Erratum: Food sources of fructose-containing sugars and glycaemic control: Systematic review and meta-analysis of controlled intervention studies (The BMJ (2018) 363 (k4644) DOI: 10.1136/bmj.k4644);Food sources of fructose-containing sugars and glycaemic control: Systematic review and meta-analysis of controlled intervention studies

The BMJ

Volumn 363, Issue , 2018, Pages

  Choo, Vivian L ^a,b,c   Viguiliouk, Effie ^a,b   Blanco Mejia, Sonia ^a,b   Cozma, Adrian I ^a,b   Khan, Tauseef A ^a,b   Ha, Vanessa ^a,d,e   Wolever, Thomas M S ^a,b,f   Leiter, Lawrence A ^a,b,f   Vuksan, Vladimir ^a,b,f   Kendall, Cyril W C ^a,b,g   De Souza, Russell J ^a,b,e   Jenkins, David J A ^a,b,f   Sievenpiper, John L ^a,b,f  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF CALGARY   (Canada)

^d QUEEN S UNIVERSITY   (Canada)

^e MCMASTER UNIVERSITY   (Canada)

^f ST MICHAEL'S HOSPITAL   (Canada)

^g UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FRUCTOSE; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; INSULIN; SUGAR; CORN SYRUP; HEMOGLOBIN A1C PROTEIN, HUMAN;

ARTICLE; DIABETES MELLITUS; DIET; ENERGY BALANCE; EVIDENCE BASED MEDICINE; FOOD; FRUIT; FRUIT JUICE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; MACRONUTRIENT; MILK; PRIORITY JOURNAL; SUGAR-SWEETENED BEVERAGE; SYSTEMATIC REVIEW; BEVERAGE; DIET RESTRICTION; FRUIT AND VEGETABLE JUICE; HONEY; META ANALYSIS; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; SUGAR INTAKE;

BEVERAGES; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIETARY SUGARS; FASTING; FRUCTOSE; FRUIT; FRUIT AND VEGETABLE JUICES; GLYCATED HEMOGLOBIN A; HIGH FRUCTOSE CORN SYRUP; HONEY; HUMANS; INSULIN;

EID: 85056916444     PISSN: 09598146     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.l5524     Document Type: Erratum

References (181)

1. Bray GA, Popkin BM. Dietary sugar and body weight: have we reached a crisis in the epidemic of obesity and diabetes?: health be damned! Pour on the sugar. Diabetes Care 2014;37:950-6. 10.2337/dc13-2085
2. Kahn R, Sievenpiper JL. Dietary sugar and body weight: have we reached a crisis in the epidemic of obesity and diabetes?: we have, but the pox on sugar is overwrought and overworked. Diabetes Care 2014;37:957-62. 10.2337/dc13-2506
3. Gross LS, Li L, Ford ES, Liu S. Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment. Am J Clin Nutr 2004;79:774-9. doi:10.1093/ajcn/79.5.774
4. Goran MI, Ulijaszek SJ, Ventura EE. High fructose corn syrup and diabetes prevalence: a global perspective. Glob Public Health 2013;8:55-64. doi:10.1080/17441692.2012. 736257
5. Bantle JP, Laine DC, Thomas JW. Metabolic effects of dietary fructose and sucrose in types I and II diabetic subjects. JAMA 1986;256:3241-6. doi:10.1001/ jama.1986.03380230065027
6. Lustig RH. Fructose: it's "alcohol without the buzz". Adv Nutr 2013;4:226-35. doi:10.3945/an.112.002998
7. Huang BW, Chiang MT, Yao HT, Chiang W. The effect of high-fat and high-fructose diets on glucose tolerance and plasma lipid and leptin levels in rats. Diabetes Obes Metab 2004;6:120-6. doi:10.1111/j.1462-8902.2004.00323.x
8. de Moura RF, Ribeiro C, de Oliveira JA, Stevanato E, de Mello MA. Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols. Br J Nutr 2009;101:1178-84. doi:10.1017/S0007114508066774
9. Hwang IS, Ho H, Hoffman BB, Reaven GM. Fructose-induced insulin resistance and hypertension in rats. Hypertension 1987;10:512-6. doi:10.1161/01.HYP.10.5.512
10. Hendler R, Bonde AA. Effects of sucrose on resting metabolic rate, nitrogen balance, leucine turnover and oxidation during weight loss with low calorie diets. Int J Obes 1990;14:927-38.
11. Hendler RG, Walesky M, Sherwin RS. Sucrose substitution in prevention and reversal of the fall in metabolic rate accompanying hypocaloric diets. Am J Med 1986;81:280-4. doi:10.1016/0002-9343(86)90264-0
12. Yudkin J, Szanto S. Increased levels of plasma insulin and eleven hydroxycorticosteroid induced by sucrose, and their reduction by phenformin. Hormone Metab Res 1972;4:417-20.
