메뉴 건너뛰기




Volumn 4, Issue 1, 2018, Pages 67-76

Taste receptors in the upper airway

Author keywords

Antimicrobial peptide; Chronic rhinosinusitis; Cilia; Gustation; Innate immunity; Nasal disease; Nitric oxide; Respiratory infection

Indexed keywords

ANTIBIOTIC AGENT; NITRIC OXIDE;

EID: 85063427664     PISSN: 20958811     EISSN: 25891081     Source Type: Journal    
DOI: 10.1016/j.wjorl.2018.02.004     Document Type: Review
Times cited : (35)

References (145)
  • 1
    • 84855357959 scopus 로고    scopus 로고
    • Taste receptor signalling – from tongues to lungs
    • Kinnamon, S.C., Taste receptor signalling – from tongues to lungs. Acta Physiol (Oxf) 204 (2012), 158–168.
    • (2012) Acta Physiol (Oxf) , vol.204 , pp. 158-168
    • Kinnamon, S.C.1
  • 2
    • 84955326758 scopus 로고    scopus 로고
    • Bitter taste bodyguards
    • Lee, R.J., Cohen, N.A., Bitter taste bodyguards. Sci Am 314 (2016), 38–43.
    • (2016) Sci Am , vol.314 , pp. 38-43
    • Lee, R.J.1    Cohen, N.A.2
  • 3
    • 84920647529 scopus 로고    scopus 로고
    • Taste receptors in innate immunity
    • Lee, R.J., Cohen, N.A., Taste receptors in innate immunity. Cell Mol Life Sci 72 (2015), 217–236.
    • (2015) Cell Mol Life Sci , vol.72 , pp. 217-236
    • Lee, R.J.1    Cohen, N.A.2
  • 4
    • 84870314938 scopus 로고    scopus 로고
    • Extraoral bitter taste receptors as mediators of off-target drug effects
    • Clark, A.A., Liggett, S.B., Munger, S.D., Extraoral bitter taste receptors as mediators of off-target drug effects. FASEB J 26 (2012), 4827–4831.
    • (2012) FASEB J , vol.26 , pp. 4827-4831
    • Clark, A.A.1    Liggett, S.B.2    Munger, S.D.3
  • 6
    • 84899503308 scopus 로고    scopus 로고
    • The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14
    • Levit, A., Nowak, S., Peters, M., et al. The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14. FASEB J 28 (2014), 1181–1197.
    • (2014) FASEB J , vol.28 , pp. 1181-1197
    • Levit, A.1    Nowak, S.2    Peters, M.3
  • 7
    • 84882909947 scopus 로고    scopus 로고
    • The bad taste of medicines: overview of basic research on bitter taste
    • Mennella, J.A., Spector, A.C., Reed, D.R., Coldwell, S.E., The bad taste of medicines: overview of basic research on bitter taste. Clin Ther 35 (2013), 1225–1246.
    • (2013) Clin Ther , vol.35 , pp. 1225-1246
    • Mennella, J.A.1    Spector, A.C.2    Reed, D.R.3    Coldwell, S.E.4
  • 8
    • 84880681249 scopus 로고    scopus 로고
    • Taste perception: from the tongue to the testis
    • Li, F., Taste perception: from the tongue to the testis. Mol Hum Reprod 19 (2013), 349–360.
    • (2013) Mol Hum Reprod , vol.19 , pp. 349-360
    • Li, F.1
  • 9
    • 84975726301 scopus 로고    scopus 로고
    • Sweet taste-sensing receptors expressed in pancreatic β-cells: sweet molecules act as biased agonists
    • Kojima, I., Nakagawa, Y., Ohtsu, Y., Medina, A., Nagasawa, M., Sweet taste-sensing receptors expressed in pancreatic β-cells: sweet molecules act as biased agonists. Endocrinol Metab (Seoul) 29 (2014), 12–19.
    • (2014) Endocrinol Metab (Seoul) , vol.29 , pp. 12-19
    • Kojima, I.1    Nakagawa, Y.2    Ohtsu, Y.3    Medina, A.4    Nagasawa, M.5
  • 10
    • 84906832000 scopus 로고    scopus 로고
    • Expression of the glucose-sensing receptor T1R3 in pancreatic islet: changes in the expression levels in various nutritional and metabolic states
    • Medina, A., Nakagawa, Y., Ma, J., et al. Expression of the glucose-sensing receptor T1R3 in pancreatic islet: changes in the expression levels in various nutritional and metabolic states. Endocr J 61 (2014), 797–805.
    • (2014) Endocr J , vol.61 , pp. 797-805
    • Medina, A.1    Nakagawa, Y.2    Ma, J.3
  • 11
    • 84886993360 scopus 로고    scopus 로고
    • Multimodal function of the sweet taste receptor expressed in pancreatic β-cells: generation of diverse patterns of intracellular signals by sweet agonists
    • Nakagawa, Y., Nagasawa, M., Mogami, H., Lohse, M., Ninomiya, Y., Kojima, I., Multimodal function of the sweet taste receptor expressed in pancreatic β-cells: generation of diverse patterns of intracellular signals by sweet agonists. Endocr J 60 (2013), 1191–1206.
    • (2013) Endocr J , vol.60 , pp. 1191-1206
    • Nakagawa, Y.1    Nagasawa, M.2    Mogami, H.3    Lohse, M.4    Ninomiya, Y.5    Kojima, I.6
  • 12
    • 84857426294 scopus 로고    scopus 로고
    • Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion
    • Kyriazis, G.A., Soundarapandian, M.M., Tyrberg, B., Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion. Proc Natl Acad Sci U S A 109 (2012), E524–E532.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. E524-E532
    • Kyriazis, G.A.1    Soundarapandian, M.M.2    Tyrberg, B.3
  • 14
    • 70349560878 scopus 로고    scopus 로고
    • Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones
    • Kokrashvili, Z., Mosinger, B., Margolskee, R.F., Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones. Am J Clin Nutr 90 (2009), 822S–825S.
    • (2009) Am J Clin Nutr , vol.90 , pp. 822S-825S
    • Kokrashvili, Z.1    Mosinger, B.2    Margolskee, R.F.3
  • 15
    • 14644415512 scopus 로고    scopus 로고
    • Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells
    • Dyer, J., Salmon, K.S., Zibrik, L., Shirazi-Beechey, S.P., Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells. Biochem Soc Trans 33 (2005), 302–305.
    • (2005) Biochem Soc Trans , vol.33 , pp. 302-305
    • Dyer, J.1    Salmon, K.S.2    Zibrik, L.3    Shirazi-Beechey, S.P.4
  • 16
    • 84871129066 scopus 로고    scopus 로고
    • Functional characterization of bitter-taste receptors expressed in mammalian testis
    • Xu, J., Cao, J., Iguchi, N., Riethmacher, D., Huang, L., Functional characterization of bitter-taste receptors expressed in mammalian testis. Mol Hum Reprod 19 (2013), 17–28.
    • (2013) Mol Hum Reprod , vol.19 , pp. 17-28
    • Xu, J.1    Cao, J.2    Iguchi, N.3    Riethmacher, D.4    Huang, L.5
  • 17
    • 84880656949 scopus 로고    scopus 로고
    • Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility
    • Mosinger, B., Redding, K.M., Parker, M.R., et al. Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility. Proc Natl Acad Sci U S A 110 (2013), 12319–12324.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 12319-12324
    • Mosinger, B.1    Redding, K.M.2    Parker, M.R.3
  • 18
    • 84861754565 scopus 로고    scopus 로고
    • Depletion of bitter taste transduction leads to massive spermatid loss in transgenic mice
    • Li, F., Zhou, M., Depletion of bitter taste transduction leads to massive spermatid loss in transgenic mice. Mol Hum Reprod 18 (2012), 289–297.
