Epithelium, Cilia, and Mucus: Their Importance in Chronic Rhinosinusitis

Immunology and Allergy Clinics of North America

Volumn 29, Issue 4, 2009, Pages 631-643

  Antunes, Marcelo B ^a   Gudis, David A ^a   Cohen, Noam A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Chronic rhinosinusitis; Cilia; Mucociliary clearance; Mucus; Respiratory epithelium

Indexed keywords

BASEMENT MEMBRANE; CHRONIC RHINOSINUSITIS; CILIARY DYSKINESIA; CILIARY MOTILITY; DISEASE COURSE; HUMAN; INFLAMMATION; INNATE IMMUNITY; MUCOCILIARY CLEARANCE; MUCOCILIARY TRANSPORT; MUCUS; MUCUS SECRETION; NOSE SECRETION; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT MUCOSA; REVIEW; RHINOSINUSITIS; UPPER RESPIRATORY TRACT INFECTION;

ANIMALS; CHRONIC DISEASE; CILIA; HUMANS; MUCUS; RESPIRATORY MUCOSA; RHINITIS; SINUSITIS;

EID: 70350352914     PISSN: 08898561     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.iac.2009.07.004     Document Type: Review

References (81)

1. Murphy M.P., Fishman P., Short S.O., et al. Health care utilization and cost among adults with chronic rhinosinusitis enrolled in a health maintenance organization. Otolaryngol Head Neck Surg 127 5 (2002) 367-376
2. Gliklich R.E., and Metson R. The health impact of chronic sinusitis in patients seeking otolaryngologic care. Otolaryngol Head Neck Surg 113 1 (1995) 104-109
3. Majima Y., Harada T., Shimizu T., et al. Effect of biochemical components on rheologic properties of nasal mucus in chronic sinusitis. Am J Respir Crit Care Med 160 2 (1999) 421-426
4. Majima Y., Sakakura Y., Matsubara T., et al. Possible mechanisms of reduction of nasal mucociliary clearance in chronic sinusitis. Clin Otolaryngol 11 2 (1986) 55-60
5. Atsuta S., and Majima Y. Nasal mucociliary clearance of chronic sinusitis in relation to rheological properties of nasal mucus. Ann Otol Rhinol Laryngol 107 1 (1998) 47-51
6. Majima Y., Sakakura Y., Matsubara T., et al. Mucociliary clearance in chronic sinusitis: related human nasal clearance and in vitro bullfrog palate clearance. Biorheology 20 2 (1983) 251-262
7. Joki S., Toskala E., Saano V., et al. Correlation between ciliary beat frequency and the structure of ciliated epithelia in pathologic human nasal mucosa. Laryngoscope 108 3 (1998) 426-430
8. Braverman I., Wright E.D., Wang C.G., et al. Human nasal ciliary-beat frequency in normal and chronic sinusitis subjects. J Otolaryngol 27 3 (1998) 145-152
9. Nuutinen J., Rauch-Toskala E., Saano V., et al. Ciliary beating frequency in chronic sinusitis. Arch Otolaryngol Head Neck Surg 119 6 (1993) 645-647
10. Chen B., Shaari J., Claire S.E., et al. Altered sinonasal ciliary dynamics in chronic rhinosinusitis. Am J Rhinol 20 3 (2006) 325-329
11. Dejima K., Randell S.H., Stutts M.J., et al. Potential role of abnormal ion transport in the pathogenesis of chronic sinusitis. Arch Otolaryngol Head Neck Surg 132 12 (2006) 1352-1362
12. Schleimer R.P., Kato A., Kern R., et al. Epithelium: at the interface of innate and adaptive immune responses. J Allergy Clin Immunol 120 6 (2007) 1279-1284
13. Wagenmann M., and Naclerio R.M. Anatomic and physiologic considerations in sinusitis. J Allergy Clin Immunol 90 3 Pt 2 (1992) 419-423
14. Busse W.W., and Holgate S.T. Asthma and rhinitis. 2nd edition (2000), Blackwell Science, Oxford; Malden (MA)
15. Eliezer N., Sade J., Silberberg A., et al. The role of mucus in transport by cilia. Am Rev Respir Dis 102 1 (1970) 48-52