13. Cozma AI, Sievenpiper JL, de Souza RJ, et al. Effect of fructose on glycemic control in diabetes: a systematic review and meta-analysis of controlled feeding trials. Diabetes Care 2012;35:1611-20. doi:10.2337/dc12-0073
14. White JS. Challenging the fructose hypothesis: new perspectives on fructose consumption and metabolism. Adv Nutr 2013;4:246-56. doi:10.3945/an.112.003137
15. Theytaz F, de Giorgi S, Hodson L, et al. Metabolic fate of fructose ingested with and without glucose in a mixed meal. Nutrients 2014;6:2632-49. doi:10.3390/nu6072632
16. Imamura F, O'Connor L, Ye Z, et al. Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction. BMJ 2015;351:h3576. doi:10.1136/bmj.h3576
17. Greenwood DC, Threapleton DE, Evans CE, et al. Association between sugar-sweetened and artificially sweetened soft drinks and type 2 diabetes: systematic review and dose-response meta-analysis of prospective studies. Br J Nutr 2014;112:725-34. doi:10.1017/ S0007114514001329
18. Li S, Miao S, Huang Y, et al. Fruit intake decreases risk of incident type 2 diabetes: an updated meta-analysis. Endocrine 2015;48:454-60. doi:10.1007/s12020-014-0351-6
19. Muraki I, Imamura F, Manson JE, et al. Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies [correction in: BMJ 2013;347:f6935]. BMJ 2013;347:f5001. doi:10.1136/bmj.f5001
20. Manios Y, Moschonis G, Mavrogianni C, et al. Postprandial glucose and insulin levels in type 2 diabetes mellitus patients after consumption of ready-to-eat mixed meals. Eur J Nutr 2017;56:1359-67. doi:10.1007/s00394-016-1186-0
21. Sievenpiper JL, Dworatzek PD. Food and dietary patternbased recommendations: an emerging approach to clinical practice guidelines for nutrition therapy in diabetes. Can J Diabetes 2013;37:51-7. doi:10.1016/j.jcjd.2012.11.001
22. Guideline: sugars intake for adults and children. WHO Guidelines approved by the Guidelines Review Committee. Geneva, 2015. https://www.ncbi.nlm.nih.gov/books/NBK285537/pdf/Bookshelf- NBK285537.pdf
23. Scientific Advisory Committe on Nutrition. Carbohydrates and health. Stationery Office. 2015. https://www.gov.uk/government/ uploads/system/uploads/attachment-data/file/445503/SACN- Carbohydrates-and-Health.pdf.
24. Higgins JPT, Green S. Cochrane Handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. Cochrane Collaboration. https://handbook-5-1.cochrane.org/
25. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 2010;8:336-41. doi:10.1016/j. ijsu.2010.02.007
26. Wilczynski NL, Morgan D, Haynes RB, Hedges Team. An overview of the design and methods for retrieving high-quality studies for clinical care. BMC Med Inform Decis Mak 2005;5:20. doi:10.1186/1472-6947-5-20
27. Higgins JP, Altman DG, Gøtzsche PC, et al, Cochrane Bias Methods Group, Cochrane Statistical Methods Group. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011;343:d5928. doi:10.1136/bmj.d5928
28. Elbourne DR, Altman DG, Higgins JP, Curtin F, Worthington HV, Vail A. Meta-analyses involving cross-over trials: methodological issues. Int J Epidemiol 2002;31:140-9. doi:10.1093/ije/31.1.140
29. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-60. doi:10.1136/bmj.327.7414.557
30. Borenstein M, Hedges LV, Higgins JP, Rothstein HR. Introduction to meta-analysis. John Wiley & Sons, 2008.
31. Thompson SG, Higgins JP. How should meta-regression analyses be undertaken and interpreted? Stat Med 2002;21:1559-73. doi:10.1002/sim.1187
32. US Department of Health and Human Services and US Department of Agriculture. 2015-2020 dietary guidelines for Americans. 8th ed. December 2015. https://health.gov/dietaryguidelines/2015/ guidelines/.
33. USDA. Scientific Report of the 2015 Dietary Guidelines Advisory Committee. In: DGAC-USDA, ed. 2015. https://health.gov/ dietaryguidelines/2015-scientific-report/pdfs/scientific-report-ofthe-2015-dietary-guidelines-advisory-committee.pdf.
34. Institute of Medicine. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids. National Academies Press, 2005.
35. Sterne JA, Gavaghan D, Egger M. Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature. J Clin Epidemiol 2000;53:1119-29. doi:10.1016/S0895-4356(00)00242-0
36. Duval S, Tweedie R. Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 2000;56:455-63. doi:10.1111/j.0006-341X.2000.00455.x
37. Guyatt G, Oxman AD, Akl EA, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol 2011;64:383-94. doi:10.1016/j.jclinepi.2010.04.026
38. Abdel-Sayed A, Binnert C, Lê KA, Bortolotti M, Schneiter P, Tappy L. A high-fructose diet impairs basal and stress-mediated lipid metabolism in healthy male subjects. Br J Nutr 2008;100:393-9. doi:10.1017/S000711450789547X
39. Abdulrhman MM, El-Hefnawy MH, Aly RH, et al. Metabolic effects of honey in type 1 diabetes mellitus: a randomized crossover pilot study. J Med Food 2013;16:66-72. doi:10.1089/jmf.2012.0108
40. Abraira C, Derler J. Large variations of sucrose in constant carbohydrate diets in type II diabetes. Am J Med 1988;84:193-200. doi:10.1016/0002-9343(88)90413-5
41. Aeberli I, Gerber PA, Hochuli M, et al. Low to moderate sugar-sweetened beverage consumption impairs glucose and lipid metabolism and promotes inflammation in healthy young men: a randomized controlled trial. Am J Clin Nutr 2011;94:479-85. doi:10.3945/ajcn.111.013540
42. Aeberli I, Hochuli M, Berneis K. Response to comment on: Aeberli et al. Moderate amounts of fructose consumption impair insulin sensitivity in healthy young men: a randomized controlled trial. Diabetes Care 2013;36:150-156. Diabetes Care 2013;36:e105. doi:10.2337/dc13-0299
43. Agebratt C, Ström E, Romu T, et al. A randomized study of the effects of additional fruit and nuts consumption on hepatic fat content, cardiovascular risk factors and basal metabolic rate. PLoS One 2016;11:e0147149. doi:10.1371/journal.pone.0147149
