Misconceptions about fructose-containing sugars and their role in the obesity epidemic

Nutrition Research Reviews

Volumn 27, Issue 1, 2014, Pages 119-130

  Van Buul, Vincent J ^a   Tappy, Luc ^b   Brouns, Fred J P H ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Fructose; Obesity; Sugar; Sugar sweetened beverages

Indexed keywords

CARBOHYDRATE; FRUCTOSE; URIC ACID; SUGAR INTAKE; CARBONIC ACID DERIVATIVE; GLUCOSE; WATER;

ARTICLE; BEVERAGE; BODY WEIGHT; DIET; ENERGY; EPIDEMIC; FOOD INTAKE; HUMAN; INSULIN RESISTANCE; LIFESTYLE; NONHUMAN; OBESITY; POLICY; PUBLIC HEALTH; WEIGHT GAIN; ADVERSE EFFECTS; ANIMAL; DRUG EFFECTS; METABOLISM; SUGAR INTAKE; COLA; DIETARY INTAKE; ENERGY CONSUMPTION; LIFESTYLE MODIFICATION; METABOLIC DISORDER; REVIEW;

ANIMALIA;

ANIMALS; DIET; DIETARY SUCROSE; EPIDEMICS; FRUCTOSE; HUMANS; OBESITY; WEIGHT GAIN;

EID: 84903905076     PISSN: 09544224     EISSN: 14752700     Source Type: Journal    
DOI: 10.1017/S0954422414000067     Document Type: Article

References (154)

1. Bleich SN, Wang YC, Wang Y, et al. (2009) Increasing consumption of sugar-sweetened beverages among US adults: 1988-1994 to 1999-2004. Am J Clin Nutr 89, 372-381.
2. Duffey KJ & Popkin BM (2012) Shifts in patterns and consumption of beverages between 1965 and 2002. Obesity 15, 2739-2747.
3. Nielsen SJ & Popkin BM (2004) Changes in beverage intake between 1977 and 2001. Am J Prev Med 27, 205-210. (Pubitemid 39278319)
4. Popkin BM & Nielsen SJ (2012) The sweetening of the world's diet. Obes Res 11, 1325-1332.
5. Nielsen SJ, Siega-Riz AM & Popkin BM (2012) Trends in energy intake in US between 1977 and 1996: similar shifts seen across age groups. Obes Res 10, 370-378.
6. Storey ML, Forshee RA & Anderson PA (2006) Beverage consumption in the US population. J Am Diet Assoc 106, 1992-2000. (Pubitemid 44779447)
7. Wang YC, Gortmaker SL, Sobol AM, et al. (2006) Estimating the energy gap among US children: a counterfactual approach. Pediatrics 118, e1721-e1733. (Pubitemid 46397547)
8. Euromonitor International (2011) Soft drink consumption-global. Euromonitor Passport GMID database. http://www.euromonitor.com/passport
9. Young LR & Nestle M (2003) Expanding portion sizes in the US marketplace: implications for nutrition counseling. J Am Diet Assoc 103, 231-234. (Pubitemid 38375926)
10. Wang YC, Bleich SN & Gortmaker SL (2008) Increasing caloric contribution from sugar-sweetened beverages and 100% fruit juices among US children and adolescents, 1988-2004. Pediatrics 121, e1604-e1614.
11. Welsh JA, Sharma AJ, Grellinger L, et al. (2011) Consumption of added sugars is decreasing in the United States. Am J Clin Nutr 94, 726-734.
12. Euromonitor International (2013) Bottled water consumption-global. Euromonitor Passport GMID database. http://www.euromonitor.com/passport
13. Ogden CL, Carroll MD, Kit BK, et al. (2012) Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010. JAMA 307, 483-490.
14. Euromonitor International (2013) Soft drink consumption per category-Western Europe. Euromonitor Passport GMID database. http://www.euromonitor.com/passport
15. Euromonitor International (2013) Soft drink consumption per category-North America: USA. Euromonitor Passport GMID database. http://www.euromonitor.com/passport
16. Malik VS, Schulze MB & Hu FB (2006) Intake of sugar-sweetened beverages and weight gain: a systematic review. Am J Clin Nutr 84, 274-288. (Pubitemid 44699135)
17. Hu FB & Malik VS (2010) Sugar-sweetened beverages and risk of obesity and type 2 diabetes: epidemiologic evidence. Physiol Behav 100, 47-54.
