-
1
-
-
0030978351
-
Beta-catenin is a target for the ubiquitin-proteasome pathway
-
H. Aberle, A. Bauer, J. Stappert, A. Kispert, and R. Kemler beta-catenin is a target for the ubiquitin-proteasome pathway EMBO J. 16 1997 3797 3804
-
(1997)
EMBO J.
, vol.16
, pp. 3797-3804
-
-
Aberle, H.1
Bauer, A.2
Stappert, J.3
Kispert, A.4
Kemler, R.5
-
2
-
-
0029781509
-
Functional interaction of beta-catenin with the transcription factor LEF-1
-
J. Behrens, J.P. von Kries, M. Kühl, L. Bruhn, D. Wedlich, R. Grosschedl, and W. Birchmeier Functional interaction of beta-catenin with the transcription factor LEF-1 Nature 382 1996 638 642
-
(1996)
Nature
, vol.382
, pp. 638-642
-
-
Behrens, J.1
Von Kries, J.P.2
Kühl, M.3
Bruhn, L.4
Wedlich, D.5
Grosschedl, R.6
Birchmeier, W.7
-
3
-
-
0032562603
-
Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
-
J. Behrens, B.A. Jerchow, M. Würtele, J. Grimm, C. Asbrand, R. Wirtz, M. Kühl, D. Wedlich, and W. Birchmeier Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta Science 280 1998 596 599
-
(1998)
Science
, vol.280
, pp. 596-599
-
-
Behrens, J.1
Jerchow, B.A.2
Würtele, M.3
Grimm, J.4
Asbrand, C.5
Wirtz, R.6
Kühl, M.7
Wedlich, D.8
Birchmeier, W.9
-
4
-
-
33746808398
-
Wnt/beta-catenin signaling in development and disease
-
H. Clevers Wnt/beta-catenin signaling in development and disease Cell 127 2006 469 480
-
(2006)
Cell
, vol.127
, pp. 469-480
-
-
Clevers, H.1
-
5
-
-
45849104800
-
LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin
-
C.S. Cselenyi, K.K. Jernigan, E. Tahinci, C.A. Thorne, L.A. Lee, and E. Lee LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin Proc. Natl. Acad. Sci. USA 105 2008 8032 8037
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 8032-8037
-
-
Cselenyi, C.S.1
Jernigan, K.K.2
Tahinci, E.3
Thorne, C.A.4
Lee, L.A.5
Lee, E.6
-
6
-
-
80051926611
-
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
-
W. de Lau, N. Barker, T.Y. Low, B.K. Koo, V.S. Li, H. Teunissen, P. Kujala, A. Haegebarth, P.J. Peters, and M. van de Wetering Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling Nature 476 2011 293 297
-
(2011)
Nature
, vol.476
, pp. 293-297
-
-
De Lau, W.1
Barker, N.2
Low, T.Y.3
Koo, B.K.4
Li, V.S.5
Teunissen, H.6
Kujala, P.7
Haegebarth, A.8
Peters, P.J.9
Van De Wetering, M.10
-
7
-
-
0035843148
-
Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation
-
C. Desbois-Mouthon, A. Cadoret, M.J. Blivet-Van Eggelpoël, F. Bertrand, G. Cherqui, C. Perret, and J. Capeau Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation Oncogene 20 2001 252 259
-
(2001)
Oncogene
, vol.20
, pp. 252-259
-
-
Desbois-Mouthon, C.1
Cadoret, A.2
Blivet-Van Eggelpoël, M.J.3
Bertrand, F.4
Cherqui, G.5
Perret, C.6
Capeau, J.7
-
8
-
-
33847740988
-
Wnt/beta-catenin signaling in cancer stemness and malignant behavior
-
R. Fodde, and T. Brabletz Wnt/beta-catenin signaling in cancer stemness and malignant behavior Curr. Opin. Cell Biol. 19 2007 150 158
-
(2007)
Curr. Opin. Cell Biol.