44. Anderson JW, Story LJ, Zettwoch NC, Gustafson NJ, Jefferson BS. Metabolic effects of fructose supplementation in diabetic individuals. Diabetes Care 1989;12:337-44. doi:10.2337/ diacare.12.5.337
45. Anderson JW, Weiter KM, Christian AL, Ritchey MB, Bays HE. Raisins compared with other snack effects on glycemia and blood pressure: a randomized, controlled trial. Postgrad Med 2014;126:37-43. doi:10.3810/pgm.2014.01.2723
46. Bahrami M, Ataie-Jafari A, Hosseini S, Foruzanfar MH, Rahmani M, Pajouhi M. Effects of natural honey consumption in diabetic patients: an 8-week randomized clinical trial. Int J Food Sci Nutr 2009;60:618-26. doi:10.3109/09637480801990389
47. Banini AE, Boyd LC, Allen JC, Allen HG, Sauls DL. Muscadine grape products intake, diet and blood constituents of non-diabetic and type 2 diabetic subjects. Nutrition 2006;22:1137-45. doi:10.1016/j. nut.2006.08.012
48. Bantle JP, Raatz SK, Thomas W, Georgopoulos A. Effects of dietary fructose on plasma lipids in healthy subjects. Am J Clin Nutr 2000;72:1128-34. doi:10.1093/ajcn/72.5.1128
49. Bantle JP, Swanson JE, Thomas W, Laine DC. Metabolic effects of dietary fructose in diabetic subjects. Diabetes Care 1992;15:1468-76. doi:10.2337/diacare.15.11.1468
50. Bantle JP, Swanson JE, Thomas W, Laine DC. Metabolic effects of dietary sucrose in type II diabetic subjects. Diabetes Care 1993;16:1301-5. doi:10.2337/diacare.16.9.1301
51. Basu A, Du M, Leyva MJ, et al. Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. J Nutr 2010;140:1582-7. doi:10.3945/jn.110.124701
52. Bays H, Weiter K, Anderson J. A randomized study of raisins versus alternative snacks on glycemic control and other cardiovascular risk factors in patients with type 2 diabetes mellitus. Phys Sportsmed 2015;43:37-43. doi:10.1080/00913847.2015.998410
53. Beck-Nielsen H, Pedersen O, Lindskov HO. Impaired cellular insulin binding and insulin sensitivity induced by high-fructose feeding in normal subjects. Am J Clin Nutr 1980;33:273-8. doi:10.1093/ ajcn/33.2.273
54. Behall KM, Moser PB, Kelsay JL, Prather ES. The effect of kind of carbohydrate in the diet and use of oral contraceptives on metabolism of young women. III. Serum glucose, insulin, and glucagon. Am J Clin Nutr 1980;33:1041-8. doi:10.1093/ ajcn/33.5.1041
55. Black RN, Spence M, McMahon RO, et al. Effect of eucaloric high-and low-sucrose diets with identical macronutrient profile on insulin resistance and vascular risk: a randomized controlled trial. Diabetes 2006;55:3566-72. doi:10.2337/db06-0220
56. Blayo A, Fontevieille S, Rizkalla S, Bruzzo F, Slama G. Effets métaboliques de la consommation quotidienne pendant un an de saccharose ou de fructose par des diabétiques. Med Nutr 1990;26:11-4.
57. Brymora A, Flisi?ski M, Johnson RJ, Goszka G, Stefa?ska A, Manitius J. Low-fructose diet lowers blood pressure and inflammation in patients with chronic kidney disease. Nephrol Dial Transplant 2012;27:608-12. doi:10.1093/ndt/gfr223
58. Brynes AE, Mark Edwards C, Ghatei MA, et al. A randomised fourintervention crossover study investigating the effect of carbohydrates on daytime profiles of insulin, glucose, non-esterified fatty acids and triacylglycerols in middle-aged men. Br J Nutr 2003;89:207-18. doi:10.1079/BJN2002769
59. Buysschaert M, Sory R, Mpoy M, Lambert AE. Effect of the addition of simple sugars to mixed meals on the glycemic control of insulin treated diabetic patients. Diabete Metab 1987;13:625-9.
60. Campos V, Despland C, Brandejsky V, et al. Sugar-and artificially sweetened beverages and intrahepatic fat: A randomized controlled trial. Obesity (Silver Spring) 2015;23:2335-9. doi:10.1002/ oby.21310
61. Chantelau EA, Gösseringer G, Sonnenberg GE, Berger M. Moderate intake of sucrose does not impair metabolic control in pump-treated diabetic out-patients. Diabetologia 1985;28:204-7. doi:10.1007/ BF00282233
62. Christensen AS, Viggers L, Hasselström K, Gregersen S. Effect of fruit restriction on glycemic control in patients with type 2 diabetes-a randomized trial. Nutr J 2013;12:29. doi:10.1186/1475-2891-12-29
63. Claesson AL, Holm G, Ernersson A, Lindström T, Nystrom FH. Two weeks of overfeeding with candy, but not peanuts, increases insulin levels and body weight. Scand J Clin Lab Invest 2009;69:598-605. doi:10.1080/00365510902912754
64. Colagiuri S, Miller JJ, Edwards RA. Metabolic effects of adding sucrose and aspartame to the diet of subjects with noninsulin-dependent diabetes mellitus. Am J Clin Nutr 1989;50:474-8. doi:10.1093/ ajcn/50.3.474
65. Conceição de Oliveira M, Sichieri R, Sanchez Moura A. Weight loss associated with a daily intake of three apples or three pears among overweight women. Nutrition 2003;19:253-6. doi:10.1016/S0899-9007(02)00850-X
66. Cooper PL, Wahlqvist ML, Simpson RW. Sucrose versus saccharin as an added sweetener in non-insulin-dependent diabetes: short-and medium-term metabolic effects. Diabet Med 1988;5:676-80. doi:10.1111/j.1464-5491.1988.tb01079.x
67. Costa PC, Franco LJ. [Introduction of sucrose in the diet plan of persons with type 1 diabetes: its influence in the glycemic control]. Arq Bras Endocrinol Metabol 2005;49:403-9. doi:10.1590/S0004-27302005000300012
68. Coulston AM, Hollenbeck CB, Donner CC, Williams R, Chiou YA, Reaven GM. Metabolic effects of added dietary sucrose in individuals with noninsulin-dependent diabetes mellitus (NIDDM). Metabolism 1985;34:962-6. doi:10.1016/0026-0495(85)90146-5
69. Cressey R, Kumsaiyai W, Mangklabruks A. Daily consumption of banana marginally improves blood glucose and lipid profile in hypercholesterolemic subjects and increases serum adiponectin in type 2 diabetic patients. Indian J Exp Biol 2014;52:1173-81.