18. Ambrosini GL, Oddy WH, Huang RC, et al. (2013) Prospective associations between sugar-sweetened beverage intakes and cardiometabolic risk factors in adolescents. Am J Clin Nutr 98, 327-334.
19. Agostoni C, Bresson JL, Fairweather-Tait S, et al. (2010) Scientific opinion on dietary reference values for carbohydrates and dietary fibre. EFSA J 8, 1462-1539.
20. Kaiser K, Shikany J, Keating K, et al. (2013) Will reducing sugar-sweetened beverage consumption reduce obesity? Evidence supporting conjecture is strong, but evidence when testing effect is weak. Obes Rev 14, 620-633.
21. Ervin R & Ogden C (2013) Consumption of added sugars among U.S. Adults, 2005-2010. NCHS Data Brief 122, 1-8.
22. Lustig RH, Schmidt LA & Brindis CD (2012) Public health: the toxic truth about sugar. Nature 482, 27-29.
23. Lustig RH (2010) Fructose: metabolic, hedonic, and societal parallels with ethanol. J Am Diet Assoc 110, 1307-1321.
24. Johnson RJ, Lanaspa MA & Sanchez-lozada LG (2012) Effects of excessive fructose intake on health. Ann Intern Med 156, 905-906.
25. Melanson KJ, Angelopoulos TJ, Nguyen V, et al. (2008) High-fructose corn syrup, energy intake, and appetite regulation. Am J Clin Nutr 88, 1738S-1744S.
26. Perez-Pozo S, Schold J, Nakagawa T, et al. (2009) Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response. Int J Obes 34, 454-461.
27. Rizkalla SW (2010) Health implications of fructose consumption: a review of recent data. Nutr Metab (Lond) 7, 82.
28. Bray GA (2008) Fructose: should we worry? Int J Obes 32, S127-S131.
29. Bray GA (2008) Fructose-how worried should we be? Medscape J Med 10, 159.
30. Bray GA (2012) Fructose and risk of cardiometabolic disease. Curr Atheroscler Rep 14, 570-578.
31. Bray GA (2013) Potential health risks from beverages containing fructose found in sugar or high-fructose corn syrup. Diabetes Care 36, 11-12.
32. Bray GA, Nielsen SJ & Popkin BM (2004) Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 79, 537-543. (Pubitemid 41103894)
33. Brown C, Dulloo A & Montani J (2008) Sugary drinks in the pathogenesis of obesity and cardiovascular diseases. Int J Obes 32, S28-S34.
34. Brown IJ, Stamler J, Van Horn L, et al. (2011) Sugar-sweetened beverage, sugar intake of individuals, and their blood pressure: International Study of Macro/Micronutrients and Blood Pressure. Hypertension 57, 695-701.
35. Malik VS & Hu FB (2012) Sweeteners and risk of obesity and type 2 diabetes: the role of sugar-sweetened beverages. Curr Diab Rep 12, 195-203.
36. Popkin BM (2012) Sugary beverages represent a threat to global health. Trends Endocrinol Metab 23, 591-593.
37. Klurfeld DM (2013) What do government agencies consider in the debate over added sugars? Adv Nutr 4, 257-261.
38. Elbel B, Cantor J & Mijanovich T (2012) Potential effect of the New York City policy regarding sugared beverages. N Engl J Med 367, 680-681.
39. Caprio S (2012) Calories from soft drinks-do they matter? N Engl J Med 367, 1462-1463.
40. Anonymous (2012) Regulation of sugar-sweetened beverages. N Engl J Med 367, 1464-1466.
41. Chaufan C, Hong GH & Fox P (2009) Taxing "sin foods"-obesity prevention and public health policy. N Engl J Med 361, e113.
42. Pomeranz JL & Brownell KD (2012) Portion sizes and beyond-government's legal authority to regulate food-industry practices. N Engl J Med 367, 1383-1385.
