Neuronal sensitivity to hyperoxia, hypercapnia, and inert gases at hyperbaric pressures

Journal of Applied Physiology

Volumn 95, Issue 3, 2003, Pages 883-909

  Dean, Jay B ^a,b   Mulkey, Daniel K ^a   Garcia III, Alfredo J ^a   Putnam, Robert W ^a   Henderson III, Richard A ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

^b WRIGHT STATE UNIVERSITY   (United States)

Author keywords

Anesthesia; Carbon dioxide toxicity; Free radicals; High pressure nervous syndrome; Membrane potential; Nitrogen narcosis; Oxidative stress; Oxygen toxicity; Polarographic oxygen electrode

Indexed keywords

CARBON DIOXIDE; INERT GAS; NITROGEN; OXYGEN;

ANIMAL TISSUE; ATMOSPHERIC PRESSURE; BRAIN SLICE; CARBON DIOXIDE TENSION; CARBON DIOXIDE TOXICITY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HIGH PRESSURE NEUROLOGICAL SYNDROME; HYDROSTATIC PRESSURE; HYPERBARISM; HYPERCAPNIA; HYPEROXIA; INTRACELLULAR RECORDING; MAMMAL; NERVE FUNCTION; NEURONAL SENSITIVITY; NITROGEN NARCOSIS; NITROGEN PARTIAL PRESSURE; NONHUMAN; OXIDATIVE STRESS; OXYGEN TENSION; OXYGEN TISSUE LEVEL; OXYGEN TOXICITY; PHYSICAL SENSITIVITY; PRESSURE CHAMBER; PRIORITY JOURNAL; RAT; REVIEW; SYNDROME DELINEATION;

EID: 0042536452     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00920.2002     Document Type: Review

References (229)

1. Abraini JH, Gardette-Chauffour MC, Martinez E, Rostain JC, and Lamaire C. Psychophysiological reactions in humans during an open sea dive to 500 m with a hydrogen-helium-oxygen mixture. J Appl Physiol 76: 1113-1118, 1994.
2. Agar A, Yip SS, Hill MA, and Coroneo MT. Pressure related apoptosis in neuronal cell lines. J Neurosci Res 60: 495-503, 2000.
3. Aitken PG, Breese GR, Dudek FF, Edwards F, Espanol MT, Larkman PM, Lipton P, Newman GC, Nowak TS, Panizzon KL, Raley-Susman KM, Reid KH, Rice ME, Sarvey JM, Schoepp DD, Segal M, Taylor CP, Teyler TJ, and Voulalas PJ. Preparative methods for brain slices: a discussion. J Neuresci Methods 59: 139-149, 1995.
4. Allen R. Intracranial pressure: a review of clinical problems, measurement techniques and monitoring methods. J Med Eng Technol 10: 299-320, 1986.
5. Arieli R. Latency of oxygen toxicity of the central nervous system in rats as a function of carbon dioxide production and partial pressure of oxygen. Eur J Appl Physiol 78: 454-459, 1998.
6. Auker CR, Ahlers ST, Obowa T, and Koller W. Localization of c-fos induction associated with earliest electrographic hyperbaric oxygen (HBO) seizures (Abstract). Undersea Hyperb Med 23, Suppl: 44, 1996.
7. Balentine JD. Pathogenesis of central nervous system lesions induced by exposure to hyperbaric oxygen. Am J Pathol 53: 1097-1109, 1968.
8. Balentine JD. Dendritic degeneration following hyperbaric oxygen exposure. Adv Neurol 12: 471-481, 1975.
9. Balentine JD. Pathology of Oxygen Toxicity. New York: Academic, 1982.
10. Balentine JD and Gutsche BB. Central nervous system lesions in rats exposed to oxygen at high pressure. Am J Pathol 48: 107-127, 1966.
11. Barthelemy L, Belaud A, and Saliou A. A study of the specific action of "per se" hydrostatic pressure on fish considered as a physiological model. In: Underwater Physiology. VII. Proceedings of the Sixth Symposium on Underwater Physiology, edited by Bachrach AJ and Matzen MM. Bethesda, MD: Undersea Medical Society, 1981, p. 641-649.
12. Bean JW. Effects of oxygen at increased pressure. Physiol Rev 25: 1-147, 1945.
13. 2. Am J Physiol 201: 1192-1198, 1961.
14. 2 at high pressure. J Appl Physiol 31: 235-242, 1971.
15. 2 at high pressure. J Appl Physiol 21: 521-526, 1966.
16. Bennett PB. The effects of high pressures of inert gases on auditory evoked potential in cat cortex and reticular formation. Electroencephalogr Clin Neurophysiol 17: 388-397, 1964.
17. 2 at high pressures of argon, nitrogen, helium, and oxygen. J Appl Physiol 20: 1249-1252, 1965.
18. Bennett PB. Inert gas narcosis and high pressure nervous syndrome. In: Bove and Davis' Diving Medicine (3rd ed.), edited by Bove AA. Philadelphia, PA: Saunders, 1997, p. 117-130.
19. Bennett PB, Papahadjopoulos D, and Bangham AD. The effect of raised pressure of inert gases on phospholipid membranes. Life Sci 6: 2527-2533, 1967.
20. Berger AJ. Recent advances in respiratory and neurobiology using in vitro methods. Am J Physiol Lung Cell Mol Physiol 259: L24-L29, 1990.
21. Besch SR and Hogan PM. A small chamber for making optical measurements on single living cells at elevated hydrostatic pressure. Undersea Hyperb Med 23: 175-184, 1996.