70. Despland C, Walther B, Kast C, et al. A randomized-controlled clinical trial of high fructose diets from either Robinia honey or free fructose and glucose in healthy normal weight males. Clin Nutr ESPEN 2017;19:16-22. doi:10.1016/j.clnesp.2017.01.009.
71. Dunnigan MG, Fyfe T, McKiddie MT, Crosbie SM. The effects of isocaloric exchange of dietary starch and sucrose on glucose tolerance, plasma insulin and serum lipids in man. Clin Sci 1970;38:1-9. doi:10.1042/cs0380001
72. Ellis CL, Edirisinghe I, Kappagoda T, Burton-Freeman B. Attenuation of meal-induced inflammatory and thrombotic responses in overweight men and women after 6-week daily strawberry (Fragaria) intake. A randomized placebo-controlled trial. J Atheroscler Thromb 2011;18:318-27. doi:10.5551/jat.6114
73. Emanuele MA, Abraira C, Jellish WS, DeBartolo M. A crossover trial of high and low sucrose-carbohydrate diets in type II diabetics with hypertriglyceridemia. J Am Coll Nutr 1986;5:429-37. doi:10.1080/0 7315724.1986.10720145
74. Enginyurt O, Cakir L, Karatas A, et al. The role of pure honey in the treatment of diabetes mellitus. Biomedical Research (India) 2017;28:3305-12.
75. Friedman M, Rosenman RH, Byers SO, Elevitch FR. Effect of low sugar intake upon blood lipids and insulin levels of hyperlipemic subjects. Proc Soc Exp Biol Med 1970;135:785-91. doi:10.3181/00379727-135-35144
76. Fry AJ. The effect of a 'sucrose-free' diet on oral glucose tolerance in man. Nutr Metab 1972;14:313-23. doi:10.1159/000175395
77. Grigoresco C, Rizkalla SW, Halfon P, et al. Lack of detectable deleterious effects on metabolic control of daily fructose ingestion for 2 mo in NIDDM patients. Diabetes Care 1988;11:546-50. doi:10.2337/diacare.11.7.546
78. Hallfrisch J, Ellwood KC, Michaelis OE4th, Reiser S, O'Dorisio TM, Prather ES. Effects of dietary fructose on plasma glucose and hormone responses in normal and hyperinsulinemic men. J Nutr 1983;113:1819-26. doi:10.1093/jn/113.9.1819
79. Heden TD, Liu Y, Park YM, Nyhoff LM, Winn NC, Kanaley JA. Moderate amounts of fructose-or glucose-sweetened beverages do not differentially alter metabolic health in male and female adolescents. Am J Clin Nutr 2014;100:796-805. doi:10.3945/ajcn.113.081232
80. Heden TD, Liu Y, Park YM, Winn NC, Kanaley JA. Walking reduces postprandial insulin secretion in obese adolescents consuming a high-fructose or high-glucose diet. J Phys Act Health 2015;12:1153-61. doi:10.1123/jpah.2014-0105
81. Hegde SV, Adhikari P, M N, D'Souza V. Effect of daily supplementation of fruits on oxidative stress indices and glycaemic status in type 2 diabetes mellitus. Complement Ther Clin Pract 2013;19:97-100. doi:10.1016/j.ctcp.2012.12.002
82. Hernández-Cordero S, Barquera S, Rodríguez-Ramírez S, et al. Substituting water for sugar-sweetened beverages reduces circulating triglycerides and the prevalence of metabolic syndrome in obese but not in overweight Mexican women in a randomized controlled trial. J Nutr 2014;144:1742-52. doi:10.3945/jn.114.193490
83. Hollis JH, Houchins JA, Blumberg JB, Mattes RD. Effects of concord grape juice on appetite, diet, body weight, lipid profile, and antioxidant status of adults. J Am Coll Nutr 2009;28:574-82. doi:10.1080/07315724.2009.10719789
84. Huttunen JK, Mäkinen KK, Scheinin A. Turku sugar studies XI. Effects of sucrose, fructose and xylitol diets on glucose, lipid and urate metabolism. Acta Odontol Scand 1976;34:345-51. doi:10.3109/00016357609004646
85. Jellish WS, Emanuele MA, Abraira C. Graded sucrose/ carbohydrate diets in overtly hypertriglyceridemic diabetic patients. Am J Med 1984;77:1015-22. doi:10.1016/0002-9343(84)90181-5
86. Jin R, Welsh JA, Le NA, et al. Dietary fructose reduction improves markers of cardiovascular disease risk in Hispanic-American adolescents with NAFLD. Nutrients 2014;6:3187-201. doi:10.3390/nu6083187
87. Jones JB, Provost M, Keaver L, Breen C, Ludy MJ, Mattes RD. A randomized trial on the effects of flavorings on the health benefits of daily peanut consumption. Am J Clin Nutr 2014;99:490-6. doi:10.3945/ajcn.113.069401
88. Johnston RD, Stephenson MC, Crossland H, et al. No difference between high-fructose and high-glucose diets on liver triacylglycerol or biochemistry in healthy overweight men. Gastroenterology 2013;145:1016-25 e2.