43. Cohen DA & Babey SH (2012) Candy at the cash register-A risk factor for obesity and chronic disease. N Engl J Med 367, 1381-1383.
44. Just DR & Payne CR (2009) Obesity: can behavioral economics help? Ann Behav Med 38, 47-55.
45. Wansink B, Hanks A & Just D (2012) et al. From Coke to Coors: a field study of a sugar-sweetened beverage tax and its unintended consequences. Social Science Research Network [serial on the Internet]. http://ssrn.com/ abstract2079840
46. White JS (2008) Straight talk about high-fructose corn syrup: what it is and what it ain't. Am J Clin Nutr 88, 1716S-1721S.
47. Lê K-A & Tappy L (2006) Metabolic effects of fructose. Curr Opin Clin Nutr Metab Care 9, 469-475. (Pubitemid 44097820)
48. Bogdanov S, Jurendic T, Sieber R, et al. (2008) Honey for nutrition and health: a review. J Am Coll Nutr 27, 677-689.
49. Casazza K, Fontaine KR, Astrup A, et al. (2013) Myths, presumptions, and facts about obesity. N Engl J Med 368, 446-454.
50. Agostoni C, Bresson JL, Fairweather-Tait S, et al. (2011) Scientific opinion on the substantiation of health claims related to fructose and reduction of post-prandial glycaemic responses (ID 558) pursuant to Article 13(1) of Regulation (EC) no 1924/2006. EFSA J 9, 2223-2238.
51. Bantle JP, Laine DC, Castle GW, et al. (1983) Postprandial glucose and insulin responses to meals containing different carbohydrates in normal and diabetic subjects. N Engl J Med 309, 7-12. (Pubitemid 13062887)
52. Crapo PA, Kolterman OG & Olefsky JM (1980) Effects of oral fructose in normal, diabetic, and impaired glucose tolerance subjects. Diabetes Care 3, 575-581. (Pubitemid 11245820)
53. Stanhope KL & Havel PJ (2008) Endocrine and metabolic effects of consuming beverages sweetened with fructose, glucose, sucrose, or high-fructose corn syrup. Am J Clin Nutr 88, 1733S-1737S.
54. Stanhope KL, Schwarz JM, Keim NL, et al. (2009) Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 119, 1322-1324.
55. Stanhope KL & Havel PJ (2010) Fructose consumption: recent results and their potential implications. Ann N Y Acad Sci 1190, 15-24.
56. Tappy L & Lê K-A (2010) Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev 90, 23-46.
57. Vasankari TJ & Vasankari TM (2006) Effect of dietary fructose on lipid metabolism, body weight and glucose tolerance in humans. Food Nutr Res 50, 55-63.
58. Grundy SM (1998) Multifactorial causation of obesity: implications for prevention. Am J Clin Nutr 67, 563S-572S. (Pubitemid 28117242)
59. Martinez-Gonzalez M, Alfredo Martinez J, Hu F, et al. (1999) Physical inactivity, sedentary lifestyle and obesity in the European Union. Int J Obes 23, 1192-1201.
60. Torres SJ & Nowson CA (2007) Relationship between stress, eating behavior, and obesity. Nutrition 23, 887-894. (Pubitemid 47532398)
61. Sobal J & Stunkard AJ (1989) Socioeconomic status and obesity: a review of the literature. Psychol Bull 105, 260-275.
62. de Ruyter JC, Olthof MR, Seidell JC, et al. (2012) A trial of sugar-free or sugar-sweetened beverages and body weight in children. N Engl J Med 367, 1397-1406.
63. Ebbeling CB, Feldman HA, Chomitz VR, et al. (2012) A randomized trial of sugar-sweetened beverages and adolescent body weight. N Engl J Med 367, 1407-1416.
64. Golay A & Bobbioni E (1997) The role of dietary fat in obesity. Int J Obes Relat Metab Disord 21, S2.
65. Allais O, Bertail P & Nichèle V (2010) The effects of a fat tax on French households' purchases: a nutritional approach. Am J Agric Econ 92, 228-245.
