Diltiazem blocks the pH-induced excitation of rat nociceptors together with their mechanical and electrical excitability in vitro

Journal of Neurophysiology

Volumn 75, Issue 1, 1996, Pages 1-10

  Wegner, Holger ^b   Reeh, Peter W ^b   Brehm, Susanne ^b   Kreysel, Hans W ^b   Steen, Kay H ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DILTIAZEM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PH; CONTROLLED STUDY; DRUG EFFECT; ELECTROSTIMULATION; MECHANICAL STIMULATION; NERVE CELL EXCITABILITY; NERVE CONDUCTION; NOCICEPTIVE RECEPTOR; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTIVE FIELD; SAPHENOUS NERVE; SIGNAL TRANSDUCTION; SODIUM TRANSPORT;

EID: 0030069869     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1996.75.1.1     Document Type: Article

References (48)

1. AKAIKE, N., KRISHTAL, O A., AND MARUYAMA, T. Proton-induced sodium current in frog isolated dorsal root ganglion cells. J. Neurophysiol. 63: 805-813, 1990.
2. BECK, P. W. AND HANDWERKER, H. O. Bradykinin and serotonin effects on various types of cutaneous nerve fibres. Pfluegers Arch. 347: 209-222, 1974.
3. BELMONTE, C., GALLAR, J., POZO, M. A., AND REBOLLO, I. Excitation by irritant chemical substances of sensory afferent units in the cat's cornea. J. Physiol. Lond. 437: 709-725, 1991.
4. BEVAN, S., FORBES, C. A., AND WINTER, J. Protons and capsaicin activate the same ion channels in rat isolated dorsal root ganglion neurones (Abstract). J. Physiol. Lond. 459: 401P, 1993.
5. BEVAN, S. AND YEATS, J. Protons activate a cation conductance in a subpopulation of rat dorsal root ganglion neurones. J. Physiol. Lond. 433: 145-161, 1991.
6. BRETAG, A. H. Synthetic interstitial fluid for isolated mammalian tissue. Life Sci. 8: 319-329, 1969.
7. BREUER, J. AND STEEN, K. H. Heat Stim: an integrated hard-software system for feedback controlled radiant heat stimulation in somatosensory research. In: Proceedings of the International Conference on Medical Physics and Biomedical Engineering, edited by S. Spyrou, S. Christofides, C. S. Pattichis, E. Keravnou, C. N. Schizas, and G. Christodoulides. Cyprus: Univ. of Cyprus, 1994, vol. 1, p. 242-246.
8. BUSTAMANTE, D., MIRANDA, H. F., PELISSIER, T., AND PAEILE, C. Analgesic action of clonixin, nifedepine and morphine using the formalin test. Gen. Pharmacol. 20: 319-322, 1989.
9. COURTNEY, K. R. Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA 968. J. Pharmacol. Exp. Ther. 195: 225-236, 1975.
10. DELLA PASCHOA, O. E., LUCKOW, V., TRENK, D., JAHNCHEN, E., AND SANTOS, S. R. C. J. Prolongation of the PQ interval as a measure of therapeutic inequivalence between two formulations of diltiazem. Eur. J. Clin. Pharmacol. 48: 45-49, 1995.
11. FLEISCHER, E., HANDWERKER, H. O., AND JOUKHADAR, S. Unmyelinated nociceptive units in two skin areas of the rat. Brain Res. 267: 81-92, 1983.
12. FORSTER, C. AND HANDWERKER, H. O. Automatic classification and analysis of microneurographic spike data using a PC/AT. J. Neurosci. Methods 31: 109-118, 1990.
13. GlLBERTSON, T. A., AVENET, P., KINNAMON, S. C., AND ROPER, S. D. Proton currents through amiloride-sensitive Na channels in hamster taste cells. J. Gen. Physiol. 100: 803-824, 1992.
14. HÄBLER, C. Über den K- und Ca- Gehalt von Eiter und Exsudaten und seine Beziehungen zum Entzündungsschmerz. Klin. Wochenschr. 8: 1569-1572, 1929.
15. HILLE, B. Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J. Gen. Physiol. 69: 497-515, 1977.
16. IGGO, A. The electrophysiological identification of single nerve fibres, with particular reference to the slowest-conducting vagal afferent fibres in the cat. J. Physiol. Lond. 142: 110-126, 1958.
17. JACOBUS, W. E , TAYLOR, G. J., HOLLIS, D. P., AND NUNNALLY, R. L. Phosphorus nuclear magnetic resonance of perfused working rat hearts. Nature Lond. 265: 756-758, 1977.
18. KANAKA, R., SCHAIBLE, H.-G., AND SCHMIDT, R F. Activation of fine articular afferent units by bradykinin. Brain Res. 327: 81-90, 1985.
19. KHODOROV, B., SHISHKOVA, L., PEGANOV, E., AND REVENKO, S. Inhibition of sodium currents in frog ranvier node treated with local anesthetics. Role of slow sodium inactivation. Biochim. Biophys. Acta 433: 409-435, 1976.
20. KOMAI, M. AND BRYANT, B. P. Acetazolamide specifically inhibits lingual trigeminal nerve responses to carbon dioxide. Brain Res. 612: 122-129, 1993.