22. Bickford PC, Chadman K, Williams B, Shukitt-Hale B, Holmes D, Taglialatela G, and Joseph J. Effect of normobaric hyperoxia on two indexes of synaptic function in fisher 344 rats. Free Radic Biol Med 26: 817-824, 1999.
23. 2 (Abstract). Pflügers Arch 382: R38, 1979.
24. 2 values in the superfusate on the neural activity in hippocampal slices. In: Physiology and Pharmacology of Epileptogenic Phenomenon, edited by Klee MR, Lux HD, and Speckmann EJ. New York: Raven, 1982, p. 97-104.
25. Bitterman N and Bitterman H. L-Arginine-NO pathway and CNS oxygen toxicity. J Appl Physiol 84: 1633-1638, 1998.
26. Bitterman N and Grossman Y. Increased axonal excitability during exposure to hyperbaric oxygen. Can J Physiol Pharmacol 65: 2044-2047, 1987.
27. Brauer RW, Dutcher JA, and Vorus WS. Effects of prolonged simultaneous exposure of CD-1 mice to high pressures and inert gas narcosis. J Appl Physiol 61: 2129-2135, 1986.
28. Brauer RW, Hogan PM, Hugon M, Macdonald AG, and Miller KW. Patterns of interaction of effects of light metabolically inert gases with those of hydrostatic pressure as such - a review. Undersea Biomed Res 9: 353-396, 1982.
29. Brauer RW and Way RO. Relative narcotic potencies of hydrogen, helium, nitrogen, and their mixtures. J Appl Physiol 29: 23-31, 1970.
30. Brewer GJ and Cotman CW. Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen. Brain Res 494: 65-74, 1989.
31. Brockhaus J, Ballanyi K, Smith JC, and Richter DW. Microenvironment of respiratory neurons in the in vitro brainstem-spinal cord of neonatal rats. J Physiol 462: 421-445, 1993.
32. Brown DC. Operational medicine. Submarine escape and rescue in today's Royal Navy. J R Nav Med Serv 85: 145-149, 1999.
33. Brown JA, Preul MC, and Taha A. Hyperbaric oxygen in the treatment of elevated intracranial pressure after head injury. Pediatr Neurosci 14: 286-290, 1988.
34. Bryant HJ and Blankenship JE. Action potentials in single axons: effects of hyperbaric air and hydrostatic pressure. J Appl Physiol 47: 561-567, 1979.
35. Bryant HJ and Blankenship JE. Modification of synaptic facilitation and bursting patterns in Aplysia californica by hyperbaric air. J Appl Physiol 47: 568-576, 1979.
36. Butler FK and Smith DJ. United States Navy diving techniques and equipment. In: Bove and Davis' Diving Medicine (3rd ed.), edited by Bove AA. Philadelphia, PA: Saunders, 1997, p. 372-387.
37. Butler FK and Thalmann ED. Central nervous system oxygen toxicity in closed circuit scuba divers II. Undersea Biomed Res 13: 193-223, 1986.
38. Camporesi MD. Hyperbaric Oxygen Therapy: A Committee Report. Kensington, MD: Undersea and Hyperbaric Medical Society, 1996.
39. Cater DB, Garattini S, Marina F, and Silver IA. Changes in oxygen tension in brain and somatic tissues induced by vasodilator and vasoconstrictor drugs. Proc R Soc Lond B Biol Sci 155: 136-157, 1961.
40. Chavko M, Braisted JC, and Harabin AL. Effect of MK-801 on seizures induced by exposure to hyperbaric oxygen: comparison with AP-7. Toxicol Appl Pharmacol 151: 222-228, 1998.
41. Chin JH, Trudell JR, and Cohen EN. The compression ordering and solubility - disordering effects of high pressure gases on phospholipid bilayers. Life Sci 18: 489-498, 1976.
42. Clark JM. Effects of acute and chronic hypercapnia on oxygen tolerance in rats. J Appl Physiol 50: 1036-1044, 1981.
43. Clark JM and Thom SR. Toxicity of oxygen, carbon dioxide, and carbon monoxide. In: Bove and Davis' Diving Medicine (3rd ed.), edited by Bove AA. Philadelphia, PA: Saunders, 1997, p. 131-145.
44. Clemens S, Massabuau JC, Meyrand P, and Simmers J. A modulatory role for oxygen in shaping rhythmic motor output patterns of neuronal networks. Respir Physiol 128: 299-315, 2001.
45. Coenen AML, Drinkenburg WHIM, Hoenderken R, and van Luijtelaar ELJM. Carbon dioxide euthanasia in rats: oxygen supplementation minimizes signs of agitation and asphyxia. Lab Anim 29: 262-268, 1995.
46. Colton JS and Colton CA. Effect of oxygen at high pressure on spontaneous transmitter release. Am J Physiol Cell Physiol 235: C233-C237, 1978.
47. Colton CA and Colton JS. An electrophysiological analysis of oxygen and pressure on synaptic transmission. Brain Res 251: 221-227, 1982.
48. Colton CA and Colton JS. The action of oxygen and at high pressure on inhibitory transmission. Brain Res 364: 151-158, 1986.
49. Colton JS and Freeman AR. Intracellular measurements in a closed hyperbaric chamber. J Appl Physiol 35: 578-580, 1973.
50. Conti F, Heinemann SH, and Stuhmer W. Activation and reaction volumes of ion channels in excitable membranes. London: Academic, 1987.