66. Gaby AR (2005) Adverse effects of dietary fructose. Altern Med Rev 10, 294.
67. Parker K, Salas M & Nwosu VC (2010) High fructose corn syrup: production, uses and public health concerns. Biotechnol Mol Biol Rev 5, 71-78.
68. Havel PJ (2008) Dietary fructose: implications for dys-regulation of energy homeostasis and lipid/carbohydrate metabolism. Nutr Rev 63, 133-157.
69. Hallfrisch J (1990) Metabolic effects of dietary fructose. FASEB J 4, 2652-2660.
70. Vos MB, Kimmons JE, Gillespie C, et al. (2008) Dietary fructose consumption among US children and adults: the Third National Health and Nutrition Examination Survey. Medscape J Med 10, 160.
71. Mayes PA (1993) Intermediary metabolism of fructose. Am J Clin Nutr 58, 754S-765S. (Pubitemid 23319973)
72. Shimomura I, Matsuda M, Hammer RE, et al. (2000) Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell 6, 77-86.
73. Rizkalla SW, Luo J, Guilhem I, et al. (1992) Comparative effects of 6 week fructose, dextrose and starch feeding on fat-cell lipolysis in normal rats: effects of isoproterenol, theophylline and insulin. Mol Cell Biochem 109, 127-132.
74. Havel PJ (1997) Glucose but not fructose infusion increases circulating leptin in proportion to adipose stores in rhesus monkeys. Exp Clin Endocrinol Diabetes 105, 37-38. (Pubitemid 127502754)
75. Puigserver P & Spiegelman BM (2003) Peroxisome pro-liferator- Activated receptor-g coactivator 1a (PGC-1a): transcriptional coactivator and metabolic regulator. Endocr Rev 24, 78-90. (Pubitemid 36223280)
76. McDevitt RM, Bott SJ, Harding M, et al. (2001) De novo lipogenesis during controlled overfeeding with sucrose or glucose in lean and obese women. Am J Clin Nutr 74, 737-746. (Pubitemid 33101793)
77. Teff KL, Grudziak J, Townsend RR, et al. (2009) Endocrine and metabolic effects of consuming fructose-And glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses. J Clin Endocrinol Metab 94, 1562-1569.
78. Vuorinen-Markkola H & Yki-Järvinen H (1994) Hyperurice-mia and insulin resistance. J Clin Endocrinol Metab 78, 25-29.
79. Nakagawa T, Hu H, Zharikov S, et al. (2006) A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol 290, F625-F631. (Pubitemid 43724964)
80. Lanaspa MA, Sanchez-Lozada LG, Cicerchi C, et al. (2012) Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver. PLOS ONE 7, e47948.
81. Abdelmalek MF, Suzuki A, Guy C, et al. (2010) Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. Hepatology 51, 1961-1971.
82. Togashi N, Ura N, Higashiura K, et al. (2000) The contribution of skeletal muscle tumor necrosis factor-A to insulin resistance and hypertension in fructose-fed rats. J Hypertens 18, 1605-1610.
83. Bezerra RM, Ueno M, Silva MS, et al. (2000) A high fructose diet affects the early steps of insulin action in muscle and liver of rats. J Nutr 130, 1531-1535. (Pubitemid 30340698)
84. Babsky NE, Toribio JL & Lozano JE (1986) Influence of storage on the composition of clarified apple juice concentrate. J Food Sci 51, 564-567.
85. Ventura EE, Davis JN & Goran MI (2010) Sugar content of popular sweetened beverages based on objective laboratory analysis: focus on fructose content. Obesity 19, 868-874.
86. Fung TT, Malik V, Rexrode KM, et al. (2009) Sweetened beverage consumption and risk of coronary heart disease in women. Am J Clin Nutr 89, 1037-1042.
87. Chen L, Caballero B, Mitchell DC, et al. (2010) Reducing consumption of sugar-sweetened beverages is associated with reduced blood pressure a prospective study among United States adults. Circulation 121, 2398-2406.
