메뉴 건너뛰기




Volumn 2, Issue SEP, 2015, Pages

Signaling in fibrosis: TGF-β, WNT, and YAP/TAZ converge

Author keywords

Fibrosis; Hippo; Myofibroblast; Signaling; TGF ; WNT; YAP TAZ

Indexed keywords


EID: 85050910102     PISSN: None     EISSN: 2296858X     Source Type: Journal    
DOI: 10.3389/fmed.2015.00059     Document Type: Review
Times cited : (396)

References (150)
  • 1
    • 84925060829 scopus 로고    scopus 로고
    • Fibrosis-a common pathway to organ injury and failure
    • Rockey DC, Bell P, Hill JA. Fibrosis-a common pathway to organ injury and failure. N Engl J Med (2015) 372:1138-49. doi:10.1056/NEJMra1300575
    • (2015) N Engl J Med , vol.372 , pp. 1138-1149
    • Rockey, D.C.1    Bell, P.2    Hill, J.A.3
  • 3
    • 73949096744 scopus 로고    scopus 로고
    • Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis
    • Humphreys BD, Lin S, Kobayashi A, Hudson TE, Nowlin BT, Bonventre JV, et al. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol (2010) 176:85-97. doi:10.2353/ajpath.2010.090517
    • (2010) Am J Pathol , vol.176 , pp. 85-97
    • Humphreys, B.D.1    Lin, S.2    Kobayashi, A.3    Hudson, T.E.4    Nowlin, B.T.5    Bonventre, J.V.6
  • 4
    • 84920730709 scopus 로고    scopus 로고
    • Perivascular Gli1(+) progenitors are key contributors to injury-induced organ fibrosis
    • Kramann R, Schneider RK, DiRocco DP, Machado F, Fleig S, Bondzie PA, et al. Perivascular Gli1(+) progenitors are key contributors to injury-induced organ fibrosis. Cell Stem Cell (2014) 16:51-66. doi:10.1016/j.stem.2014.11.004
    • (2014) Cell Stem Cell , vol.16 , pp. 51-66
    • Kramann, R.1    Schneider, R.K.2    DiRocco, D.P.3    Machado, F.4    Fleig, S.5    Bondzie, P.A.6
  • 5
    • 84886304100 scopus 로고    scopus 로고
    • Role of lung pericytes and resident fibroblasts in the pathogenesis of pulmonary fibrosis
    • Hung C, Linn G, Chow YH, Kobayashi A, Mittelsteadt K, Altemeier WA, et al. Role of lung pericytes and resident fibroblasts in the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med (2013) 188:820-30. doi:10.1164/rccm.201212-2297OC
    • (2013) Am J Respir Crit Care Med , vol.188 , pp. 820-830
    • Hung, C.1    Linn, G.2    Chow, Y.H.3    Kobayashi, A.4    Mittelsteadt, K.5    Altemeier, W.A.6
  • 6
    • 1342268310 scopus 로고    scopus 로고
    • Bone marrow-derived progenitor cells in pulmonary fibrosis
    • Hashimoto N, Jin H, Liu T, Chensue SW, Phan SH. Bone marrow-derived progenitor cells in pulmonary fibrosis. J Clin Invest (2004) 113:243-52. doi:10.1172/JCI18847
    • (2004) J Clin Invest , vol.113 , pp. 243-252
    • Hashimoto, N.1    Jin, H.2    Liu, T.3    Chensue, S.W.4    Phan, S.H.5
  • 8
    • 34547419062 scopus 로고    scopus 로고
    • Fibrocytes: a new insight into kidney fibrosis
    • Wada T, Sakai N, Matsushima K, Kaneko S. Fibrocytes: a new insight into kidney fibrosis. Kidney Int (2007) 72:269-73. doi:10.1038/sj.ki.5002325
    • (2007) Kidney Int , vol.72 , pp. 269-273
    • Wada, T.1    Sakai, N.2    Matsushima, K.3    Kaneko, S.4
  • 9
    • 79958779687 scopus 로고    scopus 로고
    • Scar wars: mapping the fate of epithelial-mesenchymal-myofibroblast transition
    • Quaggin SE, Kapus A. Scar wars: mapping the fate of epithelial-mesenchymal-myofibroblast transition. Kidney Int (2011) 80:41-50. doi:10.1038/ki.2011.77
    • (2011) Kidney Int , vol.80 , pp. 41-50
    • Quaggin, S.E.1    Kapus, A.2
  • 10
    • 55249103431 scopus 로고    scopus 로고
    • Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition
    • Zeisberg EM, Potenta SE, Sugimoto H, Zeisberg M, Kalluri R. Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol (2008) 19:2282-7. doi:10.1681/asn.2008050513
    • (2008) J Am Soc Nephrol , vol.19 , pp. 2282-2287
    • Zeisberg, E.M.1    Potenta, S.E.2    Sugimoto, H.3    Zeisberg, M.4    Kalluri, R.5
  • 11
    • 84926432474 scopus 로고    scopus 로고
    • Curtailing endothelial TGF-beta signaling is sufficient to reduce endothelial-mesenchymal transition and fibrosis in CKD
    • Xavier S, Vasko R, Matsumoto K, Zullo JA, Chen R, Maizel J, et al. Curtailing endothelial TGF-beta signaling is sufficient to reduce endothelial-mesenchymal transition and fibrosis in CKD. J Am Soc Nephrol (2015) 26:817-29. doi:10.1681/ASN.2013101137
    • (2015) J Am Soc Nephrol , vol.26 , pp. 817-829
    • Xavier, S.1    Vasko, R.2    Matsumoto, K.3    Zullo, J.A.4    Chen, R.5    Maizel, J.6
  • 12
    • 0028997539 scopus 로고
    • Role of the myofibroblast differentiation during liver fibrosis
    • Desmoulière A, Tuchweber B, Gabbiani G. Role of the myofibroblast differentiation during liver fibrosis. J Hepatol (1995) 22:61-4
    • (1995) J Hepatol , vol.22 , pp. 61-64
    • Desmoulière, A.1    Tuchweber, B.2    Gabbiani, G.3
  • 13
    • 33644948094 scopus 로고    scopus 로고
    • Masters and servants of the force: the role of matrix adhesions in myofibroblast force perception and transmission
    • Hinz B. Masters and servants of the force: the role of matrix adhesions in myofibroblast force perception and transmission. Eur J Cell Biol (2006) 85:175-81. doi:10.1016/j.ejcb.2005.09.004
    • (2006) Eur J Cell Biol , vol.85 , pp. 175-181
    • Hinz, B.1
  • 14
    • 0015225464 scopus 로고
    • Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction
    • Gabbiani G, Ryan GB, Majno G. Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia (1971) 27:549-50. doi:10.1007/BF02147594
    • (1971) Experientia , vol.27 , pp. 549-550
    • Gabbiani, G.1    Ryan, G.B.2    Majno, G.3
  • 15
    • 0035159094 scopus 로고    scopus 로고
    • Alpha-smooth muscle actin expression upregulates fibroblast contractile activity
    • Hinz B, Celetta G, Tomasek JJ, Gabbiani G, Chaponnier C. Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol Biol Cell (2001) 12:2730-41. doi:10.1091/mbc.12.9.2730
    • (2001) Mol Biol Cell , vol.12 , pp. 2730-2741
    • Hinz, B.1    Celetta, G.2    Tomasek, J.J.3    Gabbiani, G.4    Chaponnier, C.5
  • 16
    • 84885621343 scopus 로고    scopus 로고
    • Dynamic interplay of smooth muscle a-actin gene-regulatory proteins reflects the biological complexity of myofibroblast differentiation
    • Strauch AR, Hariharan S. Dynamic interplay of smooth muscle a-actin gene-regulatory proteins reflects the biological complexity of myofibroblast differentiation. Biology (Basel) (2013) 2:555-86. doi:10.3390/biology2020555
    • (2013) Biology (Basel) , vol.2 , pp. 555-586
    • Strauch, A.R.1    Hariharan, S.2
  • 17
    • 3543032204 scopus 로고    scopus 로고
    • Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon
    • van der Slot AJ, Zuurmond AM, van den Bogaerdt AJ, Ulrich MM, Middelkoop E, Boers W, et al. Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon. Matrix Biol (2004) 23:251-7. doi:10.1016/j.matbio.2004.06.001
    • (2004) Matrix Biol , vol.23 , pp. 251-257
    • van der Slot, A.J.1    Zuurmond, A.M.2    van den Bogaerdt, A.J.3    Ulrich, M.M.4    Middelkoop, E.5    Boers, W.6
  • 18
    • 84903694364 scopus 로고    scopus 로고
    • Fibrosis-a lethal component of systemic sclerosis
    • Ho YY, Lagares D, Tager AM, Kapoor M. Fibrosis-a lethal component of systemic sclerosis. Nat Rev Rheumatol (2014) 10:390-402. doi:10.1038/nrrheum.2014.53
    • (2014) Nat Rev Rheumatol , vol.10 , pp. 390-402
    • Ho, Y.Y.1    Lagares, D.2    Tager, A.M.3    Kapoor, M.4
  • 19
    • 84872338388 scopus 로고    scopus 로고
    • Therapy for fibrotic diseases: nearing the starting line