    • (2012) Mol Hum Reprod , vol.18 , pp. 289-297
    • Li, F.1    Zhou, M.2
  • 19
  • 20
    • 33645799951 scopus 로고    scopus 로고
    • Teaching resources. Sensory systems: taste perception
    • Margolskee, R.F., Teaching resources. Sensory systems: taste perception. Sci STKE, 2005, 2005, tr20.
    • (2005) Sci STKE , vol.2005 , pp. tr20
    • Margolskee, R.F.1
  • 21
    • 57049179732 scopus 로고    scopus 로고
    • Involvement of T1R3 in calcium-magnesium taste
    • Tordoff, M.G., Shao, H., Alarcón, L.K., et al. Involvement of T1R3 in calcium-magnesium taste. Physiol Genomics 34 (2008), 338–348.
    • (2008) Physiol Genomics , vol.34 , pp. 338-348
    • Tordoff, M.G.1    Shao, H.2    Alarcón, L.K.3
  • 22
    • 84896491736 scopus 로고    scopus 로고
    • 2+ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice
    • 2+ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice. Gastroenterology 146 (2014), 995–1005.
    • (2014) Gastroenterology , vol.146 , pp. 995-1005
    • Ozdener, M.H.1    Subramaniam, S.2    Sundaresan, S.3
  • 23
    • 77954134133 scopus 로고    scopus 로고
    • Taste preference for fatty acids is mediated by GPR40 and GPR120
    • Cartoni, C., Yasumatsu, K., Ohkuri, T., et al. Taste preference for fatty acids is mediated by GPR40 and GPR120. J Neurosci 30 (2010), 8376–8382.
    • (2010) J Neurosci , vol.30 , pp. 8376-8382
    • Cartoni, C.1    Yasumatsu, K.2    Ohkuri, T.3
  • 24
    • 60549103018 scopus 로고    scopus 로고
    • Oro-sensory perception of dietary lipids: new insights into the fat taste transduction
    • Khan, N.A., Besnard, P., Oro-sensory perception of dietary lipids: new insights into the fat taste transduction. Biochim Biophys Acta 1791 (2009), 149–155.
    • (2009) Biochim Biophys Acta , vol.1791 , pp. 149-155
    • Khan, N.A.1    Besnard, P.2
  • 25
    • 35148868260 scopus 로고    scopus 로고
    • Fat and carbohydrate preferences in mice: the contribution of alpha-gustducin and Trpm5 taste-signaling proteins
    • Sclafani, A., Zukerman, S., Glendinning, J.I., Margolskee, R.F., Fat and carbohydrate preferences in mice: the contribution of alpha-gustducin and Trpm5 taste-signaling proteins. Am J Physiol Regul Integr Comp Physiol 293 (2007), R1504–R1513.
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.293 , pp. R1504-R1513
    • Sclafani, A.1    Zukerman, S.2    Glendinning, J.I.3    Margolskee, R.F.4
  • 26
    • 27644533906 scopus 로고    scopus 로고
    • CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions
    • Laugerette, F., Passilly-Degrace, P., Patris, B., et al. CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J Clin Invest 115 (2005), 3177–3184.
    • (2005) J Clin Invest , vol.115 , pp. 3177-3184
    • Laugerette, F.1    Passilly-Degrace, P.2    Patris, B.3
  • 28
    • 77956165390 scopus 로고    scopus 로고
    • GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
    • Oh, D.Y., Talukdar, S., Bae, E.J., et al. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell. 142 (2010), 687–698.
    • (2010) Cell. , vol.142 , pp. 687-698
    • Oh, D.Y.1    Talukdar, S.2    Bae, E.J.3
  • 29
    • 84875635849 scopus 로고    scopus 로고
    • Oral and extra-oral taste perception
    • Yamamoto, K., Ishimaru, Y., Oral and extra-oral taste perception. Semin Cell Dev Biol 24 (2013), 240–246.
    • (2013) Semin Cell Dev Biol , vol.24 , pp. 240-246
    • Yamamoto, K.1    Ishimaru, Y.2
  • 30
    • 84903696086 scopus 로고    scopus 로고
    • Taste transductions in taste receptor cells: basic tastes and moreover
    • Iwata, S., Yoshida, R., Ninomiya, Y., Taste transductions in taste receptor cells: basic tastes and moreover. Curr Pharm Des 20 (2014), 2684–2692.
    • (2014) Curr Pharm Des , vol.20 , pp. 2684-2692
    • Iwata, S.1    Yoshida, R.2    Ninomiya, Y.3
  • 31
    • 84920874768 scopus 로고    scopus 로고
    • Role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis
    • Lee, R.J., Cohen, N.A., Role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis. Curr Opin Allergy Clin Immunol 15 (2015), 14–20.
    • (2015) Curr Opin Allergy Clin Immunol , vol.15 , pp. 14-20
    • Lee, R.J.1    Cohen, N.A.2
  • 32
    • 84914153160 scopus 로고    scopus 로고
    • Bitter and sweet taste receptors in the respiratory epithelium in health and disease
    • Lee, R.J., Cohen, N.A., Bitter and sweet taste receptors in the respiratory epithelium in health and disease. J Mol Med (Berl) 92 (2014), 1235–1244.
    • (2014) J Mol Med (Berl) , vol.92 , pp. 1235-1244
    • Lee, R.J.1    Cohen, N.A.2
  • 33
    • 4043143509 scopus 로고    scopus 로고
    • The sweet and the bitter of mammalian taste
    • Scott, K., The sweet and the bitter of mammalian taste. Curr Opin Neurobiol 14 (2004), 423–427.
    • (2004) Curr Opin Neurobiol , vol.14 , pp. 423-427
    • Scott, K.1
  • 35
    • 84896899700 scopus 로고    scopus 로고
    • Glucose promotes its own metabolism by acting on the cell-surface glucose-sensing receptor T1R3
    • Nakagawa, Y., Ohtsu, Y., Nagasawa, M., Shibata, H., Kojima, I., Glucose promotes its own metabolism by acting on the cell-surface glucose-sensing receptor T1R3. Endocr J 61 (2014), 119–131.
    • (2014) Endocr J , vol.61 , pp. 119-131
    • Nakagawa, Y.1    Ohtsu, Y.2    Nagasawa, M.3    Shibata, H.4    Kojima, I.5
  • 36
    • 84872392828 scopus 로고    scopus 로고
    • A novel regulatory function of sweet taste-sensing receptor in adipogenic differentiation of 3T3-L1 cells
    • Masubuchi, Y., Nakagawa, Y., Ma, J., et al. A novel regulatory function of sweet taste-sensing receptor in adipogenic differentiation of 3T3-L1 cells. PLoS One, 8, 2013, e54500.
    • (2013) PLoS One , vol.8 , pp. e54500
    • Masubuchi, Y.1    Nakagawa, Y.2    Ma, J.3
  • 37
    • 84893051272 scopus 로고    scopus 로고
    • Diet shapes the evolution of the vertebrate bitter taste receptor gene repertoire
    • Li, D., Zhang, J., Diet shapes the evolution of the vertebrate bitter taste receptor gene repertoire. Mol Biol Evol 31 (2014), 303–309.
    • (2014) Mol Biol Evol , vol.31 , pp. 303-309
    • Li, D.1    Zhang, J.2
  • 38
    • 84978401133 scopus 로고    scopus 로고
    • Comprehensive analysis of mouse bitter taste receptors reveals different molecular receptive ranges for orthologous receptors in mice and humans
    • Lossow, K., Hübner, S., Roudnitzky, N., et al. Comprehensive analysis of mouse bitter taste receptors reveals different molecular receptive ranges for orthologous receptors in mice and humans. J Biol Chem 291 (2016), 15358–15377.