16. 2. Am J Pathol 123 1 (1986) 126-133
17. Houtmeyers E., Gosselink R., Gayan-Ramirez G., et al. Regulation of mucociliary clearance in health and disease. Eur Respir J 13 5 (1999) 1177-1188
18. Satir P., and Sleigh M.A. The physiology of cilia and mucociliary interactions. Annu Rev Physiol 52 (1990) 137-155
19. Renthal R., Schneider B.G., Miller M.M., et al. Beta IV is the major beta-tubulin isotype in bovine cilia. Cell Motil Cytoskeleton 25 1 (1993) 19-29
20. Hard R., Blaustein K., and Scarcello L. Reactivation of outer-arm-depleted lung axonemes: evidence for functional differences between inner and outer dynein arms in situ. Cell Motil Cytoskeleton 21 3 (1992) 199-209
21. Brokaw C.J. Control of flagellar bending: a new agenda based on dynein diversity. Cell Motil Cytoskeleton 28 3 (1994) 199-204
22. Brokaw C.J., and Kamiya R. Bending patterns of Chlamydomonas flagella: IV. Mutants with defects in inner and outer dynein arms indicate differences in dynein arm function. Cell Motil Cytoskeleton 8 1 (1987) 68-75
23. Satir P., and Christensen S.T. Overview of structure and function of mammalian cilia. Annu Rev Physiolog 69 (2007) 377-400
24. Satir P., and Matsuoka T. Splitting the ciliary axoneme: implications for a "switch-point" model of dynein arm activity in ciliary motion. Cell Motil Cytoskeleton 14 3 (1989) 345-358
25. Sanderson M.J., and Sleigh M.A. Ciliary activity of cultured rabbit tracheal epithelium: beat pattern and metachrony. J Cell Sci 47 (1981) 331-347
26. Holwill M.E., Foster G.F., Hamasaki T., et al. Biophysical aspects and modelling of ciliary motility. Cell Motil Cytoskeleton 32 2 (1995) 114-120
27. Johnson N.T., Villalon M., Royce F.H., et al. Autoregulation of beat frequency in respiratory ciliated cells. Demonstration by viscous loading. Am Rev Respir Dis 144 5 (1991) 1091-1094
28. Satir P. The cilium as a biological nanomachine. FASEB J 13 Suppl 2 (1999) S235-S237
29. Lee C.H., Lee S.S., Mo J.H., et al. Comparison of ciliary wave disorders measured by image analysis and electron microscopy. Acta Otolaryngol 125 5 (2005) 571-576
30. Yeh T.H., Su M.C., Hsu C.J., et al. Epithelial cells of nasal mucosa express functional gap junctions of connexin 43. Acta Otolaryngol 123 2 (2003) 314-320
31. Barrera N.P., Morales B., and Villalon M. Plasma and intracellular membrane inositol 1,4,5-trisphosphate receptors mediate the Ca(2+) increase associated with the ATP-induced increase in ciliary beat frequency. Am J Physiol Cell Physiol 287 4 (2004) C1114-C1124
32. Gheber L., and Priel Z. Synchronization between beating cilia. Biophys J 55 1 (1989) 183-191
33. Hilding A.C. The role of the respiratory mucosa in health and disease. Minn Med 50 6 (1967) 915-919
34. Wong L.B., Miller I.F., and Yeates D.B. Stimulation of tracheal ciliary beat frequency by capsaicin. J Appl Physiol 68 6 (1990) 2574-2580
35. Jain B., Rubinstein I., Robbins R.A., et al. Modulation of airway epithelial cell ciliary beat frequency by nitric oxide. Biochem Biophys Res Commun 191 1 (1993) 83-88
36. Mwimbi X.K., Muimo R., Green M.W., et al. Making human nasal cilia beat in the cold: a real time assay for cell signalling. Cell Signal 15 4 (2003) 395-402
37. Schipor I., Palmer J.N., Cohen A.S., et al. Quantification of ciliary beat frequency in sinonasal epithelial cells using differential interference contrast microscopy and high-speed digital video imaging. Am J Rhinol 20 1 (2006) 124-127