    • Friedman SL, Sheppard D, Duffield JS, Violette S. Therapy for fibrotic diseases: nearing the starting line. Sci Transl Med (2013) 5:167sr1. doi:10.1126/scitranslmed.3004700
    • (2013) Sci Transl Med , vol.5 , pp. 167sr1
    • Friedman, S.L.1    Sheppard, D.2    Duffield, J.S.3    Violette, S.4
  • 21
    • 78649856684 scopus 로고    scopus 로고
    • EDA-containing cellular fibronectin induces fibroblast differentiation through binding to alpha4beta7 integrin receptor and MAPK/Erk 1/2-dependent signaling
    • Kohan M, Muro AF, White ES, Berkman N. EDA-containing cellular fibronectin induces fibroblast differentiation through binding to alpha4beta7 integrin receptor and MAPK/Erk 1/2-dependent signaling. FASEB J (2010) 24:4503-12. doi:10.1096/fj.10-154435
    • (2010) FASEB J , vol.24 , pp. 4503-4512
    • Kohan, M.1    Muro, A.F.2    White, E.S.3    Berkman, N.4
  • 22
    • 2142646426 scopus 로고    scopus 로고
    • TGF-beta signaling and the fibrotic response
    • Leask A, Abraham DJ. TGF-beta signaling and the fibrotic response. FASEB J (2004) 18:816-27. doi:10.1096/fj.03-1273rev
    • (2004) FASEB J , vol.18 , pp. 816-827
    • Leask, A.1    Abraham, D.J.2
  • 23
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling and disease
    • Clevers H, Nusse R. Wnt/β-catenin signaling and disease. Cell (2012) 149:1192-205. doi:10.1016/j.cell.2012.05.012
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 24
    • 84865408942 scopus 로고    scopus 로고
    • Specificity of latent TGF-β binding protein (LTBP) incorporation into matrix: role of fibrillins and fibronectin
    • Zilberberg L, Todorovic V, Dabovic B, Horiguchi M, Couroussé T, Sakai LY, et al. Specificity of latent TGF-β binding protein (LTBP) incorporation into matrix: role of fibrillins and fibronectin. J Cell Physiol (2012) 227:3828-36. doi:10.1002/jcp.24094
    • (2012) J Cell Physiol , vol.227 , pp. 3828-3836
    • Zilberberg, L.1    Todorovic, V.2    Dabovic, B.3    Horiguchi, M.4    Couroussé, T.5    Sakai, L.Y.6
  • 25
    • 0034650486 scopus 로고    scopus 로고
    • Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    • Yu Q, Stamenkovic I. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev (2000) 14:163-76. doi:10.1101/gad.14.2.163
    • (2000) Genes Dev , vol.14 , pp. 163-176
    • Yu, Q.1    Stamenkovic, I.2
  • 26
    • 49049110677 scopus 로고    scopus 로고
    • Integrins and the activation of latent transforming growth factor beta1-an intimate relationship
    • Wipff PJ, Hinz B. Integrins and the activation of latent transforming growth factor beta1-an intimate relationship. Eur J Cell Biol (2008) 87:601-15. doi:10.1016/j.ejcb.2008.01.012
    • (2008) Eur J Cell Biol , vol.87 , pp. 601-615
    • Wipff, P.J.1    Hinz, B.2
  • 27
    • 79959250326 scopus 로고    scopus 로고
    • Latent TGF-β structure and activation
    • Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, et al. Latent TGF-β structure and activation. Nature (2011) 474:343-9. doi:10.1038/nature10152
    • (2011) Nature , vol.474 , pp. 343-349
    • Shi, M.1    Zhu, J.2    Wang, R.3    Chen, X.4    Mi, L.5    Walz, T.6
  • 30
    • 0031685620 scopus 로고    scopus 로고
    • TGF-beta signal transduction
    • Massagué J. TGF-beta signal transduction. Annu Rev Biochem (1998) 67:753-91. doi:10.1146/annurev.biochem.67.1.753
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massagué, J.1
  • 31
    • 70350780570 scopus 로고    scopus 로고
    • Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways
    • Alarcon C, Zaromytidou AI, Xi Q, Gao S, Yu J, Fujisawa S, et al. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell (2009) 139:757-69. doi:10.1016/j.cell.2009.09.035
    • (2009) Cell , vol.139 , pp. 757-769
    • Alarcon, C.1    Zaromytidou, A.I.2    Xi, Q.3    Gao, S.4    Yu, J.5    Fujisawa, S.6
  • 32
    • 79959640061 scopus 로고    scopus 로고
    • A Smad action turnover switch operated by WW domain readers of a phosphoserine code
    • Aragón E, Goerner N, Zaromytidou AI, Xi Q, Escobedo A, Massagué J, et al. A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev (2011) 25:1275-88. doi:10.1101/gad.2060811
    • (2011) Genes Dev , vol.25 , pp. 1275-1288
    • Aragón, E.1    Goerner, N.2    Zaromytidou, A.I.3    Xi, Q.4    Escobedo, A.5    Massagué, J.6
  • 33
    • 84866742560 scopus 로고    scopus 로고
    • TGFβ signalling in context
    • Massagué J. TGFβ signalling in context. Nat Rev Mol Cell Biol (2012) 13:616-30. doi:10.1038/nrm3434
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 616-630
    • Massagué, J.1
  • 34
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Shi Y, Massagué J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell (2003) 113:685-700. doi:10.1016/S0092-8674(03)00432-X
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massagué, J.2
  • 35
    • 35848951385 scopus 로고    scopus 로고
    • Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling
    • Bujak M, Ren G, Kweon HJ, Dobaczewski M, Reddy A, Taffet G, et al. Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. Circulation (2007) 116:2127-38. doi:10.1161/CIRCULATIONAHA.107.704197
    • (2007) Circulation , vol.116 , pp. 2127-2138
    • Bujak, M.1    Ren, G.2    Kweon, H.J.3    Dobaczewski, M.4    Reddy, A.5    Taffet, G.6
  • 37
    • 77956627158 scopus 로고    scopus 로고
    • Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction
    • Dobaczewski M, Bujak M, Li N, Gonzalez-Quesada C, Mendoza LH, Wang XF, et al. Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. Circ Res (2010) 107:418-28. doi:10.1161/CIRCRESAHA.109.216101
    • (2010) Circ Res , vol.107 , pp. 418-428
    • Dobaczewski, M.1    Bujak, M.2    Li, N.3    Gonzalez-Quesada, C.4    Mendoza, L.H.5    Wang, X.F.6
  • 38
    • 17044453955 scopus 로고    scopus 로고
    • Increased expression of transforming growth factor-β1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)
    • Takizawa H, Tanaka M, Takami K, Ohtoshi T, Ito K, Satoh M, et al. Increased expression of transforming growth factor-β1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med (2001) 163:1476-83. doi:10.1164/ajrccm.163.6.9908135
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 1476-1483
    • Takizawa, H.1    Tanaka, M.2    Takami, K.3    Ohtoshi, T.4    Ito, K.5    Satoh, M.6
  • 39
    • 4344653389 scopus 로고    scopus 로고
    • SMAD-signaling in chronic obstructive pulmonary disease: transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke
    • Springer J, Scholz FR, Peiser C, Groneberg DA, Fischer A. SMAD-signaling in chronic obstructive pulmonary disease: transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke. Biol Chem (2004) 385:649-53. doi:10.1515/BC.2004.080
    • (2004) Biol Chem , vol.385 , pp. 649-653
    • Springer, J.1    Scholz, F.R.2    Peiser, C.3    Groneberg, D.A.4    Fischer, A.5
  • 40
    • 51249120776 scopus 로고    scopus 로고
    • Identification of transforming growth factor β1-driven genetic programs of acute lung fibrosis
    • Pulichino A, Wang I, Caron A, Mortimer J, Auger A, Boie Y, et al. Identification of transforming growth factor β1-driven genetic programs of acute lung fibrosis. Am J Respir Cell Mol Biol (2008) 39:324-36. doi:10.1165/rcmb.2007-0186OC
    • (2008) Am J Respir Cell Mol Biol , vol.39 , pp. 324-336
    • Pulichino, A.1    Wang, I.2    Caron, A.3    Mortimer, J.4    Auger, A.5    Boie, Y.6
  • 41
    • 80055106592 scopus 로고    scopus 로고
    • Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-β
