Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

Science

Volumn 351, Issue 6279, 2016, Pages 1329-1333

  Howitt, Michael R ^a   Lavoie, Sydney ^a   Michaud, Monia ^a   Blum, Arthur M ^b   Tran, Sara V ^c   Weinstock, Joel V ^b   Gallini, Carey Ann ^a   Redding, Kevin ^c   Margolskee, Robert F ^c   Osborne, Lisa C ^d,g   Artis, David ^d   Garrett, Wendy S ^a,e,f  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c MONELL CHEMICAL SENSES CENTER   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f DANA FARBER CANCER INSTITUTE   (United States)

^g UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 25; INTERLEUKIN 33; THYMIC STROMAL LYMPHOPOIETIN; UVOMORULIN; DCAMKL1 PROTEIN, MOUSE; GUSTDUCIN; INTERLEUKIN 17; PROTEIN SERINE THREONINE KINASE; TRANSDUCIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM5 PROTEIN, MOUSE;

CELLS AND CELL COMPONENTS; COLONIZATION; DIGESTIVE SYSTEM; EUKARYOTE; HOST-PARASITE INTERACTION; INFECTIVITY; MICROBIAL ACTIVITY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL EXPANSION; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOSYMBIOSIS; EOSINOPHIL; EPITHELIUM CELL; GOBLET CELL; HELMINTHIASIS; HOST PARASITE INTERACTION; INNATE IMMUNITY; INTESTINE CELL; INTESTINE EPITHELIUM; INTESTINE FLORA; INTESTINE PARASITE; LYMPHOID CELL; MICROBIAL COLONIZATION; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SMALL INTESTINE; TASTE CHEMOSENSORY CELL; TUFT CELL; ANIMAL; C57BL MOUSE; CHEMORECEPTOR CELL; GENETICS; HELMINTH; IMMUNOLOGY; INTESTINE INFECTION; INTESTINE MUCOSA; MICROFLORA; MUTANT MOUSE STRAIN; PARASITOLOGY; PROTOZOAL INFECTION; SIGNAL TRANSDUCTION; TASTE; TRITRICHOMONAS;

EUKARYOTA; MAMMALIA; PROTOZOA; VERMES;

ANIMALS; CHEMORECEPTOR CELLS; EOSINOPHILS; GOBLET CELLS; HELMINTHIASIS; HELMINTHS; IMMUNITY, MUCOSAL; INTERLEUKIN-13; INTERLEUKIN-17; INTESTINAL DISEASES, PARASITIC; INTESTINAL MUCOSA; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICROBIOTA; PROTEIN-SERINE-THREONINE KINASES; PROTOZOAN INFECTIONS; SIGNAL TRANSDUCTION; TASTE; TRANSDUCIN; TRITRICHOMONAS; TRPM CATION CHANNELS;

EID: 84958767810     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf1648     Document Type: Article

References (47)