, vol.19
, pp. 150-158
-
-
Fodde, R.1
Brabletz, T.2
-
9
-
-
0035907390
-
Akt participation in the Wnt signaling pathway through Dishevelled
-
S. Fukumoto, C.M. Hsieh, K. Maemura, M.D. Layne, S.F. Yet, K.H. Lee, T. Matsui, A. Rosenzweig, W.G. Taylor, and J.S. Rubin Akt participation in the Wnt signaling pathway through Dishevelled J. Biol. Chem. 276 2001 17479 17483
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 17479-17483
-
-
Fukumoto, S.1
Hsieh, C.M.2
Maemura, K.3
Layne, M.D.4
Yet, S.F.5
Lee, K.H.6
Matsui, T.7
Rosenzweig, A.8
Taylor, W.G.9
Rubin, J.S.10
-
10
-
-
84856635802
-
Triple SILAC to determine stimulus specific interactions in the Wnt pathway
-
M. Hilger, and M. Mann Triple SILAC to determine stimulus specific interactions in the Wnt pathway J. Proteome Res. 11 2012 982 994
-
(2012)
J. Proteome Res.
, vol.11
, pp. 982-994
-
-
Hilger, M.1
Mann, M.2
-
11
-
-
70349695861
-
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
-
S.M. Huang, Y.M. Mishina, S. Liu, A. Cheung, F. Stegmeier, G.A. Michaud, O. Charlat, E. Wiellette, Y. Zhang, and S. Wiessner Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling Nature 461 2009 614 620
-
(2009)
Nature
, vol.461
, pp. 614-620
-
-
Huang, S.M.1
Mishina, Y.M.2
Liu, S.3
Cheung, A.4
Stegmeier, F.5
Michaud, G.A.6
Charlat, O.7
Wiellette, E.8
Zhang, Y.9
Wiessner, S.10
-
12
-
-
0032473355
-
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
-
S. Ikeda, S. Kishida, H. Yamamoto, H. Murai, S. Koyama, and A. Kikuchi Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin EMBO J. 17 1998 1371 1384
-
(1998)
EMBO J.
, vol.17
, pp. 1371-1384
-
-
Ikeda, S.1
Kishida, S.2
Yamamoto, H.3
Murai, H.4
Koyama, S.5
Kikuchi, A.6
-
13
-
-
69249202259
-
Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions
-
Y. Jiang, W. Luo, and P.H. Howe Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions Oncogene 28 2009 2999 3007
-
(2009)
Oncogene
, vol.28
, pp. 2999-3007
-
-
Jiang, Y.1
Luo, W.2
Howe, P.H.3
-
14
-
-
55549111212
-
SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability
-
M.J. Kim, I.V. Chia, and F. Costantini SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability FASEB J. 22 2008 3785 3794
-
(2008)
FASEB J.
, vol.22
, pp. 3785-3794
-
-
Kim, M.J.1
Chia, I.V.2
Costantini, F.3
-
15
-
-
33845351956
-
Beta-catenin destruction complex: Insights and questions from a structural perspective
-
D. Kimelman, and W. Xu beta-catenin destruction complex: insights and questions from a structural perspective Oncogene 25 2006 7482 7491
-
(2006)
Oncogene
, vol.25
, pp. 7482-7491
-
-
Kimelman, D.1
Xu, W.2
-
16
-
-
0030592517
-
Lessons from hereditary colorectal cancer
-
K.W. Kinzler, and B. Vogelstein Lessons from hereditary colorectal cancer Cell 87 1996 159 170
-
(1996)
Cell
, vol.87
, pp. 159-170
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
17
-
-
0032079884
-
Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin
-
S. Kishida, H. Yamamoto, S. Ikeda, M. Kishida, I. Sakamoto, S. Koyama, and A. Kikuchi Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin J. Biol. Chem. 273 1998 10823 10826
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 10823-10826
-
-
Kishida, S.1
Yamamoto, H.2
Ikeda, S.3
Kishida, M.4
Sakamoto, I.5
Koyama, S.6
Kikuchi, A.7
-
18
-
-
0033522491
-
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin
-
M. Kitagawa, S. Hatakeyama, M. Shirane, M. Matsumoto, N. Ishida, K. Hattori, I. Nakamichi, A. Kikuchi, K. Nakayama, and K. Nakayama An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin EMBO J. 18 1999 2401 2410
-
(1999)
EMBO J.