    • (2016) J Biol Chem , vol.291 , pp. 15358-15377
    • Lossow, K.1    Hübner, S.2    Roudnitzky, N.3
  • 39
    • 77950114281 scopus 로고    scopus 로고
    • The molecular receptive ranges of human TAS2R bitter taste receptors
    • Meyerhof, W., Batram, C., Kuhn, C., et al. The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35 (2010), 157–170.
    • (2010) Chem Senses , vol.35 , pp. 157-170
    • Meyerhof, W.1    Batram, C.2    Kuhn, C.3
  • 40
    • 84895487775 scopus 로고    scopus 로고
    • Peripheral coding of taste
    • Liman, E.R., Zhang, Y.V., Montell, C., Peripheral coding of taste. Neuron 81 (2014), 984–1000.
    • (2014) Neuron , vol.81 , pp. 984-1000
    • Liman, E.R.1    Zhang, Y.V.2    Montell, C.3
  • 41
    • 84954561117 scopus 로고    scopus 로고
    • Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites
    • Gerbe, F., Sidot, E., Smyth, D.J., et al. Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Nature 529 (2016), 226–230.
    • (2016) Nature , vol.529 , pp. 226-230
    • Gerbe, F.1    Sidot, E.2    Smyth, D.J.3
  • 42
    • 84958767810 scopus 로고    scopus 로고
    • Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut
    • Howitt, M.R., Lavoie, S., Michaud, M., et al. Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science 351 (2016), 1329–1333.
    • (2016) Science , vol.351 , pp. 1329-1333
    • Howitt, M.R.1    Lavoie, S.2    Michaud, M.3
  • 43
    • 84879700974 scopus 로고    scopus 로고
    • Solitary chemosensory cells and bitter taste receptor signaling in human sinonasal mucosa
    • Barham, H.P., Cooper, S.E., Anderson, C.B., et al. Solitary chemosensory cells and bitter taste receptor signaling in human sinonasal mucosa. Int Forum Allergy Rhinol 3 (2013), 450–457.
    • (2013) Int Forum Allergy Rhinol , vol.3 , pp. 450-457
    • Barham, H.P.1    Cooper, S.E.2    Anderson, C.B.3
  • 44
    • 78651282172 scopus 로고    scopus 로고
    • Expression of taste receptors in solitary chemosensory cells of rodent airways
    • Tizzano, M., Cristofoletti, M., Sbarbati, A., Finger, T.E., Expression of taste receptors in solitary chemosensory cells of rodent airways. BMC Pulm Med, 11, 2011, 3.
    • (2011) BMC Pulm Med , vol.11 , pp. 3
    • Tizzano, M.1    Cristofoletti, M.2    Sbarbati, A.3    Finger, T.E.4
  • 45
    • 85028923546 scopus 로고    scopus 로고
    • Bacterial D-amino acids suppress sinonasal innate immunity through sweet taste receptors in solitary chemosensory cells
    • Lee, R.J., Hariri, B.M., McMahon, D.B., et al. Bacterial D-amino acids suppress sinonasal innate immunity through sweet taste receptors in solitary chemosensory cells. Sci Signal, 10, 2017.
    • (2017) Sci Signal , vol.10
    • Lee, R.J.1    Hariri, B.M.2    McMahon, D.B.3
  • 46
    • 84896770768 scopus 로고    scopus 로고
    • Bitter and sweet taste receptors regulate human upper respiratory innate immunity
    • Lee, R.J., Kofonow, J.M., Rosen, P.L., et al. Bitter and sweet taste receptors regulate human upper respiratory innate immunity. J Clin Invest 124 (2014), 1393–1405.
    • (2014) J Clin Invest , vol.124 , pp. 1393-1405
    • Lee, R.J.1    Kofonow, J.M.2    Rosen, P.L.3
  • 47
    • 84859450268 scopus 로고    scopus 로고
    • Major taste loss in carnivorous mammals
    • Jiang, P., Josue, J., Li, X., et al. Major taste loss in carnivorous mammals. Proc Natl Acad Sci U S A 109 (2012), 4956–4961.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 4956-4961
    • Jiang, P.1    Josue, J.2    Li, X.3
  • 48
    • 17844382462 scopus 로고    scopus 로고
    • Genetic and environmental determinants of bitter perception and sweet preferences
    • Mennella, J.A., Pepino, M.Y., Reed, D.R., Genetic and environmental determinants of bitter perception and sweet preferences. Pediatrics 115 (2005), e216–e222.
    • (2005) Pediatrics , vol.115 , pp. e216-e222
    • Mennella, J.A.1    Pepino, M.Y.2    Reed, D.R.3
  • 49
    • 13944250257 scopus 로고    scopus 로고
    • The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception
    • Bufe, B., Breslin, P.A., Kuhn, C., et al. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol 15 (2005), 322–327.
    • (2005) Curr Biol , vol.15 , pp. 322-327
    • Bufe, B.1    Breslin, P.A.2    Kuhn, C.3
  • 50
    • 84864246506 scopus 로고    scopus 로고
    • 3D structure prediction of TAS2R38 bitter receptors bound to agonists phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP)
    • Tan, J., Abrol, R., Trzaskowski, B., Goddard, W.A., 3D structure prediction of TAS2R38 bitter receptors bound to agonists phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP). J Chem Inf Model 52 (2012), 1875–1885.
    • (2012) J Chem Inf Model , vol.52 , pp. 1875-1885
    • Tan, J.1    Abrol, R.2    Trzaskowski, B.3    Goddard, W.A.4
  • 51
    • 77957871915 scopus 로고    scopus 로고
    • Insights into the binding of phenylthiocarbamide (PTC) agonist to its target human TAS2R38 bitter receptor
    • Biarnés, X., Marchiori, A., Giorgetti, A., et al. Insights into the binding of phenylthiocarbamide (PTC) agonist to its target human TAS2R38 bitter receptor. PLoS One, 5, 2010, e12394.
    • (2010) PLoS One , vol.5 , pp. e12394
    • Biarnés, X.1    Marchiori, A.2    Giorgetti, A.3
  • 52
    • 33749240615 scopus 로고    scopus 로고
    • Modeling the human PTC bitter-taste receptor interactions with bitter tastants
    • Floriano, W.B., Hall, S., Vaidehi, N., Kim, U., Drayna, D., Goddard, W.A., Modeling the human PTC bitter-taste receptor interactions with bitter tastants. J Mol Model 12 (2006), 931–941.
    • (2006) J Mol Model , vol.12 , pp. 931-941
    • Floriano, W.B.1    Hall, S.2    Vaidehi, N.3    Kim, U.4    Drayna, D.5    Goddard, W.A.6
  • 53
    • 84884872511 scopus 로고    scopus 로고
    • Human bitter perception correlates with bitter receptor messenger RNA expression in taste cells
    • Lipchock, S.V., Mennella, J.A., Spielman, A.I., Reed, D.R., Human bitter perception correlates with bitter receptor messenger RNA expression in taste cells. Am J Clin Nutr 98 (2013), 1136–1143.
    • (2013) Am J Clin Nutr , vol.98 , pp. 1136-1143
    • Lipchock, S.V.1    Mennella, J.A.2    Spielman, A.I.3    Reed, D.R.4
  • 54
    • 84966356381 scopus 로고    scopus 로고
    • Global diversity in the TAS2R38 bitter taste receptor: revisiting a classic evolutionary PROPosal
    • Risso, D.S., Mezzavilla, M., Pagani, L., et al. Global diversity in the TAS2R38 bitter taste receptor: revisiting a classic evolutionary PROPosal. Sci Rep, 6, 2016, 25506.
