Solitary chemosensory cells and bitter taste receptor signaling in human sinonasal mucosa

International Forum of Allergy and Rhinology

Volumn 3, Issue 6, 2013, Pages 450-457

  Barham, Henry P ^a,b   Cooper, Sarah E ^a,b   Anderson, Catherine B ^a,b   Tizzano, Marco ^a,b   Kingdom, Todd T ^a,b   Finger, Tom E ^a,b   Kinnamon, Sue C ^a,b   Ramakrishnan, Vijay R ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Bitter taste transduction; Inflammation; Respiratory epithelium; Rhinitis; Rhinosinusitis; SNOT 22; Solitary chemosensory cell

Indexed keywords

ALPHA GUSTDUCIN; PHOSPHOLIPASE BETA2; PROTEIN; TASTE RECEPTOR TYPE 2; TRANSIENT RECEPTOR POTENTIAL CHANNEL M5; UNCLASSIFIED DRUG;

ADULT; AGED; ALLERGIC RHINITIS; ARTICLE; CHRONIC RHINOSINUSITIS; CLINICAL ARTICLE; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; MALE; NASAL BIOPSY; NOSE MUCOSA; NOSE SEPTUM; NUCLEOTIDE SEQUENCE; PAIN; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION; SINO NASAL OUTCOME TEST 22; SOLITARY CHEMOSENSORY CELL; TASTE BUD; TURBINATE;

ADULT; AGED; CASE-CONTROL STUDIES; CHEMORECEPTOR CELLS; CHRONIC DISEASE; EPITHELIUM; FEMALE; HUMANS; MALE; MIDDLE AGED; NASAL MUCOSA; PAIN; PHOSPHOLIPASE C BETA; POLYMERASE CHAIN REACTION; RECEPTORS, G-PROTEIN-COUPLED; RHINITIS; RHINITIS, ALLERGIC, PERENNIAL; SINUSITIS; TRANSDUCIN; TRPM CATION CHANNELS;

EID: 84879700974     PISSN: 20426976     EISSN: 20426984     Source Type: Journal    
DOI: 10.1002/alr.21149     Document Type: Article

References (35)