    • Sandbo N, Lau A, Kach J, Ngam C, Yau D, Dulin NO. Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-β. Am J Physiol Lung Cell Mol Physiol (2011) 301:656-66. doi:10.1152/ajplung.00166.2011
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.301 , pp. 656-666
    • Sandbo, N.1    Lau, A.2    Kach, J.3    Ngam, C.4    Yau, D.5    Dulin, N.O.6
  • 42
    • 0037837754 scopus 로고    scopus 로고
    • Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent
    • Liu C, Gaça MD, Swenson E, Vellucci VF, Reiss M, Wells RG. Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent. J Biol Chem (2003) 278:11721-8. doi:10.1074/jbc.M207728200
    • (2003) J Biol Chem , vol.278 , pp. 11721-11728
    • Liu, C.1    Gaça, M.D.2    Swenson, E.3    Vellucci, V.F.4    Reiss, M.5    Wells, R.G.6
  • 43
    • 24344500807 scopus 로고    scopus 로고
    • Smad2 and Smad3 play different roles in rat hepatic stellate cell function and a-smooth muscle actin organization
    • Uemura M, Swenson ES, Gaça MD, Giordano FJ, Reiss M, Wells RG. Smad2 and Smad3 play different roles in rat hepatic stellate cell function and a-smooth muscle actin organization. Mol Biol Cell (2005) 16:4214-24. doi:10.1091/mbc.E05-02-0149
    • (2005) Mol Biol Cell , vol.16 , pp. 4214-4224
    • Uemura, M.1    Swenson, E.S.2    Gaça, M.D.3    Giordano, F.J.4    Reiss, M.5    Wells, R.G.6
  • 44
    • 34547599359 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro
    • Kaimori A, Potter J, Kaimori JY, Wang C, Mezey E, Koteish A. Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro. J Biol Chem (2007) 282:22089-101. doi:10.1074/jbc.M700998200
    • (2007) J Biol Chem , vol.282 , pp. 22089-22101
    • Kaimori, A.1    Potter, J.2    Kaimori, J.Y.3    Wang, C.4    Mezey, E.5    Koteish, A.6
  • 45
    • 2942535966 scopus 로고    scopus 로고
    • Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice
    • Fukasawa H, Yamamoto T, Togawa A, Ohashi N, Fujigaki Y, Oda T, et al. Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice. Proc Natl Acad Sci U S A (2004) 101:8687-92. doi:10.1073/pnas.0400035101
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8687-8692
    • Fukasawa, H.1    Yamamoto, T.2    Togawa, A.3    Ohashi, N.4    Fujigaki, Y.5    Oda, T.6
  • 46
    • 0347992790 scopus 로고    scopus 로고
    • Treatment with anti-TGF-beta antibody ameliorates chronic progressive nephritis by inhibiting Smad/TGF-beta signaling
    • Fukasawa H, Yamamoto T, Suzuki H, Togawa A, Ohashi N, Fujigaki Y, et al. Treatment with anti-TGF-beta antibody ameliorates chronic progressive nephritis by inhibiting Smad/TGF-beta signaling. Kidney Int (2004) 65:63-74. doi:10.1111/j.1523-1755.2004.00393.x
    • (2004) Kidney Int , vol.65 , pp. 63-74
    • Fukasawa, H.1    Yamamoto, T.2    Suzuki, H.3    Togawa, A.4    Ohashi, N.5    Fujigaki, Y.6
  • 47
    • 34447522128 scopus 로고    scopus 로고
    • Cell phenotype-specific down-regulation of Smad3 involves decreased gene activation as well as protein degradation
    • Poncelet AC, Schnaper H, Tan R, Liu Y, Runyan CE. Cell phenotype-specific down-regulation of Smad3 involves decreased gene activation as well as protein degradation. J Biol Chem (2007) 282:15534-40. doi:10.1074/jbc.M701991200
    • (2007) J Biol Chem , vol.282 , pp. 15534-15540
    • Poncelet, A.C.1    Schnaper, H.2    Tan, R.3    Liu, Y.4    Runyan, C.E.5
  • 48
    • 33746122263 scopus 로고    scopus 로고
    • Intracellular TGF-beta receptor blockade abrogates Smad-dependent fibroblast activation in vitro and in vivo
    • Ishida W, Mori Y, Lakos G, Sun L, Shan F, Bowes S, et al. Intracellular TGF-beta receptor blockade abrogates Smad-dependent fibroblast activation in vitro and in vivo. J Invest Dermatol (2006) 126:1733-44. doi:10.1038/sj.jid.5700303
    • (2006) J Invest Dermatol , vol.126 , pp. 1733-1744
    • Ishida, W.1    Mori, Y.2    Lakos, G.3    Sun, L.4    Shan, F.5    Bowes, S.6
  • 49
    • 77956548300 scopus 로고    scopus 로고
    • Smad2 protects against TGF-β/Smad3-mediated renal fibrosis
    • Meng X, Huang X, Chung AC, Qin W, Shao X, Igarashi P, et al. Smad2 protects against TGF-β/Smad3-mediated renal fibrosis. J Am Soc Nephrol (2010) 21:1477-87. doi:10.1681/ASN.2009121244
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1477-1487
    • Meng, X.1    Huang, X.2    Chung, A.C.3    Qin, W.4    Shao, X.5    Igarashi, P.6
  • 50
    • 0033195998 scopus 로고    scopus 로고
    • Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
    • Ashcroft GS, Yang X, Glick AB, Weinstein M, Letterio JJ, Mizel DE, et al. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol (1999) 1:260-6. doi:10.1038/12971
    • (1999) Nat Cell Biol , vol.1 , pp. 260-266
    • Ashcroft, G.S.1    Yang, X.2    Glick, A.B.3    Weinstein, M.4    Letterio, J.J.5    Mizel, D.E.6
  • 51
    • 33745125907 scopus 로고    scopus 로고
    • Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure
    • Arany PR, Flanders KC, Kobayashi T, Kuo CK, Stuelten C, Desai KV, et al. Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure. Proc Natl Acad Sci U S A (2006) 103:9250-5. doi:10.1073/pnas.0602473103
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 9250-9255
    • Arany, P.R.1    Flanders, K.C.2    Kobayashi, T.3    Kuo, C.K.4    Stuelten, C.5    Desai, K.V.6
  • 52
    • 76349084499 scopus 로고    scopus 로고
    • Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3
    • Masszi A, Speight P, Charbonney E, Lodyga M, Nakano H, Szászi K, et al. Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3. J Cell Biol (2010) 188:383-99. doi:10.1083/jcb.200906155
    • (2010) J Cell Biol , vol.188 , pp. 383-399
    • Masszi, A.1    Speight, P.2    Charbonney, E.3    Lodyga, M.4    Nakano, H.5    Szászi, K.6
  • 53
    • 78650982203 scopus 로고    scopus 로고
    • Smad linker region phosphorylation in the regulation of extracellular matrix synthesis
    • Burch ML, Zheng W, Little PJ. Smad linker region phosphorylation in the regulation of extracellular matrix synthesis. Cell Mol Life Sci (2011) 68:97-107. doi:10.1007/s00018-010-0514-4
    • (2011) Cell Mol Life Sci , vol.68 , pp. 97-107
    • Burch, M.L.1    Zheng, W.2    Little, P.J.3
  • 54
    • 84904668928 scopus 로고    scopus 로고
    • Opposing roles for Smad2 and Smad3 in peritoneal fibrosis in vivo and in vitro
    • Duan WJ, Yu X, Huang XR, Yu JW, Lan HY. Opposing roles for Smad2 and Smad3 in peritoneal fibrosis in vivo and in vitro. Am J Pathol (2014) 184:2275-84. doi:10.1016/j.ajpath.2014.04.014
    • (2014) Am J Pathol , vol.184 , pp. 2275-2284
    • Duan, W.J.1    Yu, X.2    Huang, X.R.3    Yu, J.W.4    Lan, H.Y.5
  • 55
    • 84940787634 scopus 로고    scopus 로고
    • Renal fibrosis is not reduced by blocking transforming growth factor-β signaling in matrix-producing interstitial cells
    • Neelisetty S, Alford C, Reynolds K, Woodbury L, Nlandu-Khodo S, Yang H, et al. Renal fibrosis is not reduced by blocking transforming growth factor-β signaling in matrix-producing interstitial cells. Kidney Int (2015). doi:10.1038/ki.2015.51
    • (2015) Kidney Int
    • Neelisetty, S.1    Alford, C.2    Reynolds, K.3    Woodbury, L.4    Nlandu-Khodo, S.5    Yang, H.6
  • 56
    • 80155137594 scopus 로고    scopus 로고
    • Master transcription factors determine cell-type-specific responses to TGF-β signaling
    • Mullen AC, Orlando DA, Newman JJ, Lovén J, Kumar RM, Bilodeau S, et al. Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell (2011) 147:565-76. doi:10.1016/j.cell.2011.08.050
