-L493 (1997).
86. SUNDAY, M. E.: Pulmonary neuroendocrine cells and lung development. Endocrine Pathol. 7: 173-201 (1996).
87. SUNDAY, M. E. and C. G. WILLETT: Induction and spontaneous regression of intense pulmonary neuroendocrine cell differentiation in a model of preneoplasmic lung injury. Cancer Res., Suppl. 52: 2677s-2686s (1992).
88. SUNDIN, L., S. HOLMGREN and S. NILSSON: The oxygen receptor of the teleost gill? Acta Zool. 79: 207-214 (1998).
89. TABASSIAN, A. R., E. S. NYLEN, R. I. LINNOILA, R. H. SNIDER, M. M. CASSIDY and K. L. BECKER: Stimulation of hamster pulmonary neuroendocrine cells and associated peptides by repeated exposure to cigarette smoke. Amer. Rev. Respir. Dis. 140: 436-440 (1989).
90. TABASSIAN, A. R., E. S. NYLEN, L. LUKACS, M. M. CASSIDY and K. L. BECKER: Cholinergic regulation of hamster pulmonary neuroendocrine cell calcitonin. Exp. Lung Res. 16: 267-277 (1990).
91. TJEN-A-LOOI, S., H. KRAICZI, R. EKMAN and I. M. KEITH: Sensory CGRP depletion by capsaicin exacerbates hypoxia-induced pulmonary hypertension in rats. Regul. Pept. 74: 1-10 (1998).
92. UDDMAN, R., A. LUTS, A. ARIMURA and F. SUNDLER: Pituitary adenylate cyclase-activating peptide (PACAP), a new vasoactive intestinal peptide (VIP)-like peptide in the respiratory tract. Cell Tiss. Res. 265: 197-201 (1991).
93. VAN DEN STEEN, P., A. VAN LOMMEL and J. M. LAUWERYNS: Neuroepithelial bodies in the lung of Basiliscus vittatus (Reptilia, Iguanidae). Anat. Rec. 239: 158-169 (1994).
94. VAN DEN STEEN, P., E. K. VERBEKEN, A. VAN LOMMEL and J. M. LAUWERYNS: Immunoreactivity for the pituitary glycoprotein hormones in pulmonary neuroendocrine cells of developing human lung and various perinatal diseases. Regul. Pept. 70: 37-48 (1997).
95. VAN LOMMEL, A. T. L. and J. M. LAUWERYNS: Ultrastructure and innervation of neuroepithelial bodies in the lungs of newborn cats. Anat. Rec. 236: 181-190 (1993a).
96. _ _: Neuroepithelial bodies in the Fawn Hooded rat lungs: morphological and neuroanatomical evidence for a sensory innervation. J. Anat. 183: 553-566 (1993b).
97. _ _: Postnatal development of the pulmonary neuroepithelial bodies in various animal species. J. Auton. Nerv. Syst. 65: 17-24 (1997).
98. VAN LOMMEL, A., J. M. LAUWERYNS, P. DE LEYN, P. WOUTERS, H. SCHREINEMAKERS and T. LERUT: Pulmonary neuroepithelial bodies in neonatal and adult dogs: histochemistry, ultrastructure and effects of unilateral hilar lung denervation. Lung 173: 13-23 (1995a).
99. VAN LOMMEL, A., J. M. LAUWERYNS, M. MARCUS and J. D. VERTOMMEN: Neuroepithelial bodies in relatively mature lungs: an investigation in prenatal and newborn lambs. Acta Anat. 153: 203-209 (1995b).
100. VAN LOMMEL, A., P. VAN DEN STEEN and J. M. LAUWERYNS: Association of immune cells with neuroepithelial bodies in the lungs of neonatal dogs, cats and hamsters. Cell Tiss. Res. 282: 519-522 (1995c).
101. VAN LOMMEL, A., J. M. LAUWERYNS and H. R. BERTHOUD: Pulmonary neuroepithelial bodies are innervated by vagal afferent nerves: an investigation with in vivo anterograde DiI tracing and confocal microscopy. Anat. Embryol. 197: 325-330 (1998).
102. WANG, D., H. YEGER and E. CUTZ: Expression of gastrin-releasing peptide receptor gene in developing lung. Amer. J. Respir. Cell Mol. Biol. 14: 409-416 (1996).
103. + channel may function as an oxygen sensor complex in airway chemoreceptors and small cell lung carcinoma cell lines. Proc. Nat. Acad. Sci. USA 93: 13182-13187 (1996).
104. WANG, Y. Y. and E. CUTZ: Localization of cholecystokinin-like peptide in neuroendocrine cells of mammalian lungs: a light and electron microscopic immunohistochemical study. Anat. Rec. 236: 198-205 (1993).
105. WILLIAMS, D.: Pulmonary endocrine cells and the pulmonary circulation in various species in the Himalaya. Physiol. Bohemoslov. 39: 297-300 (1990).
106. WILLIAMS, D., D. HEATH, J. GOSNEY and J. RIOSDALENZ: Pulmonary endocrine cells of Aymara indians from the Bolivian Andes. Thorax 48: 52-56 (1993).
107. WILSON, N. J. E., J. R. GOSNEY and F. MAYALL: Endocrine cells in diffuse pulmonary fibrosis. Thorax 48: 1252-1256 (1993).
108. YAMATAKA, T. and P. PURI: Increased intracellular levels of calcitonin gene-related peptide-like immunoreactivity in pulmonary endocrine cells in an experimental model of congenital diaphragmatic hernia. Pediatr. Surg. Int. 11: 448-452 (1996).
109. YEGER, H., V. SPEIRS, C. YOUNGSON and E. CUTZ: Pulmonary neuroendocrine cells in cultures of human infant airway mucosa from postmortem tissues. Amer. J. Respir. Cell Mol. Biol. 15: 232-236 (1996).
110. 2-sensing protein (NADPH oxidase) in chemoreceptor cells. Microsc. Res. Tech. 37: 101-106 (1997).
111. YOUNGSON, C., C. NURSE, H. YEGER and E. CUTZ: Oxygen sensing in airway chemoreceptors. Nature 365: 153-155 (1993).
112. YOUSEM, S. A. and A. ISAACS: Pulmonary neuroendocrine cells in the airways of lung allografts. Transplantation 59: 1070-1073 (1995).
113. IJSSELSTYN, H., J. L. J. GAILLARD, J. C. DE JONGSTE, D. TIBBOEL and E. CUTZ: Abnormal expression of pulmonary bombesin-like peptide immunostaining cells in infants with congenital diaphragmatic hernia. Ped. Research 42: 715-720 (1997).
114. IJSSELSTYN, H., N. HUNG, J. C. DE JONGSTE, D. TIBBOEL and E. CUTZ: Calcitonin gene-related peptide expression is altered in pulmonary neuroendocrine cells in developing lungs of rats with congenital diaphragmatic hernia. Amer. J. Respir. Cell Mol. Biol. 19: 278-285 (1998).
115. ZACCONE, G., L. GONIAKOWSKA-WITALINSKA, J. M. LAUWERYNS, S. FASULO and G. TAGLIAFIERRO: Fine structure and serotonin immunohistochemistry of the neuroendocrine cells in the lungs of the bichirs Polypterus delhezi and P. ornatipinnis. Bas. Appl. Histochem. 33: 277-287 (1989).