51. Cragg PA, Drysdale DB, and Hamilton JH. Ventilation in intact and glossopharyngeal nerve sectioned anaesthetized rats exposed to oxygen at high pressure. J Physiol 370: 489-499, 1986.
52. Cross BA and Silver IA. Some factors affecting oxygen tension in the brain and other organs. Proc R Soc Lond B Biol Sci 156: 483-499, 1962.
53. Danneman PJ, Stein S, and Walshaw SO. Humane and practical implications of using carbon dioxide mixed with oxygen for anesthesia or euthanasia of rats. Lab Anim Sci 47: 376-385, 1997.
54. Dean JB, Bayliss DA, Erickson JT, Lawing WL, and Millhorn DE. Depolarization and stimulation of neurons in nucleus tractus solitarii by carbon dioxide does not require chemical synaptic input. Neuroscience 36: 207-216, 1990.
55. Dean JB, Huang RQ, Erlichman JS, Southard TL, and Hellard DT. Cell-cell coupling occurs in dorsal medullary neurons after minimizing anatomical-coupling artifacts. Neuroscience 80: 21-40, 1997.
56. +-excited neurons in brainstem slices. Respir Physiol 129: 83-100, 2001.
57. Dean JB, Kinkade EA, and Putnam RW. Intracellular pH and cell-cell coupling in locus coeruleus neurons during mild and severe hypercapnic acidosis (Abstract). FASEB J 16: A812, 2002.
58. Dean JB and Mulkey DK. Continuous intracellular recording from mammalian neurons exposed to hyperbaric helium, oxygen, or air. J Appl Physiol 89: 807-822, 2000.
59. Dean JB, Mulkey DK, and Arehart JT. Details on building a hyperbaric chamber for intracellular recording in brain tissue slices. J Appl Physiol 89: 807-822, 2000 (http://jap.physiology.org/cgi/content/full/89/2/807/DC1).
60. Demchenko IT, Atochin DN, Boso AE, Astern J, Huang PL, and Piantadosi CA. Oxygen seizure latency and peroxynitrite formation in mice lacking neuronal or endothelial nitric oxide synthases. Neurosci Lett 344: 53-56, 2003.
61. Demchenko IT, Boso AE, Bennett PB, Whorton AR, and Piantadosi CA. Hyperbaric oxygen reduces cerebral blood flow by inactivating nitric oxide. Nitric Oxide 4: 597-608, 2000.
62. Demchenko IT, Boso AE, O'Neil TJ, Bennett PB, and Piantadosi CA. Nitric oxide and cerebral blood flow responses to hyperbaric oxygen. J Appl Physiol 88: 1381-1389, 2000.
63. Demchenko IT, Boso AE, Whorton AR, and Piantadosi CA. Nitric oxide production is enhanced in rat brain before oxygen-induced convulsions. Brain Res 917: 253-261, 2001.
64. Dietrich WD, Alonso OF, Busto R, and Ginsberg MD. Widespread metabolic depression and reduced somatosensory circuit activation following traumatic brain injury in rats. J Neurotrauma 11: 629-640, 1994.
65. Dillon GH and Waldrop TG. In vitro responses of caudal hypothalamic neurons to hypoxia and hypercapnia. Neuroscience 51: 941-950, 1992.
66. Dodson BA, Furmaniuk ZW Jr, and Miller KW. The physiological effects of hydrostatic pressure are not equivalent to those of helium pressure on Rana pipiens. J Physiol 362: 233-244, 1985.
67. Droge W. Free radicals in the physiological control of cell function. Physiol Rev 82: 47-95, 2001.
68. Dromsky DM, Toner CB, Survanshi S, Fahlman A, Parker E, and Weathersby P. Natural history of severe decompression sickness after rapid ascent from air staturation in a porcine model. J Appl Physiol 89: 791-798, 2000.
69. Edwards FA, Konnerth A, Sakmann B, and Takahashi T. A thin slice preparation for patch clamp recordings from neurones of the mammalian central nervous system. Pflügers Arch 414: 600-612, 1989.
70. Elayan IM, Axley MJ, Prasad PV, Ahlers ST, and Auker CR. Effect of hyperbaric oxygen treatment on nitric oxide and oxygen free radicals in rat brain. J Neurophysiol 83: 2022-2029, 2000.
71. Erecinska M and Silver IA. Tissue oxygen tension and brain sensitivity to hypoxia. Respir Physiol 128: 263-276, 2001.
72. Etzion Y and Grossman Y. Potassium currents modulation of calcium spike firing in dendrites of cerebellar Purkinje cells. Exp Brain Res 122: 283-294, 1998.
73. 2+ spike firing of cerebellar Purkinje neurons at high pressure. Pflügers Arch 437: 276-284, 1999.
74. 2+ channels. Eur J Neurosci 12: 1-11, 2000.
75. Fagni L, Hugon M, Folco A, and Imbert G. A versatile chamber for microphysiologic studies with gas mixtures under high pressure. Undersea Biomed Res 14: 161-168, 1987.
76. Fagni L, Zinebi F, and Hugon M. Helium pressure potentiates the N-methyl-D-aspartate- and D,L-homocysteate-induced decreases of field potentials in the rat hippocampal slice preparation. Neurosci Lett 81: 285-290, 1987.
77. Fessel J, Arneson Weitlauf C, Winder D, and Roberts LJ. Standard brain slice protocols result in neuronal oxidative injury in hippocampal slices (Abstract). Free Radic Biol Med 33: S433, 2002.
78. Filosa J, Dean JB, and Putnam RW. Role of intracellular and extracellular pH in the chemosensitive response of rat locus coeruleus neurones. J Physiol 541.2: 493-509, 2002.