38. 2+, purinergic signaling, tonicity, and viscosity. Am J Physiol Lung Cell Mol Physiol 292 (2007) L614-L624
39. Andrade Y.N., Fernandes J., Vazquez E., et al. TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity. J Cell Biol 168 6 (2005) 869-874
40. Sanderson M.J., and Dirksen E.R. Mechanosensitivity of cultured ciliated cells from the mammalian respiratory tract: implications for the regulation of mucociliary transport. Proc Natl Acad Sci U S A 83 19 (1986) 7302-7306
41. Jain B., Rubinstein I., Robbins R.A., et al. TNF-alpha and IL-1 beta upregulate nitric oxide-dependent ciliary motility in bovine airway epithelium. Am J Physiol 268 6 Pt 1 (1995) L911-L917
42. Korngreen A., Ma W., Priel Z., et al. Extracellular ATP directly gates a cation-selective channel in rabbit airway ciliated epithelial cells. J Physiol 508 Pt 3 (1998) 703-720
43. Sanderson M.J., and Dirksen E.R. Mechanosensitive and beta-adrenergic control of the ciliary beat frequency of mammalian respiratory tract cells in culture. Am Rev Respir Dis 139 2 (1989) 432-440
44. Sutto Z., Conner G.E., and Salathe M. Regulation of human airway ciliary beat frequency by intracellular pH. J Physiol 560 Pt 2 (2004) 519-532
45. Reddy M.M., Kopito R.R., and Quinton P.M. Cytosolic pH regulates GCl through control of phosphorylation states of CFTR. Am J Physiol 275 4 Pt 1 (1998) C1040-C1047
46. Keskes L., Giroux-Widemann V., Serres C., et al. The reactivation of demembranated human spermatozoa lacking outer dynein arms is independent of pH. Mol Reprod Dev 49 4 (1998) 416-425
47. Green A., Smallman L.A., Logan A.C., et al. The effect of temperature on nasal ciliary beat frequency. Clin Otolaryngol 20 2 (1995) 178-180
48. Picher M., and Boucher R.C. Human airway ecto-adenylate kinase. A mechanism to propagate ATP signaling on airway surfaces. J Biol Chem 278 13 (2003) 11256-11264
49. Wyatt T.A., and Sisson J.H. Chronic ethanol downregulates PKA activation and ciliary beating in bovine bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 281 3 (2001) L575-L581
50. Yang B., Schlosser R.J., and McCaffrey T.V. Dual signal transduction mechanisms modulate ciliary beat frequency in upper airway epithelium. Am J Physiol 270 5 Pt 1 (1996) L745-L751
51. Salathe M., Lipson E.J., Ivonnet P.I., et al. Muscarinic signaling in ciliated tracheal epithelial cells: dual effects on Ca2+ and ciliary beating. Am J Physiol 272 2 Pt 1 (1997) L301-L310
52. Zagoory O., Braiman A., and Priel Z. The mechanism of ciliary stimulation by acetylcholine: roles of calcium, PKA, and PKG. J Gen Physiol 119 4 (2002) 329-339
53. Wong L.B., Miller I.F., and Yeates D.B. Pathways of substance P stimulation of canine tracheal ciliary beat frequency. J Appl Physiol 70 1 (1991) 267-273
54. Wong L.B., Park C.L., and Yeates D.B. Neuropeptide Y inhibits ciliary beat frequency in human ciliated cells via nPKC, independently of PKA. Am J Physiol 275 2 Pt 1 (1998) C440-C448
55. Salathe M., and Bookman R.J. Coupling of [Ca2+]i and ciliary beating in cultured tracheal epithelial cells. J Cell Sci 108 Pt 2 (1995) 431-440
56. Korngreen A., and Priel Z. Simultaneous measurement of ciliary beating and intracellular calcium. Biophys J 67 1 (1994) 377-380
57. Lansley A.B., and Sanderson M.J. Regulation of airway ciliary activity by Ca2+: simultaneous measurement of beat frequency and intracellular Ca2+. Biophys J 77 1 (1999) 629-638