, vol.18
, pp. 2401-2410
-
-
Kitagawa, M.1
Hatakeyama, S.2
Shirane, M.3
Matsumoto, M.4
Ishida, N.5
Hattori, K.6
Nakamichi, I.7
Kikuchi, A.8
Nakayama, K.9
Nakayama, K.10
-
19
-
-
0030975671
-
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
-
V. Korinek, N. Barker, P.J. Morin, D. van Wichen, R. de Weger, K.W. Kinzler, B. Vogelstein, and H. Clevers Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma Science 275 1997 1784 1787
-
(1997)
Science
, vol.275
, pp. 1784-1787
-
-
Korinek, V.1
Barker, N.2
Morin, P.J.3
Van Wichen, D.4
De Weger, R.5
Kinzler, K.W.6
Vogelstein, B.7
Clevers, H.8
-
20
-
-
4243067196
-
The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway
-
E. Lee, A. Salic, R. Kruger, R. Heinrich, and M.W. Kirschner The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway PLoS Biol. 1 2003 E10
-
(2003)
PLoS Biol.
, vol.1
, pp. 10
-
-
Lee, E.1
Salic, A.2
Kruger, R.3
Heinrich, R.4
Kirschner, M.W.5
-
21
-
-
0033780630
-
Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling
-
W. Liu, X. Dong, M. Mai, R.S. Seelan, K. Taniguchi, K.K. Krishnadath, K.C. Halling, J.M. Cunningham, L.A. Boardman, and C. Qian Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling Nat. Genet. 26 2000 146 147
-
(2000)
Nat. Genet.
, vol.26
, pp. 146-147
-
-
Liu, W.1
Dong, X.2
Mai, M.3
Seelan, R.S.4
Taniguchi, K.5
Krishnadath, K.K.6
Halling, K.C.7
Cunningham, J.M.8
Boardman, L.A.9
Qian, C.10
-
22
-
-
0037155691
-
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
-
C. Liu, Y. Li, M. Semenov, C. Han, G.H. Baeg, Y. Tan, Z. Zhang, X. Lin, and X. He Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism Cell 108 2002 837 847
-
(2002)
Cell
, vol.108
, pp. 837-847
-
-
Liu, C.1
Li, Y.2
Semenov, M.3
Han, C.4
Baeg, G.H.5
Tan, Y.6
Zhang, Z.7
Lin, X.8
He, X.9
-
23
-
-
27844516613
-
Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins
-
X. Liu, J.S. Rubin, and A.R. Kimmel Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins Curr. Biol. 15 2005 1989 1997
-
(2005)
Curr. Biol.
, vol.15
, pp. 1989-1997
-
-
Liu, X.1
Rubin, J.S.2
Kimmel, A.R.3
-
24
-
-
8444251784
-
The Wnt signaling pathway in development and disease
-
C.Y. Logan, and R. Nusse The Wnt signaling pathway in development and disease Annu. Rev. Cell Dev. Biol. 20 2004 781 810
-
(2004)
Annu. Rev. Cell Dev. Biol.