89. Kaliora AC, Kokkinos A, Diolintzi A, et al. The effect of minimal dietary changes with raisins in NAFLD patients with non-significant fibrosis: a randomized controlled intervention. Food Funct 2016;7:4533-44. doi:10.1039/C6FO01040G
90. Kanellos PT, Kaliora AC, Tentolouris NK, et al. A pilot, randomized controlled trial to examine the health outcomes of raisin consumption in patients with diabetes. Nutrition 2014;30:358-64. doi:10.1016/j.nut.2013.07.020
91. Kelsay JL, Behall KM, Holden JM, Prather ES. Diets high in glucose or sucrose and young women. Am J Clin Nutr 1974;27:926-36. doi:10.1093/ajcn/27.9.926
92. Koh ET, Ard NF, Mendoza F. Effects of fructose feeding on blood parameters and blood pressure in impaired glucose-tolerant subjects. J Am Diet Assoc 1988;88:932-8.
93. Koivisto VA, Yki-Järvinen H. Fructose and insulin sensitivity in patients with type 2 diabetes. J Intern Med 1993;233:145-53. doi:10.1111/j.1365-2796.1993.tb00667.x
94. Kolehmainen M, Mykkänen O, Kirjavainen PV, et al. Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome. Mol Nutr Food Res 2012;56:1501-10. doi:10.1002/ mnfr.201200195
95. Koopman KE, Caan MW, Nederveen AJ, et al. Hypercaloric diets with increased meal frequency, but not meal size, increase intrahepatic triglycerides: a randomized controlled trial. Hepatology 2014;60:545-53. doi:10.1002/hep.27149
96. Lê KA, Faeh D, Stettler R, et al. A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans. Am J Clin Nutr 2006;84:1374-9. doi:10.1093/ ajcn/84.6.1374
97. Lê KA, Ith M, Kreis R, et al. Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes. Am J Clin Nutr 2009;89:1760-5. doi:10.3945/ajcn.2008.27336
98. Lehtonen HM, Suomela JP, Tahvonen R, et al. Berry meals and risk factors associated with metabolic syndrome. Eur J Clin Nutr 2010;64:614-21. doi:10.1038/ejcn.2010.27
99. Lewis AS, McCourt HJ, Ennis CN, et al. Comparison of 5% versus 15% sucrose intakes as part of a eucaloric diet in overweight and obese subjects: effects on insulin sensitivity, glucose metabolism, vascular compliance, body composition and lipid profile. A randomised controlled trial. Metabolism 2013;62:694-702. doi:10.1016/j. metabol.2012.11.008
100. Liu G, Coulston A, Hollenbeck C, Reaven G. The effect of sucrose content in high and low carbohydrate diets on plasma glucose, insulin, and lipid responses in hypertriglyceridemic humans. J Clin Endocrinol Metab 1984;59:636-42. doi:10.1210/jcem-59-4-636
101. Lock S, Ford MA, Bagley R, Green LF. The effect on plasma lipids of the isoenergetic replacement of table sucrose by dried glucose syrup (maize-syrup solids) in the normal diet of adult men over a period of 1 year. Br J Nutr 1980;43:251-6. doi:10.1079/BJN19800088
102. Lowndes J, Sinnett SS, Rippe JM. No Effect of Added Sugar Consumed at Median American Intake Level on Glucose Tolerance or Insulin Resistance. Nutrients 2015;7:8830-45. doi:10.3390/nu7105430
103. Madero M, Arriaga JC, Jalal D, et al. The effect of two energy-restricted diets, a low-fructose diet versus a moderate natural fructose diet, on weight loss and metabolic syndrome parameters: a randomized controlled trial. Metabolism 2011;60:1551-9. doi:10.1016/j. metabol.2011.04.001
104. Maersk M, Belza A, Stødkilde-Jørgensen H, et al. Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study. Am J Clin Nutr 2012;95:283-9. doi:10.3945/ajcn.111.022533
105. Majid M, Younis MA, Naveed AK, Shah MU, Azeem Z, Tirmizi SH. Effects of natural honey on blood glucose and lipid profile in young healthy Pakistani males. J Ayub Med Coll Abbottabad 2013;25:44-7.
106. Maki KC, Nieman KM, Schild AL, et al. Sugar-sweetened product consumption alters glucose homeostasis compared with dairy product consumption in men and women at risk of type 2 diabetes mellitus. J Nutr 2015;145:459-66. doi:10.3945/ jn.114.204503
107. Malerbi DA, Paiva ES, Duarte AL, Wajchenberg BL. Metabolic effects of dietary sucrose and fructose in type II diabetic subjects. Diabetes Care 1996;19:1249-56. doi:10.2337/diacare.19.11.1249
108. Mark AB, Poulsen MW, Andersen S, et al. Consumption of a diet low in advanced glycation end products for 4 weeks improves insulin sensitivity in overweight women. Diabetes Care 2014;37:88-95. doi:10.2337/dc13-0842
109. Markey O, Le Jeune J, Lovegrove JA. Energy compensation following consumption of sugar-reduced products: a randomized controlled trial. Eur J Nutr 2016;55:2137-49.
