Proton sensitivity of the GABAA receptor is associated with the receptor subunit composition

Journal of Physiology

Volumn 492, Issue 2, 1996, Pages 431-443

  Krishek, Belinda J ^a   Amato, Alessandra ^a   Connolly, Christopher N ^b   Moss, Stephen J ^b   Smart, Trevor G ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; PROTON; RECEPTOR SUBUNIT;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL PH; EMBRYO; FEMALE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; KIDNEY CELL; NERVE CELL CULTURE; NONHUMAN; OOCYTE; PH; PRIORITY JOURNAL; SYMPATHETIC NERVE CELL; XENOPUS LAEVIS;

ANIMALS; CELL LINE; ELECTROPHYSIOLOGY; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; HYDROGEN; HYDROGEN-ION CONCENTRATION; ISOMERISM; KIDNEY; OOCYTES; PROTONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; XENOPUS LAEVIS;

EID: 0029967758     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.1996.sp021319     Document Type: Article

References (41)

1. A receptor subunits: α1β1 and α1β1γ2S subunits produce simple unique ion channels with dissimilar single-channel properties. Journal of Neuroscience 13, 1429-1440.
2. ANTOSIEWICZ, J., MCCAMMON, J. A. & GILSON, M. K. (1994). Prediction of pH-dependent properties of proteins. Journal of Molecular Biology 238, 415-436.
3. CHEN, J. C. T. & CHESLER, M. (1992). Modulation of extracellular pH by glutamate and GABA in rat hippocampal slices. Journal of Neurophysiology 67, 29-36.
4. CHESLER, M. (1990). The regulation and modulation of pH in the nervous system. Progress in Neurobiology 34, 401-427.
5. CHESLER, M. & CHAN, C. Y. (1988). Stimulus-induced extracellular pH transients in the in vivo turtle cerebellum. Neuroscience 27, 941-948.
6. CHESLER, M. & KAILA, K. (1992). Modulation of pH by neuronal activity. Trends in Neurosciences 15, 396-402.
7. 2+. Neuron 5, 781-788.
8. EISNER, D. A., KENNING, N. A., O'NEILL, S. C., POCOCK, G., RICHARDS, C. D. & VALDEOLMILLOS, M. (1989). A novel method for absolute calibration of intracellular pH indicators. Pflügers Archiv 413, 553-558.
9. EVANS, G. I., LEWIS, G., RAMSAY, G. & BISHOP, J. M. (1985). Isolation of monoclonal antibodies specific for the human c-myc oncogene product. Molecular and Cellular Biology 5, 3610-3616.
10. - pump inhibitors on GABA responses recorded from cat dorsal root ganglia. Brain Research 267, 249-259.
11. GROUL, D. L., BARKER, J. L., HUANG, L.-Y., MACDONALD, J. F. & SMITH, T. G. (1980). Hydrogen ions have multiple effects on the excitability of cultured mammalian neurons. Brain Research 183, 247-262.
12. 2+: an endogenous modulator of ligand- and voltage-gated ion channels. Neuropharmacology 33, 935-952.
13. A receptor channel function in the nervous system. Progress in Neurobiology 42, 489-537.
14. KAILA, K. & VOIPIO, J. (1987). Postsynaptic fall in intracellular pH induced by GABA-activated bicarbonate conductance. Nature 330, 163-165.
15. KRAIG, R. P., FERREIRA-FILHO, C. R. & NICHOLSON, C. (1983). Alkaline and acid transients in cerebellar microenvironment. Journal of Neurophysiology 49, 831-850.
16. KRISHEK, B. J., XIE, X., BLACKSTONE, C., HUGANIR, R. L., MOSS, S. J. & SMART, T. G. (1994). Regulation of GABAA receptor function by protein kinase C phosphorylation. Neuron 12, 1081-1095.
17. A receptor channels. Annual Review of Neuroscience 17, 569-602.
18. MAHLER, H. R. & CORDES, E. H. (1971). Biological Chemistry, 2nd edn, p. 44. Harper & Row, New York.
19. MAYER, M. L. & VYKLICKY, L. (1989). The action of zinc on synaptic transmission and neuronal excitability in cultures of mouse hippocampus. Journal of Physiology 415, 351-365.
20. 3-free solution. Canadian Journal of Physiology and Pharmacology 70, S293-300.
21. A receptor populations with novel subunit combinations and drug binding profiles identified in brain by α5 and δ-subunit-specific immunopurification. Journal of Biological Chemistry 268, 5965-5973.
22. NAKAGAWA, T., WAKAMORI, M., SHIRASAKI, T., NAKAYE, T. & AKAIKE, N. (1991). γ-Aminobutyric acid-induced response in acutely isolated nucleus solitarii neurons of the rat. American Journal of Physiology 260, C745-749.
23. A receptor determined by electron microscopic image analysis. Journal of Neurochemistry 62, 815-818.
24. PASTERNACK, M., BOUNTRA, C., VOIPIO, J. & KAILA, K. (1992). Influence of extracellular and intracellular pH on GABA-gated chloride conductance in crayfish muscle fibres Neuroscience 47, 921-929.
25. A receptor subunit for benzodiazepine pharmacology. Nature 338, 582-585.
26. 2+ in lymphocytes. Journal of Cell Biology 95, 189-196.
27. A receptor subunits; Role of the δ subunit. Journal of Neuroscience, 14, 7077-7086.
28. A receptor subunits exist in distinct neuronal subpopulations. Neuron 3, 327-337.
29. A receptor subtypes. Pharmacological Reviews 47, 181-234.
30. SIGEL, E., BAUR, R., TRUDE, G., MOHLER, H. & MALHERBE, P. (1990). The effect of subunit composition of rat brain GABAA receptors on channel function. Neuron 5, 703-711.
31. A receptor complex in cultured rat neurones. Journal of Physiology 447, 587-625.
32. A receptors. In Amino Acid Neurotransmission. Portland Press, London (in the Press).
33. A receptors are differentially sensitive to zinc: dependence on subunit composition. British Journal of Pharmacology 103, 1837-1839.
34. SMART, T. G., XIE, X. & KRISHEK, B. J. (1994). Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc. Progress in Neurobiology 42, 393-441.
35. TAKEUCHI, A. & TAKEUCHI, N. (1967). Anion permeability of the inhibitory postsynaptic membrane of the crayfish neuromuscular junction. Journal of Physiology 191, 575-590.
36. +. Proceedings of the National Academy of Sciences of the USA 87, 6445-6558.
37. TRAYNELIS, S. F. & CULL-CANDY, S. G. (1990). Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurones. Nature 345, 347-350.
38. + activities during and after direct electrical stimulation of the brain cortex. Pflügers Archiv 378, 47-53.
39. A receptors depend upon subunit composition. Neuron 4, 919-928.
40. VYKLICKY, L., VLACHOVA, V. & KRUSEK, J. (1990). The effect of external pH changes on responses to excitatory amino acids in mouse hippocampal neurones. Journal of Physiology 430, 497-517.
41. B receptors. Molecular Brain Research 16, 204-210.