, vol.20
, pp. 781-810
-
-
Logan, C.Y.1
Nusse, R.2
-
25
-
-
79956128376
-
The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling
-
T.T. Lui, C. Lacroix, S.M. Ahmed, S.J. Goldenberg, C.A. Leach, A.M. Daulat, and S. Angers The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling Mol. Cell. Biol. 31 2011 2053 2065
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 2053-2065
-
-
Lui, T.T.1
Lacroix, C.2
Ahmed, S.M.3
Goldenberg, S.J.4
Leach, C.A.5
Daulat, A.M.6
Angers, S.7
-
26
-
-
33947600085
-
Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex
-
W. Luo, A. Peterson, B.A. Garcia, G. Coombs, B. Kofahl, R. Heinrich, J. Shabanowitz, D.F. Hunt, H.J. Yost, and D.M. Virshup Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex EMBO J. 26 2007 1511 1521
-
(2007)
EMBO J.
, vol.26
, pp. 1511-1521
-
-
Luo, W.1
Peterson, A.2
Garcia, B.A.3
Coombs, G.4
Kofahl, B.5
Heinrich, R.6
Shabanowitz, J.7
Hunt, D.F.8
Yost, H.J.9
Virshup, D.M.10
-
27
-
-
0036149985
-
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors
-
B. Lustig, B. Jerchow, M. Sachs, S. Weiler, T. Pietsch, U. Karsten, M. van de Wetering, H. Clevers, P.M. Schlag, W. Birchmeier, and J. Behrens Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors Mol. Cell. Biol. 22 2002 1184 1193
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 1184-1193
-
-
Lustig, B.1
Jerchow, B.2
Sachs, M.3
Weiler, S.4
Pietsch, T.5
Karsten, U.6
Van De Wetering, M.7
Clevers, H.8
Schlag, P.M.9
Birchmeier, W.10
Behrens, J.11
-
28
-
-
67650230896
-
Wnt/beta-catenin signaling: Components, mechanisms, and diseases
-
B.T. MacDonald, K. Tamai, and X. He Wnt/beta-catenin signaling: components, mechanisms, and diseases Dev. Cell 17 2009 9 26
-
(2009)
Dev. Cell
, vol.17
, pp. 9-26
-
-
MacDonald, B.T.1
Tamai, K.2
He, X.3
-
29
-
-
77956300964
-
Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: Implications for signaling
-
M.T. Maher, R. Mo, A.S. Flozak, O.N. Peled, and C.J. Gottardi Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling PLoS ONE 5 2010 e10184
-
(2010)
PLoS ONE
, vol.5
, pp. 10184
-
-
Maher, M.T.1
Mo, R.2
Flozak, A.S.3
Peled, O.N.4
Gottardi, C.J.5
-
30
-
-
70350759551
-
The kinase TNIK is an essential activator of Wnt target genes
-
T. Mahmoudi, V.S. Li, S.S. Ng, N. Taouatas, R.G. Vries, S. Mohammed, A.J. Heck, and H. Clevers The kinase TNIK is an essential activator of Wnt target genes EMBO J. 28 2009 3329 3340
-
(2009)
EMBO J.
, vol.28
, pp. 3329-3340
-
-
Mahmoudi, T.1
Li, V.S.2
Ng, S.S.3
Taouatas, N.4
Vries, R.G.5
Mohammed, S.6
Heck, A.J.7
Clevers, H.8
-
31
-
-
33645888429
-
Dishevelled: A mobile scaffold catalyzing development
-
C.C. Malbon, and H.Y. Wang Dishevelled: a mobile scaffold catalyzing development Curr. Top. Dev. Biol. 72 2006 153 166
-
(2006)
Curr. Top. Dev. Biol.
, vol.72
, pp. 153-166
-
-
Malbon, C.C.1
Wang, H.Y.2
-
32
-
-
18244427021
-
Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway
-
J. Mao, J. Wang, B. Liu, W. Pan, G.H. Farr III, C. Flynn, H. Yuan, S. Takada, D. Kimelman, L. Li, and D. Wu Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway Mol. Cell 7 2001 801 809
-
(2001)
Mol. Cell
, vol.7
, pp. 801-809
-
-
Mao, J.1
Wang, J.2
Liu, B.3
Pan, W.4
Farr Iii, G.H.5
Flynn, C.6
Yuan, H.7
Takada, S.8
Kimelman, D.9
Li, L.10
Wu, D.11
-
33
-
-
0026894053
-
Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene
-
Y. Miyoshi, H. Nagase, H. Ando, A. Horii, S. Ichii, S. Nakatsuru, T. Aoki, Y. Miki, T. Mori, and Y. Nakamura Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene Hum. Mol. Genet. 1 1992 229 233
-
(1992)
Hum. Mol. Genet.