110. McAteer EJ, O'Reilly G, Hadden DR. The effects of one month high fructose intake on plasma glucose and lipid levels in non-insulin-dependent diabetes. Diabet Med 1987;4:62-4. doi:10.1111/j.1464-5491.1987.tb00831.x
111. Mitsou EK, Kougia E, Nomikos T, Yannakoulia M, Mountzouris KC, Kyriacou A. Effect of banana consumption on faecal microbiota: a randomised, controlled trial. Anaerobe 2011;17:384-7. doi:10.1016/j.anaerobe.2011.03.018
112. Moazen S, Amani R, Homayouni Rad A, Shahbazian H, Ahmadi K, Taha Jalali M. Effects of freeze-dried strawberry supplementation on metabolic biomarkers of atherosclerosis in subjects with type 2 diabetes: a randomized double-blind controlled trial. Ann Nutr Metab 2013;63:256-64. doi:10.1159/000356053
113. Ngo Sock ET, Lê KA, Ith M, Kreis R, Boesch C, Tappy L. Effects of a short-term overfeeding with fructose or glucose in healthy young males. Br J Nutr 2010;103:939-43. doi:10.1017/ S0007114509992819
114. Njike VY, Faridi Z, Shuval K, et al. Effects of sugar-sweetened and sugar-free cocoa on endothelial function in overweight adults. Int J Cardiol 2011;149:83-8. doi:10.1016/j.ijcard.2009.12.010
115. Osei K, Bossetti B. Dietary fructose as a natural sweetener in poorly controlled type 2 diabetes: a 12-month crossover study of effects on glucose, lipoprotein and apolipoprotein metabolism. Diabet Med 1989;6:506-11. doi:10.1111/j.1464-5491.1989. tb01218.x
116. Osei K, Falko J, Bossetti BM, Holland GC. Metabolic effects of fructose as a natural sweetener in the physiologic meals of ambulatory obese patients with type II diabetes. Am J Med 1987;83:249-55. doi:10.1016/0002-9343(87)90693-0
117. Paganus A, Mäenpää J, Akerblom HK, Stenman UH, Knip M, Simell O. Beneficial effects of palatable guar and guar plus fructose diets in diabetic children. Acta Paediatr Scand 1987;76:76-81. doi:10.1111/j.1651-2227.1987.tb10418.x
118. Paineau DL, Beaufils F, Boulier A, et al. Family dietary coaching to improve nutritional intakes and body weight control: a randomized controlled trial. Arch Pediatr Adolesc Med 2008;162:34-43. doi:10.1001/archpediatrics.2007.2
119. Pelkonen R, Aro A, Nikkilä EA. Metabolic effects of dietary fructose in insulin dependent diabetes of adults. Acta Med Scand Suppl 1972;542:187-93.
120. Peterson DB, Lambert J, Gerring S, et al. Sucrose in the diet of diabetic patients-just another carbohydrate? Diabetologia 1986;29:216-20. doi:10.1007/BF00454878
121. Poppitt SD, Keogh GF, Prentice AM, et al. Long-term effects of ad libitum low-fat, high-carbohydrate diets on body weight and serum lipids in overweight subjects with metabolic syndrome. Am J Clin Nutr 2002;75:11-20. doi:10.1093/ajcn/75.1.11
122. Porta M, Pigino M, Minonne A, Morisio Guidetti L. Moderate amounts of sucrose with mixed meals do not impair metabolic control in patients with type II (non-insulin dependent) diabetes. Diabetes Nutr Metab 1989;2:133-7.
123. Puglisi MJ, Vaishnav U, Shrestha S, et al. Raisins and additional walking have distinct effects on plasma lipids and inflammatory cytokines. Lipids Health Dis 2008;7:14. doi:10.1186/1476-511X-7-14
124. Raben A, Astrup A. Leptin is influenced both by predisposition to obesity and diet composition. Int J Obes Relat Metab Disord 2000;24:450-9.
125. Raben A, Møller BK, Flint A, et al. Increased postprandial glycaemia, insulinemia, and lipidemia after 10 weeks' sucrose-rich diet compared to an artificially sweetened diet: a randomised controlled trial. Food Nutr Res 2011;55:55. doi:10.3402/fnr.v55i0.5961
126. Rath R, Masek J, Kujalová V, Slabochová Z. Effect of a high sugar intake on some metabolic and regulatory indicators in young men. Nahrung 1974;18:343-53. doi:10.1002/food.19740180402
127. Ravn-Haren G, Dragsted LO, Buch-Andersen T, et al. Intake of whole apples or clear apple juice has contrasting effects on plasma lipids in healthy volunteers. Eur J Nutr 2013;52:1875-89. doi:10.1007/s00394-012-0489-z
128. Reiser S, Hallfrisch J, Fields M, et al. Effects of sugars on indices of glucose tolerance in humans. Am J Clin Nutr 1986;43:151-9. doi:10.1093/ajcn/43.1.151
129. Reiser S, Powell AS, Scholfield DJ, Panda P, Fields M, Canary JJ. Day-long glucose, insulin, and fructose responses of hyperinsulinemic and nonhyperinsulinemic men adapted to diets containing either fructose or high-amylose cornstarch. Am J Clin Nutr 1989;50:1008-14. doi:10.1093/ajcn/50.5.1008
130. Ribeiro C, Dourado G, Cesar T. Orange juice allied to a reducedcalorie diet results in weight loss and ameliorates obesity-related biomarkers: A randomized controlled trial. Nutrition 2017;38:13-9. doi:10.1016/j.nut.2016.12.020
131. Rodríguez MC, Parra MD, Marques-Lopes I, De Morentin BE, González A, Martínez JA. Effects of two energy-restricted diets containing different fruit amounts on body weight loss and macronutrient oxidation. Plant Foods Hum Nutr 2005;60:219-24. doi:10.1007/s11130-005-8622-2
132. Santacroce G, Forlani G, Giangiulio S, Galuppi V, Pagani M, Vannini P. Long-term effects of eating sucrose on metabolic control of type 1 (insulin-dependent) diabetic outpatients. Acta Diabetol Lat 1990;27:365-70. doi:10.1007/BF02580942
133. Saris WH, Astrup A, Prentice AM, et al. Randomized controlled trial of changes in dietary carbohydrate/fat ratio and simple vs complex carbohydrates on body weight and blood lipids: the CARMEN study. The Carbohydrate Ratio Management in European National diets. Int J Obes Relat Metab Disord 2000;24:1310-8.