    • (2016) Sci Rep , vol.6 , pp. 25506
    • Risso, D.S.1    Mezzavilla, M.2    Pagani, L.3
  • 55
    • 84995799664 scopus 로고    scopus 로고
    • A review of the associations between single nucleotide polymorphisms in taste receptors, eating behaviors, and health
    • Chamoun, E., Mutch, D.M., Allen-Vercoe, E., et al. A review of the associations between single nucleotide polymorphisms in taste receptors, eating behaviors, and health. Crit Rev Food Sci Nutr 58 (2018), 194–207.
    • (2018) Crit Rev Food Sci Nutr , vol.58 , pp. 194-207
    • Chamoun, E.1    Mutch, D.M.2    Allen-Vercoe, E.3
  • 56
    • 84958982886 scopus 로고    scopus 로고
    • Sweet taste receptor TAS1R2 polymorphism (Val191Val) is associated with a higher carbohydrate intake and hypertriglyceridemia among the population of west Mexico
    • Ramos-Lopez, O., Panduro, A., Martinez-Lopez, E., Roman, S., Sweet taste receptor TAS1R2 polymorphism (Val191Val) is associated with a higher carbohydrate intake and hypertriglyceridemia among the population of west Mexico. Nutrients, 8, 2016, 101.
    • (2016) Nutrients , vol.8 , pp. 101
    • Ramos-Lopez, O.1    Panduro, A.2    Martinez-Lopez, E.3    Roman, S.4
  • 57
    • 65249129179 scopus 로고    scopus 로고
    • Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion
    • Nakagawa, Y., Nagasawa, M., Yamada, S., et al. Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. PLoS One, 4, 2009, e5106.
    • (2009) PLoS One , vol.4 , pp. e5106
    • Nakagawa, Y.1    Nagasawa, M.2    Yamada, S.3
  • 58
    • 0032213167 scopus 로고    scopus 로고
    • Effects of artificial sweeteners on insulin release and cationic fluxes in rat pancreatic islets
    • Malaisse, W.J., Vanonderbergen, A., Louchami, K., Jijakli, H., Malaisse-Lagae, F., Effects of artificial sweeteners on insulin release and cationic fluxes in rat pancreatic islets. Cell Signal 10 (1998), 727–733.
    • (1998) Cell Signal , vol.10 , pp. 727-733
    • Malaisse, W.J.1    Vanonderbergen, A.2    Louchami, K.3    Jijakli, H.4    Malaisse-Lagae, F.5
  • 59
    • 84886820170 scopus 로고    scopus 로고
    • Glucose sensing mechanisms in hypothalamic cell models: glucose inhibition of AgRP synthesis and secretion
    • Chalmers, J.A., Jang, J.J., Belsham, D.D., Glucose sensing mechanisms in hypothalamic cell models: glucose inhibition of AgRP synthesis and secretion. Mol Cell Endocrinol 382 (2014), 262–270.
    • (2014) Mol Cell Endocrinol , vol.382 , pp. 262-270
    • Chalmers, J.A.1    Jang, J.J.2    Belsham, D.D.3
  • 60
    • 84865770759 scopus 로고    scopus 로고
    • Neuronal expression of bitter taste receptors and downstream signaling molecules in the rat brainstem
    • Dehkordi, O., Rose, J.E., Fatemi, M., et al. Neuronal expression of bitter taste receptors and downstream signaling molecules in the rat brainstem. Brain Res 1475 (2012), 1–10.
    • (2012) Brain Res , vol.1475 , pp. 1-10
    • Dehkordi, O.1    Rose, J.E.2    Fatemi, M.3
  • 61
    • 65649131584 scopus 로고    scopus 로고
    • Contribution of the T1r3 taste receptor to the response properties of central gustatory neurons
    • Lemon, C.H., Margolskee, R.F., Contribution of the T1r3 taste receptor to the response properties of central gustatory neurons. J Neurophysiol 101 (2009), 2459–2471.
    • (2009) J Neurophysiol , vol.101 , pp. 2459-2471
    • Lemon, C.H.1    Margolskee, R.F.2
  • 63
    • 85023615613 scopus 로고    scopus 로고
    • Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction
    • Martin, B., Wang, R., Cong, W.N., et al. Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction. J Biol Chem 292 (2017), 11508–11530.
    • (2017) J Biol Chem , vol.292 , pp. 11508-11530
    • Martin, B.1    Wang, R.2    Cong, W.N.3
  • 65
    • 84907058830 scopus 로고    scopus 로고
    • Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components
    • Lee, R.J., Chen, B., Redding, K.M., Margolskee, R.F., Cohen, N.A., Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components. Innate Immun 20 (2014), 606–617.
    • (2014) Innate Immun , vol.20 , pp. 606-617
    • Lee, R.J.1    Chen, B.2    Redding, K.M.3    Margolskee, R.F.4    Cohen, N.A.5
  • 66
    • 84883441174 scopus 로고    scopus 로고
    • The emerging role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis
    • Lee, R.J., Cohen, N.A., The emerging role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis. Am J Rhinol Allergy 27 (2013), 283–286.
    • (2013) Am J Rhinol Allergy , vol.27 , pp. 283-286
    • Lee, R.J.1    Cohen, N.A.2
  • 67
    • 84868610108 scopus 로고    scopus 로고
    • T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection
    • Lee, R.J., Xiong, G., Kofonow, J.M., et al. T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest 122 (2012), 4145–4159.
    • (2012) J Clin Invest , vol.122 , pp. 4145-4159
    • Lee, R.J.1    Xiong, G.2    Kofonow, J.M.3
  • 68
    • 0036194724 scopus 로고    scopus 로고
    • Mucus clearance as a primary innate defense mechanism for mammalian airways
    • Knowles, M.R., Boucher, R.C., Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest 109 (2002), 571–577.
    • (2002) J Clin Invest , vol.109 , pp. 571-577
    • Knowles, M.R.1    Boucher, R.C.2
  • 69
    • 85040201361 scopus 로고    scopus 로고
    • Protease-activated receptor 2 activates airway apical membrane chloride permeability and increases ciliary beating
    • McMahon, D.B., Workman, A.D., Kohanski, M.A., et al. Protease-activated receptor 2 activates airway apical membrane chloride permeability and increases ciliary beating. FASEB J 32 (2018), 155–167.
    • (2018) FASEB J , vol.32 , pp. 155-167
    • McMahon, D.B.1    Workman, A.D.2    Kohanski, M.A.3
  • 70
    • 84986880488 scopus 로고    scopus 로고
    • New insights into upper airway innate immunity
    • Hariri, B.M., Cohen, N.A., New insights into upper airway innate immunity. Am J Rhinol Allergy 30 (2016), 319–323.
    • (2016) Am J Rhinol Allergy , vol.30 , pp. 319-323
    • Hariri, B.M.1    Cohen, N.A.2
  • 71
    • 33748923448 scopus 로고    scopus 로고
    • Sinonasal mucociliary clearance in health and disease
    • Cohen, N.A., Sinonasal mucociliary clearance in health and disease. Ann Otol Rhinol Laryngol Suppl 196 (2006), 20–26.
    • (2006) Ann Otol Rhinol Laryngol Suppl , vol.196 , pp. 20-26
    • Cohen, N.A.1
  • 72
    • 33947367829 scopus 로고    scopus 로고
    • Regulation of mammalian ciliary beating
    • Salathe, M., Regulation of mammalian ciliary beating. Annu Rev Physiol 69 (2007), 401–422.