79. Florio JT, Morrison JB, and Butt WS. Breathing pattern and ventilatory response to carbon dioxide in divers. J Appl Physiol 46: 1076-1080, 1979.
80. Franks NP and Lieb WR. Molecular mechanisms of general anesthesia. Nature 300: 487-493, 1982.
81. 2 values and electrical activities. Pflügers Arch 393: 83-87, 1982.
82. Garcia AJ III, Henderson RA III, and Dean JB. Acute exposure to hyperbaric oxygen stimulates firing rate of CA1 neurons of the hippocampus (Abstract). FASEB J 16: A1168, 2002.
83. Garcia AJ III, Henderson RA III, Putnam RW, and Dean JB. Oxidative stress induced by hyperbaric oxygen increases the synaptic response of CA1 neurons in the rat hippocampus (Abstract). FASEB J 17: A71, 2003.
84. Garcia AJ III, Rittuci NA, Putnam RW, Henderson RA III, and Dean JB. Effects of hyperbaric oxygen on intracellular pH of neurons in rat brain slices (Abstract). Free Radic Biol Med 33: S435, 2002.
85. o, and high pressure interactions at crustacean excitatory synapses. Synapse 18: 328-336, 1994.
86. Gonzalez C, Dinger BF, and Fidone SJ. Mechanisms of carotid body chemoreception. In: Regulation of Breathing, edited by Dempsey JA and Pack AI. New York: Dekker, 1995, p. 391-471.
87. Gottlieb SF, Koehler GJ, and Rhodes LVG. An oxygen- and pressure-sensitive enzyme: Na-K-adenosinetriphosphatase. In: Underwater Physiology. V. Proceedings of the Fifth Symposium on Underwater Physiology, edited by Lambersen CJ. Bethesda, MD: FASEB, 1976, p. 431-442.
88. Gozal D. Potentiation of hypoxic ventilatory response by hyperoxia in the concious rat: putative role of nitric oxide. J Appl Physiol 85: 129-132, 1998.
89. Halsey MJ. Effects of high pressure on the central nervous system. Physiol Rev 62: 1341-1377, 1982.
90. Heal RD, Rogers AT, Lunt GG, Pointer SA, and Parson AT. Development of a neuronal pressure sensor. Biosens Bioelectron 16: 905-909, 2001.
91. Heinemann SH, Stuhmer W, and Conti F. Single acetylcholine receptor channel currents recorded at high hydrostatic pressures. Proc Natl Acad Sci USA 84: 3229-3233, 1987.
92. Henderson JV and Gilbert DL. Slowing of ionic currents in the voltage-clamped squid axon by helium pressure. Nature 258: 351-352, 1975.
93. Henderson JV Jr, Morin RA, and Lanphier EH. Apparatus for intracellular electrophysiological measurements at 200 ATA. J Appl Physiol 38: 353-355, 1975.
94. Heremans K. High pressure effects on proteins and other biomolecules. Annu Rev Biophys Bioeng 11: 1-21, 1982.
95. Hesser CM, Fagraeus L, and Adolfson J. Roles of nitrogen, oxygen, and carbon dioxide in compressed-air narcosis. Undersea Biomed Res 5: 391-400, 1978.
96. Hogan PM, Ornhagen HC, Doubt TJ, Laraway BS, Morin RA, and Zaharkin J. Hyperbaric chamber for evaluating hydrostatic pressure effects on tissues and cells. Undersea Biomed Res 8: 51-58, 1981.
97. Hornbein TF, Townes BD, Schoene RB, Sutton JR, and Houston CS. The cost to the central nervous system of climbing to extremely high altitude. N Engl J Med 321: 1714-1719, 1989.
98. 2-excited neurons in the dorsal medulla oblongata. Neuroscience 80: 41-57, 1997.
99. Hunt R, Blackburn J, Ogilvie R, and Balentine D. Oxygen tension in the globus pallidus and neostriatum of unanesthetized rats during exposure to hyperbaric oxygen. Exp Neurol 62: 698-707, 1978.
100. Hunter WL and Bennett PB. The causes, mechanisms and prevention of the high pressure nervous syndrome. Undersea Biomed Res 1: 1-28, 1974.
101. Iadecola C, Pelligrino DA, Moskowitz MA, and Lassen N. Nitric oxide synthase inhibition and cerebrovascular regulation. J Cereb Blood Flow Metab 14: 175-192, 1994.
102. 2 and mixtures. Undersea Biomed Res 19: 49-53, 1992.
103. Jaenicke R. Biochemical processes under high hydrostatic pressure. Physico-chemical approaches to barosensitivity. Naturwissenschaften 70: 332-341, 1983.
104. Jain KK. High pressure neurological syndrome (HPNS). Acta Neurol Scand 90: 45-50, 1994.
105. Jain KK. Oxygen toxicity. In: Textbook of Hyperbaric Medicine (2nd ed.), edited by Jain KK. Seattle, WA: Hogrefe and Huber, 1996, p. 63-78.
106. Jain KK and Fischer B. Oxygen toxicity and free radicals in medicine. In: Oxygen in Physiology and Medicine. Springfield, IL: Thomas, 1989, chapt. 6, p. 143-170.
107. Jamieson D, Chance B, Cadenas E, and Boveris A. The relation of free radical production to hyperoxia. Annu Rev Physiol 48: 703-719, 1986.
108. Jamieson D and Van den Brenk A. Measurement of oxygen tensions in cerebral tissues of rats exposed to high pressures of oxygen. J Appl Physiol 18: 869-876, 1962.
