Short-term high dietary fructose intake had no effects on insulin sensitivity and secretion or glucose and lipid metabolismin healthy, obese adolescents

Journal of Pediatric Endocrinology and Metabolism

Volumn 21, Issue 3, 2008, Pages 225-235

  Sunehag, Agneta L ^a   Toffolo, Gianna ^b   Campioni, Marco ^b   Bier, Dennis M ^a   Haymond, Morey W ^a  

^a CHILDREN S NUTRITION RESEARCH CENTER   (United States)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Fructose; Gluconeogenesis; Glucose production; Insulin secretion; Insulin sensitivity; Stable isotopes

Indexed keywords

ADIPONECTIN; C PEPTIDE; FRUCTOSE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADOLESCENT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE INTAKE; GLUCOSE METABOLISM; GLYCOGENOLYSIS; HUMAN; INSULIN RELEASE; INSULIN SENSITIVITY; INTRAVENOUS GLUCOSE TOLERANCE TEST; LIPID BLOOD LEVEL; LIPID METABOLISM; LIPOLYSIS; MALE; OBESITY;

EID: 42449103471     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.2008.21.3.225     Document Type: Article

References (48)

1. Ogden CL, Carrol MD, Curtin LR, McDowell MA, Tabak CL, Flegal KM. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006; 295: 1549-1555.
2. Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH. Prevalence of a metabolic syndrome phenotype in adolescents. Findings from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Pediatr Adolesc Med 2003; 157: 821-827.
3. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Shervin RS, Caprio S. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 2004; 350: 2362-2374.
4. Goran MI. Metabolic precursors and effects of obesity in children: a decade of progress, 1990-1999. Am J Clin Nutr 2001; 73: 158-171.
5. Rosenbloom AL, Joe JR, Young RS, Winter WE. Emerging epidemic of type 2 diabetes in youth. Diabetes Care 1999; 22: 345-354.
6. Pinhas-Hamiel O, Dolan ML, Daniels SR, Standiford D, Khoury PR, Zeitler P. Increased incidence of noninsulin-dependent diabetes mellitus among adolescents. J Pediatr. 1996; 28: 608-615.
7. American Diabetes Association. Type 2 diabetes in children and adolescents. Diabetes Care 2000; 23: 381-389.
8. Dietz WH. Overweight and precursors of type 2 diabetes mellitus in children and adolescents. J Pediatr 2001; 138: 453-454.
9. Bouchard C, Savard R, Despres JP, Tremblay A, Leblanc C. Body composition in adopted and biological siblings. Hum Biol 1985; 57: 61-75.
10. Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz W. Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med 1997; 337: 869-873.
11. Bray GA. Dietary fat intake does affect obesity! Am J Clin Nutr 1998; 68:1157-1173.
12. Proserpi C, Sparti A, Schutz Y, Di Vetta V, Milton H, Jequier E. Ad libitum intake of a high-carbohydrate or high-fat diet in young men: effects on nutrient balance. Am J Clin Nutr 1997; 66: 539-545.
13. McGloin AF, Livingstone MB, Green LC, Webb SE, Gibson JM, Jebb SA, Cole TJ, Coward WA, Wright A, Prentice AM. Energy and fat intake in obese and lean children at varying risk of obesity. Int J Obes Relat Metab Disord 2002; 26: 200-207.
14. Jequier E. Is fat intake a risk factor for fat gain in children? J Clin Endocrinol Metab 2001; 86: 980-983.
15. Gillis LJ, Kennedy LC, Gillis AM, Bar-Or O. Relationship between juvenile obesity, dietary energy and fat intake and physical activity. Int J Obes Relat Metab Disord 2002; 26: 458-463.
16. Andersen R, Crespo CJ, Bartlett SJ, Cheskin LJ, Pratt M. Relationship of physical activity and television watching with body weight and level of fatness among children: results from the Third National Health and Nutrition Examination Survey. JAMA 1998; 279: 938-942.
17. Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 2004; 79: 537-543.
18. Ludwig DS, Peterson KE, Gortmaker SL. Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis. Lancet 2001; 357: 505-508.
19. Morton JF, Guthrie JF. Changes in children's total fat intakes and their food group sources of fat, 1989-91 vs. 1994-95: implications for diet quality. Fam Econ Nutr Rev 1998; 11: 44-57.
20. Guthrie JF, Morton JF. Food sources of added sweeteners in the diets of Americans. J Am Diet Assoc 2000; 100:43-51.
21. Hallfrisch J, Lazar F, Jorgensen C, Reiser S. Insulin and glucose responses in rats fed sucrose and starch. Am J Clin Nutr 1979; 32: 787-793.
22. Reiser S, Hallfrisch J. lnsulin sensitivity and adipose tissue weight of rats fed starch or sucrose ad libitum or in meals. J Nutr 1977; 107: 147-155.