    • (2007) Annu Rev Physiol , vol.69 , pp. 401-422
    • Salathe, M.1
  • 74
    • 85015781860 scopus 로고    scopus 로고
    • Nitric oxide production is stimulated by bitter taste receptors ubiquitously expressed in the sinonasal cavity
    • Yan, C.H., Hahn, S., McMahon, D., et al. Nitric oxide production is stimulated by bitter taste receptors ubiquitously expressed in the sinonasal cavity. Am J Rhinol Allergy 31 (2017), 85–92.
    • (2017) Am J Rhinol Allergy , vol.31 , pp. 85-92
    • Yan, C.H.1    Hahn, S.2    McMahon, D.3
  • 75
    • 85019593482 scopus 로고    scopus 로고
    • Flavones modulate respiratory epithelial innate immunity: anti-inflammatory effects and activation of the T2R14 receptor
    • Hariri, B.M., McMahon, D.B., Chen, B., et al. Flavones modulate respiratory epithelial innate immunity: anti-inflammatory effects and activation of the T2R14 receptor. J Biol Chem 292 (2017), 8484–8497.
    • (2017) J Biol Chem , vol.292 , pp. 8484-8497
    • Hariri, B.M.1    McMahon, D.B.2    Chen, B.3
  • 76
    • 0030739789 scopus 로고    scopus 로고
    • Nitric oxide and antimicrobial activity of reactive oxygen intermediates
    • Marcinkiewicz, J., Nitric oxide and antimicrobial activity of reactive oxygen intermediates. Immunopharmacology 37 (1997), 35–41.
    • (1997) Immunopharmacology , vol.37 , pp. 35-41
    • Marcinkiewicz, J.1
  • 77
    • 0031570501 scopus 로고    scopus 로고
    • Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity
    • Fang, F.C., Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity. J Clin Invest 99 (1997), 2818–2825.
    • (1997) J Clin Invest , vol.99 , pp. 2818-2825
    • Fang, F.C.1
  • 78
    • 85031700434 scopus 로고    scopus 로고
    • Plant flavones enhance antimicrobial activity of respiratory epithelial cell secretions against Pseudomonas aeruginosa
    • Hariri, B.M., McMahon, D.B., Chen, B., et al. Plant flavones enhance antimicrobial activity of respiratory epithelial cell secretions against Pseudomonas aeruginosa. PLoS One, 12, 2017, e0185203.
    • (2017) PLoS One , vol.12 , pp. e0185203
    • Hariri, B.M.1    McMahon, D.B.2    Chen, B.3
  • 79
    • 84979710925 scopus 로고    scopus 로고
    • In vitro effects of anthocyanidins on sinonasal epithelial nitric oxide production and bacterial physiology
    • Hariri, B.M., Payne, S.J., Chen, B., et al. In vitro effects of anthocyanidins on sinonasal epithelial nitric oxide production and bacterial physiology. Am J Rhinol Allergy 30 (2016), 261–268.
    • (2016) Am J Rhinol Allergy , vol.30 , pp. 261-268
    • Hariri, B.M.1    Payne, S.J.2    Chen, B.3
  • 80
    • 85019868984 scopus 로고    scopus 로고
    • Relative susceptibility of airway organisms to antimicrobial effects of nitric oxide
    • Workman, A.D., Carey, R.M., Kohanski, M.A., et al. Relative susceptibility of airway organisms to antimicrobial effects of nitric oxide. Int Forum Allergy Rhinol 7 (2017), 770–776.
    • (2017) Int Forum Allergy Rhinol , vol.7 , pp. 770-776
    • Workman, A.D.1    Carey, R.M.2    Kohanski, M.A.3
  • 81
    • 84866617309 scopus 로고    scopus 로고
    • Quorum sensing: how bacteria can coordinate activity and synchronize their response to external signals
    • Li, Z., Nair, S.K., Quorum sensing: how bacteria can coordinate activity and synchronize their response to external signals. Protein Sci 21 (2012), 1403–1417.
    • (2012) Protein Sci , vol.21 , pp. 1403-1417
    • Li, Z.1    Nair, S.K.2
  • 82
    • 80051626877 scopus 로고    scopus 로고
    • Innate immunity in the respiratory epithelium
    • Parker, D., Prince, A., Innate immunity in the respiratory epithelium. Am J Respir Cell Mol Biol 45 (2011), 189–201.
    • (2011) Am J Respir Cell Mol Biol , vol.45 , pp. 189-201
    • Parker, D.1    Prince, A.2
  • 83
    • 84896740586 scopus 로고    scopus 로고
    • Host-microbial interactions in patients with chronic rhinosinusitis
    • Hamilos, D.L., Host-microbial interactions in patients with chronic rhinosinusitis. J Allergy Clin Immunol 133 (2014), 640–653.
    • (2014) J Allergy Clin Immunol , vol.133 , pp. 640-653
    • Hamilos, D.L.1
  • 85
    • 26444491047 scopus 로고    scopus 로고
    • Resistance to antibiotics: are we in the post-antibiotic era
    • Alanis, A.J., Resistance to antibiotics: are we in the post-antibiotic era. Arch Med Res 36 (2005), 697–705.
    • (2005) Arch Med Res , vol.36 , pp. 697-705
    • Alanis, A.J.1
  • 86
    • 0037024691 scopus 로고    scopus 로고
    • National Ambulatory Medical Care Survey: 2000 summary
    • Cherry, D.K., Woodwell, D.A., National Ambulatory Medical Care Survey: 2000 summary. Adv Data, 2002, 1–32.
    • (2002) Adv Data , pp. 1-32
    • Cherry, D.K.1    Woodwell, D.A.2
  • 87
    • 0037019117 scopus 로고    scopus 로고
    • National Hospital Ambulatory Medical Care Survey: 2000 outpatient department summary
    • Ly, N., McCaig, L.F., National Hospital Ambulatory Medical Care Survey: 2000 outpatient department summary. Adv Data, 2002, 1–27.
    • (2002) Adv Data , pp. 1-27
    • Ly, N.1    McCaig, L.F.2
  • 88
    • 0033017152 scopus 로고    scopus 로고
    • Healthcare expenditures for sinusitis in 1996: contributions of asthma, rhinitis, and other airway disorders
    • Ray, N.F., Baraniuk, J.N., Thamer, M., et al. Healthcare expenditures for sinusitis in 1996: contributions of asthma, rhinitis, and other airway disorders. J Allergy Clin Immunol 103 (1999), 408–414.
    • (1999) J Allergy Clin Immunol , vol.103 , pp. 408-414
    • Ray, N.F.1    Baraniuk, J.N.2    Thamer, M.3
  • 89
    • 84858815725 scopus 로고    scopus 로고
    • Recurrent acute rhinosinusitis: epidemiology and health care cost burden
    • Bhattacharyya, N., Grebner, J., Martinson, N.G., Recurrent acute rhinosinusitis: epidemiology and health care cost burden. Otolaryngol Head Neck Surg 146 (2012), 307–312.
    • (2012) Otolaryngol Head Neck Surg , vol.146 , pp. 307-312
    • Bhattacharyya, N.1    Grebner, J.2    Martinson, N.G.3
  • 90
    • 84882967387 scopus 로고    scopus 로고
    • Antibiotic resistance: a “dark side” of biofilm-associated chronic infections
    • Marcinkiewicz, J., Strus, M., Pasich, E., Antibiotic resistance: a “dark side” of biofilm-associated chronic infections. Pol Arch Med Wewn 123 (2013), 309–313.
    • (2013) Pol Arch Med Wewn , vol.123 , pp. 309-313
    • Marcinkiewicz, J.1    Strus, M.2    Pasich, E.3
  • 91
    • 84890962955 scopus 로고    scopus 로고
    • Chronic rhinosinusitis and antibiotics: the good, the bad, and the ugly
    • Kennedy, J.L., Borish, L., Chronic rhinosinusitis and antibiotics: the good, the bad, and the ugly. Am J Rhinol Allergy 27 (2013), 467–472.
