Hypercaloric diets with increased meal frequency, but not meal size, increase intrahepatic triglycerides: A randomized controlled trial

Hepatology

Volumn 60, Issue 2, 2014, Pages 545-553

  Koopman, Karin ^a   Caan, Matthan ^a   Nederveen, Aart ^a   Pels, Anouk ^a   Ackermans, Mariette ^a   Fliers, Eric ^a   la Fleur, Susanne ^a   Serlie, Mireille ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

FAT; GLUCOSE; INTRAHEPATIC TRIGLYCERIDE; ISOTOPE; LEPTIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ABDOMINAL FAT; ADULT; ANALYSIS OF VARIANCE; ARTICLE; BODY MASS; CALORIC INTAKE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY COMPLIANCE; FAT INTAKE; GLUCOSE METABOLISM; HUMAN; HUMAN EXPERIMENT; HYPERINSULINEMIA; INSULIN SENSITIVITY; ISOTOPE ANALYSIS; LIPID BLOOD LEVEL; MALE; MEAL; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUTRITIONAL PARAMETERS; NUTRITIONAL STATUS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RANDOMIZED CONTROLLED TRIAL; SUGAR INTAKE; WEIGHT GAIN;

ABDOMINAL FAT; ADULT; BLOOD GLUCOSE; BODY MASS INDEX; DIETARY FATS; DIETARY SUCROSE; ENERGY INTAKE; ENERGY METABOLISM; FATTY LIVER; FEEDING BEHAVIOR; GLUCOSE CLAMP TECHNIQUE; HUMANS; LEPTIN; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; OBESITY; TRIGLYCERIDES; YOUNG ADULT;

EID: 84904699278     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27149     Document Type: Article

References (41)

