Fructose improves the ability of hyperglycemia per se to regulate glucose production in type 2 diabetes

Diabetes

Volumn 51, Issue 3, 2002, Pages 606-614

  Hawkins, Meredith ^a   Gabriely, Ilan ^a   Wozniak, Robert ^a   Vilcu, Cristian ^a   Shamoon, Harry ^a   Rossetti, Luciano ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; FRUCTOSE; GLIMEPIRIDE; GLIPIZIDE; GLUCAGON; GLUCOKINASE; GLUCOSE; GROWTH HORMONE; INSULIN; METFORMIN; SOMATOSTATIN; TROGLITAZONE;

ARTICLE; CATALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GLUCONEOGENESIS; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; HYPERGLYCEMIA; LIVER; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL;

EID: 0036310219     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.3.606     Document Type: Article

References (72)

1. Lilly lecture 1987: The triumvirate: Beta-cell, muscle, liver: A collusion responsible for NIDDM
2. Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects
3. Hepatic and peripheral insulin resistance: A common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus
4. Hyperglycemia inhibits glucose production in man independent of changes in glucoregulatory hormone
5. Regulation of endogenous glucose production by glucose per se is in impaired in type 2 diabetes mellitus
6. Contribution of abnormal muscle and liver glucose metabolism to postprandial hypergycemia in NIDDM
7. Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes
8. Analysis of the cooperativity of human beta-cell glucokinase through the stimulatory effect of glucose on fructose phosphorylation
9. Autoregulation of hepatic glucose production
10. Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats: Implications for the pathophysiology of fasting hyperglycemia in diabetes
11. Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog
12. Regulation of glucokinase in liver
13. Cell-specific roles of glucokinase in glucose homeostasis
14. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase
15. Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production
16. Abnormal regulation of HGP by hyperglycenua in mice with a disrupted glucokinase allele
17. Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus
18. Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes
19. Liver glucokinase: Decreased activity in patients with type II diabetes
20. A protein from rat liver confers to glucokinase the property of being antagonistically regulated by fructose-6-phosphate and fructose-1-phosphate
21. Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase
22. Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase
23. Intracellular distribution of hepatic glucokinase and glucokinase regulatory protein during the fasted to refed transition in rats
24. Glucokinase regulatory protein may interact with glucokinase in the hepatocyte nucleus
25. Regulation of hepatic glucose metabolism by translocation of glucokinase between the nucleus and the cytoplasm in hepatocytes
26. Intracellular binding of glucokinase in hepatocytes and translocation by glucose, fructose and insulin
27. The regulatory protein of glucokinase binds to the hepatocyte matrix, but, unlike glucokinase, does not translocate during substrate stimulation
28. Study of the regulatory properties of glucokinase by site-directed mutagenesis: Conversion of glucokinase to an enzyme with high affinity for glucose
29. Small amounts of fructose markedly augment net hepatic glucose uptake in the conscious dog
30. Small amounts of fructose markedly improve glucose tolerance in the dog
31. Glucose 6-phosphate produced by glucokinase, but not hexokinase I, promotes the activation of hepatic glycogen synthase
32. Evidence for a role of glucose-induced translocation of glucokinase in the control of hepatic glycogen synthesis
33. Stimulating effects of low-dose fructose on insulin-stimulated hepatic glycogen synthesis in humans
34. Increased epinephrine and skeletal muscle responses to hypoglycemia in noninsulin-dependent diabetes mellitus
35. Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamp: Comparison of unlabeled and labeled glucose infusates
36. Increase in urinary calcium and oxalate after fructose infusion
37. Lipid metabolism and substrate oxidation during intravenous fructose administration in cirrhosis
38. Effect of ethanol and fructose on plasma uridine and purine bases
39. Effects of infused fructose on endogenous glucose production, gluconeogenesis, and glycogen metabolism
40. 14C) labels
41. Regulation of counterregulatory hormone secretion in man during exercise and hypoglycemia
42. D-lactate
43. The Kjeldahl method
44. D-fructose
45. Influences of glucose loading and of injected insulin on hepatic glucose output
46. Overnight normalization of glucose concentrations improves hepatic but not extrahepatic insulin action in subjects with type 2 diabetes mellitus
47. Effect of overnight restoration of euglycemia on glucose effectiveness in type 2 diabetes mellitus
48. Factors which regulate net hepatic glucose uptake in vivo
49. The effect of glycemic control on hepatic and peripheral glucose (Glc) effectiveness in type 2 diabetes mellitus (DM2)
50. Ribozyme-mediated attenuatior of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion
51. Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene
52. Correction of diabetic alterations by glucokinase
53. Glucokinase overexpression restores glucose utilization and storage in cultured hepatocytes from male Zucker diabetic fatty rats
54. Expression of human hepatic glucokinase in transgenic mice liver results in decreased glucose levels and reduced body weight
55. Acute fructose administration decreases the glycemic response to an oral glucose tolerance test in normal adults
56. Acute fructose administration improves oral glucose tolerance in adults with type 2 diabetes
57. Differential metabolic effects of adenovirus-mediated glucokinase and hexokinase I overexpression in rat primary hepatocytes
58. Impaired net hepatic glycogen synthesis in insulin-dependent diabetic subjects during mixed meal ingestion: A 13C nuclear magnetic resonance spectroscopy study
59. The effect of fructose on fructose 2,6-bisphosphate level and fructose-6-phosphate, 2-kinase activity in the perfused rat liver
60. Stimulation of glucose utilization by fructose in isolated rat hepatocytes
61. Activation of liver pyruvate kinase by fructose-1-phosphate
62. Effects of ingested fructose and infused glucagon on endogenous glucose production in obese NIDDM patients, obese non-diabetic subjects, and healthy subjects
63. Current issues in fructose metabolism
64. Metabolic impact of glucokinase overexpression in liver: Lowering of blood glucose in fed rats is accompanied by hyperlipidemia
65. 2O
66. Effects of graded intravenous doses of fructose on glycogen synthase in the liver of fasted rats
67. Stimulation of glucose-6-phosphatase gene expression by glucose and fructose-2,6-bisphosphate
68. Glucose regulates in vivo glucose-6-phophatase gene expression in the liver of diabetic rats
69. Phlorizin treatment of diabetic rats partially reverses the abnormal expression of genes involved in hepatic glucose metabolism
70. Hyperglycemia contributes insulin resistance in hepatic and adipose tissue but not skeletal muscle of ZDF rats
71. Carbon flux via the pentose phosphate pathway regulates the hepatic expression of the glucose-6-phosphatase and phospoenolpyruvate carboxykinase genes in conscious rats