    • (2011) Cell , vol.147 , pp. 565-576
    • Mullen, A.C.1    Orlando, D.A.2    Newman, J.J.3    Lovén, J.4    Kumar, R.M.5    Bilodeau, S.6
  • 57
    • 84870252814 scopus 로고    scopus 로고
    • The complex world of WNT receptor signalling
    • Niehrs C. The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol (2012) 13:767-79. doi:10.1038/nrm3470
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 767-779
    • Niehrs, C.1
  • 58
    • 71149111905 scopus 로고    scopus 로고
    • Wnt signaling and the polarity of the primary body axis
    • Petersen CP, Reddien PW. Wnt signaling and the polarity of the primary body axis. Cell (2009) 139:1056-68. doi:10.1016/j.cell.2009.11.035
    • (2009) Cell , vol.139 , pp. 1056-1068
    • Petersen, C.P.1    Reddien, P.W.2
  • 59
    • 55749102279 scopus 로고    scopus 로고
    • Alternative wnt signaling is initiated by distinct receptors
    • van Amerongen R, Mikels A, Nusse R. Alternative wnt signaling is initiated by distinct receptors. Sci Signal (2008) 1:re9. doi:10.1126/scisignal.135re9
    • (2008) Sci Signal , vol.1
    • van Amerongen, R.1    Mikels, A.2    Nusse, R.3
  • 60
    • 0030978351 scopus 로고    scopus 로고
    • beta-catenin is a target for the ubiquitin-proteasome pathway
    • Aberle H, Bauer A, Stappert J, Kispert A, Kemler R. beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J (1997) 16:3797-804. doi:10.1093/emboj/16.13.3797
    • (1997) EMBO J , vol.16 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3    Kispert, A.4    Kemler, R.5
  • 61
    • 0037155691 scopus 로고    scopus 로고
    • Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    • Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, et al. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell (2002) 108:837-47. doi:10.1016/S0092-8674(02)00685-2
    • (2002) Cell , vol.108 , pp. 837-847
    • Liu, C.1    Li, Y.2    Semenov, M.3    Han, C.4    Baeg, G.H.5    Tan, Y.6
  • 62
    • 28644444440 scopus 로고    scopus 로고
    • Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction
    • Davidson G, Wu W, Shen J, Bilic J, Fenger U, Stannek P, et al. Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature (2005) 438:867-72. doi:10.1038/nature04170
    • (2005) Nature , vol.438 , pp. 867-872
    • Davidson, G.1    Wu, W.2    Shen, J.3    Bilic, J.4    Fenger, U.5    Stannek, P.6
  • 63
    • 28644439005 scopus 로고    scopus 로고
    • A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
    • Zeng X, Tamai K, Doble B, Li S, Huang H, Habas R, et al. A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature (2005) 438:873-7. doi:10.1038/nature04185
    • (2005) Nature , vol.438 , pp. 873-877
    • Zeng, X.1    Tamai, K.2    Doble, B.3    Li, S.4    Huang, H.5    Habas, R.6
  • 64
    • 84861972831 scopus 로고    scopus 로고
    • Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex
    • Li VS, Ng SS, Boersema PJ, Low TY, Karthaus WR, Gerlach JP, et al. Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell (2012) 149:1245-56. doi:10.1016/j.cell.2012.05.002
    • (2012) Cell , vol.149 , pp. 1245-1256
    • Li, V.S.1    Ng, S.S.2    Boersema, P.J.3    Low, T.Y.4    Karthaus, W.R.5    Gerlach, J.P.6
  • 65
    • 34250827150 scopus 로고    scopus 로고
    • Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation
    • Bilic J, Huang YL, Davidson G, Zimmermann T, Cruciat CM, Bienz M, et al. Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science (2007) 316:1619-22. doi:10.1126/science.1137065
    • (2007) Science , vol.316 , pp. 1619-1622
    • Bilic, J.1    Huang, Y.L.2    Davidson, G.3    Zimmermann, T.4    Cruciat, C.M.5    Bienz, M.6
  • 66
    • 78650484935 scopus 로고    scopus 로고
    • Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes
    • Taelman VF, Dobrowolski R, Plouhinec JL, Fuentealba LC, Vorwald PP, Gumper I, et al. Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes. Cell (2010) 143:1136-48. doi:10.1016/j.cell.2010.11.034
    • (2010) Cell , vol.143 , pp. 1136-1148
    • Taelman, V.F.1    Dobrowolski, R.2    Plouhinec, J.L.3    Fuentealba, L.C.4    Vorwald, P.P.5    Gumper, I.6
  • 67
    • 0029781509 scopus 로고    scopus 로고
    • Functional interaction of beta-catenin with the transcription factor LEF-1
    • Behrens J, von Kries J, Kühl M, Bruhn L, Wedlich D, Grosschedl R, et al. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature (1996) 382:638-42. doi:10.1038/382638a0
    • (1996) Nature , vol.382 , pp. 638-642
    • Behrens, J.1    von Kries, J.2    Kühl, M.3    Bruhn, L.4    Wedlich, D.5    Grosschedl, R.6
  • 68
    • 0001003110 scopus 로고    scopus 로고
    • XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
    • Molenaar M, van de Wetering M, Oosterwegel M, Peterson-Maduro J, Godsave S, Korinek V, et al. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell (1996) 86:391-9. doi:10.1016/S0092-8674(00)80112-9
    • (1996) Cell , vol.86 , pp. 391-399
    • Molenaar, M.1    van de Wetering, M.2    Oosterwegel, M.3    Peterson-Maduro, J.4    Godsave, S.5    Korinek, V.6
  • 70
    • 58149333154 scopus 로고    scopus 로고
    • Secreted frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction
    • Kobayashi K, Luo M, Zhang Y, Wilkes DC, Ge G, Grieskamp T, et al. Secreted frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction. Nat Cell Biol (2008) 11:46-55. doi:10.1038/ncb1811
    • (2008) Nat Cell Biol , vol.11 , pp. 46-55
    • Kobayashi, K.1    Luo, M.2    Zhang, Y.3    Wilkes, D.C.4    Ge, G.5    Grieskamp, T.6
  • 71
    • 84857192566 scopus 로고    scopus 로고
    • Wnt1/β-catenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair
    • Duan J, Gherghe C, Liu D, Hamlett E, Srikantha L, Rodgers L, et al. Wnt1/β-catenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. EMBO J (2012) 31:429-42. doi:10.1038/emboj.2011.418
    • (2012) EMBO J , vol.31 , pp. 429-442
    • Duan, J.1    Gherghe, C.2    Liu, D.3    Hamlett, E.4    Srikantha, L.5    Rodgers, L.6
  • 72
    • 84870915167 scopus 로고    scopus 로고
    • Canonical Wnt/β-catenin signaling in epicardial fibrosis of failed pediatric heart allografts with diastolic dysfunction
    • Ye B, Ge Y, Perens G, Hong L, Xu H, Fishbein MC, et al. Canonical Wnt/β-catenin signaling in epicardial fibrosis of failed pediatric heart allografts with diastolic dysfunction. Cardiovasc Pathol (2013) 22:54-7. doi:10.1016/j.carpath.2012.03.004
    • (2013) Cardiovasc Pathol , vol.22 , pp. 54-57
    • Ye, B.1    Ge, Y.2    Perens, G.3    Hong, L.4    Xu, H.5    Fishbein, M.C.6
  • 73
    • 77956288500 scopus 로고    scopus 로고
    • Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis
    • Henderson WR, Chi EY, Ye X, Nguyen C, Tien YT, Zhou B, et al. Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A (2010) 107:14309-14. doi:10.1073/pnas.1001520107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 14309-14314
    • Henderson, W.R.1    Chi, E.Y.2    Ye, X.3    Nguyen, C.4    Tien, Y.T.5    Zhou, B.6
  • 74
    • 79958077377 scopus 로고    scopus 로고
    • Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation
    • Lam AP, Flozak AS, Russell S, Wei J, Jain M, Mutlu GM, et al. Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation. Am J Respir Cell Mol Biol (2011) 45:915-22. doi:10.1165/rcmb.2010-0113OC
    • (2011) Am J Respir Cell Mol Biol , vol.45 , pp. 915-922
    • Lam, A.P.1    Flozak, A.S.2    Russell, S.3    Wei, J.4    Jain, M.5    Mutlu, G.M.6
  • 75
