Diethyl pyrocarbonate (DEPC) inhibits CO2 chemosensitivity in Helix aspersa

Respiration Physiology

Volumn 111, Issue 1, 1998, Pages 65-78

  Lu, Daniel C ^a   Erlichman, Joseph S ^a   Leiter, J C ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Alphastat; Chemoreceptors, central, CO2; Control of breathing; Hypercapnia; Invertebrates, pulmonate snail, Helix aspersa; Pharmacological agents, diethyl pyrocarbonate

Indexed keywords

CARBON DIOXIDE; DIETHYL PYROCARBONATE; HISTIDINE; NITROPRUSSIDE SODIUM;

ARTICLE; CELL PH; CHEMORECEPTOR; CHEMOSENSITIVITY; CONTROLLED STUDY; EXTRACELLULAR SPACE; HELIX ASPERSA; HYPOXIA; NONHUMAN; PRIORITY JOURNAL;

AMMONIUM CHLORIDE; ANIMALS; ANOXIA; CARBON DIOXIDE; CHEMORECEPTORS; DIETHYL PYROCARBONATE; HELIX (SNAILS); HISTIDINE; HYDROGEN-ION CONCENTRATION; HYDROXYLAMINE; HYPERCAPNIA; NITROPRUSSIDE; RESPIRATION;

EID: 0031963437     PISSN: 00345687     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5687(97)00111-4     Document Type: Article

References (30)

1. Balestrino M., Somjen G.G. Concentration of carbon dioxide, interstitial pH and synaptic transmission in hippocampal formation of the rat. J. Physiol. (London). 396:1988;247-266.
2. Barnhart M.C. Control of acid-base status in active and dormant land snails, Otala lactea (Pulmonata Helicidae). J. Comp. Physiol. B. 156:1986;347-354.
3. Barnhart M.C. Respiratory gas tensions and gas exchange in active and dormant land snails Otala lactea. Physiol. Zool. 59:1986;733-745.
4. - on intracellular pH in isolated type-I cells of the neonatal rat carotid body J. Physiol. (London). 444:1991;703-721.
5. Burton R.F. The role of imidazole ionization in the control of breathing. Comp. Biochem. Physiol. 83A:1986;333-336.
6. Dahr E. Studien über die respiration der Landpulmonaten. Acta Univ. Lundensis. 20:1924;1-19.
7. Ehrenberg L., Fedorcsak I., Solymosy F. Diethyl pyrocarbonate in nucleic acid research. Prog. Nucleic Acid Res. Mol. Biol. 16:1976;189-262.
8. 2 chemoreception in the pulmonate snail, Helix aspersa. Respir. Physiol. 93:1993;347-363.
9. 2 chemoreception in the pulmonate snail, Helix aspersa. Respir. Physiol. 98:1994;27-41.
10. Erlichman J.S., Leiter J.C. Central chemoreceptor stimulus in the terrestrial, pulmonate snail, Helix aspersa. Respir. Physiol. 95:1994;209-226.
11. 2 chemoreception. Respir. Physiol., (in press).
12. 2 chemoreceptors in Helix pomatia. Am. Zool. 37:1997;54-64.
13. + antiporter in Eshericia coli. Proc. Natl. Acad. Sci. 90:1993;1212-1216.
14. Hitzig B.M. Temperature-induced changes in turtle CSF pH and central control of ventilation. Respir. Physiol. 49:1982;205-222.
15. 1H-NMR measurement of fractional dissociation of imidazole in intact animals. Am. J. Physiol. 266:1994;R1008-R1015.
16. Janse C., van der Wilt J., van der Plas J., van der Roest M. Central and peripheral neurones involved in oxygen perception in the pulmonate snail Lymnaea stagnalis (Mollusca Gastropoda). Comp. Biochem. Physiol. 82A:1985;459-469.
17. Kiley J.P., Eldridge F.L., Millhorn D.E. The effect of hypothermia on central neural control of respiration. Respir. Physiol. 58:1984;295-312.
18. Miles, E.W., 1977. Modification of hystidyl residues in proteins by diethylpyrocarbonate. In: Hirs, C.H.W., Timashell, S.N. (Eds.), Methods in Enzymology, vol. 47. Academic Press, New York, pp. 431-442.
19. 2 sensitivity. J. Appl. Physiol. 61:1986;843-850.
20. - and ventilation in hypercapnia. J. Appl. Physiol. 65:1988;242-248.
21. Rahn H., Reeves R.B., Howell B.J. Hydrogen ion regulation, temperature, and evolution. Am. Rev. Respir. Dis. 112:1975;165-172.
22. Reeves R.B. An imidazole alphastat hypothesis for vertebrate acid-base regulation: Tissue carbon dioxide content and body temperature in bullfrogs. Respir. Physiol. 14:1972;219-236.
23. Reeves R.B. The interaction of body temperature and acid-base balance in ectothermic vertebrates. Ann. Rev. Physiol. 39:1977;559-586.
24. + antiporter of Esherichia coli. J. Biol. Chem. 270:1995;26813-26817.
25. Ritucci N.A., Dean J.B., Putnam R.W. Intracellular pH responses to hypercapnia in neurons from chemosensitive areas of the medulla. Am. J. Physiol. 273:1997;R433-R441.
26. Sekler I., Kobayashi S., Kopito R.R. A cluster of cytoplasmic histidine residues specifies pH dependence of the AE2 plasma membrane anion exchanger. Cell. 86:1996;929-935.
27. Thomas R.C. Intracellular pH of snail neurones measured with a new pH-sensitive glass micro-electrode. J. Physiol. (London). 238:1974;159-180.
28. Thomas R.C. The effect of carbon dioxide on the intracellular pH and buffering power of snail neurones. J. Physiol. (London). 255:1976;715-735.
29. Thomas R.C. The role of bicarbonate, chloride and sodium ions in the regulation of intracellular pH in snail neurones. J. Physiol. (London). 273:1977;317-338.
30. Thomas R.C. Experimental displacement of intracellular pH and the mechanism of its subsequent recovery. J. Physiol. (London). 354:1984;3P-22P.