109. Jennings T. Space adaptation syndrome is caused by elevated intracranial pressure. Med Hypotheses 32: 289-291, 1990.
110. 2 tension in adult and neonatal brain slices under several experimental conditions. Brain Res 568: 159-164, 1991.
111. Jiang J and Tyssebotn I. Measurement of cerebrospinal fluid pressure in conscious rats. Undersea Hyperb Med 24: 39-43, 1997.
112. Kaplan FS, Brighton CT, Boytim MJ, Selzer ME, Lee V, Spindler K, Silberberg D, and Black J. Enhanced survival of rat neonatal cerebral cortical neurons at subatmospheric oxygen tensions in vitro. Brain Res 384: 199-203, 1986.
113. Kendig JJ. Nitrogen narcosis and pressure reversal of anesthetic effects in node of Ranvier. Am J Physiol Cell Physiol 246: C91-C95, 1984.
114. Kendig JJ, Grossman Y, and Heinemann SH. Ion channels and nerve cell function. In: Advances in Comparative and Environmental Physiology, Effect of High Pressure on Biological Systems, edited by Macdonald AG. Berlin: Springer-Verlag, 1993, p. 87-124.
115. Kendig JJ, Trudell JR, and Cohen EN. Effects of pressure and anesthetics on conduction and synaptic transmission. J Pharmacol Exp Ther 195: 216-224, 1975.
116. 2 at 1 ATA. Undersea Biomed Res 7: 17-26, 1980.
117. Kindwall EP. Compressed air tunneling and caisson work decompression procedures: development, problems, and solutions. Undersea Hyperb Med 24: 337-345, 1997.
118. King GL and Parmentier JL. Oxygen toxicity of hippocampal tissue in vitro. Brain Res 260: 139-142, 1983.
119. Kovachich G and Mishra O. Lipid peroxidation in rat brain cortical slices as measured by the thiobarbituric acid test. J Neurochem 35: 1449-1452, 1980.
120. Kozloski LD. Space shuttle suits. In: U.S. Space Gear. Outfitting the Astronaut (1st ed.). Washington, DC: Smithsonian Institution Press, 1994, chapt.7, p. 123-144.
121. Lahiri S, Mulligan E, Andronikou S, Shirahata M, and Mokashi A. Carotid body chemosensory function in prolonged normobaric hyperoxia in the cat. J Appl Physiol 62: 1924-1931, 1987.
122. 2 at 3.5 atmospheres ambient pressure. J Appl Physiol 8: 255-263, 1955.
123. Leske MC, Connell AMS, Wu S-Y, Hyman L, and Schachat AP. Distribution of intraocular pressure. Arch Ophthalmol 115: 1051-1057, 1997.
124. Li M, Hong SK, Paganelli CV, and Hogan PM. Assay of inert gas contamination in studies of hydrostatic pressure effects. Undersea Hyperb Med 20: 163-169, 1993.
125. Lipton SA. Nitric oxide and respiration. Nature 413: 118-121, 2001.
126. Lipton AJ, Johnson MA, Macdonald T, Lieberman MW, Gozal D, and Gaston B. S-nitrosothiols signal the ventilatory response to hypoxia. Nature 413: 171-174, 2001.
127. MacDonald AG. The effects of pressure on the molecular structure and physiological functions of cell membranes. Philos Trans R Soc Lond B Biol Sci 304: 47-68, 1984.
128. MacDonald AG. The role of membrane fluidity in complex processes under high pressure. In: Current Perspectives in High Pressure Biology, edited by Jannasch HW, Marquis RE, and Zimmerman AM. Orlando, FL: Academic, 1987, p. 207-223.
129. Macdonald AG. Hydrostatic pressure as an environmental factor in life processes. Comp Biochem Physiol 116A: 291-297, 1997.
130. Macdonald AG. Ion channels under high pressure. Comp Biochem Physiol A Mol Integr Physiol 131: 587-593, 2002.
131. Macdonald AG and Fraser PJ. The transduction of very small hydrostatic pressures. Comp Biochem Physiol A Mol Integr Physiol 122: 13-36, 1999.
132. MacDonald AG, Ramsey RL, Drewry J, and Usherwood PNR. Effects of high pressure on the channel gated by the quisqualate-sensitive glutamate receptor of locust muscle and its blockade by ketamine; a single-channel analysis. Biochim Biophys Acta 1151: 13-20, 1993.
133. MacDonald AG and Vjotosh AN. Patch clamp recording of BKCa channels in hyperbaric oxygen (Abstract). J Physiol 518: 111P, 1999.
134. 2 effects in producing convulsions and death in mice. J Appl Physiol 16: 1-7, 1961.
135. Massabuau JC. From low arterial- to low tissue-oxygenation strategy. An evolutionary theory. Respir Physiol 128: 249-261, 2001.
136. Mastrangelo CJ, Kendig JJ, Trudell JR, and Cohen EN. Nerve membrane lipid fluidity: opposing effects of high pressure and ethanol. Undersea Biomed Res 6: 47-53, 1979.
137. Max B. This and that: the neurotoxicity of carbon dioxide. Trends Pharmacol Sci 12: 408-411, 1991.
138. McCarter GC, Reichling DB, and Levine JD. Mechanical transduction by rat dorsal root ganglion neurons in vitro. Neurosci Lett 273: 179-182, 1999.
