Inactivation of evenness interrupted (EVI) reduces experimental fibrosis by combined inhibition of canonical and non-canonical Wnt signalling

Annals of the Rheumatic Diseases

Volumn 73, Issue 3, 2014, Pages 624-627

  Distler, Alfiya ^a   Ziemer, Clara ^a   Beyer, Christian ^a   Lin, Neng Yu ^a   Chen, Chih Wei ^a   Palumbo Zerr, Katrin ^a   Dees, Clara ^a   Weidemann, Alexander ^a   Distler, Oliver ^b   Schett, Georg ^a   Distler, Jörg H W ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLASTS; SYSTEMIC SCLEROSIS; TREATMENT;

ANIMALS; BETA CATENIN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FIBROBLASTS; FIBROSIS; GENE KNOCKDOWN TECHNIQUES; GENETIC THERAPY; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE KINASE 4; MICE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-JUN; RECEPTORS, G-PROTEIN-COUPLED; RNA, SMALL INTERFERING; SCLERODERMA, SYSTEMIC; SKIN; WNT SIGNALING PATHWAY;

EID: 84893767540     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2013-203995     Document Type: Article

References (20)

1. Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004;20:781-810. (Pubitemid 39488658)
2. Gordon MD, Nusse R. Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 2006;281:22429-33.
3. Akhmetshina A, Palumbo K, Dees C, et al. Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis. Nat Commun 2012;3:735.
4. Bergmann C, Akhmetshina A, Dees C, et al. Inhibition of glycogen synthase kinase 3beta induces dermal fibrosis by activation of the canonical Wnt pathway. Ann Rheum Dis 2011;70:2191-8.
5. Beyer C, Reichert H, Akan H, et al. Blockade of canonical Wnt signaling inhibits experimental dermal fibrosis. Ann Rheum Dis 2013;72:1255-8.
6. Beyer C, Schramm A, Akhmetshina A, et al. beta-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis. Ann Rheum Dis 2013;72:1255-8.
7. Distler A, Deloch L, Huang J, et al. Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signaling. Ann Rheum Dis 2013;72:1575-80.
8. Lam AP, Flozak AS, Russell S, et al. Nuclear beta-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation. Am J Respir Cell Mol Biol 2011;45:915-22.
9. Wei J, Fang F, Lam AP, et al. Wnt/beta-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells. Arthritis Rheum 2012;64:2734-45.
10. Wei J, Melichian D, Komura K, et al. Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma? Arthritis Rheum 2011;63:1707-17.
11. Zhang P, Cai Y, Soofi A, et al. Activation of Wnt11 by transforming growth factor-beta drives mesenchymal gene expression through non-canonical Wnt protein signaling in renal epithelial cells. J Biol Chem 2012;287:21290-302.
12. Banziger C, Soldini D, Schutt C, et al. Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells. Cell 2006;125:509-22.
13. Bartscherer K, Pelte N, Ingelfinger D, et al. Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell 2006;125:523-33.
14. Horn A, Kireva T, Palumbo-Zerr K, et al. Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis. Ann Rheum Dis 2012;71:785-9.
15. Dees C, Akhmetshina A, Zerr P, et al. Platelet-derived serotonin links vascular disease and tissue fibrosis. J Exp Med 2011;208:961-72.
16. Avouac J, Palumbo K, Tomcik M, et al. Inhibition of activator protein 1 signaling abrogates transforming growth factor beta-mediated activation of fibroblasts and prevents experimental fibrosis. Arthritis Rheum 2012;64:1642-52.
17. Reich N, Tomcik M, Zerr P, et al. Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis. Ann Rheum Dis 2012;71:737-45.
18. Palumbo K, Zerr P, Tomcik M, et al. The transcription factor JunD mediates transforming growth factor {beta}-induced fibroblast activation and fibrosis in systemic sclerosis. Ann Rheum Dis 2011;70:1320-6.
19. Beyer C, Schett G, Distler O, et al. Animal models of systemic sclerosis: Prospects and limitations. Arthritis Rheum 2010.
20. Lum L, Clevers H. Cell biology. The unusual case of Porcupine. Science 2012;337:922-3.