1. Ong JP, Younossi ZM. Epidemiology and natural history of NAFLD and NASH. Clin Liver Dis 2007;11:1-16, vii.
2. Heilbronn LK, Coster AC, Campbell LV, Greenfield JR, Lange K, Christopher MJ, et al. The effect of short-term overfeeding on serum lipids in healthy humans. Obesity (Silver Spring) 2013;21:E649-E659.
3. van der Meer RW, Hammer S, Lamb HJ, Frolich M, Diamant M, Rijzewijk LJ, et al. Effects of short-term high-fat, high-energy diet on hepatic and myocardial triglyceride content in healthy men. J Clin Endocrinol Metab 2008;93:2702-2708.
4. Westerbacka J, Lammi K, Hakkinen AM, Rissanen A, Salminen I, Aro A, et al. Dietary fat content modifies liver fat in overweight nondiabetic subjects. J Clin Endocrinol Metab 2005;90:2804-2809.
5. Meli R, Mattace RG, Irace C, Simeoli R, Di PA, Paciello O, et al. High fat diet induces liver steatosis and early dysregulation of iron metabolism in rats. PLoS One 2013;8:e66570.
6. Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005;115:1343-1351.
7. Maersk M, Belza A, Stodkilde-Jorgensen H, Ringgaard S, Chabanova E, Thomsen H, et al. Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study. Am J Clin Nutr 2012;95:283-289.
8. Le KA, Ith M, Kreis R, Faeh D, Bortolotti M, Tran C, et al. Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes. Am J Clin Nutr 2009;89:1760-1765.
9. Assy N, Nasser G, Kamayse I, Nseir W, Beniashvili Z, Djibre A, et al. Soft drink consumption linked with fatty liver in the absence of traditional risk factors. Can J Gastroenterol 2008;22:811-816.
10. Lecoultre V, Egli L, Carrel G, Theytaz F, Kreis R, Schneiter P, et al. Effects of fructose and glucose overfeeding on hepatic insulin sensitivity and intrahepatic lipids in healthy humans. Obesity (Silver Spring) 2013;21:782-785.
11. Johnston RD, Stephenson MC, Crossland H, Cordon SM, Palcidi E, Cox EF, et al. No difference between high-fructose and high-glucose diets on liver triacylglycerol or biochemistry in healthy overweight men. Gastroenterology 2013;145:1016-1025.
12. Piernas C, Popkin BM. Trends in snacking among U.S. children. Health Aff (Millwood) 2010;29:398-404.
13. Corbalan-Tutau MD, Madrid JA, Garaulet M. Timing and duration of sleep and meals in obese and normal weight women. Association with increase blood pressure. Appetite 2012;59:9-16.
14. la Fleur SE, Luijendijk MC, van der Zwaal EM, Brans MA, Adan RA. The snacking rat as model of human obesity: effects of a free-choice high-fat high-sugar diet on meal patterns. Int J Obes (Lond) 2013 [Epub ahead of print].
15. Fan JG, Li F, Cai XB, Peng YD, Ao QH, Gao Y. Effects of nonalcoholic fatty liver disease on the development of metabolic disorders. J Gastroenterol Hepatol 2007;22:1086-1091.
16. Ortiz-Lopez C, Lomonaco R, Orsak B, Finch J, Chang Z, Kochunov VG, et al. Prevalence of prediabetes and diabetes and metabolic profile of patients with nonalcoholic fatty liver disease (NAFLD). Diabetes Care 2012;35:873-878.
17. Visser ME, Lammers NM, Nederveen AJ, van der Graaf M, Heerschap A, Ackermans MT, et al. Hepatic steatosis does not cause insulin resistance in people with familial hypobetalipoproteinaemia. Diabetologia 2011;54:2113-2121.
18. Dirlewanger M, Schneiter P, Jequier E, Tappy L. Effects of fructose on hepatic glucose metabolism in humans. Am J Physiol Endocrinol Metab 2000;279:E907-E911.
19. Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL, et al. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 2009;119:1322-1334.
20. Diepenbroek C, Eggels L, Ackermans M, Fliers E, Serlie M, Kalsbeek A, et al. Obesogenic diets with fat and sugar reduce site specific sensitivity to insulin [Abstract]. Appetite 2011;57:13.
21. Sese MA, Jimenez-Pavon D, Gilbert CC, Gonzalez-Gross M, Gottrand F, de HS, et al. Eating behaviour, insulin resistance and cluster of metabolic risk factors in European adolescents. The HELENA study. Appetite 2012;59:140-147.
22. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2003;26 Suppl 1:S5-20.
23. Health Council of the Netherlands. Guidelines for a Healthy Diet 2006. The Hague, Netherlands: 2006.
24. Koopman KE, Booij J, Fliers E, Serlie MJ, la Fleur SE. Diet-induced changes in the lean brain: hypercaloric high-fat-high-sugar snacking decreases serotonin transporters in the human hypothalamic region. Mol Metab 2013;2:417-422.
25. Frayn KN. Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 1983;55:628-634.
26. van Werven JR, Hoogduin JM, Nederveen AJ, van Vliet AA, Wajs E, Vandenberk P, et al. Reproducibility of 3.0 Tesla magnetic resonance spectroscopy for measuring hepatic fat content. J Magn Reson Imaging 2009;30:444-448.
27. Tustison NJ, Avants BB, Cook PA, Zheng Y, Egan A, Yushkevich PA, et al. N4ITK: improved N3 bias correction. IEEE Trans Med Imaging 2010;29:1310-1320.
28. Siegel MJ, Hildebolt CF, Bae KT, Hong C, White NH. Total and intra-abdominal fat distribution in preadolescents and adolescents: measurement with MR imaging. Radiology 2007;242:846-856.
29. Ackermans MT, Pereira Arias AM, Bisschop PH, Endert E, Sauerwein HP, Romijn JA. The quantification of gluconeogenesis in healthy men by (2)H2O and [2-(13)C]glycerol yields different results: rates of gluconeogenesis in healthy men measured with (2)H2O are higher than those measured with [2-(13)C]glycerol. J Clin Endocrinol Metab 2001;86:2220-2226.
30. Brands M, Swat M, Lammers NM, Sauerwein HP, Endert E, Ackermans MT, et al. Effects of a hypercaloric diet on beta-cell responsivity in lean healthy men. Clin Endocrinol (Oxf) 2013;78:217-225.
31. Yokoyama H, Emoto M, Fujiwara S, Motoyama K, Morioka T, Komatsu M, et al. Quantitative insulin sensitivity check index and the reciprocal index of homeostasis model assessment are useful indexes of insulin resistance in type 2 diabetic patients with wide range of fasting plasma glucose. J Clin Endocrinol Metab 2004;89:1481-1484.
32. Finegood DT, Bergman RN, Vranic M. Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates. Diabetes 1987;36:914-924.
33. Steele R. Influences of glucose loading and of injected insulin on hepatic glucose output. Ann N Y Acad Sci 1959;82:420-430.
34. Acheson KJ, Flatt JP, Jequier E. Glycogen synthesis versus lipogenesis after a 500 gram carbohydrate meal in man. Metabolism 1982;31:1234-1240.
35. Gao M, Bu L, Ma Y, Liu D. Concurrent activation of liver x receptor and peroxisome proliferator-activated receptor alpha exacerbates hepatic steatosis in high fat diet-induced obese mice. PLoS One 2013;8:e65641.
36. Herman MA, Peroni OD, Villoria J, Schon MR, Abumrad NA, Bluher M, et al. A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature 2012;484:333-338.
37. Item F, Konrad D. Visceral fat and metabolic inflammation: the portal theory revisited. Obes Rev 2012;13(Suppl 2):30-39.
38. Tanaka S, Yamazaki T, Asano S, Mitsumoto A, Kobayashi D, Kudo N, et al. Increased lipid synthesis and decreased beta-oxidation in the liver of SHR/NDmcr-cp (cp/cp) rats, an animal model of metabolic syndrome. Lipids 2013;48:1115-1134.
39. InterAct Consortium. Consumption of sweet beverages and type 2 diabetes incidence in European adults: results from EPIC-InterAct. Diabetologia 2013;56:1520-1530.
40. Danaei G, Finucane MM, Lu Y, Singh GM, Cowan MJ, Paciorek CJ, et al. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet 2011;378:31-40.
41. Fagot-Campagna A, Pettitt DJ, Engelgau MM, Burrows NR, Geiss LS, Valdez R, et al. Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective. J Pediatr 2000;136:664-672.