Differential sensitivity of kv1.4, Kv1.2, and Their tandem channel to acidic ph: Involvement of a histidine residue in high sensitivity to acidic ph

Journal of Pharmacology and Experimental Therapeutics

Volumn 296, Issue 2, 2001, Pages 405-411

  Ishii, Kuniaki ^a   Nunoki, Kazuo ^b   Yamagishi, Toshio ^b   Okada, Hitoshi ^b   Taira, Norio ^b  

^a YAMAGATA UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL; POTASSIUM ION; PROTON;

ACIDITY; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL MEMBRANE TRANSPORT; CHANNEL GATING; CONTROLLED STUDY; NONHUMAN; OOCYTE; POTASSIUM CURRENT; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; TRANSPORT KINETICS; XENOPUS;

EID: 0035141130     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Current inactivation involves a histidine residue in the pore of the rat lymphocyte potassium channel RGK5
2. Sensitivity to H, Li and Mg ions of the slow inward sodium current in frog atrial fibres
3. Heteropolymeric potassium channels expressed in Xenopus oocytes from cloned subunits
4. Identification and molecular localization of a pH-sensing domain for the inward rectifier potassium channel HIR
5. Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH
6. Effects of acid-base changes on excitation-contraction coupling in guinea-pig and rabbit cardiac ventricular muscle
7. Studies of acidosis in the ischaemic heart by phosphorus nuclear magnetic resonance
8. Surface charges and ion channel function
9. + channels
10. Charges and potentials at the nerve surface. Divalent ions and pH
11. Is ischemia-induced pH decrease of dog myocardium respiratory or metabolic acidosis?
12. Evidence for the formation of heteromultimeric potassium channels in Xenopus oocytes
13. Cloning and modulation by endothelin-1 of rat cardiac K channel
14. + channel of guinea-pig ventricular cell membrane
15. Inhibition of the calcium channel by intracellular protons in single ventricular myocytes of the guinea-pig
16. Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel
17. The effects of intracellular protons on the electrical activity of single ventricular cells
18. + channel subunits from heteromultimeric channels with novel functional properties
19. Isolation of a cDNA clone coding for a putative second potassium channel indicates the existence of a gene family
20. Hybrid potassium channels by tandem linkage of inactivating and non-inactivating subunits
21. Acidosis and arrhythmias in cardiac muscle
22. Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila
23. Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current?
24. Shaker encodes a family of putative potassium channel proteins in the nervous system of Drosophila
25. Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart
26. Heteromultimeric channels formed by rat brain potassium-channel proteins
27. + channels detected in vivo
28. Ionic conductance changes in voltage clamped crayfish axons at low pH
29. Differential sensitivity of voltage-gated potassium channels Kv1.5 and Kv1.2 to acidic pH and molecular identification of pH sensor
30. Molecular basis of functional diversity of voltagegated potassium channels in mammalian brain
31. Molecular cloning and functional expression of a potassium channel cDNA isolated from a rat cardiac library
32. + channels in terminal and juxtaparanodal regions of neurons
33. Changes in extracellular and intracellular pH in ischemic rabbit papillary muscle