, vol.1
, pp. 229-233
-
-
Miyoshi, Y.1
Nagase, H.2
Ando, H.3
Horii, A.4
Ichii, S.5
Nakatsuru, S.6
Aoki, T.7
Miki, Y.8
Mori, T.9
Nakamura, Y.10
-
34
-
-
0001003110
-
XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
-
M. Molenaar, M. van de Wetering, M. Oosterwegel, J. Peterson-Maduro, S. Godsave, V. Korinek, J. Roose, O. Destrée, and H. Clevers XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos Cell 86 1996 391 399
-
(1996)
Cell
, vol.86
, pp. 391-399
-
-
Molenaar, M.1
Van De Wetering, M.2
Oosterwegel, M.3
Peterson-Maduro, J.4
Godsave, S.5
Korinek, V.6
Roose, J.7
Destrée, O.8
Clevers, H.9
-
35
-
-
0030949463
-
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
-
P.J. Morin, A.B. Sparks, V. Korinek, N. Barker, H. Clevers, B. Vogelstein, and K.W. Kinzler Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC Science 275 1997 1787 1790
-
(1997)
Science
, vol.275
, pp. 1787-1790
-
-
Morin, P.J.1
Sparks, A.B.2
Korinek, V.3
Barker, N.4
Clevers, H.5
Vogelstein, B.6
Kinzler, K.W.7
-
36
-
-
0028987249
-
Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
-
S. Munemitsu, I. Albert, B. Souza, B. Rubinfeld, and P. Polakis Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein Proc. Natl. Acad. Sci. USA 92 1995 3046 3050
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 3046-3050
-
-
Munemitsu, S.1
Albert, I.2
Souza, B.3
Rubinfeld, B.4
Polakis, P.5
-
37
-
-
0027146559
-
Mutations of the APC (adenomatous polyposis coli) gene
-
H. Nagase, and Y. Nakamura Mutations of the APC (adenomatous polyposis coli) gene Hum. Mutat. 2 1993 425 434
-
(1993)
Hum. Mutat.
, vol.2
, pp. 425-434
-
-
Nagase, H.1
Nakamura, Y.2
-
38
-
-
72149109797
-
Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade
-
S.S. Ng, T. Mahmoudi, E. Danenberg, I. Bejaoui, W. de Lau, H.C. Korswagen, M. Schutte, and H. Clevers Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade J. Biol. Chem. 284 2009 35308 35313
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 35308-35313
-
-
Ng, S.S.1
Mahmoudi, T.2
Danenberg, E.3
Bejaoui, I.4
De Lau, W.5
Korswagen, H.C.6
Schutte, M.7
Clevers, H.8
-
39
-
-
58149185151
-
Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling
-
S. Piao, S.H. Lee, H. Kim, S. Yum, J.L. Stamos, Y. Xu, S.J. Lee, J. Lee, S. Oh, and J.K. Han Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling PLoS ONE 3 2008 e4046
-
(2008)
PLoS ONE
, vol.3
, pp. 4046
-
-
Piao, S.1
Lee, S.H.2
Kim, H.3
Yum, S.4
Stamos, J.L.5
Xu, Y.6
Lee, S.J.7
Lee, J.8
Oh, S.9
Han, J.K.10
-
40
-
-
17244376814
-