    • 84863133508 scopus 로고    scopus 로고
    • Axin pathway activity regulates in vivo pY654-β-catenin accumulation and pulmonary fibrosis
    • Ulsamer A, Wei Y, Kim KK, Tan K, Wheeler S, Xi Y, et al. Axin pathway activity regulates in vivo pY654-β-catenin accumulation and pulmonary fibrosis. J Biol Chem (2012) 297:5164-72. doi:10.1074/jbc.M111.322123
    • (2012) J Biol Chem , vol.297 , pp. 5164-5172
    • Ulsamer, A.1    Wei, Y.2    Kim, K.K.3    Tan, K.4    Wheeler, S.5    Xi, Y.6
  • 76
    • 28444468088 scopus 로고    scopus 로고
    • Wnt-dependent β-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis
    • Surendran K, Schiavi S, Hruska KA. Wnt-dependent β-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol (2005) 16:2373-84. doi:10.1681/ASN.2004110949
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2373-2384
    • Surendran, K.1    Schiavi, S.2    Hruska, K.A.3
  • 77
    • 65249134946 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling promotes renal interstitial fibrosis
    • He W, Dai C, Li Y, Zeng G, Monga SP, Liu Y. Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol (2009) 20:765-76. doi:10.1681/ASN.2008060566
    • (2009) J Am Soc Nephrol , vol.20 , pp. 765-776
    • He, W.1    Dai, C.2    Li, Y.3    Zeng, G.4    Monga, S.P.5    Liu, Y.6
  • 78
    • 80052335469 scopus 로고    scopus 로고
    • Targeted inhibition of β-catenin/CBP signaling ameliorates renal interstitial fibrosis
    • Hao S, He W, Li Y, Ding H, Hou Y, Nie J, et al. Targeted inhibition of β-catenin/CBP signaling ameliorates renal interstitial fibrosis. J Am Soc Nephrol (2011) 22:1642-53. doi:10.1681/ASN.2010101079
    • (2011) J Am Soc Nephrol , vol.22 , pp. 1642-1653
    • Hao, S.1    He, W.2    Li, Y.3    Ding, H.4    Hou, Y.5    Nie, J.6
  • 79
    • 84872867267 scopus 로고    scopus 로고
    • LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1
    • Ren S, Johnson BG, Kida Y, Ip C, Davidson KC, Lin SL, et al. LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1. Proc Natl Acad Sci U S A (2013) 110:1440-5. doi:10.1073/pnas.1211179110
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 1440-1445
    • Ren, S.1    Johnson, B.G.2    Kida, Y.3    Ip, C.4    Davidson, K.C.5    Lin, S.L.6
  • 81
    • 33746513742 scopus 로고    scopus 로고
    • Upregulation of the Wnt/β-catenin pathway induced by transforming growth factor-β in hypertrophic scars and keloids
    • Sato M. Upregulation of the Wnt/β-catenin pathway induced by transforming growth factor-β in hypertrophic scars and keloids. Acta Derm Venereol (2006) 86:300-7. doi:10.2340/00015555-0101
    • (2006) Acta Derm Venereol , vol.86 , pp. 300-307
    • Sato, M.1
  • 82
    • 84863923526 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells
    • Wei J, Fang F, Lam AP, Sargent JL, Hamburg E, Hinchcliff ME, et al. Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells. Arthritis Rheum (2012) 64:2734-45. doi:10.1002/art.34424
    • (2012) Arthritis Rheum , vol.64 , pp. 2734-2745
    • Wei, J.1    Fang, F.2    Lam, A.P.3    Sargent, J.L.4    Hamburg, E.5    Hinchcliff, M.E.6
  • 83
    • 55849132694 scopus 로고    scopus 로고
    • GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism
    • Kapoor M, Liu S, Shi-wen X, Huh K, McCann M, Denton CP, et al. GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism. J Clin Invest (2008) 118:3279-90. doi:10.1172/JCI35381
    • (2008) J Clin Invest , vol.118 , pp. 3279-3290
    • Kapoor, M.1    Liu, S.2    Shi-wen, X.3    Huh, K.4    McCann, M.5    Denton, C.P.6
  • 84
    • 82755197822 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase 3β induces dermal fibrosis by activation of the canonical Wnt pathway
    • Bergmann C, Akhmetshina A, Dees C, Palumbo K, Zerr P, Beyer C, et al. Inhibition of glycogen synthase kinase 3β induces dermal fibrosis by activation of the canonical Wnt pathway. Ann Rheum Dis (2011) 70:2191-8. doi:10.1136/ard.2010.147140
    • (2011) Ann Rheum Dis , vol.70 , pp. 2191-2198
    • Bergmann, C.1    Akhmetshina, A.2    Dees, C.3    Palumbo, K.4    Zerr, P.5    Beyer, C.6
  • 85
    • 84866393033 scopus 로고    scopus 로고
    • Sustained β-catenin activity in dermal fibroblasts is sufficient for skin fibrosis
    • Hamburg EJ, Atit RP. Sustained β-catenin activity in dermal fibroblasts is sufficient for skin fibrosis. J Invest Dermatol (2012) 235:686-97. doi:10.1038/jid.2012.155
    • (2012) J Invest Dermatol , vol.235 , pp. 686-697
    • Hamburg, E.J.1    Atit, R.P.2
  • 86
    • 84859500585 scopus 로고    scopus 로고
    • β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis
    • Beyer C, Schramm A, Akhmetshina A, Dees C, Kireva T, Gelse K, et al. β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis. Ann Rheum Dis (2012) 71:761-7. doi:10.1136/annrheumdis-2011-200568
    • (2012) Ann Rheum Dis , vol.71 , pp. 761-767
    • Beyer, C.1    Schramm, A.2    Akhmetshina, A.3    Dees, C.4    Kireva, T.5    Gelse, K.6
  • 87
    • 84893767540 scopus 로고    scopus 로고
    • Inactivation of evenness interrupted (EVI) reduces experimental fibrosis by combined inhibition of canonical and non-canonical Wnt signalling
    • Distler A, Ziemer C, Beyer C, Lin NY, Chen CW, Palumbo-Zerr K, et al. Inactivation of evenness interrupted (EVI) reduces experimental fibrosis by combined inhibition of canonical and non-canonical Wnt signalling. Ann Rheum Dis (2014) 73:624-7. doi:10.1136/annrheumdis-2013-203995
    • (2014) Ann Rheum Dis , vol.73 , pp. 624-627
    • Distler, A.1    Ziemer, C.2    Beyer, C.3    Lin, N.Y.4    Chen, C.W.5    Palumbo-Zerr, K.6
  • 88
    • 0038783316 scopus 로고    scopus 로고
    • Secreted antagonists of the Wnt signalling pathway
    • Kawano Y, Kypta R. Secreted antagonists of the Wnt signalling pathway. J Cell Sci (2003) 116:2627-34. doi:10.1242/jcs.00623
    • (2003) J Cell Sci , vol.116 , pp. 2627-2634
    • Kawano, Y.1    Kypta, R.2
  • 89
    • 84899914231 scopus 로고    scopus 로고
    • The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis
    • Dees C, Schlottmann I, Funke R, Distler A, Palumbo-Zerr K, Zerr P, et al. The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis. Ann Rheum Dis (2014) 73:1232-9. doi:10.1136/annrheumdis-2012-203194
    • (2014) Ann Rheum Dis , vol.73 , pp. 1232-1239
    • Dees, C.1    Schlottmann, I.2    Funke, R.3    Distler, A.4    Palumbo-Zerr, K.5    Zerr, P.6
  • 90
    • 23744458034 scopus 로고    scopus 로고
    • The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP
    • Huang J, Wu S, Barrera J, Matthews K, Pan D. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP. Cell (2005) 122:421-34. doi:10.1016/j.cell.2005.06.007
    • (2005) Cell , vol.122 , pp. 421-434
    • Huang, J.1    Wu, S.2    Barrera, J.3    Matthews, K.4    Pan, D.5
  • 91
    • 36549074631 scopus 로고    scopus 로고
    • YAP1 increases organ size and expands undifferentiated progenitor cells
    • Camargo FD, Gokhale S, Johnnidis JB, Fu D, Bell GW, Jaenisch R, et al. YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol (2007) 17:2054-60. doi:10.1016/j.cub.2007.10.039
    • (2007) Curr Biol , vol.17 , pp. 2054-2060
    • Camargo, F.D.1    Gokhale, S.2    Johnnidis, J.B.3    Fu, D.4    Bell, G.W.5    Jaenisch, R.6
  • 92
    • 84916633921 scopus 로고    scopus 로고
    • The biology of YAP/TAZ: hippo signaling and beyond
    • Piccolo S, Dupont S, Cordenonsi M. The biology of YAP/TAZ: hippo signaling and beyond. Physiol Rev (2014) 94:1287-312. doi:10.1152/physrev.00005.2014