139. Miller JD. Volume and pressure in the craniospinal axis. Clin Neurosurg 22: 76-105, 1975.
140. Miller JD, Becker DP, Ward JD, Sullivan HG, Adams WE, and Rosner MJ. Significance of intracranial hypertension in severe head injury. J Neurosurg 47: 503-516, 1977.
141. Miller KW. The opposing physiological effects of high pressures and inert gases. Fed Proc 36: 1663-1667, 1977.
142. Miller MJ and Tenney SM. Hyperoxic hyperventilation in carotid-deafferented cats. Respir Physiol 23: 23-30, 1975.
143. Mitaka KT, Mizuguchi T, and Moxhizuki Y. Effects of oxygen scavengers on connexins 32 and 26 expression in primary cultures of adult rat hepatocytes. Carcinogenesis 17: 537-544, 1996.
144. Mokashi A and Lahiri S. Aortic and carotid body chemoreception in prolonged hyperoxia in the cat. Respir Physiol 86: 233-243, 1991.
145. Morrison JB and Florio JT. Respiratory function during a simulated dive to 1,500 ft. J Appl Physiol 30: 724-732, 1971.
146. Morrison JB, Florio JT, and Butt WS. Observations after loss of consciousness under water. Undersea Biomed Res 5: 179-187, 1978.
147. 2 insensitivity and respiratory pattern on respiration in divers. Undersea Biomed Res 8: 209-217, 1981.
148. Mulkey DK and Dean JB. Effects of hyperbaric and hypobaric pressures on membrane potential of solitary complex neurons in rat brainstem slices (Abstract). Undersea Hyperb Med 25: 20, 1998.
149. Mulkey DK and Dean JB. Hyperbaric oxygen and hyperbaric helium depolarize medullary neurons by separate mechanisms (Abstract). FASEB J 14: A713, 2000.
150. Mulkey DK, Henderson RA III, and Dean JB. Hyperbaric oxygen depolarizes solitary complex neurons in tissue slices of rat medulla oblongata. Adv Exp Med Biol 475: 465-476, 2000.
151. Mulkey DK, Henderson RA III, Olson JE, Putnam RW, and Dean JB. Oxygen measurement in brainstem slices exposed to normobaric hyperoxia and hyperbaric oxygen. J Appl Physiol 90: 1887-1899, 2001.
152. +-sensitive neurons in rat brain stem slices. J Appl Physiol 95: 910-921, 2003.
153. Mulkey DK, Henderson RA III, Putnam RW, and Dean JB. Pressure (≤4 ATA) increases membrane conductance and firing rate in the rat solitary complex. J Appl Physiol 95: 922-930, 2003.
154. Mulkey DK, Reich JL, and Dean JB. Comparison of neuronal barosensitivity in the solitary complex to 1 to 8 atmospheres of helium or air (Abstract). FASEB J 13: A825, 1999.
155. Nagle D. Navy diving community supports miners' rescue [Online]. Naval Sea Systems Command (NAVSEA). http://www.navsea.navy.mil/featurestories_content.asp?txtDataID= 6057&txtTypeID=4 [17 June 2003].
156. Nattie EE. Central Chemoreception. New York: Dekker, 1995.
157. 2, brainstem chemoreceptors and breathing. Prog Neurobiol 59: 299-331, 1999.
158. Neubauer RA, Gottlieb SF, and Pevsner NH. Hyperbaric oxygen for treatment of closed head injury. South Med J 87: 933-936, 1994.
159. Neuman RC Jr, Kauzmann W, and Zipp A. Pressure dependence of weak acid ionization in aqueous buffers. J Phys Chem 77: 2687-2691, 1973.
160. Noda Y, McGeer PL, and McGeer EG. Lipid peroxide distribution in brain and the effect of hyperbaric oxygen. J Neurochem 40: 1329-1332, 1983.
161. 2 in the isolated brain stem-spinal cord of the neonatal rat. Respir Physiol 93: 315-326, 1993.
162. Olgilvie RW and Balentine JD. Oxygen tension in spinal cord gray matter during exposure to hyperbaric oxygen. J Neurosurg 43: 156-161, 1975.
163. Ornhagen HC. Influence of nitrous oxide, nitrogen, neon, and helium on the beating frequency of the mouse sinus node at high pressure. Undersea Biomed Res 6: 27-40, 1979.
164. Pagliaro L, Reitz F, and Wang J. An optical pressure chamber designed for high numerical aperture studies on adherent living cells. Undersea Hyperb Med 22: 171-181, 1995.
165. Parker EC, Ball R, Tibbles PM, and Weathersby PK. Escape from a disabled submarine: decompression sickness risk estimation. Aviat Space Environ Med 71: 109-114, 2000.
166. Parmentier JL, Shirivastav BB, and Bennett PB. A versatile high pressure chamber for electrophysiological measurements. J Appl Physiol 48: 562-566, 1980.
167. Parmentier JL, Shrivastav BB, Bennett PB, and Wilson KM. Effect of interaction of volatile anesthetics and high hydrostatic pressure on central neurons. Undersea Biomed Res 6: 75-91, 1979.
168. Pellmar TC. Electrophysiological correlates of peroxide damage in guinea pig hippocampus in vitro. Brain Res 364: 377-381, 1986.
169. Pellmar TC. Use of brain slices in the study of free-radical actions. J Neurosci Methods 59: 93-98, 1995.
170. Pellmar TC, Gilman SC, Keyser DO, Lee KH, Lepinski DL, Livengood D, and Myers LS Jr. Reactive oxygen species on neural transmission. Ann N Y Acad Sci 738: 121-129, 1994.