58. Braiman A., Zagoory O., and Priel Z. PKA induces Ca2+ release and enhances ciliary beat frequency in a Ca2+-dependent and -independent manner. Am J Physiol 275 3 Pt 1 (1998) C790-C797
59. Zhang L., and Sanderson M.J. The role of cGMP in the regulation of rabbit airway ciliary beat frequency. J Physiol 551 Pt 3 (2003) 765-776
60. Wyatt T.A., Spurzem J.R., May K., et al. Regulation of ciliary beat frequency by both PKA and PKG in bovine airway epithelial cells. Am J Physiol 275 4 Pt 1 (1998) L827-L835
61. Yang B., Schlosser R.J., and McCaffrey T.V. Signal transduction pathways in modulation of ciliary beat frequency by methacholine. Ann Otol Rhinol Laryngol 106 3 (1997) 230-236
62. Uzlaner N., and Priel Z. Interplay between the NO pathway and elevated [Ca2+]i enhances ciliary activity in rabbit trachea. J Physiol 516 Pt 1 (1999) 179-190
63. Mwimbi X.K., Muimo R., Green M., et al. Protein kinase C regulates the flow rate-dependent decline in human nasal ciliary beat frequency in vitro. J Aerosol Med 13 3 (2000) 273-279
64. Porter M.E., and Sale W.S. The 9 + 2 axoneme anchors multiple inner arm dyneins and a network of kinases and phosphatases that control motility. J Cell Biol 151 5 (2000) F37-F42
65. Kamiya R. Functional diversity of axonemal dyneins as studied in Chlamydomonas mutants. Int Rev Cytol 219 (2002) 115-155
66. Smith E.F. Regulation of flagellar dynein by the axonemal central apparatus. Cell Motil Cytoskeleton 52 1 (2002) 33-42
67. Tos M. Mucous elements in the nose. Rhinology 14 4 (1976) 155-162
68. Adkinson N.F., and Middleton E. Middleton's allergy: principles & practice. 6th edition (2003), Mosby, St. Louis
69. Lamblin G., Aubert J.P., Perini J.M., et al. Human respiratory mucins. Eur Respir J 5 2 (1992) 247-256
70. Baumgarten C.R., Togias A.G., Naclerio R.M., et al. Influx of kininogens into nasal secretions after antigen challenge of allergic individuals. J Clin Invest 76 1 (1985) 191-197
71. Donald P.J., Gluckman J.L., and Rice D.H. The sinuses (1995), Raven Press, New York
72. Accurso F.J. Update in cystic fibrosis 2005. Am J Respir Crit Care Med 173 9 (2006) 944-947
73. Wine J.J. The genesis of cystic fibrosis lung disease. J Clin Invest 103 3 (1999) 309-312
74. Van de Water T.R., and Staecker H. Otolaryngology: basic science and clinical review (2005), Thieme, New York
75. Jones N. The nose and paranasal sinuses physiology and anatomy. Adv Drug Deliv Rev 51 1-3 (2001) 5-19
76. Noone P.G., Leigh M.W., Sannuti A., et al. Primary ciliary dyskinesia: diagnostic and phenotypic features. Am J Respir Crit Care Med 169 4 (2004) 459-467
77. Rutland J., and de Iongh R.U. Random ciliary orientation. A cause of respiratory tract disease. N Engl J Med 323 24 (1990) 1681-1684
78. Ferguson J.L., McCaffrey T.V., Kern E.B., et al. The effects of sinus bacteria on human ciliated nasal epithelium in vitro. Otolaryngol Head Neck Surg 98 4 (1988) 299-304
79. Wilson R., Sykes D.A., Currie D., et al. Beat frequency of cilia from sites of purulent infection. Thorax 41 6 (1986) 453-458
80. Passali D., Ferri R., Becchini G., et al. Alterations of nasal mucociliary transport in patients with hypertrophy of the inferior turbinates, deviations of the nasal septum and chronic sinusitis. Eur Arch Otorhinolaryngol 256 7 (1999) 335-337
81. Chen B., Antunes M.B., Claire S.E., et al. Reversal of chronic rhinosinusitis-associated sinonasal ciliary dysfunction. Am J Rhinol 21 3 (2007) 346-353