    • (2014) Physiol Rev , vol.94 , pp. 1287-1312
    • Piccolo, S.1    Dupont, S.2    Cordenonsi, M.3
  • 93
    • 0028997651 scopus 로고
    • Characterization of the mammalian YAP (Yes-associated Protein) gene and its role in defining a novel protein module, the WW domain
    • Sudol M, Bork P, Einbond A, Kastury K, Druck T, Negrini M, et al. Characterization of the mammalian YAP (Yes-associated Protein) gene and its role in defining a novel protein module, the WW domain. J Biol Chem (1995) 270:14733-41. doi:10.1074/jbc.270.24.14733
    • (1995) J Biol Chem , vol.270 , pp. 14733-14741
    • Sudol, M.1    Bork, P.2    Einbond, A.3    Kastury, K.4    Druck, T.5    Negrini, M.6
  • 94
    • 17744380191 scopus 로고    scopus 로고
    • TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins
    • Kanai F, Marignani P, Sarbassova D, Yagi R, Hall R, Donowitz M, et al. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J (2000) 19:6778-91. doi:10.1093/emboj/19.24.6778
    • (2000) EMBO J , vol.19 , pp. 6778-6791
    • Kanai, F.1    Marignani, P.2    Sarbassova, D.3    Yagi, R.4    Hall, R.5    Donowitz, M.6
  • 95
    • 23644431709 scopus 로고    scopus 로고
    • TAZ, a transcriptional modulator of mesenchymal stem cell differentiation
    • Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, et al. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (2005) 309:1074-8. doi:10.1126/science.1110955
    • (2005) Science , vol.309 , pp. 1074-1078
    • Hong, J.H.1    Hwang, E.S.2    McManus, M.T.3    Amsterdam, A.4    Tian, Y.5    Kalmukova, R.6
  • 96
    • 0042232429 scopus 로고    scopus 로고
    • Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts
    • Wu S, Huang J, Dong J, Pan D. Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell (2003) 114:445-56. doi:10.1016/S0092-8674(03)00549-X
    • (2003) Cell , vol.114 , pp. 445-456
    • Wu, S.1    Huang, J.2    Dong, J.3    Pan, D.4
  • 97
    • 35948961118 scopus 로고    scopus 로고
    • Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
    • Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev (2007) 21:2747-61. doi:10.1101/gad.1602907
    • (2007) Genes Dev , vol.21 , pp. 2747-2761
    • Zhao, B.1    Wei, X.2    Li, W.3    Udan, R.S.4    Yang, Q.5    Kim, J.6
  • 98
    • 78549275131 scopus 로고    scopus 로고
    • The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCFbeta-TrCP E3 ligase
    • Liu CY, Zha ZY, Zhou X, Zhang H, Huang W, Zhao D, et al. The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCFbeta-TrCP E3 ligase. J Biol Chem (2010) 285:37159-69. doi:10.1074/jbc.M110.152942
    • (2010) J Biol Chem , vol.285 , pp. 37159-37169
    • Liu, C.Y.1    Zha, Z.Y.2    Zhou, X.3    Zhang, H.4    Huang, W.5    Zhao, D.6
  • 99
    • 55549098921 scopus 로고    scopus 로고
    • Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP)
    • Oka T, Mazack V, Sudol M. Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP). J Biol Chem (2008) 283:27534-46. doi:10.1074/jbc.M804380200
    • (2008) J Biol Chem , vol.283 , pp. 27534-27546
    • Oka, T.1    Mazack, V.2    Sudol, M.3
  • 100
    • 73549095761 scopus 로고    scopus 로고
    • A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)
    • Zhao B, Li L, Tumaneng K, Wang CY, Guan KL. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes Dev (2010) 24:72-85. doi:10.1101/gad.1843810
    • (2010) Genes Dev , vol.24 , pp. 72-85
    • Zhao, B.1    Li, L.2    Tumaneng, K.3    Wang, C.Y.4    Guan, K.L.5
  • 101
    • 0035873391 scopus 로고    scopus 로고
    • TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm
    • Vassilev A, Kaneko K, Shu H, Zhao Y, DePamphilis MTEAD./TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. Genes Dev (2001) 15:1229-41. doi:10.1101/gad.888601
    • (2001) Genes Dev , vol.15 , pp. 1229-1241
    • Vassilev, A.1    Kaneko, K.2    Shu, H.3    Zhao, Y.4    De Pamphilis, M.T.E.A.D.5
  • 102
    • 47549095853 scopus 로고    scopus 로고
    • TEAD mediates YAP-dependent gene induction and growth control
    • Zhao B, Ye X, Yu J, Li L, Li W, Li S, et al. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev (2008) 22:1962-71. doi:10.1101/gad.1664408
    • (2008) Genes Dev , vol.22 , pp. 1962-1971
    • Zhao, B.1    Ye, X.2    Yu, J.3    Li, L.4    Li, W.5    Li, S.6
  • 103
    • 19544393341 scopus 로고    scopus 로고
    • The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members
    • Mahoney WM, Hong JH, Yaffe MB, Farrance IK. The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members. Biochem J (2005) 388:217-25. doi:10.1042/BJ20041434
    • (2005) Biochem J , vol.388 , pp. 217-225
    • Mahoney, W.M.1    Hong, J.H.2    Yaffe, M.B.3    Farrance, I.K.4
  • 104
    • 67649412006 scopus 로고    scopus 로고
    • TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition
    • Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, et al. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem (2009) 284:13355-62. doi:10.1074/jbc.M900843200
    • (2009) J Biol Chem , vol.284 , pp. 13355-13362
    • Zhang, H.1    Liu, C.Y.2    Zha, Z.Y.3    Zhao, B.4    Yao, J.5    Zhao, S.6
  • 106
    • 80051923057 scopus 로고    scopus 로고
    • Hippo pathway regulation by cell morphology and stress fibers
    • Wada K, Itoga K, Okano T, Yonemura S, Sasaki H. Hippo pathway regulation by cell morphology and stress fibers. Development (2011) 138:3907-14. doi:10.1242/dev.070987
    • (2011) Development , vol.138 , pp. 3907-3914
    • Wada, K.1    Itoga, K.2    Okano, T.3    Yonemura, S.4    Sasaki, H.5
  • 107
    • 79958851169 scopus 로고    scopus 로고
    • Modulating F-actin organization induces organ growth by affecting the Hippo pathway
    • Sansores-Garcia L, Bossuyt W, Wada K, Yonemura S, Tao C, Sasaki H, et al. Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J (2011) 30:2325-35. doi:10.1038/emboj.2011.157
    • (2011) EMBO J , vol.30 , pp. 2325-2335
    • Sansores-Garcia, L.1    Bossuyt, W.2    Wada, K.3    Yonemura, S.4    Tao, C.5    Sasaki, H.6
  • 109
    • 84983102616 scopus 로고    scopus 로고
    • The Hippo pathway effector YAP controls mouse hepatic stellate cell activation
    • Mannaerts I, Leite SB, Verhulst S, Claerhout S, Eysackers N, Thoen LF, et al. The Hippo pathway effector YAP controls mouse hepatic stellate cell activation. J Hepatol (2015) 63:679-88. doi:10.1016/j.jhep.2015.04.011
    • (2015) J Hepatol , vol.63 , pp. 679-688
    • Mannaerts, I.1    Leite, S.B.2    Verhulst, S.3    Claerhout, S.4    Eysackers, N.5    Thoen, L.F.6
  • 110
    • 68849118748 scopus 로고    scopus 로고
    • Transcriptional coactivator with PDZ-binding motif is essential for normal alveolarization in mice
    • Mitani A, Nagase T, Fukuchi K, Aburatani H, Makita R, Kurihara H. Transcriptional coactivator with PDZ-binding motif is essential for normal alveolarization in mice. Am J Respir Crit Care Med (2009) 180:326-38. doi:10.1164/rccm.200812-1827OC
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 326-338
    • Mitani, A.1    Nagase, T.2    Fukuchi, K.3    Aburatani, H.4    Makita, R.5    Kurihara, H.6
  • 112
    • 84904746093 scopus 로고    scopus 로고
    • Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model
    • Lin Z, von Gise A, Zhou P, Gu F, Ma Q, Jiang J, et al. Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. Circ Res (2014) 115:354-63. doi:10.1161/CIRCRESAHA.115.303632
    • (2014) Circ Res , vol.115 , pp. 354-363
    • Lin, Z.1    von Gise, A.2    Zhou, P.3    Gu, F.4    Ma, Q.5    Jiang, J.6
  • 114