23. Thornburn AW, Storlien LH, Jenkins AB, Khouri S, Kraeger EW. Fructose-induced in vivo insulin resistance and elevated plasma triglyceride levels in rats. Am J Clin Nutr 1989; 49: 1155-1163.
24. Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ. Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 2002; 76: 911-922.
25. Havel PJ. Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. Nutr Rev 2005; 63: 133-157.
26. Daly M. Sugars, insulin sensitivity, and the postprandial state. Am J Clin Nutr 2003; 78 (Suppl): 865S-872S.
27. Sunehag AL, Toffolo G, Treuth MS, Butte NF, Cobelli C, Bier DM, Haymond MW. Effects of dietary macronutrient content on glucose metabolism in children. J Clin Endocrinol Metab 2002; 87: 5168-5178.
28. Koivisto VA, Yki-Jarvinen H. Fructose and insulin sensitivity in patients with type 2 diabetes. J Intern Med 1993; 233: 145-153.
29. Beck-Nielsen H, Pedersen O, Lindskov HO. Impaired cellular insulin binding and insulin sensitivity induced by high-fructose feeding in normal subjects. Am J Clin Nutr 1980; 33: 273-278.
30. Bantle JP, Swanson JE, Thomas W, Laine DC. Metabolic effects of dietary fructose in diabetic subjects. Diabetes Care 1992; 15: 1468-1472.
31. Bantle JP, Raatz SK, Thomas W, Georopoulos A. Effects of dietary fructose on plasma lipids in healthy subject. Am J Clin Nutr 2000; 72: 1128-1134.
32. Swanson JE, Laine DC, Thomas W, Bantle JP. Metabolic effects of dietary fructose in healthy subjects. Am J Clin Nutr 1992; 55: 851-856.
33. Teff KL, Elliott SS, Tschöp M, Kieffer TJ, Rader D, Heiman M, Townsend RR, Keim NL, D'Alessio D, Havel PJ. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin and increases triglycerides in women. J Clin Endocrinol Metab 2004; 89: 2963-2972.
34. Abraha A, Humphreys SM, Clark ML, Matthews DR, Frayn KN. Acute effect of fructose on postprandial lipaemia in diabetic and non-diabetic subjects. Br J Nutr 1998; 80: 169-175.
35. Treuth MS, Sunehag AL, Trautwein LM, Bier DM, Haymond MW, Butte NF. Metabolic adaptation to high-fat and high-carbohydrate diets in children and adolescents. Am J Clin Nutr 2003; 77: 479-489.
36. Schofield WN. Predicting basal metabolic rate, new standards and review of previous work. Hum Clin Nutr 1985; 39: 5-41.
37. Sunehag AL, Toffolo G, Bier DM, Haymond MW. Effecta of dietary macronutrient intake on insulin sensitivity and secretion, and glucose and lipid metabolism in healthy, obese adolescents. J Clin Endocrinol Metab 2005; 90: 4496-4502.
38. Landau BR, Wahren J, Chandramouli V, Schumann WC, Ekberg K, Kalhan SC. Contributions of gluconeogenesis to glucose production in the fasted state. J Clin Invest 1996; 98: 378-385.
39. Avogaro A, Bristow JD, Bier DM, Cobelli C, Toffolo G. Stable-label intravenous glucose tolerance test minimal model. Diabetes 1989; 38: 1048-1055.
40. Toffolo G, De Grandi F, Cobelli C. Estimation of β-cell sensitivity from intravenous glucose tolerance test C-peptide data. Knowledge of the kinetics avoids errors in modeling insulin secretion. Diabetes 1995; 44: 845-854.
41. Sinha R, Fisch G, Teague B, Tamborlane WV, Banyas B, Allen K, Savoye M, Rieger V, Taksali S, Barbetta G, Sherwin RS, Caprio S. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 2002; 346: 802-810.
42. Gower BA, Nagy TR, Goran MI. Visceral fat, insulin sensitivity, and lipids in pre-pubertal children. Diabetes 1999;48: 515-1521.
43. Hoffman RP, Armstrong PT. Glucose effectiveness, peripheral and hepatic insulin sensitivity, in obese and lean pre-pubertal children. Int J Obes Relat Metab Disord 1996; 20: 521-525.
44. Bacha F, Saad R, Gungor N, Janosky J, Arslanian SA. Obesity, regional fat distribution, and syndrome X in obese Black versus White adolescents: race differential in diabetogenic and atherogenic factors. J Clin Endocrinol Metab 2003; 88: 2534-2540.
45. Albrink MJ, Ullrich IH. Interaction of dietary sucrose and fiber on serum lipids in healthy young men fed high carbohydrate diets. Am J Clin Nutr 1986; 43: 419-428.
46. Faeh D, Minehira K, Schwartz J-M, Periasami R, Seongsu P, Tappy L. Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men. Diabetes 2005; 54: 1907-1913.
47. Schwartz J-M, Neese RA, Turner S, Dare D, Hellerstein MK. Short-term alterations in carbohydrate energy intake in humans. Striking effects on hepatic glucose production, de novo lipogenesis, lipolysis, and whole body fuel selection. J Clin Invest 1995; 96: 2735-2743.
48. Chen M, Bergman R, Porte D. Insulin resistance and beta-cell dysfunction in aging. The importance of dietary carbohydrate. J Clin Endocrinol Metab 1988; 67: 951-957.