TAS2R activation promotes airway smooth muscle relaxation despite β2-adrenergic receptor tachyphylaxis

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 303, Issue 4, 2012, Pages

  An, Steven S ^a   Wang, Wayne C H ^b   Koziol White, Cynthia J ^c   Ahn, Kwangmi ^d   Lee, Danielle Y ^a   Kurten, Richard C ^e   Panettieri, Reynold A ^c   Liggett, Stephen B ^f  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^f UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Airway smooth muscle; Asthma; Bitter taste receptor; Chloroquine

Indexed keywords

ACETYLCHOLINE; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BITTER TASTE RECEPTOR; CALCIUM ION; CARBACHOL; CHLOROQUINE; CYCLIC AMP; ISOPRENALINE; RECEPTOR; SALBUTAMOL; SALMETEROL; UNCLASSIFIED DRUG;

AIRWAY; AIRWAY CONSTRICTION; ANIMAL CELL; ARTICLE; BRONCHODILATATION; BRONCHOSPASM; BRONCHUS; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOMETRY; DESENSITIZATION; EX VIVO STUDY; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LONG TERM EXPOSURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RIGIDITY; SMOOTH MUSCLE RELAXATION; TACHYPHYLAXIS; TRACHEA;

EID: 84865126124     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00126.2012     Document Type: Article

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