Polymodal regulation of hTREK1 by pH, arachidonic acid, and hypoxia: Physiological impact in acidosis and alkalosis

American Journal of Physiology - Cell Physiology

Volumn 286, Issue 2 55-2, 2004, Pages

  Miller, Paula ^a   Peers, Chris ^a   Kemp, Paul J ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Potassium channel; Tandem P domain

Indexed keywords

ARACHIDONIC ACID; FATTY ACID; OXYGEN; POTASSIUM CHANNEL;

ACIDIFICATION; ACIDOSIS; ALKALINIZATION; ALKALOSIS; ARTICLE; BRAIN ISCHEMIA; CELL MEMBRANE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; HYPOXIA; PARAMETER; PATCH CLAMP; PH; PRIORITY JOURNAL; PROTEIN DOMAIN; REGULATORY MECHANISM; TANDEM P DOMAIN POTASSIUM CHANNEL;

EID: 0742270740     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00334.2003     Document Type: Article

References (24)

1. Bonnet U, Bingmann D, and Wiemann M. Intracellular pH modulates spontaneous and epileptiform bioelectric activity of hippocampal CA3-neurones. Eur Neuropsychopharmacol 10: 97-103, 2000.
2. + channels TREK-1 and TRAAK. Mol Pharmacol 57: 906-912, 2000.
3. Eisner DA, Kenning NA, O'Neill SC, Pocock G, Richards CD, and Valdeolmillos M. A novel method for absolute calibration of intracellular pH indicators. Pflügers Arch 413: 553-558, 1989.
4. + channel. EMBO J 15: 6854-6862, 1996.
5. Hervieu GJ, Cluderay JE, Gray CW, Green PJ, Ranson JL, Randall AD, and Meadows HJ. Distribution and expression of TREK-1, a two-pore-domain potassium channel, in the adult rat CNS. Neuroscience 103: 899-919, 2001.
6. Hoffman WE, Charbel FT, Gonzalez-Portillo G, and Ausman JI. Measurement of ischemia by changes in tissue oxygen, carbon dioxide, and pH. Surg Neurol 51: 654-658, 1999.
7. + channel TREK-1. EMBO J 21: 2968-2976, 2002.
8. Kemp PJ, Searle GJ, Hartness ME, Lewis A, Miller P, Williams SE, Wootten P, Adriaensen D, and Peers C. Acute oxygen sensing in cellular models: relevance to the physiology of pulmonary neuroepithelial bodies. Anat Rec 270A: 41-50, 2003.
9. Lau KR, Elliott PD, and Brown PD. Acetylcholine-induced intracellular acidosis in rabbit salivary gland acinar cells. Am J Physiol Cell Physiol 256: C288-C295, 1989.
10. Lauritzen I, Blondeau N, Heurteaux C, Widmann C, Romey G, and Lazdunski M. Polyunsaturated fatty acids are potent neuroprotectors. EMBO J 19: 1784-1793, 2000.
11. Lopez-Barneo J, Pardal R, and Ortega-Saenz P. Cellular mechanism of oxygen sensing. Annu Rev Physiol 63: 259-287, 2001.
12. + channel. EMBO J 19: 2483-2491, 2000.
13. Maingret F, Patel AJ, Lesage F, Lazdunski M, and Honore E. Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel. J Biol Chem 274: 26691-26696, 1999.
14. + channels TREK-1 and TRAAK. J Biol Chem 275: 10128-10133, 2000.
15. Meadows HJ, Benham CD, Cairns W, Gloger I, Jennings C, Medhurst AD, Murdock P, and Chapman CG. Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel. Pflügers Arch 439: 714-722, 2000.
16. + channels TREK-1 and TRAAK. Brain Res 892: 94-101, 2001.
17. Medhurst AD, Rennie G, Chapman CG, Meadows H, Duckworth MD, Kelsell RE, Gloger II, and Pangalos MN. Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery. Brain Res Mol Brain Res 86: 101-114, 2001.
18. + channels in central neuroprotection. J Physiol 548: 31-37, 2003.
19. Mojet MH, Mills E, and Duchen MR. Hypoxia-induced catecholamine secretion in isolated newborn rat adrenal chromaffin cells is mimicked by inhibition of mitochondrial respiration. J Physiol 504: 175-189, 1997.
20. 2 sensing by airway chemoreceptor-derived cells: protein kinase C activation reveals functional evidence for involvement of NADPH oxidase. J Biol Chem 275: 7684-7692, 2000.
21. Patel AJ and Honore E. Molecular physiology of oxygen-sensitive channels. Eur Respir J 18: 221-227, 2001.
22. + channels. Nat Neurosci 2: 422-426, 1999.
23. Patel AJ, Lauritzen I, Lazdunski M, and Honore E. Disruption of mitochondrial respiration inhibits volume-regulated anion channels and provokes neuronal cell swelling. J Neurosci 18: 3117-3123, 1998.
24. White BC, Sullivan JM, DeGracia DJ, O'Neil BJ, Neumar RW, Grossman LI, Rafols JA, and Krause GS. Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J Neurol Sci 179: 1-33, 2000.