88. Dhingra R, Sullivan L, Jacques PF, et al. (2007) Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-Aged adults in the community. Circulation 116, 480-488. (Pubitemid 47450256)
89. Meyer KA, Kushi LH, Jacobs DR, et al. (2000) Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. Am J Clin Nutr 71, 921-930. (Pubitemid 30176574)
90. Janket S-J, Manson JE, Sesso H, et al. (2003) A prospective study of sugar intake and risk of type 2 diabetes in women. Diabetes Care 26, 1008-1015. (Pubitemid 36929240)
91. Abdelmalek MF, Lazo M, Horska A, et al. (2012) Higher dietary fructose is associated with impaired hepatic adeno-sine triphosphate homeostasis in obese individuals with type 2 diabetes. Hepatology 56, 952-960.
92. Paynter NP, Yeh H-C, Voutilainen S, et al. (2006) Coffee and sweetened beverage consumption and the risk of type 2 diabetes mellitus. Am J Epidemiol 164, 1075-1084.
93. Forshee RA, Anderson PA & Storey ML (2008) Sugar-sweetened beverages and body mass index in children and adolescents: a meta-Analysis. Am J Clin Nutr 87, 1662-1671. (Pubitemid 351872628)
94. Duffey KJ & Popkin BM (2008) High-fructose corn syrup: is this what's for dinner? Am J Clin Nutr 88, 1722S-1732S.
95. de Koning L, Malik VS, Rimm EB, et al. (2011) Sugar-sweetened and artificially sweetened beverage consumption and risk of type 2 diabetes in men. Am J Clin Nutr 93, 1321-1327.
96. Goran MI, Ulijaszek SJ & Ventura EE (2012) High fructose corn syrup and diabetes prevalence: a global perspective. Glob Public Health 8, 55-64.
97. Kmietowicz Z (2012) Countries that use large amounts of high fructose corn syrup have higher rates of type 2 diabetes. BMJ 345, e7994.
98. European Commission ( 2012) Production data of HFCS (isoglucose) in the EU [database on the Internet]. http://ec.europa.eu/agriculture/sugar/balance- sheets/balance-sheet-en.pdf (accessed 27 March 2013)
99. Gustavsson J, Cederberg C, Sonesson U, et al (2011) Global Food Losses and Food Waste. Rome: UNFAO.
100. Basu S, Yoffe P, Hills N, et al. (2013) The relationship of sugar to population-level diabetes prevalence: an econometric analysis of repeated cross-sectional data. PLOS ONE 8, e57873.
101. Strom S (2012) U.S. cuts estimate of sugar intake. New York Times, 27 October 2012, section B1. http://www.nytimes. com/2012/10/27/business/us-cuts- estimate-of-sugar-intake-of-typical-American.html?-r0 (accessed February 2014).
102. Muth MK (2011) Consumer-Level Food Loss Estimates and Their Use in the ERS Loss-Adjusted Food Availability Data. Darby, PA: Diane Publishing.
103. Lê K-A, Ith M, Kreis R, et al. (2009) Fructose overconsump-tion causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes. Am J Clin Nutr 89, 1760-1765.
104. Faeh D, Minehira K, Schwarz J-M, et al. (2005) Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men. Diabetes 54, 1907-1913. (Pubitemid 40911251)
105. Hamburg NM, McMackin CJ, Huang AL, et al. (2007) Physical inactivity rapidly induces insulin resistance and micro-vascular dysfunction in healthy volunteers. Arterioscler Thromb Vasc Biol 27, 2650-2656. (Pubitemid 350158918)
106. Egli L, Lecoultre V, Theytaz F, et al. (2013) Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects. Diabetes 62, 2259-2265.
107. Koutsari C, Karpe F, Humphreys SM, et al. (2001) Exercise prevents the accumulation of triglyceride-rich lipo-proteins and their remnants seen when changing to a high-carbohydrate diet. Arterioscler Thromb Vasc Biol 21, 1520-1525. (Pubitemid 34219818)
108. Elliott SS, Keim NL, Stern JS, et al. (2002) Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 76, 911-922. (Pubitemid 35244659)
109. Bantle JP, Raatz SK, Thomas W, et al. (2000) Effects of dietary fructose on plasma lipids in healthy subjects. Am J Clin Nutr 72, 1128-1134.
110. Couchepin C, Lê K-A, Bortolotti M, et al. (2008) Markedly blunted metabolic effects of fructose in healthy young female subjects compared with male subjects. Diabetes Care 31, 1254-1256.