171. 2 concentration in rat brain after hyperoxic convulsions. J Appl Physiol 69: 1761-1766, 1990.
172. Prabhakar NR. Sleep apneas: an oxidative stress? Am J Respir Crit Care Med 165: 934-939, 2002.
173. Qureshi IA. Intraocular pressure: a comparative analysis in two sexes. Clin Physiol 17: 247-255, 1997.
174. 2. J Cereb Blood Flow Metab 9: 65-70, 1989.
175. Reid G and Tervit H. Sudden infant death syndrome: oxidative stress. Med Hypotheses 52: 577-580, 1999.
176. Ritucci NA, Chambers-Kersh L, Dean JB, and Putnam RW. Intracellular pH regulation in neurons from chemosensitive and non-chemosensitive areas of the medulla. Am J Physiol Regul Integr Comp Physiol 275: R1152-R1163, 1998.
177. Ritucci NA, Dean JB, and Putnam RW. Intracellular pH response to hypercapnia in neurons from chemosensitive areas of the medulla. Am J Physiol Regul Integr Comp Physiol 273: R433-R441, 1997.
178. Ritucci NA, Erlichman JS, Dean JB, and Putnam RW. A fluorescence technique to measure intracellular pH of single neurons in brainstem slices. J Neurosci Methods 68: 149-163, 1996.
179. Roth SH. Anesthesia and pressure: antagonism and enhancement. In: Molecular Mechanisms of Anesthesia, edited by Fink BR. New York: Raven, 1975, p. 405-420.
180. Salmon ED and Ellis GW. A new miniature hydrostatic pressure chamber for microscopy. Strain-free optical glass windows facilitate phase-contrasted and polarized-light microscopy of living cells. Optional fixture permits simultaneous control of pressure and temperature. J Cell Biol 65: 587-602, 1975.
181. Sanders MJ, Dietrich WD, and Green EJ. Behavioral, electrophysiological, and histopathological consequences of mild fluid-percussive injury in the rat. Brain Res 904: 141-144, 2001.
182. Sauter JF. Electrophysiological activity of a mammalian sympathetic ganglion under hydrostatic and inert gas pressure. Neuropharmacology 18: 77-81, 1979.
183. Scheid P, guest editors: Putnam RW, Dean JB, and Ballantyne D. Special Issue: Central chemosensitivity. Respir Physiol 129: 1-278, 2001.
184. Schmalwasser H, Neef A, Elliott AA, and Heinemann SH. Two-electrode voltage clamp of Xenopus oocytes under high hydrostatic pressure. J Neurosci Methods 81: 1-7, 1998.
185. Sheffield PJ and Desautels DA. Hyperbaric and hypobaric chamber fires: a 73-year analysis. Undersea Hyperb Med 24: 153-164, 1997.
186. 2 impairs thermosensitivity of hypothalamic thermosensitive neurons in slice preparations. Brain Res Bull 26: 467-471, 1991.
187. Siesjo BK, Folbergrova J, and MacMillan V. The effect of hypercapnia upon intracellular pH in the brain, evaluated by the bicarbonate-carbonic acid method and from the creatine phosphokinase equilibrium. J Neurochem 19: 2483-2495, 1972.
188. Siesjo BK, Katsura K, Mellergard P, Ekholm A, Lundren J, and Smith ML. Acidosis-related brain damage. Prog Brain Res 96: 23-48, 1993.
189. Simon AJ and Torbati D. Effects of hyperbaric oxygen on heart, brain and lung functions in rat. Undersea Biomed Res 9: 263-275, 1982.
190. 2-chemoreception and respiratory control. Respir Physiol 131: 155-173, 2002.
191. Southan AP and Wann KT. Methods for intracellular recording from hippocampal brain slices under high helium pressure. J Appl Physiol 71: 365-371, 1991.
192. Southan AP and Wann KT. Effects of high helium pressure on intracellular and field potential responses in the CA1 region of the in vitro rat hippocampus. Eur J Neurosci 8: 2571-2581, 1996.
193. Stamler JS, Jia L, Eu JP, McMahon TJ, Demchenko IT, Bonaventura J, Gernet K, and Piantadosi CA. Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science 258: 1898-1902, 1996.
194. Sterba JA. Hypercapnia During Deep Air and Mixed Gas Diving. Panama City, FL: Department of the Navy, Navy Experimental Diving Unit, 1990.
195. Stuart GJ, Dodt HU, and Sakmann B. Patch-clamp recordings from the soma and dendrites of neurons in brain slices using infrared video microscopy. Pflügers Arch 423: 511-518, 1993.
196. Sunberg H, Hartveit E, and Jellestad F. Electrophysiological effects of hyperbaric oxygen exposure in freely moving rats. In: Diving and Hyperbaric Medicine. Proceedings of the XIIIth Annual Meeting of the European Undersea Biomedical Society, edited by Marroni A and Oriani G. Palermo, Italy: EUBS, 1987, p. 141-147.
197. Tarasiuk A and Grossman Y. High pressure modifies respiratory activity in isolated rat brain stem-spinal cord. J Appl Physiol 71: 537-545, 1991.
198. Tarasiuk A and Grossman Y. High pressure reduces pH sensitivity of respiratory center in isolated rat brainstem. Respir Physiol 86: 369-379, 1991.
199. Taylor CD. The effect of pressure upon the solubility of oxygen in water. Arch Biochem Biophys 191: 375-384, 1978.
200. Taylor CD. Solubility properties of oxygen and helium in hyperbaric systems and the influence of high pressure oxyhelium upon bacterial growth, metabolism, and viability. In: Current Perspectives in High Pressure Biology, edited by Jannasch HW and Marquis RE. London: Academic, 1987, p. 111-128.