    • 79956200232 scopus 로고    scopus 로고
    • Wnt3a induces myofibroblast differentiation by upregulating TGF-β signaling through SMAD2 in a β-catenin-dependent manner
    • Carthy JM, Garmaroudi FS, Luo Z, McManus BM. Wnt3a induces myofibroblast differentiation by upregulating TGF-β signaling through SMAD2 in a β-catenin-dependent manner. PLoS One (2011) 6:e19809. doi:10.1371/journal.pone.0019809
    • (2011) PLoS One , vol.6
    • Carthy, J.M.1    Garmaroudi, F.S.2    Luo, Z.3    McManus, B.M.4
  • 116
    • 84859179083 scopus 로고    scopus 로고
    • Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
    • Akhmetshina A, Palumbo K, Dees C, Bergmann C, Venalis P, Zerr P, et al. Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis. Nat Commun (2012) 3:735. doi:10.1038/ncomms1734
    • (2012) Nat Commun , vol.3 , pp. 735
    • Akhmetshina, A.1    Palumbo, K.2    Dees, C.3    Bergmann, C.4    Venalis, P.5    Zerr, P.6
  • 117
    • 0031587828 scopus 로고    scopus 로고
    • The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
    • Hayashi H, Abdollah S, Qiu Y, Cai J, Xu Y, Grinnell B, et al. The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell (1997) 89:1165-73. doi:10.1016/S0092-8674(00)80303-7
    • (1997) Cell , vol.89 , pp. 1165-1173
    • Hayashi, H.1    Abdollah, S.2    Qiu, Y.3    Cai, J.4    Xu, Y.5    Grinnell, B.6
  • 118
    • 0037173716 scopus 로고    scopus 로고
    • Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling
    • Ferrigno O, Lallemand F, Verrecchia F, L'Hoste S, Camonis J, Atfi A, et al. Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling. Oncogene (2002) 21:4879-84. doi:10.1038/sj.onc.1205623
    • (2002) Oncogene , vol.21 , pp. 4879-4884
    • Ferrigno, O.1    Lallemand, F.2    Verrecchia, F.3    L'Hoste, S.4    Camonis, J.5    Atfi, A.6
  • 119
    • 33747866023 scopus 로고    scopus 로고
    • Smad7-induced beta-catenin degradation alters epidermal appendage development
    • Han G, Li AG, Liang YY, Owens P, He W, Lu S, et al. Smad7-induced beta-catenin degradation alters epidermal appendage development. Dev Cell (2006) 11:301-12. doi:10.1016/j.devcel.2006.06.014
    • (2006) Dev Cell , vol.11 , pp. 301-312
    • Han, G.1    Li, A.G.2    Liang, Y.Y.3    Owens, P.4    He, W.5    Lu, S.6
  • 120
    • 53049085564 scopus 로고    scopus 로고
    • Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion
    • Tang Y, Liu Z, Zhao L, Clemens TL, Cao X. Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion. J Biol Chem (2008) 283:23956-63. doi:10.1074/jbc.M800351200
    • (2008) J Biol Chem , vol.283 , pp. 23956-23963
    • Tang, Y.1    Liu, Z.2    Zhao, L.3    Clemens, T.L.4    Cao, X.5
  • 121
    • 33646132747 scopus 로고    scopus 로고
    • Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia
    • Liu W, Rui H, Wang J, Lin S, He Y, Chen M, et al. Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J (2006) 25:1646-58. doi:10.1038/sj.emboj.7601057
    • (2006) EMBO J , vol.25 , pp. 1646-1658
    • Liu, W.1    Rui, H.2    Wang, J.3    Lin, S.4    He, Y.5    Chen, M.6
  • 122
    • 0034947962 scopus 로고    scopus 로고
    • Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway
    • Furuhashi M, Yagi K, Yamamoto H, Furukawa Y, Shimada S, Nakamura Y, et al. Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway. Mol Cell Biol (2001) 21:5132-41. doi:10.1128/MCB.21.15.5132-5141.2001
    • (2001) Mol Cell Biol , vol.21 , pp. 5132-5141
    • Furuhashi, M.1    Yagi, K.2    Yamamoto, H.3    Furukawa, Y.4    Shimada, S.5    Nakamura, Y.6
  • 124
    • 84904043132 scopus 로고    scopus 로고
    • YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response
    • Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, et al. YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response. Cell (2014) 158:157-70. doi:10.1016/j.cell.2014.06.013
    • (2014) Cell , vol.158 , pp. 157-170
    • Azzolin, L.1    Panciera, T.2    Soligo, S.3    Enzo, E.4    Bicciato, S.5    Dupont, S.6
  • 125
    • 84923333865 scopus 로고    scopus 로고
    • Repression of intestinal stem cell function and tumorigenesis through direct phosphorylation of beta-catenin and Yap by PKCzeta
    • Llado V, Nakanishi Y, Duran A, Reina-Campos M, Shelton PM, Linares JF, et al. Repression of intestinal stem cell function and tumorigenesis through direct phosphorylation of beta-catenin and Yap by PKCzeta. Cell Rep (2015) 10:740-54. doi:10.1016/j.celrep.2015.01.007
    • (2015) Cell Rep , vol.10 , pp. 740-754
    • Llado, V.1    Nakanishi, Y.2    Duran, A.3    Reina-Campos, M.4    Shelton, P.M.5    Linares, J.F.6
  • 126
    • 78649969033 scopus 로고    scopus 로고
    • The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway
    • Varelas X, Samavarchi-Tehrani P, Narimatsu M, Weiss A, Cockburn K, Larsen BG, et al. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell (2010) 19:831-44. doi:10.1016/j.devcel.2010.11.012
    • (2010) Dev Cell , vol.19 , pp. 831-844
    • Varelas, X.1    Samavarchi-Tehrani, P.2    Narimatsu, M.3    Weiss, A.4    Cockburn, K.5    Larsen, B.G.6
  • 127
    • 33646241997 scopus 로고    scopus 로고
    • Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context
    • Mikels AJ, Nusse R. Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol (2006) 4:e115. doi:10.1371/journal.pbio.0040115
    • (2006) PLoS Biol , vol.4
    • Mikels, A.J.1    Nusse, R.2
  • 128
    • 84858002052 scopus 로고    scopus 로고
    • A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling
    • Imajo M, Miyatake K, Iimura A, Miyamoto A, Nishida E. A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling. EMBO J (2012) 31:1109-22. doi:10.1038/emboj.2011.487
    • (2012) EMBO J , vol.31 , pp. 1109-1122
    • Imajo, M.1    Miyatake, K.2    Iimura, A.3    Miyamoto, A.4    Nishida, E.5
  • 129
    • 58149264873 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of Smad proteins
    • Hill CS. Nucleocytoplasmic shuttling of Smad proteins. Cell Res (2009) 19:36-46. doi:10.1038/cr.2008.325
    • (2009) Cell Res , vol.19 , pp. 36-46
    • Hill, C.S.1
  • 130
    • 71149092489 scopus 로고    scopus 로고
    • Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling
    • Goentoro L, Kirschner MW. Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling. Mol Cell (2009) 36:872-84. doi:10.1016/j.molcel.2009.11.017
    • (2009) Mol Cell , vol.36 , pp. 872-884
    • Goentoro, L.1    Kirschner, M.W.2
  • 131
    • 84873050284 scopus 로고    scopus 로고
    • Regulatory networks defining EMT during cancer initiation and progression
    • De Craene B, Berx G. Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer (2013) 13:97-110. doi:10.1038/nrc3447
    • (2013) Nat Rev Cancer , vol.13 , pp. 97-110
    • De Craene, B.1    Berx, G.2
  • 132
    • 79951805332 scopus 로고    scopus 로고
    • Epithelial-mesenchymal interactions in pulmonary fibrosis
    • Chapman HA. Epithelial-mesenchymal interactions in pulmonary fibrosis. Annu Rev Physiol (2011) 73:413-35. doi:10.1146/annurev-physiol-012110-142225
    • (2011) Annu Rev Physiol , vol.73 , pp. 413-435
    • Chapman, H.A.1
  • 133
    • 46049087598 scopus 로고    scopus 로고
    • TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
    • Varelas X, Sakuma R, Samavarchi-Tehrani P, Peerani R, Rao BM, Dembowy J, et al. TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol (2008) 10:837-48. doi:10.1038/ncb1748
    • (2008) Nat Cell Biol , vol.10 , pp. 837-848