134. Schwarz JM, Noworolski SM, Wen MJ, et al. Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat. J Clin Endocrinol Metab 2015;100:2434-42. doi:10.1210/jc.2014-3678
135. Schwingshandl J, Rippel S, Unterluggauer M, Borkenstein M. Effect of the introduction of dietary sucrose on metabolic control in children and adolescents with type I diabetes. Acta Diabetol 1994;31:205-9. doi:10.1007/BF00571952
136. Silbernagel G, Machann J, Unmuth S, et al. Effects of 4-week veryhigh-fructose/glucose diets on insulin sensitivity, visceral fat and intrahepatic lipids: an exploratory trial. Br J Nutr 2011;106:79-86. doi:10.1017/S000711451000574X
137. Singh RB, Rastogi SS, Singh R, Niaz MA, Singh NK, Madhu SV. Effects on plasma ascorbic acid and coronary risk factors of adding guava fruit to the usual diet in hypertensives with mild to moderate hypercholesterolaemia. J Nutr Environ Med 1997;7:5-14. doi:10.1080/13590849762754.
138. Sobrecases H, Lê KA, Bortolotti M, et al. Effects of short-term overfeeding with fructose, fat and fructose plus fat on plasma and hepatic lipids in healthy men. Diabetes Metab 2010;36:244-6. doi:10.1016/j.diabet.2010.03.003
139. Souto DL, Zajdenverg L, Rodacki M, Rosado EL. Does sucrose intake affect antropometric variables, glycemia, lipemia and C-reactive protein in subjects with type 1 diabetes?: a controlled-trial. Diabetol Metab Syndr 2013;5:67. doi:10.1186/1758-5996-5-67
140. Stanhope KL, Griffen SC, Bremer AA, et al. Metabolic responses to prolonged consumption of glucose-and fructose-sweetened beverages are not associated with postprandial or 24-h glucose and insulin excursions. Am J Clin Nutr 2011;94:112-9. doi:10.3945/ ajcn.110.002246
141. Stanhope KL, Bremer AA, Medici V, et al. Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDLcholesterol, and apolipoprotein-B in young men and women. J Clin Endocrinol Metab 2011;96:E1596-605. doi:10.1210/jc.2011-1251
142. Sunehag AL, Toffolo G, Campioni M, Bier DM, Haymond MW. Short-term high dietary fructose intake had no effects on insulin sensitivity and secretion or glucose and lipid metabolism in healthy, obese adolescents. J Pediatr Endocrinol Metab 2008;21:225-35. doi:10.1515/JPEM.2008.21.3.225
143. Sunehag AL, Toffolo G, Treuth MS, et al. Effects of dietary macronutrient content on glucose metabolism in children. J Clin Endocrinol Metab 2002;87:5168-78. doi:10.1210/jc.2002-020674
144. Surwit RS, Feinglos MN, McCaskill CC, et al. Metabolic and behavioral effects of a high-sucrose diet during weight loss. Am J Clin Nutr 1997;65:908-15. doi:10.1093/ajcn/65.4.908
145. Swanson JE, Laine DC, Thomas W, Bantle JP. Metabolic effects of dietary fructose in healthy subjects. Am J Clin Nutr 1992;55:851-6. doi:10.1093/ajcn/55.4.851
146. Swarbrick MM, Stanhope KL, Elliott SS, et al. Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese women. Br J Nutr 2008;100:947-52. doi:10.1017/ S0007114508968252
147. Szanto S, Yudkin J. The effect of dietary sucrose on blood lipids, serum insulin, platelet adhesiveness and body weight in human volunteers. Postgrad Med J 1969;45:602-7. doi:10.1136/ pgmj.45.527.602
148. Tate DF, Turner-McGrievy G, Lyons E, et al. Replacing caloric beverages with water or diet beverages for weight loss in adults: main results of the Choose Healthy Options Consciously Everyday (CHOICE) randomized clinical trial. Am J Clin Nutr 2012;95:555-63. doi:10.3945/ajcn.111.026278
149. Vaisman N, Niv E, Izkhakov Y. Catalytic amounts of fructose may improve glucose tolerance in subjects with uncontrolled non-insulin-dependent diabetes. Clin Nutr 2006;25:617-21. doi:10.1016/j.clnu.2005.11.013
150. van Meijl LE, Mensink RP. Low-fat dairy consumption reduces systolic blood pressure, but does not improve other metabolic risk parameters in overweight and obese subjects. Nutr Metab Cardiovasc Dis 2011;21:355-61. doi:10.1016/j.numecd.2009.10.008
151. Volp AC, Hermsdorff HH, Bressan J. Glycemia and insulinemia evaluation after high-sucrose and high-fat diets in lean and overweight/obese women. J Physiol Biochem 2008;64:103-13. doi:10.1007/BF03168238
152. Volp AC, Hermsdorff HM, Bressan J. [Effect of high sucrose-and highfat diets ingested under free-living conditions in insulin resistance in normal weight and overweight women]. Nutr Hosp 2007;22:46-60.
153. Lin L, Chu H, Hodges JS. Alternative measures of between-study heterogeneity in meta-analysis: Reducing the impact of outlying studies. Biometrics 2017;73:156-66. doi:10.1111/biom.12543
154. Livesey G, Taylor R. Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies. Am J Clin Nutr 2008;88:1419-37.
155. Sievenpiper JL. Sickeningly sweet: does sugar cause chronic disease? No. Can J Diabetes 2016;40:287-95. doi:10.1016/j. jcjd.2016.05.006
156. Tsilas CS, de Souza RJ, Mejia SB, et al. Relation of total sugars, fructose and sucrose with incident type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies. CMAJ 2017;189:E711-20.
