An intracellular proton sensor commands lipid- and mechano-gating of the K+ channel TREK-1

EMBO Journal

Volumn 21, Issue 12, 2002, Pages 2968-2976

  Honoré, Eric ^a   Maingret, François ^a   Lazdunski, Michel ^a   Patel, Amanda Jane ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

2P domain K+ channels; Acidosis; Arachidonic acid; KCNK2; Phosphorylation

Indexed keywords

ARACHIDONIC ACID; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; POTASSIUM CHANNEL; PROTEIN; PROTEIN TREK 1; UNCLASSIFIED DRUG;

ACIDOSIS; AMINO ACID SUBSTITUTION; ANIMAL CELL; APLYSIA; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CONTROLLED STUDY; CYTOSKELETON; DOWN REGULATION; ELECTROPHYSIOLOGY; HYPERPOLARIZATION; INTERNEURON; ION CURRENT; MEMBRANE CURRENT; MEMBRANE STRUCTURE; MOLECULAR MODEL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; PROTON TRANSPORT;

ANIMALS; COS CELLS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GLUTAMIC ACID; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; POTASSIUM CHANNELS; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

ANIMALIA; APLYSIA;

EID: 0037124318     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf288     Document Type: Article

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