111. Tran C, Jacot-Descombes D, Lecoultre V, et al. (2010) Sex differences in lipid and glucose kinetics after ingestion of an acute oral fructose load. Br J Nutr 104, 1139-1147.
112. Daly M (2003) Sugars, insulin sensitivity, and the postprandial state. Am J Clin Nutr 78, 865S-872S.
113. Lakhan SE (2013) Kirchgessner A The emerging role of dietary fructose in obesity and cognitive decline. Nutr J 12, 114.
114. Klurfeld D, Foreyt J, Angelopoulos T, et al. (2013) Lack of evidence for high fructose corn syrup as the cause of the obesity epidemic. Int J Obes 37, 771-773.
115. DiMeglio DP & Mattes RD (2000) Liquid versus solid carbohydrate: effects on food intake and body weight. Int J Obes 24, 794-800. (Pubitemid 30339280)
116. Melanson KJ, Zukley L, Lowndes J, et al. (2007) Effects of high-fructose corn syrup and sucrose consumption on circulating glucose, insulin, leptin, and ghrelin and on appetite in normal-weight women. Nutrition 23, 103-112. (Pubitemid 46099026)
117. Mærsk M, Belza A, Holst JJ, et al. (2012) Satiety scores and satiety hormone response after sucrose-sweetened soft drink compared with isocaloric semi-skimmed milk and with non-caloric soft drink: a controlled trial. Eur J Clin Nutr 66, 523-529.
118. SoenenS & Westerterp-Plantenga MS (2007) Nodifferencesin satiety or energy intake after high-fructose corn syrup, sucrose, or milk preloads. Am J Clin Nutr 86, 1586-1594. (Pubitemid 350232171)
119. Reid M, Hammersley R, Duffy M, et al. (2014) Effects on obese women of the sugar sucrose added to the diet over 28 d: a quasi-randomised, single-blind, controlled trial. Br J Nutr 111, 563-570.
120. Allison DB (2014) Liquid calories, energy compensation and weight: what we know and what we still need to learn. Br J Nutr 111, 384-386.
121. Welsh JA, Sharma A, Cunningham SA, et al. (2011) Consumption of added sugars and indicators of cardiovascular disease risk among US adolescents: clinical perspective. Circulation 123, 249-257.
122. Rodin J (1990) Comparative effects of fructose, aspartame, glucose, and water preloads on calorie and macronutrient intake. Am J Clin Nutr 51, 428-435.
123. Rodin J, Reed D & Jamner L (1988) Metabolic effects of fructose and glucose: implications for food intake. Am J Clin Nutr 47, 683-689.
124. Te Morenga L, Mallard S & Mann J (2013) Dietary sugars and body weight: systematic review and meta-Analyses of randomised controlled trials and cohort studies. BMJ 346, e7492.
125. Moran TH (2009) Fructose and satiety. J Nutr 139, 1253S-1256S.
126. Sievenpiper JL, de Souza RJ & Jenkins DJ (2012) Sugar: fruit fructose is still healthy. Nature 482, 470.
127. Slavin J (2012) Beverages and body weight: challenges in the evidence-based review process of the Carbohydrate Subcommittee from the 2010 Dietary Guidelines Advisory Committee. Nutr Rev 70, S111-S120.
128. Page KA, Chan O, Arora J, et al. (2013) Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways fructose consumption and weight gain. JAMA 309, 63-70.
129. Chong MF, Fielding BA & Frayn KN (2007) Mechanisms for the acute effect of fructose on postprandial lipemia. Am J Clin Nutr 85, 1511-1520. (Pubitemid 46890417)
130. Hellerstein MK, Schwarz J-M & Neese RA (1996) Regulation of hepatic de novo lipogenesis in humans. Annu Rev Nutr 16, 523-557. (Pubitemid 26286864)
131. Acheson K, Schutz Y, Bessard T, et al. (1988) Glycogen storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man. Am J Clin Nutr 48, 240-247.
132. Sun SZ & Empie MW (2012) Fructose metabolism in humans-what isotopic tracer studies tell us. Nutr Metab 9, 89.
133. Johnson RJ, Perez-Pozo SE, Sautin YY, et al. (2009) Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes? Endocr Rev 30, 96-116.