    • Varelas, X.1    Sakuma, R.2    Samavarchi-Tehrani, P.3    Peerani, R.4    Rao, B.M.5    Dembowy, J.6
  • 134
    • 84866747307 scopus 로고    scopus 로고
    • Convergent signaling in the regulation of connective tissue growth factor in malignant mesothelioma: TGFbeta signaling and defects in the Hippo signaling cascade
    • Fujii M, Nakanishi H, Toyoda T, Tanaka I, Kondo Y, Osada H, et al. Convergent signaling in the regulation of connective tissue growth factor in malignant mesothelioma: TGFbeta signaling and defects in the Hippo signaling cascade. Cell Cycle (2012) 11:3373-9. doi:10.4161/cc.21397
    • (2012) Cell Cycle , vol.11 , pp. 3373-3379
    • Fujii, M.1    Nakanishi, H.2    Toyoda, T.3    Tanaka, I.4    Kondo, Y.5    Osada, H.6
  • 135
    • 84900424727 scopus 로고    scopus 로고
    • The transcriptional regulators TAZ and YAP direct transforming growth factor β-induced tumorigenic phenotypes in breast cancer cells
    • Hiemer SE, Szymaniak AD, Varelas X. The transcriptional regulators TAZ and YAP direct transforming growth factor β-induced tumorigenic phenotypes in breast cancer cells. J Biol Chem (2014) 289:13461-74. doi:10.1074/jbc.M113.529115
    • (2014) J Biol Chem , vol.289 , pp. 13461-13474
    • Hiemer, S.E.1    Szymaniak, A.D.2    Varelas, X.3
  • 136
    • 84863229401 scopus 로고    scopus 로고
    • Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP)
    • Zhou B, Liu Y, Kahn M, Ann DK, Han A, Wang H, et al. Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP). J Biol Chem (2012) 287:7026-38. doi:10.1074/jbc.M111.276311
    • (2012) J Biol Chem , vol.287 , pp. 7026-7038
    • Zhou, B.1    Liu, Y.2    Kahn, M.3    Ann, D.K.4    Han, A.5    Wang, H.6
  • 137
    • 82655173709 scopus 로고    scopus 로고
    • beta-catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition
    • Charbonney E, Speight P, Masszi A, Nakano H, Kapus A. beta-catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition. Mol Biol Cell (2011) 22:4472-85. doi:10.1091/mbc.E11-04-0335
    • (2011) Mol Biol Cell , vol.22 , pp. 4472-4485
    • Charbonney, E.1    Speight, P.2    Masszi, A.3    Nakano, H.4    Kapus, A.5
  • 138
    • 33846456632 scopus 로고    scopus 로고
    • Transcriptional cooperation between the transforming growth factor-beta and Wnt pathways in mammary and intestinal tumorigenesis
    • Labbé E, Lock L, Letamendia A, Gorska AE, Gryfe R, Gallinger S, et al. Transcriptional cooperation between the transforming growth factor-beta and Wnt pathways in mammary and intestinal tumorigenesis. Cancer Res (2007) 67:75-84. doi:10.1158/0008-5472.CAN-06-2559
    • (2007) Cancer Res , vol.67 , pp. 75-84
    • Labbé, E.1    Lock, L.2    Letamendia, A.3    Gorska, A.E.4    Gryfe, R.5    Gallinger, S.6
  • 139
    • 84872405841 scopus 로고    scopus 로고
    • Dynamic phosphorylation patterns of RNA polymerase II CTD during transcription
    • Heidemann M, Hintermair C, Voss K, Eick D. Dynamic phosphorylation patterns of RNA polymerase II CTD during transcription. Biochim Biophys Acta (2013) 1829:55-62. doi:10.1016/j.bbagrm.2012.08.013
    • (2013) Biochim Biophys Acta , vol.1829 , pp. 55-62
    • Heidemann, M.1    Hintermair, C.2    Voss, K.3    Eick, D.4
  • 140
    • 84946490100 scopus 로고    scopus 로고
    • SMADs and YAP compete to control elongation of beta-catenin:LEF-1-recruited RNAPII during hESC differentiation
    • Estarás C, Benner C, Jones KA. SMADs and YAP compete to control elongation of beta-catenin:LEF-1-recruited RNAPII during hESC differentiation. Mol Cell (2015) 58:780-93. doi:10.1016/j.molcel.2015.04.001
    • (2015) Mol Cell , vol.58 , pp. 780-793
    • Estarás, C.1    Benner, C.2    Jones, K.A.3
  • 141
    • 58149239730 scopus 로고    scopus 로고
    • Phospho-control of TGF-beta superfamily signaling
    • Wrighton KH, Lin X, Feng XH. Phospho-control of TGF-beta superfamily signaling. Cell Res (2009) 19:8-20. doi:10.1038/cr.2008.327
    • (2009) Cell Res , vol.19 , pp. 8-20
    • Wrighton, K.H.1    Lin, X.2    Feng, X.H.3
  • 142
    • 70350785179 scopus 로고    scopus 로고
    • Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling
    • Gao S, Alarcon C, Sapkota G, Rahman S, Chen PY, Goerner N, et al. Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell (2009) 36:457-68. doi:10.1016/j.molcel.2009.09.043
    • (2009) Mol Cell , vol.36 , pp. 457-468
    • Gao, S.1    Alarcon, C.2    Sapkota, G.3    Rahman, S.4    Chen, P.Y.5    Goerner, N.6
  • 143
    • 34250203586 scopus 로고    scopus 로고
    • Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation
    • Zhang S, Fei T, Zhang L, Zhang R, Chen F, Ning Y, et al. Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol Cell Biol (2007) 27:4488-99. doi:10.1128/MCB.01636-06
    • (2007) Mol Cell Biol , vol.27 , pp. 4488-4499
    • Zhang, S.1    Fei, T.2    Zhang, L.3    Zhang, R.4    Chen, F.5    Ning, Y.6
  • 144
    • 84936791793 scopus 로고    scopus 로고
    • Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients
    • Rice LM, Padilla CM, McLaughlin SR, Mathes A, Ziemek J, Goummih S, et al. Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients. J Clin Invest (2015) 125:2795-807. doi:10.1172/JCI77958
    • (2015) J Clin Invest , vol.125 , pp. 2795-2807
    • Rice, L.M.1    Padilla, C.M.2    McLaughlin, S.R.3    Mathes, A.4    Ziemek, J.5    Goummih, S.6
  • 145
    • 84866985855 scopus 로고    scopus 로고
    • Targeting the TGFβ signalling pathway in disease
    • Akhurst RJ, Hata A. Targeting the TGFβ signalling pathway in disease. Nat Rev Drug Discov (2012) 11:790-811. doi:10.1038/nrd3810
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 790-811
    • Akhurst, R.J.1    Hata, A.2
  • 146
    • 84903767326 scopus 로고    scopus 로고
    • Can we safely target the WNT pathway?
    • Kahn M. Can we safely target the WNT pathway? Nat Rev Drug Discov (2014) 13:513-32. doi:10.1038/nrd4233
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 513-532
    • Kahn, M.1
  • 147
    • 84891748709 scopus 로고    scopus 로고
    • The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment
    • Johnson R, Halder G. The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov (2013) 13:63-79. doi:10.1038/nrd4161
    • (2013) Nat Rev Drug Discov , vol.13 , pp. 63-79
    • Johnson, R.1    Halder, G.2
  • 148
    • 1642512639 scopus 로고    scopus 로고
    • Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex
    • Lepourcelet M, Chen YPN, France DS, Wang H, Crews P, Petersen F, et al. Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell (2014) 5:91-102. doi:10.1016/S1535-6108(03)00334-9
    • (2014) Cancer Cell , vol.5 , pp. 91-102
    • Lepourcelet, M.1    Chen, Y.P.N.2    France, D.S.3    Wang, H.4    Crews, P.5    Petersen, F.6
  • 149
    • 84857116198 scopus 로고    scopus 로고
    • Fibrosis: is it a coactivator disease
    • Ghosh AK, Vaughan DE. Fibrosis: is it a coactivator disease. Front Biosci (Elite Ed) (2012) 4:1556-70. doi:10.2741/E480
    • (2012) Front Biosci (Elite Ed) , vol.4 , pp. 1556-1570
    • Ghosh, A.K.1    Vaughan, D.E.2
  • 150
    • 84862605178 scopus 로고    scopus 로고
    • Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP
    • Liu-Chittenden Y, Huang B, Shim JS, Chen Q, Lee SJ, Anders RA, et al. Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev (2012) 26:1300-5. doi:10.1101/gad.192856.112
    • (2012) Genes Dev , vol.26 , pp. 1300-1305
    • Liu-Chittenden, Y.1    Huang, B.2    Shim, J.S.3    Chen, Q.4    Lee, S.J.5    Anders, R.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.