Targeted inhibition of β-catenin/CBP signaling ameliorates renal interstitial fibrosis

Journal of the American Society of Nephrology

Volumn 22, Issue 9, 2011, Pages 1642-1653

  Hao, Sha ^a,b   He, Weichun ^a   Li, Yingjian ^a   Ding, Hong ^a   Hou, Yayi ^b   Nie, Jing ^c   Hou, Fan Fan ^c   Kahn, Michael ^d   Liu, Youhua ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANTIFIBROTIC AGENT; BETA CATENIN; CALVASCULIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; FIBRONECTIN; ICG 001; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN SNAIL1; PROTEIN SNAIL2; SMAD PROTEIN; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; UVOMORULIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG EFFECT; DRUG EFFICACY; ENZYME INHIBITION; EPITHELIUM CELL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; KIDNEY DISEASE; KIDNEY FIBROSIS; MALE; MOUSE; NONHUMAN; OBSTRUCTIVE NEPHROPATHY; PRIORITY JOURNAL; RENAL INTERSTITIAL FIBROSIS; SIGNAL TRANSDUCTION;

EID: 80052335469     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2010101079     Document Type: Article

References (47)

1. Coresh J., Selvin E., Stevens L.A., Manzi J., Kusek J.W., Eggers P., Van Lente F., Levey A.S.: Prevalence of chronic kidney disease in the United States. JAMA 298: 2038-2047, 2007 (Pubitemid 350074801)
2. U.S. Renal Data System: USRDS 2009 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States, Bethesda, MD, National Institute of Health, National Institute of Diabetes and Digestive and Kidney Disease, 2009
3. Zeisberg M., Neilson E.G.: Mechanisms of tubulointerstitial fibrosis. J Am Soc Nephrol 21: 1819-1834, 2010
4. Boor P., Ostendorf T., Floege J.: Renal fibrosis: Novel insights into mechanisms and therapeutic targets. Nat Rev Nephrol 6: 643-656, 2010
5. Liu Y.: Renal fibrosis: New insights into the pathogenesis and therapeutics. Kidney Int 69: 213-217, 2006
6. Angers S., Moon R.T.: Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol 10: 468-477, 2009
7. White BD, Nguyen NK, Moon RT: Wnt signaling: It gets more humorous with age. Curr Biol 17: R923-R925, 2007
8. Yu J., Carroll T.J., Rajagopal J., Kobayashi A., Ren Q., McMahon A.P.: A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development 136: 161-171, 2009
9. Schmidt-Ott K.M., Barasch J.: WNT/beta-catenin signaling in nephron progenitors and their epithelial progeny. Kidney Int 74: 1004-1008, 2008
10. Iglesias D.M., Hueber P.A., Chu L., Campbell R., Patenaude A.M., Dziarmaga A.J., Quinlan J., Mohamed O., Dufort D., Goodyer P.R.: Canonical WNT signaling during kidney development. Am J Physiol Renal Physiol 293: F494-F500, 2007 (Pubitemid 47358119)
11. He W., Kang Y.S., Dai C., Liu Y.: Blockade of Wnt/ ≲βτα∀-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury. J Am Soc Nephrol 22: 90-103, 2011
12. von Toerne C, Schmidt C, Adams J, Kiss E, Bedke J, Porubsky S, Gretz N, Lindenmeyer MT, Cohen CD, Grone HJ, Nelson PJ: Wnt pathway regulation in chronic renal allograft damage. Am J Transplant 9: 2223-2239, 2009
13. Dai C., Stolz D.B., Kiss L.P., Monga S.P., Holzman L.B., Liu Y.: Wnt/≲βτα∀-catenin signaling promotes podocyte dysfunction and albuminuria. J Am Soc Nephrol 20: 1997-2008, 2009
14. Surendran K., Schiavi S., Hruska K.A.: Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol 16: 2373-2384, 2005 (Pubitemid 41725055)
15. He W., Tan R., Dai C., Li Y., Wang D., Hao S., Kahn M., Liu Y.: Plasminogen activator inhibitor-1 is a transcriptional target of the canonical pathway of Wnt/≲βτα∀-catenin signaling. J Biol Chem 285: 24665-24675, 2010
16. McDonald P.C., Fielding A.B., Dedhar S.: Integrin-linked kinase-Essential roles in physiology and cancer biology. J Cell Sci 121: 3121-3132, 2008
17. Liu Y.: New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol 21: 212-222, 2010
18. Kang Y.S., Li Y., Dai C., Kiss L.P., Wu C., Liu Y.: Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria. Kidney Int 78: 363-373, 2010
19. Heikkila E., Juhila J., Lassila M., Messing M., Perala N., Lehtonen E., Lehtonen S., Sjef Verbeek J., Holthofer H.: ≲βτα∀- Catenin mediates adriamycin- induced albuminuria and podocyte injury in the adult mouse kidneys. Nephrol Dial Transplant 25: 2437-2446, 2010
20. Li Y., Tan X., Dai C., Stolz D.B., Wang D., Liu Y.: Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis. J Am Soc Nephrol 20: 1907-1918, 2009
21. Henderson W.R. Jr, Chi E.Y., Ye X., Nguyen C., Tien Y.T., Zhou B., Borok Z., Knight D.A., Kahn M.: Inhibition of Wnt/≲βτα∀- catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A 107: 14309-14314, 2010