21. KONNERTH, A., LUX, H. D., AND MORAD, M. Proton-induced transformation of calcium channel in chick dorsal root ganglion cells. J. Physiol. Lond. 386: 603-633, 1987.
22. KRISHTAL, O. A. AND PIDOPLICHKO, V. I. A receptor for protons in the nerve cell membrane. Neuroscience 5: 2325-2327, 1980.
23. KRISHTAL, O. A. AND PIDOPLICHKO, V. I. A receptor for protons in the membrane of sensory neurons may participate in nociception. Neuroscience 6: 2599-2601, 1981.
24. KUMAZAWA, T., MIZUMURA, K., AND SATO, J. Response properties of polymodal receptors studied using in vitro testis superior spermatic nerve preparation of dogs. J. Neurophysiol. 57: 702-711, 1987.
25. LANG, E., NOVAK, A., REEH, P. W., AND HANDWERKER, H. O. Chemosensitivity of fine afferents from rat skin in vitro. J. Neurophysiol. 63: 887-901, 1990.
26. LINDAHL, O. Experimental skin pain. Acta Physiol. Scand. 51, Suppl. 179: 1-90, 1961.
27. LYNN, B. AND CARPENTER, S. E. Primary afferent units from the hairy skin of the rat hind limb. Brain Res. 238: 29-43, 1982.
28. MIRANDA, H. F. AND PAEILE, C. Interactions between analgesics and calcium channel blockers. Gen. Pharmacol. 21: 171-174, 1990.
29. 2+-channel: Possible mechanism and physiological role. In: The Calcium Channel: Structure, Function and Implications, Bayer AG-Centenary-Symposium, Stresa, Italy, edited by M. Martin. Berlin: Springer, 1988, p. 71-80.
30. NISHI, K., AKAIKE, N., OYAMA, Y., AND ITO, H. Actions of calcium antagonists on calcium currents in Helix neurons. Circ. Res. 52, Suppl. I: 53-59, 1983.
31. PEER, L. A. Transplantation of Tissues. Baltimore, MD: Williams & Wilkins, 1955.
32. POZO, M. A., GALLEGO, R., GALLAR, J., AND BELMONTE, C. Blockade by calcium antagonists of chemical excitation and sensitization of polymodal nociceptors in the cat's cornea. J. Physiol. Lond. 450: 179-189, 1992.
33. RANG, H. P., BEVAN, S., AND DRAY, A. Nociceptive peripheral neurons: cellular properties. In: Textbook of Pain, edited by P. D. Wall and R. Melzack. Edinburgh: Churchill Livingstone, 1994, p. 57-78.
34. REEH, P W. Sensory receptors in mammalian skin in an in vitro preparation. Neurosci. Lett. 66: 141-146, 1986.
35. SCHMIDTMAYER, J. AND ULBRICHT, W. Interaction of lidocaine and benzocaine in blocking sodium channels. Pfluegers Arch. 387: 47-54, 1980.
36. 2+-channels in rat DRG neurons (Abstract). Pfluegers Arch. 426, Suppl.: R35, 1994.
37. SCHWARZ, W., PALADE, P. T., AND HILLE, B. Local anesthetics: effect of pH on use-dependent block of sodium channels in frog muscle. Biophys. J. 20: 343-368, 1977.
38. STEEN, K. H. AND REEH, P. W. Sustained graded pain and hyperalgesia from harmless experimental tissue acidosis in human skin. Neurosci. Lett. 154: 113-116, 1993.
39. STEEN, K. H., REEH, P. W., ANTON, F., AND HANDWERKER, H. O. Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceplors in rat skin, in vitro. J. Neurosci. 12: 86-95, 1992.
40. STEEN, K. H., REEH, P. W., AND KREYSEL, H. W. Dose-dependent competitive block by topical acetylsalicylic and salicylic acid of low pH-induced cutaneous pain. Pain 1995a. In press.
41. STEEN, K. H., REEH, P. W., AND KREYSEL, H. W. Topical acetylsalicylic, salicylic acid and indomethacin suppress pain from experimental tissue acidosis in human skin. Pain 62: 339-347, 1995b.
42. STEEN, K. H., STEEN, A. E., AND REEH, P. W. A dominant role of acid pH in inflammatory excitation and sensitization of nociceptors in rat skin, in vitro. J. Neurosci. 15: 3982-3989, 1995c.
43. STEEN, A. E., REEH, P. W., KREYSEL, H. W., AND STEEN, K. H. Experimental tissue acidosis potentiates pain induced by inflammatory mediators. IASP Abstr.: R39, 1993.
44. +] and is increased under amiloride, in vitro. Soc. Neurosci. Abstr. 21: 648, 1995d.
45. STEFANIDIS, D., REEH, P. W., KREYSEL, H. W., AND STEEN, K. H. Acetylsalicylic and salicylic acid suppress pH induced excitation of rat nociceptors, in vitro. Soc. Neurosci. Abstr. 20: 15, 1994.
46. STRICHARTZ, G. R. The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J. Gen. Physiol. 62: 37-57, 1973.
47. STRICHARTZ, G. Use-dependent conduction block produced by volatile general anesthetic agents. Acta Anaesth. Scand. 24: 402-406, 1980.
48. WEGNER, H., BREHM, S., REEH, P. W., KREYSEL, H. W., AND STEEN, K. H. Diltiazem blocks the pH induced excitation of rat nociceptors together with their mechanical and electrical excitability, in vitro. Pfluegers Arch. 426 Suppl.: R49, 1994.