    • (2013) Am J Rhinol Allergy , vol.27 , pp. 467-472
    • Kennedy, J.L.1    Borish, L.2
  • 93
    • 84858678454 scopus 로고    scopus 로고
    • Bacteriology and antibiotic resistance in chronic rhinosinusitis
    • Manes, R.P., Batra, P.S., Bacteriology and antibiotic resistance in chronic rhinosinusitis. Facial Plast Surg Clin North Am 20 (2012), 87–91.
    • (2012) Facial Plast Surg Clin North Am , vol.20 , pp. 87-91
    • Manes, R.P.1    Batra, P.S.2
  • 95
    • 49849095285 scopus 로고    scopus 로고
    • Assessment of trends in antimicrobial resistance in chronic rhinosinusitis
    • Bhattacharyya, N., Kepnes, L.J., Assessment of trends in antimicrobial resistance in chronic rhinosinusitis. Ann Otol Rhinol Laryngol 117 (2008), 448–452.
    • (2008) Ann Otol Rhinol Laryngol , vol.117 , pp. 448-452
    • Bhattacharyya, N.1    Kepnes, L.J.2
  • 96
    • 4344592126 scopus 로고    scopus 로고
    • The microbiology and antimicrobial resistance patterns in chronic rhinosinusitis
    • Kingdom, T.T., Swain, R.E., The microbiology and antimicrobial resistance patterns in chronic rhinosinusitis. Am J Otolaryngol 25 (2004), 323–328.
    • (2004) Am J Otolaryngol , vol.25 , pp. 323-328
    • Kingdom, T.T.1    Swain, R.E.2
  • 97
    • 0022503120 scopus 로고
    • Possible mechanisms of reduction of nasal mucociliary clearance in chronic sinusitis
    • Majima, Y., Sakakura, Y., Matsubara, T., Miyoshi, Y., Possible mechanisms of reduction of nasal mucociliary clearance in chronic sinusitis. Clin Otolaryngol Allied Sci 11 (1986), 55–60.
    • (1986) Clin Otolaryngol Allied Sci , vol.11 , pp. 55-60
    • Majima, Y.1    Sakakura, Y.2    Matsubara, T.3    Miyoshi, Y.4
  • 98
    • 0031855106 scopus 로고    scopus 로고
    • Human nasal ciliary-beat frequency in normal and chronic sinusitis subjects
    • Braverman, I., Wright, E.D., Wang, C.G., Eidelman, D., Frenkiel, S., Human nasal ciliary-beat frequency in normal and chronic sinusitis subjects. J Otolaryngol 27 (1998), 145–152.
    • (1998) J Otolaryngol , vol.27 , pp. 145-152
    • Braverman, I.1    Wright, E.D.2    Wang, C.G.3    Eidelman, D.4    Frenkiel, S.5
  • 99
    • 33746149026 scopus 로고    scopus 로고
    • Altered sinonasal ciliary dynamics in chronic rhinosinusitis
    • Chen, B., Shaari, J., Claire, S.E., et al. Altered sinonasal ciliary dynamics in chronic rhinosinusitis. Am J Rhinol 20 (2006), 325–329.
    • (2006) Am J Rhinol , vol.20 , pp. 325-329
    • Chen, B.1    Shaari, J.2    Claire, S.E.3
  • 100
    • 84980332255 scopus 로고    scopus 로고
    • Correlation of T2R38 taste phenotype and in vitro biofilm formation from nonpolypoid chronic rhinosinusitis patients
    • Adappa, N.D., Truesdale, C.M., Workman, A.D., et al. Correlation of T2R38 taste phenotype and in vitro biofilm formation from nonpolypoid chronic rhinosinusitis patients. Int Forum Allergy Rhinol 6 (2016), 783–791.
    • (2016) Int Forum Allergy Rhinol , vol.6 , pp. 783-791
    • Adappa, N.D.1    Truesdale, C.M.2    Workman, A.D.3
  • 101
    • 84891595945 scopus 로고    scopus 로고
    • The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery
    • Adappa, N.D., Zhang, Z., Palmer, J.N., et al. The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery. Int Forum Allergy Rhinol 4 (2014), 3–7.
    • (2014) Int Forum Allergy Rhinol , vol.4 , pp. 3-7
    • Adappa, N.D.1    Zhang, Z.2    Palmer, J.N.3
  • 102
    • 84875042411 scopus 로고    scopus 로고
    • Genetics of the taste receptor T2R38 correlates with chronic rhinosinusitis necessitating surgical intervention
    • Adappa, N.D., Howland, T.J., Palmer, J.N., et al. Genetics of the taste receptor T2R38 correlates with chronic rhinosinusitis necessitating surgical intervention. Int Forum Allergy Rhinol 3 (2013), 184–187.
    • (2013) Int Forum Allergy Rhinol , vol.3 , pp. 184-187
    • Adappa, N.D.1    Howland, T.J.2    Palmer, J.N.3
  • 103
    • 84953786087 scopus 로고    scopus 로고
    • TAS2R38 genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis
    • Adappa, N.D., Farquhar, D., Palmer, J.N., et al. TAS2R38 genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis. Int Forum Allergy Rhinol 6 (2016), 25–33.
    • (2016) Int Forum Allergy Rhinol , vol.6 , pp. 25-33
    • Adappa, N.D.1    Farquhar, D.2    Palmer, J.N.3
  • 104
    • 84991783869 scopus 로고    scopus 로고
    • TAS2R38 taste receptor gene and chronic rhinosinusitis: new data from an Italian population
    • Gallo, S., Grossi, S., Montrasio, G., et al. TAS2R38 taste receptor gene and chronic rhinosinusitis: new data from an Italian population. BMC Med Genet, 17, 2016, 54.
    • (2016) BMC Med Genet , vol.17 , pp. 54
    • Gallo, S.1    Grossi, S.2    Montrasio, G.3
  • 105
    • 84994681089 scopus 로고    scopus 로고
    • The correlation of TAS2R38 gene variants with higher risk for chronic rhinosinusitis in Polish patients
    • Dżaman, K., Zagor, M., Sarnowska, E., Krzeski, A., Kantor, I., The correlation of TAS2R38 gene variants with higher risk for chronic rhinosinusitis in Polish patients. Otolaryngol Pol 70 (2016), 13–18.
    • (2016) Otolaryngol Pol , vol.70 , pp. 13-18
    • Dżaman, K.1    Zagor, M.2    Sarnowska, E.3    Krzeski, A.4    Kantor, I.5
  • 106
    • 85019199184 scopus 로고    scopus 로고
    • The impact of bitter taste receptor genetics on culturable bacteria in chronic rhinosinusitis
    • Rom, D.I., Christensen, J.M., Alvarado, R., Sacks, R., Harvey, R.J., The impact of bitter taste receptor genetics on culturable bacteria in chronic rhinosinusitis. Rhinology 55 (2017), 90–94.
    • (2017) Rhinology , vol.55 , pp. 90-94
    • Rom, D.I.1    Christensen, J.M.2    Alvarado, R.3    Sacks, R.4    Harvey, R.J.5
  • 107
    • 84938505828 scopus 로고    scopus 로고
    • Tasting Pseudomonas aeruginosa biofilms: human neutrophils express the bitter receptor T2R38 as sensor for the quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone
    • Maurer, S., Wabnitz, G.H., Kahle, N.A., et al. Tasting Pseudomonas aeruginosa biofilms: human neutrophils express the bitter receptor T2R38 as sensor for the quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone. Front Immunol, 6, 2015, 369.