1. K. S. Kobayashi et al., Science 307, 731-734 (2005).
2. S. Rakoff-Nahoum, J. Paglino, F. Eslami-Varzaneh, S. Edberg, R. Medzhitov, Cell 118, 229-241 (2004).
3. S. Vaishnava, C. L. Behrendt, A. S. Ismail, L. Eckmann, L. V. Hooper, Proc. Natl. Acad. Sci. U. S. A. 105, 20858-20863 (2008).
4. S. Vaishnava et al., Science 334, 255-258 (2011).
5. P. M. Smith et al., Science 341, 569-573 (2013).
6. M. H. Kim, S. G. Kang, J. H. Park, M. Yanagisawa, C. H. Kim, Gastroenterology 145, 396-406.e10 (2013).
7. Y. Zhang et al., Cell 112, 293-301 (2003).
8. P. K. Mishra, M. Palma, D. Bleich, P. Loke, W. C. Gause, Mucosal Immunol. 7, 753-762 (2014).
9. G. T. Wong, K. S. Gannon, R. F. Margolskee, Nature 381, 796-800 (1996).
10. R. J. Lee et al., J. Clin. Invest. 122, 4145-4159 (2012).
11. Y. Huang et al., Nat. Immunol. 16, 161-169 (2015).
12. S. D. Hurst et al., J. Immunol. 169, 443-453 (2002).
13. M. Tizzano et al., Proc. Natl. Acad. Sci. U. S. A. 107, 3210-3215 (2010).
14. R. J. Lee et al., J. Clin. Invest. 124, 1393-1405 (2014).
15. C. J. Saunders, M. Christensen, T. E. Finger, M. Tizzano, Proc. Natl. Acad. Sci. U. S. A. 111, 6075-6080 (2014).
16. C. Bezençon et al., J. Comp. Neurol. 509, 514-525 (2008).
17. L. W. Peterson, D. Artis, Nat. Rev. Immunol. 14, 141-153 (2014).
18. W. Meyerhof et al., Chem. Senses 35, 157-170 (2010).
19. F. Gerbe et al., J. Cell Biol. 192, 767-780 (2011).
20. C. B. Westphalen et al., J. Clin. Invest. 124, 1283-1295 (2014).
21. F. Gerbe, C. Legraverend, P. Jay, Cell. Mol. Life Sci. 69, 2907-2917 (2012).
22. Z. Kang et al., Immunity 36, 821-833 (2012).
23. M. Bjerknes et al., Dev. Biol. 362, 194-218 (2012).
24. I. I. Ivanov et al., Cell 139, 485-498 (2009).
25. G. J. McKenzie, A. Bancroft, R. K. Grencis, A. N. J. McKenzie, Curr. Biol. 8, 339-342 (1998).
26. J. F. Urban Jr. et al., Immunity 8, 255-264 (1998).
27. D. G. Baker, in Flynn's Parasites of Laboratory Animals, D. G. Baker, Ed. (Blackwell Publishing, 2008), pp. 303-397.
28. H. Saeki, M. Togo, S. Imai, T. Ishii, Japan. J. Vet. Sci. 45, 151-156 (1983).
29. B. Schütz et al., Front. Physiol. 6, 87 (2015).
30. S. Kusumakshi et al., Chem. Senses 40, 413-425 (2015).
31. C. A. Pérez et al., Nat. Neurosci. 5, 1169-1176 (2002).
32. W. I. Khan, P. Blennerhasset, C. Ma, K. I. Matthaei, S. M. Collins, Parasite Immunol. 23, 39-42 (2001).
33. J. von Moltke, M. Ji, H. E. Liang, R. M. Locksley, Nature 529, 221-225 (2016).
34. F. Gerbe et al., Nature 529, 226-230 (2016).
35. D. R. Neill et al., Nature 464, 1367-1370 (2010).
36. S. A. Saenz et al., Nature 464, 1362-1366 (2010).
37. H. Miyoshi, T. S. Stappenbeck, Nat. Protoc. 8, 2471-2482 (2013).
38. T. Sato et al., Nature 459, 262-265 (2009).
39. P. G. Fallon et al., J. Exp. Med. 203, 1105-1116 (2006).
40. H.-E. Liang et al., Nat. Immunol. 13, 58-66 (2012).
41. A. E. Price et al., Proc. Natl. Acad. Sci. U. S. A. 107, 11489-11494 (2010).
42. L. W. Parfrey et al., Front. Microbiol. 5, 298 (2014).
43. P. J. Hotez et al., J. Clin. Invest. 118, 1311-1321 (2008).
44. L. C. Osborne et al., Science 345, 578-582 (2014).
45. T. A. Reese et al., Science 345, 573-577 (2014).
46. H. Helmby, R. K. Grencis, Eur. J. Immunol. 33, 2974-2979 (2003).
47. L. A. Reynolds et al., J. Immunol. 193, 2984-2993 (2014).