Wnt signalling in stem cells and cancer
-
T. Reya, and H. Clevers Wnt signalling in stem cells and cancer Nature 434 2005 843 850
-
(2005)
Nature
, vol.434
, pp. 843-850
-
-
Reya, T.1
Clevers, H.2
-
41
-
-
79957597124
-
Deconstructing the ßcatenin destruction complex: Mechanistic roles for the tumor suppressor APC in regulating Wnt signaling
-
D.M. Roberts, M.I. Pronobis, J.S. Poulton, J.D. Waldmann, E.M. Stephenson, S. Hanna, and M. Peifer Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling Mol. Biol. Cell 22 2011 1845 1863
-
(2011)
Mol. Biol. Cell
, vol.22
, pp. 1845-1863
-
-
Roberts, D.M.1
Pronobis, M.I.2
Poulton, J.S.3
Waldmann, J.D.4
Stephenson, E.M.5
Hanna, S.6
Peifer, M.7
-
42
-
-
0033578918
-
Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1
-
J. Roose, G. Huls, M. van Beest, P. Moerer, K. van der Horn, R. Goldschmeding, T. Logtenberg, and H. Clevers Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1 Science 285 1999 1923 1926
-
(1999)
Science
, vol.285
, pp. 1923-1926
-
-
Roose, J.1
Huls, G.2
Van Beest, M.3
Moerer, P.4
Van Der Horn, K.5
Goldschmeding, R.6
Logtenberg, T.7
Clevers, H.8
-
43
-
-
0029664368
-
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
-
B. Rubinfeld, I. Albert, E. Porfiri, C. Fiol, S. Munemitsu, and P. Polakis Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly Science 272 1996 1023 1026
-
(1996)
Science
, vol.272
, pp. 1023-1026
-
-
Rubinfeld, B.1
Albert, I.2
Porfiri, E.3
Fiol, C.4
Munemitsu, S.5
Polakis, P.6
-
44
-
-
0032539945
-
Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription
-
C. Sakanaka, J.B. Weiss, and L.T. Williams Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription Proc. Natl. Acad. Sci. USA 95 1998 3020 3023
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 3020-3023
-
-
Sakanaka, C.1
Weiss, J.B.2
Williams, L.T.3
-
45
-
-
67349123408
-
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
-
T. Sato, R.G. Vries, H.J. Snippert, M. van de Wetering, N. Barker, D.E. Stange, J.H. van Es, A. Abo, P. Kujala, P.J. Peters, and H. Clevers Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche Nature 459 2009 262 265
-
(2009)
Nature
, vol.459
, pp. 262-265
-
-
Sato, T.1
Vries, R.G.2
Snippert, H.J.3
Van De Wetering, M.4
Barker, N.5
Stange, D.E.6
Van Es, J.H.7
Abo, A.8
Kujala, P.9
Peters, P.J.10
Clevers, H.11
-
46
-
-
0036166297
-
Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin
-
F.J. Staal, M. Noort Mv, G.J. Strous, and H.C. Clevers Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin EMBO Rep. 3 2002 63 68
-
(2002)
EMBO Rep.