1. Mattos JL, Woodard CR, Payne SC. Trends in common rhinologic illnesses: analysis of U.S. healthcare surveys 1995-2007. Int Forum Allergy Rhinol. 2011;1:3-12.
2. Bhattacharyya N. The economic burden and symptom manifestations of chronic rhinosinusitis. Am J Rhinol. 2003;17:27-32.
3. Benninger MS, Ferguson BJ, Hadley JA, et al. Adult chronic rhinosinusitis: definitions, diagnosis, epidemiology, and pathophysiology. Otolaryngol Head Neck Surg. 2003;129:S1-S32.
4. Jones NS. Sinogenic facial pain: diagnosis and management. Otolaryngol Clin North Am. 2005;38:1311-1325.
5. Gliklich RE, Metson R. The health impact of chronic sinusitis in patients seeking otolaryngologic care. Otolaryngol Head Neck Surg. 1995;113:104-109.
6. Fokkens W, Lund V, Mullol J. European Position Paper on Rhinosinusitis and Nasal Polyps group. European position paper on rhinosinusitis and nasal polyps. Rhinol Suppl. 2007;(20):1-136.
7. Finger TE, Bottger B, Hansen A, et al. Solitary chemoreceptor cells in the nasal cavity serve as sentinels of respiration. Proc Natl Acad Sci USA. 2003;100:8981-8986.
8. Tizzano M, Finger TE. Nasal epithelium inflammation: involvement of solitary chemosensory cells after short term presentation of the irritating compound denatonium benzoate. Chem Senses. 2012:Abst #p49 (2013).
9. Tizzano M, Cristofoletti M, Sbarbati A, Finger TE. Expression of taste receptors in solitary chemosensory cells of rodent airways. BMC Pulm Med. 2011;11:3.
10. Tizzano M, Gulbransen BD, Vandenbeuch A, et al. Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals. Proc Natl Acad Sci USA. 2010;107:3210-3215.
11. Gulbransen BD, Clapp TR, Finger TE, Kinnamon SC. Nasal solitary chemoreceptor cell responses to bitter and trigeminal stimulants in vitro. J Neurophysiol. 2008;99:2929-2937.
12. Finger TE, Kinnamon SC. Taste isn't just for taste buds anymore. F1000 Biol Rep. 2011;3:20.
13. Kinnamon SC. Taste receptor signaling - from tongues to lungs. Acta Physiol (Oxf). 2012;204:158-168.
14. Ogura T, Krosnowski K, Zhang L, et al. Chemoreception regulates chemical access to mouse vomeronasal organ: role of solitary chemosensory cells. PLoS One. 2010;5:e11924.
15. Krasteva G, Canning BJ, Hartmann P, et al. Cholinergic chemosensory cells in the trachea regulate breathing. Proc Natl Acad Sci USA. 2011;108:9478-9483.
16. Tizzano M, Merigo F, Sbarbati A. Evidence of solitary chemosensory cells in a large mammal: the diffuse chemosensory system in Bos Taurus airways. J Anat. 2006;209:333-337.
17. Meltzer EO, Hamilos DL, Hadley JA, et al. Rhinosinusitis: establishing definitions for clinical research and patient care. J Allergy Clin Immunol. 2004;114:155-212.
18. Lund VJ, Kennedy DW. Quantification for staging sinusitis. The Staging and Therapy Group. Ann Otol Rhinol Laryngol Suppl. 1995;167:17-21.
19. Lund VJ, Mackay IS. Staging in rhinosinusitus. Rhinology. 1993;31:183-184.
20. Paul A. Harris, Robert Taylor, Robert Thielke, et al. Research electronic data capture (REDCap) - a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42:377-381.
21. Lee BJ, Naclerio RM, Bochner BS, et al. Nasal challenge with allergen upregulates the local expression of vascular endothelial adhesion molecules. J Allergy Clin Immunol. 1994;94:1006-1016.
22. Liu F, Zhang J, Liu Y, et a. Inflammatory profiles in nasal mucosa of patients with persistent vs intermittent allergic rhinitis. Allergy. 2010;65:1149-1157.
23. Kennedy DW. Functional endoscopic sinus surgery: concepts, surgical indications, and instrumentation. In: Kennedy DW, Bolger WE, Zinreich SJ, eds. Diseases of the sinuses: diagnosis and management. 1st ed. Ontario: B.C. Decker, Inc.; 2001:197-210.
24. Keyhani K, Scherer PW, Mozell MM. Numerical simulation of airflow in the human nasal cavity. J Biomech Eng. 1995;117:429-441.
25. Schroeter JD, Kimbell JS, Asgharian B. Analysis of particle deposition in the turbinate and olfactory regions using a human nasal computational fluid dynamics model. J Aerosol Med. 2006;19:301-313.
26. Zhao K, Scherer PW, Hajiloo SA, Dalton P. Effect of anatomy on human nasal air flow and odorant transport patterns: implications for olfaction. Chem Senses. 2004;29:365-379.
27. Vandenbeuch A, Tizzano M, Anderson CB, et al. Evidence for a role of glutamate as an efferent transmitter in taste buds. BMC Neurosci. 2010;11:77.
28. Ozdener MH, Brand JG, Spielman AI, et al. Characterization of human fungiform papillae cells in culture. Chem Senses. 2011;36:601-612.
29. Zhang Z, Zhao Z, Margolskee R, Liman E. The transduction channel TRPM5 is gated by intracellular calcium in taste cells. J Neurosci. 2007;27:5777-5786.
30. Lee RJ, Xiong G, Kofonow JM, et.al. T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest. 2012;122:4145-4159.
31. Shah AS, Ben-Shahar Y, Moninger TO, et al. Motile cilia of human airway epithelia are chemosensory. Science. 2009;325:1131-1134.
32. Whitear M. Solitary chemoreceptor cells. In: Hara TJ, ed. Chemoreception in fishes. 2nd ed. London: Elsevier Press; 1992:103-125.
33. Braun T, Mack B, Kramer MF. Solitary chemosensory cells in the respiratory and vomeronasal epithelium of the human nose: a pilot study. Rhinology. 2011;49:507-512.
34. Gerth van Wijk RG, de Graaf-in 't Veld C, Garrelds IM. Nasal hyperreactivity. Rhinology. 1999;37:50-55.
35. Knipping S, Holzhausen HJ, Riederer A, Schrom T. Allergic and idiopathic rhinitis: an ultrastructural study. Eur Arch Otorhinolaryngol. 2009;266:1249-1256.