22. Ma H., Nguyen C., Lee K.S., Kahn M.: Differential roles for the coactivators CBP and p300 on TCF/≲βτα∀-catenin- mediated survivin gene expression. Oncogene 24: 3619-3631, 2005 (Pubitemid 40756231)
23. Eguchi M., Nguyen C., Lee S.C., Kahn M.: ICG-001, a novel small molecule regulator of TCF/≲βτα∀-catenin transcription. Med Chem 1: 467-472, 2005
24. McMillan M., Kahn M.: Investigating Wnt signaling: A chemogenomic safari. Drug Discov Today 10: 1467-1474, 2005 (Pubitemid 41483876)
25. Emami K.H., Nguyen C., Ma H., Kim D.H., Jeong K.W., Eguchi M., Moon R.T., Teo J.L., Kim H.Y., Moon S.H., Ha J.R., Kahn M.: A small molecule inhibitor of ≲βτα∀-catenin/CREB-binding protein transcription. Proc Natl Acad Sci U S A 101: 12682-12687, 2004 (Pubitemid 39122083)
26. He W., Dai C., Li Y., Zeng G., Monga S.P., Liu Y.: Wnt/ ≲βτα∀-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol 20: 765-776, 2009
27. Kalluri R., Neilson E.G.: Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112: 1776-1784, 2003 (Pubitemid 38063698)
28. Schnaper H.W., Jandeska S., Runyan C.E., Hubchak S.C., Basu R.K., Curley J.F., Smith R.D., Hayashida T.: TGF-beta signal transduction in chronic kidney disease. Front Biosci 14: 2448-2465, 2009
29. Zavadil J., Bottinger E.P.: TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 24: 5764-5774, 2005
30. Boutet A., De Frutos C.A., Maxwell P.H., Mayol M.J., Romero J., Nieto M.A.: Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. EMBO J 25: 5603-5613, 2006 (Pubitemid 44847200)
31. Lange-Sperandio B., Trautmann A., Eickelberg O., Jayachandran A., Oberle S., Schmidutz F., Rodenbeck B., Homme M., Horuk R., Schaefer F.: Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal mice. Am J Pathol 171: 861-871, 2007 (Pubitemid 47440985)
32. Yang J., Liu Y.: Delayed administration of hepatocyte growth factor reduces renal fibrosis in obstructive nephropathy. Am J Physiol Renal Physiol 284: F349-F357, 2003 (Pubitemid 36114697)
33. Cano A., Perez-Moreno M.A., Rodrigo I., Locascio A., Blanco M.J., Del Barrio M.G., Portillo F., Nieto M.A.: The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2: 76-83, 2000
34. Thiery J.P., Acloque H., Huang R.Y., Nieto M.A.: Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890, 2009
35. Schmalhofer O., Brabletz S., Brabletz T.: E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer. Cancer Metastasis Rev 28: 151-166, 2009
36. Polette M., Mestdagt M., Bindels S., Nawrocki-Raby B., Hunziker W., Foidart J.M., Birembaut P., Gilles C.: Beta-catenin and ZO-1: Shuttle molecules involved in tumor invasion-associated epithelial-mesenchymal transition processes. Cells Tissues Organs 185: 61-65, 2007 (Pubitemid 46956844)
37. Wang Z., Havasi A., Gall J.M., Mao H., Schwartz J.H., Borkan S.C.: Betacatenin promotes survival of renal epithelial cells by inhibiting Bax. J Am Soc Nephrol 20: 1919-1928, 2009
38. Teo J.L., Ma H., Nguyen C., Lam C., Kahn M.: Specific inhibition of CBP/≲βτα∀-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation. Proc Natl Acad Sci U S A 102: 12171-12176, 2005 (Pubitemid 41291147)
39. Okada H., Danoff T.M., Kalluri R., Neilson E.G.: Early role of Fsp1 in epithelial-mesenchymal transformation. Am J Physiol 273: F563-F574, 1997
40. Stein U., Arlt F., Walther W., Smith J., Waldman T., Harris E.D., Mertins S.D., Heizmann C.W., Allard D., Birchmeier W., Schlag P.M., Shoemaker R.H.: The metastasis-associated gene S100A4 is a novel target of betacatenin/ T-cell factor signaling in colon cancer. Gastroenterology 131: 1486-1500, 2006 (Pubitemid 44708942)
41. Yang J., Liu Y.: Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 159: 1465-1475, 2001 (Pubitemid 32947976)
42. Eddy A.A., Fogo A.B.: Plasminogen activator inhibitor-1 in chronic kidney disease: Evidence and mechanisms of action. J Am Soc Nephrol 17: 2999-3012, 2006 (Pubitemid 44707760)
43. Ma L.J., Fogo A.B.: PAI-1 and kidney fibrosis. Front Biosci 14: 2028-2041, 2009
44. Gradl D., Kuhl M., Wedlich D.: The Wnt/Wg signal transducer betacatenin controls fibronectin expression. Mol Cell Biol 19: 5576-5587, 1999 (Pubitemid 29339915)
45. Tan R., Zhang X., Yang J., Li Y., Liu Y.: Molecular basis for the cell type specific induction of SnoN expression by hepatocyte growth factor. J Am Soc Nephrol 18: 2340-2349, 2007 (Pubitemid 47203850)
46. Hao S., Shen H., Hou Y., Mars W.M., Liu Y.: tPA is a potent mitogen for renal interstitial fibroblasts: Role of ≲βτα∀1 integrin/focal adhesion kinase. Am J Pathol 177: 1164-1175, 2010
47. Dai C., Liu Y.: Hepatocyte growth factor antagonizes the profibrotic action of TGF-≲βτα∀1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF. J Am Soc Nephrol 15: 1402-1412, 2004 (Pubitemid 38679665)