GSK-3β in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism (Journal of Clinical Investigation (2008) 118, (3279-3290) DOI: 10.1172/JCI35381);GSK-3β in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism

Journal of Clinical Investigation

Volumn 118, Issue 10, 2008, Pages 3279-3290

  Kapoor, Mohit ^a   Liu, Shangxi ^a   Xu, Shi Wen ^b   Huh, Kun ^a   McCann, Matthew ^a   Denton, Christopher P ^b   Woodgett, James R ^c   Abraham, David J ^b   Leask, Andrew ^a,d  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c MOUNT SINAI HOSPITAL   (Canada)

^d WESTERN UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; ENDOTHELIN 1; GLYCOGEN SYNTHASE KINASE 3; BETA CATENIN; BOSENTAN; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; GLYCOGEN SYNTHASE KINASE 3 BETA; SULFONAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL MIGRATION; CELL SPREADING; CONTROLLED STUDY; FIBROBLAST; FIBROGENESIS; IN VIVO STUDY; KNOCKOUT MOUSE; MOUSE; MYOFIBROBLAST; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TISSUE REPAIR; WOUND HEALING; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; FIBROSIS; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; SCAR; SIGNAL TRANSDUCTION; TIME;

ANIMALS; APOPTOSIS; BETA CATENIN; CELL LINE; CICATRIX; COLLAGEN; ENDOTHELIN-1; FEMALE; FIBROBLASTS; FIBROSIS; GENE EXPRESSION REGULATION; GLYCOGEN SYNTHASE KINASE 3; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; SEQUENCE DELETION; SIGNAL TRANSDUCTION; SULFONAMIDES; TIME FACTORS; WOUND HEALING;

EID: 55849132694     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI35381R1     Document Type: Erratum

References (29)

1. Martin, P. 1997. Wound healing - aiming for perfect skin regeneration. Science. 276:75-81.
2. Eckes, B., Kessler, D., Aumailley, M., and Krieg, T. 1999. Interactions of fibroblasts with the extracellular matrix: implications for the understanding of fibrosis. Springer Semin. Immunopathol. 21:415-429.
3. Gabbiani, G. 2003. The myofibroblast in wound healing and fibrocontractive diseases. J. Pathol. 200:500-503.
4. Chen, Y., et al. 2005. Matrix contraction by dermal fibroblasts requires TGFbeta/ALK5, heparan sulfate containing proteoglycans and MEK/ERK: insights into pathological scarring in chronic fibrotic disease Am. J. Pathol. 167:1699-1711.
5. Patel, S., Doble, B., and Woodgett, J.R. 2004. Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword? Biochem. Soc. Trans. 32:803-808.
6. Doble, B.W., and Woodgett, J.R. 2003. GSK-3: tricks of the trade for a multi-tasking kinase. J. Cell Sci. 116:1175-1186.
7. Mitsiades, C.S., Mitsiades, N., and Koutsilieris, M. 2004. The Akt pathway: molecular targets for anticancer drug development. Curr. Cancer Drug Targets. 4:235-256.
8. Nelson, W.J., and Nusse, R. 2004. Convergence of Wnt, beta-catenin, and cadherin pathways. Science. 303:1483-1487.
9. Aberle, H., Bauer, A., Stappert, J., Kispert, A., and Kemler, R. 1997. beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 16:3797-3804.
10. Orford, K., Crockett, C., Jensen, J.P., Weissman, A.M., and Byers, S.W. 1997. Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin. J. Biol. Chem. 272:24735-24738.
11. Behrens, J., et al. 1996. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature. 382:638-642.
12. Alman, B.A., Li, C., Pajerski, M.E., Diaz-Cano, S., and Wolfe, H.J. 1997. Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors). Am. J. Pathol. 151:329-334.
13. Cheon, S.S., et al. 2002. beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. Proc. Natl. Acad. Sci. U. S. A. 99:6973-6978.
14. Cheon, S., et al. 2005. Prolonged beta-catenin stabilization and tcf-dependent transcriptional activation in hyperplastic cutaneous wounds. Lab. Invest. 85:416-425.
15. Hoeflich, K.P., et al. 2000. Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature. 406:86-90.
16. Zheng, B., Zhang, Z., Black, C.M., de Crombrugghe, B., and Denton, C.P. 2002. Ligand-dependent genetic recombination in fibroblasts: a potentially powerful technique for investigating gene function in fibrosis. Am. J. Pathol. 160:1609-1617.
17. Shi-Wen, X., et al. 2004. Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. Mol. Biol. Cell. 15:2707-2719.
18. Shi-wen, X., et al. 2006. Constitutive ALK5-indepenent JNK activation contributes to endothelin-1 over-expression in pulmonary fibrosis. Mol. Cell. Biol. 26:5518-5527.
19. Shi-wen, X., et al. 2007. Endogenous endothelin-1 signaling contributes to Col1a2 and CCN2 overexpression in fibrotic fibroblasts. Matrix Biol. 26:625-632.
20. Ponticos, M., et al. 2004. Col1a2 enhancer regulates collagen activity during development and in adult tissue repair. Matrix Biol. 22:619-628.
21. Clozel, M., and Salloukh, H. 2005. Role of endothelin in fibrosis and anti-fibrotic potential of bosentan. Ann. Med. 37:2-12.
22. Leask, A. 2008. Targeting the TGFβ, endothelin-1 and CCN2 axis to combat fibrosis in scleroderma. Cell. Signal. 20:1409-1414.
23. Chen, S., McLean, S., Carter, D.E., and Leask, A. 2007. The gene expression profile induced by Wnt 3a in NIH 3T3 fibroblasts. J. Cell. Commun. Signal. 1:175-183.
24. Kim, T.H., Xiong, H., Zhang, Z., and Ren, B. 2005. beta-Catenin activates the growth factor endothelin-1 in colon cancer cells. Oncogene. 24:597-604.
25. Tanabe, K., et al. 2008. Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. PLoS Biol. 6:e37.
26. Kennedy, L., et al. 2007. CCN2 is essential for fibroblast function. Exp. Cell Res. 313:952-964.
27. Shi-wen, X., et al. 2006. CCN2 is necessary for adhesive responses to TGFβ1 in embryonic fibroblasts. J. Biol. Chem. 281:10715- 10726.
28. Reddy, G.K., and Enwemeka, C.S. 1996. A simplified method for the analysis of hydroxyproline in biological tissues. Clin. Biochem. 29:225-229.
29. Neuman, R.E., and Logan, M.A. 1950. The determination of hydroxyproline. J. Biol. Chem. 184:299-306.