157. Atkinson FS, Foster-Powell K, Brand-Miller JC. International tables of glycemic index and glycemic load values: 2008. Diabetes Care 2008;31:2281-3. doi:10.2337/dc08-1239
158. Livesey G, Taylor R, Hulshof T, Howlett J. Glycemic response and health-a systematic review and meta-analysis: relations between dietary glycemic properties and health outcomes. Am J Clin Nutr 2008;87:258S-68S. doi:10.1093/ajcn/87.1.258S
159. Brand-Miller JC, Petocz P, Colagiuri S. Meta-analysis of low-glycemic index diets in the management of diabetes: response to Franz. Diabetes Care 2003;26:3363-4, author reply 3364-5. doi:10.2337/diacare.26.12.3363
160. Jenkins DJ, Wolever TM, Collier GR, et al. Metabolic effects of a low-glycemic-index diet. Am J Clin Nutr 1987;46:968-75. doi:10.1093/ajcn/46.6.968
161. Ford ES, Liu S. Glycemic index and serum high-density lipoprotein cholesterol concentration among us adults. Arch Intern Med 2001;161:572-6. doi:10.1001/archinte.161.4.572
162. Liu S, Manson JE, Stampfer MJ, et al. Dietary glycemic load assessed by food-frequency questionnaire in relation to plasma high-density-lipoprotein cholesterol and fasting plasma triacylglycerols in postmenopausal women. Am J Clin Nutr 2001;73:560-6. doi:10.1093/ajcn/73.3.560
163. Lattimer JM, Haub MD. Effects of dietary fiber and its components on metabolic health. Nutrients 2010;2:1266-89. doi:10.3390/nu2121266
164. Jenkins DJ, Srichaikul K, Kendall CW, et al. The relation of low glycaemic index fruit consumption to glycaemic control and risk factors for coronary heart disease in type 2 diabetes. Diabetologia 2011;54:271-9. doi:10.1007/s00125-010-1927-1
165. Hawkins M, Gabriely I, Wozniak R, Vilcu C, Shamoon H, Rossetti L. Fructose improves the ability of hyperglycemia per se to regulate glucose production in type 2 diabetes. Diabetes 2002;51:606-14. doi:10.2337/diabetes.51.3.606
166. Petersen KF, Laurent D, Yu C, Cline GW, Shulman GI. Stimulating effects of low-dose fructose on insulin-stimulated hepatic glycogen synthesis in humans. Diabetes 2001;50:1263-8. doi:10.2337/ diabetes.50.6.1263
167. Braunstein CR, Noronha JC, Glenn AJ, et al. A double-blind, randomized controlled, acute feeding equivalence trial of small, catalytic doses of fructose and allulose on postprandial blood glucose metabolism in healthy participants: the Fructose and Allulose Catalytic Effects (FACE) Trial. Nutrients 2018;10:E750. doi:10.3390/ nu10060750
168. Noronha JC, Braunstein CR, Glenn AJ, et al. The effect of small doses of fructose and allulose on postprandial glucose metabolism in type 2 diabetes: A double-blind, randomized, controlled, acute feeding, equivalence trial. Diabetes Obes Metab 2018;20:2361-70. doi:10.1111/dom.13374
169. Lan-Pidhainy X, Wolever TM. The hypoglycemic effect of fat and protein is not attenuated by insulin resistance. Am J Clin Nutr 2010;91:98-105. doi:10.3945/ajcn.2009.28125
170. Wolever TM, van Klinken BJ, Bordenave N, et al. Reformulating cereal bars: high resistant starch reduces in vitro digestibility but not in vivo glucose or insulin response; whey protein reduces glucose but disproportionately increases insulin. Am J Clin Nutr 2016;104:995-1003. doi:10.3945/ajcn.116.132431
171. Jakubowicz D, Froy O, Ahrén B, et al. Incretin, insulinotropic and glucose-lowering effects of whey protein pre-load in type 2 diabetes: a randomised clinical trial. Diabetologia 2014;57:1807-11. doi:10.1007/s00125-014-3305-x
172. Mozaffarian D. Dietary and policy priorities for cardiovascular disease, diabetes, and obesity: a comprehensive review. Circulation 2016;133:187-225. doi:10.1161/ CIRCULATIONAHA.115.018585
173. Sievenpiper JL, de Souza RJ, Mirrahimi A, et al. Effect of fructose on body weight in controlled feeding trials: a systematic review and meta-analysis. Ann Intern Med 2012;156:291-304. doi:10.7326/0003-4819-156-4-201202210-00007
174. Silbernagel G, Kovarova M, Cegan A, et al. High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet. J Clin Endocrinol Metab 2012;97:E2288-92. doi:10.1210/jc.2012-2152
175. Wang DD, Sievenpiper JL, de Souza RJ, et al. The effects of fructose intake on serum uric acid vary among controlled dietary trials. J Nutr 2012;142:916-23. doi:10.3945/jn.111.151951
176. Chiu S, Sievenpiper JL, de Souza RJ, et al. Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of controlled feeding trials. Eur J Clin Nutr 2014;68:416-23. doi:10.1038/ejcn.2014.8
177. David Wang D, Sievenpiper JL, de Souza RJ, et al. Effect of fructose on postprandial triglycerides: a systematic review and meta-analysis of controlled feeding trials. Atherosclerosis 2014;232:125-33. doi:10.1016/j.atherosclerosis.2013.10.019
178. van Buul VJ, Tappy L, Brouns FJ. Misconceptions about fructose-containing sugars and their role in the obesity epidemic. Nutr Res Rev 2014;27:119-30. doi:10.1017/ S0954422414000067
179. Mozaffarian D, Hao T, Rimm EB, Willett WC, Hu FB. Changes in diet and lifestyle and long-term weight gain in women and men. N Engl J Med 2011;364:2392-404. doi:10.1056/NEJMoa1014296
180. Kaiser KA, Shikany JM, Keating KD, Allison DB. Will reducing sugar-sweetened beverage consumption reduce obesity? Evidence supporting conjecture is strong, but evidence when testing effect is weak. Obes Rev 2013;14:620-33. doi:10.1111/obr.12048
181. Te Morenga L, Mallard S, Mann J. Dietary sugars and body weight: systematic review and meta-analyses of randomised controlled trials and cohort studies. BMJ 2012;346:e7492. doi:10.1136/bmj.e7492