Insights into the binding of phenyltiocarbamide (PTC) agonist to its target human TAS2R38 bitter receptor

PLoS ONE

Volumn 5, Issue 8, 2010, Pages

  Biarnés, Xevi ^c   Marchiori, Alessandro ^e   Giorgetti, Alejandro ^b   Lanzara, Carmela ^e,f   Gasparini, Paolo ^e,f   Carloni, Paolo ^c,d   Born, Stephan ^a   Brockhoff, Anne ^a   Behrens, Maik ^a   Meyerhof, Wolfgang ^a  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b UNIVERSITY OF VERONA   (Italy)

^c SISSA   (Italy)

^d German Research School for Simulation Sciences ^*  (Germany)

^e UNIVERSITY OF TRIESTE   (Italy)

^f INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; PHENYLTHIOUREA; CALCIUM; LIGAND; TASTE RECEPTORS, TYPE 2;

ARTICLE; BINDING KINETICS; BINDING SITE; BITTER TASTE; CALCIUM CELL LEVEL; CONTROLLED STUDY; INTRACELLULAR SIGNALING; MEMBRANE MODEL; MEMBRANE STRUCTURE; MOLECULAR DOCKING; MOLECULAR INTERACTION; PREDICTION; RECEPTOR BINDING; RECEPTOR SENSITIVITY; RESIDUE ANALYSIS; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; STRUCTURAL BIOINFORMATICS; TASTE ACUITY; TASTE AVERSION; TASTE BUD; TASTE DISCRIMINATION; AMINO ACID SEQUENCE; BIOLOGY; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; GENETICS; HUMAN; INTRACELLULAR SPACE; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE;

AMINO ACID SEQUENCE; CALCIUM; CELL LINE; COMPUTATIONAL BIOLOGY; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INTRACELLULAR SPACE; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHENYLTHIOUREA; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, G-PROTEIN-COUPLED;

EID: 77957871915     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012394     Document Type: Article

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