134. Feig DI, Kang D-H & Johnson RJ (2008) Uric acid and cardiovascular risk. N Engl J Med 359, 1811-1821.
135. Sánchez-Lozada LG, Mu W, Roncal C, et al. (2010) Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver. Eur J Nutr 49, 1-9.
136. Oberhaensli R, Taylor D, Rajagopalan B, et al. (1987) Study of hereditary fructose intolerance by use of 31P magnetic resonance spectroscopy. Lancet 330, 931-934. (Pubitemid 17150284)
137. Lecoultre V, Egli L, Theytaz F, et al. (2013) Fructose-induced hyperuricemia is associated with a decreased renal uric acid excretion in humans. Diabetes Care 36, e149-e150.
138. Lin W, Huang H, Huang M, et al. (2012) Effects on uric acid, body mass index and blood pressure in adolescents of consuming beverages sweetened with high-fructose corn syrup. Int J Obes 37, 532-539.
139. Dodd KW, Guenther PM, Freedman LS, et al. (2006) Statistical methods for estimating usual intake of nutrients and foods: a review of the theory. J Am Diet Assoc 106, 1640-1650. (Pubitemid 44415594)
140. Angelopoulos TJ, Lowndes J, Zukley L, et al. (2009) The effect of high-fructose corn syrup consumption on triglycerides and uric acid. J Nutr 139, 1242S-1245S.
141. Akhavan T & Anderson GH (2007) Effects of glucose-to-fructose ratios in solutions on subjective satiety, food intake, and satiety hormones in young men. Am J Clin Nutr 86, 1354-1363. (Pubitemid 350126238)
142. Buemann B, Toubro S, Holst JJ, et al. (2000) d-Tagatose, a stereoisomer of d-fructose, increases blood uric acid concentration. Metabolism 49, 969-976. (Pubitemid 30641431)
143. Wang DD, Sievenpiper JL, de Souza RJ, et al. (2012) The effects of fructose intake on serum uric acid vary among controlled dietary trials. J Nutr 142, 916-923.
144. Zgaga L, Theodoratou E, Kyle J, et al. (2012) The association of dietary intake of purine-rich vegetables, sugar-sweetened beverages and dairy with plasma urate, in a cross-sectional study. PLOS ONE 7, e38123.
145. Sun SZ, Flickinger BD, Williamson-Hughes PS, et al. (2010) Lack of association between dietary fructose and hyper-uricemia risk in adults. Nutr Metab (Lond) 7, 16.
146. Livesey G & Taylor R (2008) Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-Analyses and meta-regression models of intervention studies. Am J Clin Nutr 88, 1419-1437.
147. Livesey G (2013) Is there really a link between diabetes and the ingestion of fructose? Nutr Bull 38, 337-343.
148. Gibson S (2008) Sugar-sweetened soft drinks and obesity: a systematic review of the evidence from observational studies and interventions. Nutr Res Rev 21, 134-147.
149. Ebbeling CB, Feldman HA, Osganian SK, et al. (2006) Effects of decreasing sugar-sweetened beverage consumption on body weight in adolescents: a randomized, controlled pilot study. Pediatrics 117, 673-680. (Pubitemid 46063208)
150. Pollock NK, Bundy V, Kanto W, et al. (2012) Greater fructose consumption is associated with cardiometabolic risk markers and visceral adiposity in adolescents. J Nutr 142, 251-257.
151. Cullen KW, Ash DM, Warneke C, et al. (2002) Intake of soft drinks, fruit-flavored beverages, and fruits and vegetables by children in grades 4 through 6. Am J Public Health 92, 1475-1477.
152. Livesey G (2009) Fructose ingestion: dose-dependent responses in health research. J Nutr 139, 1246S-1252S.
153. Sievenpiper JL & de Souza RJ (2013) Are sugar-sweetened beverages the whole story? Am J Clin Nutr 98, 261-263.
154. Tappy L & Mittendorfer B (2012) Fructose toxicity: is the science ready for public health actions? Curr Opin Clin Nutr Metab Care 15, 357-361.