    • (2015) Front Immunol , vol.6 , pp. 369
    • Maurer, S.1    Wabnitz, G.H.2    Kahle, N.A.3
  • 108
    • 85012929713 scopus 로고    scopus 로고
    • Sensing developing biofilms: the bitter receptor T2R38 on myeloid cells
    • Gaida, M.M., Dapunt, U., Hänsch, G.M., Sensing developing biofilms: the bitter receptor T2R38 on myeloid cells. Pathog Dis, 74, 2016.
    • (2016) Pathog Dis , vol.74
    • Gaida, M.M.1    Dapunt, U.2    Hänsch, G.M.3
  • 110
    • 85031682535 scopus 로고    scopus 로고
    • Bitter and sweet taste tests are reflective of disease status in chronic rhinosinusitis
    • pii: S2213-2198(17)30739-0. [Epub ahead of print]
    • Workman, A.D., Brooks, S.G., Kohanski, M.A., et al. Bitter and sweet taste tests are reflective of disease status in chronic rhinosinusitis. J Allergy Clin Immunol Pract, 2017 Oct 17, 10.1016/j.jaip.2017.09.014 pii: S2213-2198(17)30739-0. [Epub ahead of print].
    • (2017) J Allergy Clin Immunol Pract
    • Workman, A.D.1    Brooks, S.G.2    Kohanski, M.A.3
  • 111
    • 77649260272 scopus 로고    scopus 로고
    • Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals
    • Tizzano, M., Gulbransen, B.D., Vandenbeuch, A., et al. Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals. Proc Natl Acad Sci U S A 107 (2010), 3210–3215.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 3210-3215
    • Tizzano, M.1    Gulbransen, B.D.2    Vandenbeuch, A.3
  • 112
    • 84899050450 scopus 로고    scopus 로고
    • Cholinergic neurotransmission links solitary chemosensory cells to nasal inflammation
    • Saunders, C.J., Christensen, M., Finger, T.E., Tizzano, M., Cholinergic neurotransmission links solitary chemosensory cells to nasal inflammation. Proc Natl Acad Sci U S A 111 (2014), 6075–6080.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 6075-6080
    • Saunders, C.J.1    Christensen, M.2    Finger, T.E.3    Tizzano, M.4
  • 113
    • 84907448696 scopus 로고    scopus 로고
    • Sinonasal solitary chemosensory cells “taste” the upper respiratory environment to regulate innate immunity
    • Lee, R.J., Cohen, N.A., Sinonasal solitary chemosensory cells “taste” the upper respiratory environment to regulate innate immunity. Am J Rhinol Allergy 28 (2014), 366–373.
    • (2014) Am J Rhinol Allergy , vol.28 , pp. 366-373
    • Lee, R.J.1    Cohen, N.A.2
  • 114
    • 84868513768 scopus 로고    scopus 로고
    • Sweet talk: insights into the nature and importance of glucose transport in lung epithelium
    • Garnett, J.P., Baker, E.H., Baines, D.L., Sweet talk: insights into the nature and importance of glucose transport in lung epithelium. Eur Respir J 40 (2012), 1269–1276.
    • (2012) Eur Respir J , vol.40 , pp. 1269-1276
    • Garnett, J.P.1    Baker, E.H.2    Baines, D.L.3
  • 115
    • 84922394858 scopus 로고    scopus 로고
    • Fructose transport-deficient Staphylococcus aureus reveals important role of epithelial glucose transporters in limiting sugar-driven bacterial growth in airway surface liquid
    • Garnett, J.P., Braun, D., McCarthy, A.J., et al. Fructose transport-deficient Staphylococcus aureus reveals important role of epithelial glucose transporters in limiting sugar-driven bacterial growth in airway surface liquid. Cell Mol Life Sci 71 (2014), 4665–4673.
    • (2014) Cell Mol Life Sci , vol.71 , pp. 4665-4673
    • Garnett, J.P.1    Braun, D.2    McCarthy, A.J.3
  • 116
    • 79251636742 scopus 로고    scopus 로고
    • Glucose depletion in the airway surface liquid is essential for sterility of the airways
    • Pezzulo, A.A., Gutiérrez, J., Duschner, K.S., et al. Glucose depletion in the airway surface liquid is essential for sterility of the airways. PLoS One, 6, 2011, e16166.
    • (2011) PLoS One , vol.6 , pp. e16166
    • Pezzulo, A.A.1    Gutiérrez, J.2    Duschner, K.S.3
  • 117
    • 34247867897 scopus 로고
    • Hyperglycemia and cystic fibrosis alter respiratory fluid glucose concentrations estimated by breath condensate analysis
    • Baker, E.H., Clark, N., Brennan, A.L., et al. Hyperglycemia and cystic fibrosis alter respiratory fluid glucose concentrations estimated by breath condensate analysis. J Appl Physiol 2007:102 (1985), 1969–1975.
    • (1985) J Appl Physiol , vol.2007 , Issue.102 , pp. 1969-1975
    • Baker, E.H.1    Clark, N.2    Brennan, A.L.3
  • 119
    • 17644389240 scopus 로고    scopus 로고
    • Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste
    • Jiang, P., Cui, M., Zhao, B., et al. Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste. J Biol Chem 280 (2005), 15238–15246.
    • (2005) J Biol Chem , vol.280 , pp. 15238-15246
    • Jiang, P.1    Cui, M.2    Zhao, B.3
  • 120
    • 84887948601 scopus 로고    scopus 로고
    • The taste of D- and L-amino acids: in vitro binding assays with cloned human bitter (TAS2Rs) and sweet (TAS1R2/TAS1R3) receptors
    • Bassoli, A., Borgonovo, G., Caremoli, F., Mancuso, G., The taste of D- and L-amino acids: in vitro binding assays with cloned human bitter (TAS2Rs) and sweet (TAS1R2/TAS1R3) receptors. Food Chem 150 (2014), 27–33.
    • (2014) Food Chem , vol.150 , pp. 27-33
    • Bassoli, A.1    Borgonovo, G.2    Caremoli, F.3    Mancuso, G.4
  • 121
    • 84903820663 scopus 로고    scopus 로고
    • Bacterial synthesis of D-amino acids
    • Radkov, A.D., Moe, L.A., Bacterial synthesis of D-amino acids. Appl Microbiol Biotechnol 98 (2014), 5363–5374.
    • (2014) Appl Microbiol Biotechnol , vol.98 , pp. 5363-5374
    • Radkov, A.D.1    Moe, L.A.2
  • 122
    • 18744369608 scopus 로고    scopus 로고
    • Genes and molecules involved in Aspergillus fumigatus virulence
    • Rementeria, A., López-Molina, N., Ludwig, A., et al. Genes and molecules involved in Aspergillus fumigatus virulence. Rev Iberoam Micol 22 (2005), 1–23.
    • (2005) Rev Iberoam Micol , vol.22 , pp. 1-23
    • Rementeria, A.1    López-Molina, N.2    Ludwig, A.3
  • 124
    • 84875736516 scopus 로고    scopus 로고
    • Genetics of chronic rhinosinusitis: state of the field and directions forward
    • 993.e1–993.e5
    • Hsu, J., Avila, P.C., Kern, R.C., Hayes, M.G., Schleimer, R.P., Pinto, J.M., Genetics of chronic rhinosinusitis: state of the field and directions forward. J Allergy Clin Immunol 131 (2013), 977–993 993.e1–993.e5.
    • (2013) J Allergy Clin Immunol , vol.131 , pp. 977-993
    • Hsu, J.1    Avila, P.C.2    Kern, R.C.3    Hayes, M.G.4    Schleimer, R.P.5    Pinto, J.M.6
  • 125
    • 79953247858 scopus 로고    scopus 로고
    • Polymorphisms in the nitric oxide synthase 1 gene are associated with severe chronic rhinosinusitis
    • Zhang, Y., Endam, L.M., Filali-Mouhim, A., Bossé Y., Castano, R., Desrosiers, M., Polymorphisms in the nitric oxide synthase 1 gene are associated with severe chronic rhinosinusitis. Am J Rhinol Allergy 25 (2011), e49–e54.