, vol.3
, pp. 63-68
-
-
Staal, F.J.1
Noort Mv, M.2
Strous, G.J.3
Clevers, H.C.4
-
47
-
-
0034723073
-
Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription
-
E.T. Strovel, D. Wu, and D.J. Sussman Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription J. Biol. Chem. 275 2000 2399 2403
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 2399-2403
-
-
Strovel, E.T.1
Wu, D.2
Sussman, D.J.3
-
48
-
-
56849086074
-
APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase
-
Y. Su, C. Fu, S. Ishikawa, A. Stella, M. Kojima, K. Shitoh, E.M. Schreiber, B.W. Day, and B. Liu APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase Mol. Cell 32 2008 652 661
-
(2008)
Mol. Cell
, vol.32
, pp. 652-661
-
-
Su, Y.1
Fu, C.2
Ishikawa, S.3
Stella, A.4
Kojima, M.5
Shitoh, K.6
Schreiber, E.M.7
Day, B.W.8
Liu, B.9
-
49
-
-
78650484935
-
Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes
-
V.F. Taelman, R. Dobrowolski, J.L. Plouhinec, L.C. Fuentealba, P.P. Vorwald, I. Gumper, D.D. Sabatini, and E.M. De Robertis Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes Cell 143 2010 1136 1148
-
(2010)
Cell
, vol.143
, pp. 1136-1148
-
-
Taelman, V.F.1
Dobrowolski, R.2
Plouhinec, J.L.3
Fuentealba, L.C.4
Vorwald, P.P.5
Gumper, I.6
Sabatini, D.D.7
De Robertis, E.M.8
-
50
-
-
1642564513
-
A mechanism for Wnt coreceptor activation
-
K. Tamai, X. Zeng, C. Liu, X. Zhang, Y. Harada, Z. Chang, and X. He A mechanism for Wnt coreceptor activation Mol. Cell 13 2004 149 156
-
(2004)
Mol. Cell
, vol.13
, pp. 149-156
-
-
Tamai, K.1
Zeng, X.2
Liu, C.3
Zhang, X.4
Harada, Y.5
Chang, Z.6
He, X.7
-
51
-
-
77649259009
-
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl
-
D.V. Tauriello, A. Haegebarth, I. Kuper, M.J. Edelmann, M. Henraat, M.R. Canninga-van Dijk, B.M. Kessler, H. Clevers, and M.M. Maurice Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl Mol. Cell 37 2010 607 619
-
(2010)
Mol. Cell
, vol.37
, pp. 607-619
-
-
Tauriello, D.V.1
Haegebarth, A.2
Kuper, I.3
Edelmann, M.J.4
Henraat, M.5
Canninga-Van Dijk, M.R.6
Kessler, B.M.7
Clevers, H.8
Maurice, M.M.9
-
52
-
-
0033119801
-
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
-
O. Tetsu, and F. McCormick Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells Nature 398 1999 422 426
-
(1999)
Nature
, vol.398
, pp. 422-426
-
-
Tetsu, O.1
McCormick, F.2
-
53
-
-
0037343952
-
Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity
-
N.S. Tolwinski, M. Wehrli, A. Rives, N. Erdeniz, S. DiNardo, and E. Wieschaus Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity Dev. Cell 4 2003 407 418
-
(2003)
Dev. Cell
, vol.4
, pp. 407-418
-
-
Tolwinski, N.S.1
Wehrli, M.2
Rives, A.3
Erdeniz, N.4
Dinardo, S.5
Wieschaus, E.6
-
54
-
-
25444513654
-
Re-evaluating the role of Frat in Wnt-signal transduction
-
R. van Amerongen, and A. Berns Re-evaluating the role of Frat in Wnt-signal transduction Cell Cycle 4 2005 1065 1072
-
(2005)
Cell Cycle
, vol.4
, pp. 1065-1072
-
-
Van Amerongen, R.1
Berns, A.2
-
55
-
-
13844292692
-
Frat is dispensable for canonical Wnt signaling in mammals
-
R. van Amerongen, M. Nawijn, J. Franca-Koh, J. Zevenhoven, H. van der Gulden, J. Jonkers, and A. Berns Frat is dispensable for canonical Wnt signaling in mammals Genes Dev. 19 2005 425 430
-
(2005)
Genes Dev.
, vol.19
, pp. 425-430
-
-
Van Amerongen, R.1
Nawijn, M.2
Franca-Koh, J.3
Zevenhoven, J.4
Van Der Gulden, H.5
Jonkers, J.6
Berns, A.7
-
56
-
-
0035138178
-
Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling
-
M. van de Wetering, N. Barker, I.C. Harkes, M. van der Heyden, N.J. Dijk, A. Hollestelle, J.G. Klijn, H. Clevers, and M. Schutte Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling Cancer Res. 61 2001 278 284
-
(2001)
Cancer Res.