201. Thom SR. Inert gas enhancement of superoxide radical production. Arch Biochem Biophys 295: 391-396, 1992.
202. Thom SR and Marquis RE. Microbial growth modification by compressed gases and hydrostatic pressure. Appl Environ Microbiol 47: 780-787, 1984.
203. Tibbles PM and Edelsberg JS. Hyperbaric-oxygen therapy. N Engl J Med 334: 1642-1648, 1996.
204. Torbati D. Regional cerebral metabolic rate for glucose immediately following exposure to two atmospheres absolute oxygen in concious rats. Neurosci Lett 55: 109-112, 1985.
205. Torbati D, Church DF, Keller JM, and Pryor WA. Free radical generation in the brain precedes hyperbaric oxygen-induced convulsions. Free Radic Biol Med 13: 101-106, 1992.
206. Torbati D, Greenberg J, and Lambertsen CJ. Correlation of brain glucose utilization and cortical electrical activity during development of brain oxygen toxicity. Brain Res 262: 267-273, 1983.
207. Torbati D and Lambertsen CJ. Regional cerebral metabolic rate for glucose during hyperbaric oxygen-induced convulsions. Brain Res 279: 382-386, 1983.
208. Torbati D, Lambertsen CJ, and Greenberg J. Regional cerebral glucose utilization rates in rats during asymptomatic period of exposure to 1, 2 and 3 atmospheres of absolute oxygen. Neuroscience 11: 947-950, 1984.
209. Torbati D, Mokashi A, and Lahiri S. Effects of acute hyperbaric oxygenation on respiratory control in cats. J Appl Physiol 67: 2351-2356, 1989.
210. 2 of the rat's brain under high oxygen pressure. Exp Neurol 50: 439-447, 1976.
211. 2 in newborn rats. Undersea Hyperb Med 22: 209-218, 1995.
212. Upham BL, Kang KS, Cho HY, and Trosko JE. Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione sufficient but not glutathione deficient cells. Carcinogenesis 18: 37-42, 1997.
213. Wann KT and Macdonald AG. The effects of pressure on excitable cells. Comp Biochem Physiol 66A: 1-12, 1980.
214. Wann KT, MacDonald AG, and Harper AA. The effects of high hydrostatic pressure on the electrical characteristics of Helix neurons. Comp Biochem Physiol 64A: 149-159, 1979.
215. Wann KT, MacDonald AG, Harper AA, and Wilcock SE. Electrophysiological measurements at high hydrostatic pressure: methods for intracellular recording from isolated ganglia and for extracellular recording in vivo. Comp Biochem Physiol 64A: 141-147, 1979.
216. Wann KT and Southan AP. The action of anaesthetics and high pressure on neuronal discharge patterns. Gen Pharmacol 23: 993-1004, 1992.
217. 2 retention with minimal symptoms but severe dysfunction during wet simulated dives to 6.8 atm abs. Undersea Biomed Res 17: 515-523, 1990.
218. Waterfall AH, Singh G, Fry JR, and Marsden CA. Acute acidosis elevates malonaldehyde in rat brain in vivo. Brain Res 712: 102-106, 1996.
219. Watson PL, Weiner JL, and Carlen PL. Effects of variations in hippocampal slice preparation protocol on the electrophysiological stability, epileptogenicity and graded hypoxia responses of CA1 neurons. Brain Res 775: 134-143, 1997.
220. Webb JT, Pilmanis AA, Kannan N, and Olson RM. The effect of staged decompression while breathing 100% oxygen on altitude decompression sickness. Aviat Space Environ Med 71: 692-698, 2000.
221. West JB, Hackett PH, Maret KH, Milledge JS, Peters RM Jr, Pizzo CJ, and Winslow RM. Pulmonary gas exchange on the summit of Mt. Everest. J Appl Physiol 55: 678-687, 1983.
222. 2 and pH of the working heat-brain stem preparation during vascular perfusion with aqueous medium. Am J Physiol Regul Integr Comp Physiol 281: R528-R538, 2001.
223. 2 in hyperbaric oxygen toxicity. Undersea Biomed Res 9: 15-21, 1982.
224. Wood EH. Hydrostatic homeostatic effects during changing force environments. Aviat Space Environ Med 61: 366-373, 1990.
225. Woodbury DM and Karler R. The role of carbon dioxide in the nervous system. Anesthesiology 21: 686-703, 1960.
226. Yermolaieva O, Brot N, Weissbach H, Heinemann SH, and Hoshi T. Reactive oxygen species and nitric oxide mediate plasticity of neuronal calicum signaling. Proc Natl Acad Sci USA 97: 448-453, 2000.
227. Zhang J, Sam AD, Klitzman B, and Piantadosi CA. Inhibition of nitric oxide synthase on brain oxygenation in anesthetized rats exposed to hyperbaric oxygen. Undersea Hyperb Med 22: 377-382, 1995.
228. Zinebi F, Fagni L, and Hugon M. The influence of helium pressure on the reduction induced in field potentials by various amino acids and on the GABA-mediated inhibition in the CA1 region of hippocampal slices in the rat. Neuropharmacology 27: 57-65, 1988.
229. Zinebi F, Fagni L, and Hugon M. Excitatory and inhibitory amino-acidergic determinants of the pressure-induced neuronal hyperexcitability in rat hippocampal slices. Undersea Biomed Res 17: 487-493, 1990.