    • (2011) Am J Rhinol Allergy , vol.25 , pp. e49-e54
    • Zhang, Y.1    Endam, L.M.2    Filali-Mouhim, A.3    Bossé, Y.4    Castano, R.5    Desrosiers, M.6
  • 127
    • 85040741361 scopus 로고    scopus 로고
    • Bitter substances from plants used in traditional Chinese medicine exert biased activation of human bitter taste receptors
    • Behrens, M., Gu, M., Fan, S., Huang, C., Meyerhof, W., Bitter substances from plants used in traditional Chinese medicine exert biased activation of human bitter taste receptors. Chem Biol Drug Des 91 (2018), 422–433.
    • (2018) Chem Biol Drug Des , vol.91 , pp. 422-433
    • Behrens, M.1    Gu, M.2    Fan, S.3    Huang, C.4    Meyerhof, W.5
  • 128
    • 84877317364 scopus 로고    scopus 로고
    • Amino acid regulation of autophagy through the GPCR TAS1R1–TAS1R3
    • Wauson, E.M., Zaganjor, E., Cobb, M.H., Amino acid regulation of autophagy through the GPCR TAS1R1–TAS1R3. Autophagy 9 (2013), 418–419.
    • (2013) Autophagy , vol.9 , pp. 418-419
    • Wauson, E.M.1    Zaganjor, E.2    Cobb, M.H.3
  • 129
    • 84866846953 scopus 로고    scopus 로고
    • The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy
    • Wauson, E.M., Zaganjor, E., Lee, A.Y., et al. The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy. Mol Cell. 47 (2012), 851–862.
    • (2012) Mol Cell. , vol.47 , pp. 851-862
    • Wauson, E.M.1    Zaganjor, E.2    Lee, A.Y.3
  • 130
    • 84901849511 scopus 로고    scopus 로고
    • Role of nutrient-sensing taste 1 receptor (T1R) family members in gastrointestinal chemosensing
    • Shirazi-Beechey, S.P., Daly, K., Al-Rammahi, M., Moran, A.W., Bravo, D., Role of nutrient-sensing taste 1 receptor (T1R) family members in gastrointestinal chemosensing. Br J Nutr 111:suppl 1 (2014), S8–S15.
    • (2014) Br J Nutr , vol.111 , pp. S8-S15
    • Shirazi-Beechey, S.P.1    Daly, K.2    Al-Rammahi, M.3    Moran, A.W.4    Bravo, D.5
  • 131
    • 84859478593 scopus 로고    scopus 로고
    • G-protein-coupled receptors in intestinal chemosensation
    • Reimann, F., Tolhurst, G., Gribble, F.M., G-protein-coupled receptors in intestinal chemosensation. Cell Metab 15 (2012), 421–431.
    • (2012) Cell Metab , vol.15 , pp. 421-431
    • Reimann, F.1    Tolhurst, G.2    Gribble, F.M.3
  • 132
    • 79960786009 scopus 로고    scopus 로고
    • Gut bitter taste receptor signalling induces ABCB1 through a mechanism involving CCK
    • Jeon, T.I., Seo, Y.K., Osborne, T.F., Gut bitter taste receptor signalling induces ABCB1 through a mechanism involving CCK. Biochem J 438 (2011), 33–37.
    • (2011) Biochem J , vol.438 , pp. 33-37
    • Jeon, T.I.1    Seo, Y.K.2    Osborne, T.F.3
  • 134
    • 42249094149 scopus 로고    scopus 로고
    • Taste cells of the gut and gastrointestinal chemosensation
    • Egan, J.M., Margolskee, R.F., Taste cells of the gut and gastrointestinal chemosensation. Mol Interv 8 (2008), 78–81.
    • (2008) Mol Interv , vol.8 , pp. 78-81
    • Egan, J.M.1    Margolskee, R.F.2
  • 135
    • 58049095069 scopus 로고    scopus 로고
    • Bitter taste receptors influence glucose homeostasis
    • Dotson, C.D., Zhang, L., Xu, H., et al. Bitter taste receptors influence glucose homeostasis. PLoS One, 3, 2008, e3974.
    • (2008) PLoS One , vol.3 , pp. e3974
    • Dotson, C.D.1    Zhang, L.2    Xu, H.3
  • 136
    • 35448986920 scopus 로고    scopus 로고
    • Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1
    • Jang, H.J., Kokrashvili, Z., Theodorakis, M.J., et al. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A 104 (2007), 15069–15074.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 15069-15074
    • Jang, H.J.1    Kokrashvili, Z.2    Theodorakis, M.J.3
  • 139
    • 85011923274 scopus 로고    scopus 로고
    • Taste and smell GPCRs in the lung: evidence for a previously unrecognized widespread chemosensory system
    • An, S.S., Liggett, S.B., Taste and smell GPCRs in the lung: evidence for a previously unrecognized widespread chemosensory system. Cell Signal 41 (2018), 82–88.
    • (2018) Cell Signal , vol.41 , pp. 82-88
    • An, S.S.1    Liggett, S.B.2
  • 141
    • 84865126124 scopus 로고    scopus 로고
    • TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis
    • An, S.S., Wang, W.C., Koziol-White, C.J., et al. TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis. Am J Physiol Lung Cell Mol Physiol 303 (2012), L304–L311.
    • (2012) Am J Physiol Lung Cell Mol Physiol , vol.303 , pp. L304-L311
    • An, S.S.1    Wang, W.C.2    Koziol-White, C.J.3
  • 142
    • 78149355561 scopus 로고    scopus 로고
    • Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction
    • Deshpande, D.A., Wang, W.C., McIlmoyle, E.L., et al. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat Med 16 (2010), 1299–1304.
    • (2010) Nat Med , vol.16 , pp. 1299-1304
    • Deshpande, D.A.1    Wang, W.C.2    McIlmoyle, E.L.3
  • 143
    • 79952138344 scopus 로고    scopus 로고
    • Bitter taste receptors and α-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying
    • Janssen, S., Laermans, J., Verhulst, P.J., Thijs, T., Tack, J., Depoortere, I., Bitter taste receptors and α-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying. Proc Natl Acad Sci U S A 108 (2011), 2094–2099.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 2094-2099
    • Janssen, S.1    Laermans, J.2    Verhulst, P.J.3    Thijs, T.4    Tack, J.5    Depoortere, I.6
  • 144
    • 70350352914 scopus 로고    scopus 로고
    • Epithelium, cilia, and mucus: their importance in chronic rhinosinusitis
    • Antunes, M.B., Gudis, D.A., Cohen, N.A., Epithelium, cilia, and mucus: their importance in chronic rhinosinusitis. Immunol Allergy Clin North Am 29 (2009), 631–643.
    • (2009) Immunol Allergy Clin North Am , vol.29 , pp. 631-643
    • Antunes, M.B.1    Gudis, D.A.2    Cohen, N.A.3
  • 145
    • 34247558990 scopus 로고    scopus 로고
    • Nitric oxide-dependent cilia regulatory enzyme localization in bovine bronchial epithelial cells
    • Stout, S.L., Wyatt, T.A., Adams, J.J., Sisson, J.H., Nitric oxide-dependent cilia regulatory enzyme localization in bovine bronchial epithelial cells. J Histochem Cytochem 55 (2007), 433–442.
    • (2007) J Histochem Cytochem , vol.55 , pp. 433-442
    • Stout, S.L.1    Wyatt, T.A.2    Adams, J.J.3    Sisson, J.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.