, vol.61
, pp. 278-284
-
-
Van De Wetering, M.1
Barker, N.2
Harkes, I.C.3
Van Der Heyden, M.4
Dijk, N.J.5
Hollestelle, A.6
Klijn, J.G.7
Clevers, H.8
Schutte, M.9
-
57
-
-
18644373146
-
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
-
M. van de Wetering, E. Sancho, C. Verweij, W. de Lau, I. Oving, A. Hurlstone, K. van der Horn, E. Batlle, D. Coudreuse, and A.P. Haramis The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells Cell 111 2002 241 250
-
(2002)
Cell
, vol.111
, pp. 241-250
-
-
Van De Wetering, M.1
Sancho, E.2
Verweij, C.3
De Lau, W.4
Oving, I.5
Hurlstone, A.6
Van Der Horn, K.7
Batlle, E.8
Coudreuse, D.9
Haramis, A.P.10
-
58
-
-
0037124057
-
Wnt signaling controls the phosphorylation status of beta-catenin
-
M. van Noort, J. Meeldijk, R. van der Zee, O. Destree, and H. Clevers Wnt signaling controls the phosphorylation status of beta-catenin J. Biol. Chem. 277 2002 17901 17905
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 17901-17905
-
-
Van Noort, M.1
Meeldijk, J.2
Van Der Zee, R.3
Destree, O.4
Clevers, H.5
-
59
-
-
62849125293
-
Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6
-
G. Wu, H. Huang, J. Garcia Abreu, and X. He Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6 PLoS ONE 4 2009 e4926
-
(2009)
PLoS ONE
, vol.4
, pp. 4926
-
-
Wu, G.1
Huang, H.2
Garcia Abreu, J.3
He, X.4
-
60
-
-
0344442773
-
Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex
-
Y. Xing, W.K. Clements, D. Kimelman, and W. Xu Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex Genes Dev. 17 2003 2753 2764
-
(2003)
Genes Dev.
, vol.17
, pp. 2753-2764
-
-
Xing, Y.1
Clements, W.K.2
Kimelman, D.3
Xu, W.4
-
61
-
-
28644439005
-
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
-
X. Zeng, K. Tamai, B. Doble, S. Li, H. Huang, R. Habas, H. Okamura, J. Woodgett, and X. He A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation Nature 438 2005 873 877
-
(2005)
Nature
, vol.438
, pp. 873-877
-
-
Zeng, X.1
Tamai, K.2
Doble, B.3
Li, S.4
Huang, H.5
Habas, R.6
Okamura, H.7
Woodgett, J.8
He, X.9
-
62
-
-
79955831978
-
Improved peptide identification by targeted fragmentation using CID, HCD and ETD on an LTQ-Orbitrap Velos
-
Frese, C.K.; Altelaar, A.F.; Hennrich, M.L.; Nolting, D.; Zeller, M.; Griep-Raming, J.; Heck, A.J.R.; and Mohammed, S. (2011). Improved peptide identification by targeted fragmentation using CID, HCD and ETD on an LTQ-Orbitrap Velos. J. Proteome Res. 10, 2377-2388.
-
(2011)
J. Proteome Res.
, vol.10
, pp. 2377-2388
-
-
Frese, C.K.1
Altelaar, A.F.2
Hennrich, M.L.3
Nolting, D.4
Zeller, M.5
Griep-Raming, J.6
Heck, A.J.R.7
Mohammed, S.8
-
63
-
-
56149086397
-
Decision tree-driven tandem mass spectrometry for shotgun proteomics
-
Swaney, D.L.; McAlister, G.C.; and Coon, J.J. (2008). Decision tree-driven tandem mass spectrometry for shotgun proteomics. Nat. Methods 5, 959-964.
-
(2008)
Nat. Methods
, vol.5
, pp. 959-964
-
-
Swaney, D.L.1
McAlister, G.C.2
Coon, J.J.3
|