메뉴 건너뛰기




Volumn 149, Issue 6, 2012, Pages 1245-1256

Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

Author keywords

[No Author keywords available]

Indexed keywords

AXIN1 COMPLEX; BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3; PROTEASOME; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 84861972831     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2012.05.002     Document Type: Article
Times cited : (722)

References (63)
  • 1
    • 0030978351 scopus 로고    scopus 로고
    • Beta-catenin is a target for the ubiquitin-proteasome pathway
    • H. Aberle, A. Bauer, J. Stappert, A. Kispert, and R. Kemler beta-catenin is a target for the ubiquitin-proteasome pathway EMBO J. 16 1997 3797 3804
    • (1997) EMBO J. , vol.16 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3    Kispert, A.4    Kemler, R.5
  • 4
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • H. Clevers Wnt/beta-catenin signaling in development and disease Cell 127 2006 469 480
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 5
    • 45849104800 scopus 로고    scopus 로고
    • LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin
    • C.S. Cselenyi, K.K. Jernigan, E. Tahinci, C.A. Thorne, L.A. Lee, and E. Lee LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin Proc. Natl. Acad. Sci. USA 105 2008 8032 8037
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 8032-8037
    • Cselenyi, C.S.1    Jernigan, K.K.2    Tahinci, E.3    Thorne, C.A.4    Lee, L.A.5    Lee, E.6
  • 7
    • 0035843148 scopus 로고    scopus 로고
    • Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation
    • C. Desbois-Mouthon, A. Cadoret, M.J. Blivet-Van Eggelpoël, F. Bertrand, G. Cherqui, C. Perret, and J. Capeau Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation Oncogene 20 2001 252 259
    • (2001) Oncogene , vol.20 , pp. 252-259
    • Desbois-Mouthon, C.1    Cadoret, A.2    Blivet-Van Eggelpoël, M.J.3    Bertrand, F.4    Cherqui, G.5    Perret, C.6    Capeau, J.7
  • 8
    • 33847740988 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in cancer stemness and malignant behavior
    • R. Fodde, and T. Brabletz Wnt/beta-catenin signaling in cancer stemness and malignant behavior Curr. Opin. Cell Biol. 19 2007 150 158
    • (2007) Curr. Opin. Cell Biol. , vol.19 , pp. 150-158
    • Fodde, R.1    Brabletz, T.2
  • 10
    • 84856635802 scopus 로고    scopus 로고
    • Triple SILAC to determine stimulus specific interactions in the Wnt pathway
    • M. Hilger, and M. Mann Triple SILAC to determine stimulus specific interactions in the Wnt pathway J. Proteome Res. 11 2012 982 994
    • (2012) J. Proteome Res. , vol.11 , pp. 982-994
    • Hilger, M.1    Mann, M.2
  • 12
    • 0032473355 scopus 로고    scopus 로고
    • Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
    • S. Ikeda, S. Kishida, H. Yamamoto, H. Murai, S. Koyama, and A. Kikuchi Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin EMBO J. 17 1998 1371 1384
    • (1998) EMBO J. , vol.17 , pp. 1371-1384
    • Ikeda, S.1    Kishida, S.2    Yamamoto, H.3    Murai, H.4    Koyama, S.5    Kikuchi, A.6
  • 13
    • 69249202259 scopus 로고    scopus 로고
    • Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions
    • Y. Jiang, W. Luo, and P.H. Howe Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions Oncogene 28 2009 2999 3007
    • (2009) Oncogene , vol.28 , pp. 2999-3007
    • Jiang, Y.1    Luo, W.2    Howe, P.H.3
  • 14
    • 55549111212 scopus 로고    scopus 로고
    • SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability
    • M.J. Kim, I.V. Chia, and F. Costantini SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability FASEB J. 22 2008 3785 3794
    • (2008) FASEB J. , vol.22 , pp. 3785-3794
    • Kim, M.J.1    Chia, I.V.2    Costantini, F.3
  • 15
    • 33845351956 scopus 로고    scopus 로고
    • Beta-catenin destruction complex: Insights and questions from a structural perspective
    • D. Kimelman, and W. Xu beta-catenin destruction complex: insights and questions from a structural perspective Oncogene 25 2006 7482 7491
    • (2006) Oncogene , vol.25 , pp. 7482-7491
    • Kimelman, D.1    Xu, W.2
  • 16
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • K.W. Kinzler, and B. Vogelstein Lessons from hereditary colorectal cancer Cell 87 1996 159 170
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 17
    • 0032079884 scopus 로고    scopus 로고
    • Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin
    • S. Kishida, H. Yamamoto, S. Ikeda, M. Kishida, I. Sakamoto, S. Koyama, and A. Kikuchi Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin J. Biol. Chem. 273 1998 10823 10826
    • (1998) J. Biol. Chem. , vol.273 , pp. 10823-10826
    • Kishida, S.1    Yamamoto, H.2    Ikeda, S.3    Kishida, M.4    Sakamoto, I.5    Koyama, S.6    Kikuchi, A.7
  • 20
    • 4243067196 scopus 로고    scopus 로고
    • The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway
    • E. Lee, A. Salic, R. Kruger, R. Heinrich, and M.W. Kirschner The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway PLoS Biol. 1 2003 E10
    • (2003) PLoS Biol. , vol.1 , pp. 10
    • Lee, E.1    Salic, A.2    Kruger, R.3    Heinrich, R.4    Kirschner, M.W.5
  • 22
    • 0037155691 scopus 로고    scopus 로고
    • Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    • C. Liu, Y. Li, M. Semenov, C. Han, G.H. Baeg, Y. Tan, Z. Zhang, X. Lin, and X. He Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism Cell 108 2002 837 847
    • (2002) Cell , vol.108 , pp. 837-847
    • Liu, C.1    Li, Y.2    Semenov, M.3    Han, C.4    Baeg, G.H.5    Tan, Y.6    Zhang, Z.7    Lin, X.8    He, X.9
  • 23
    • 27844516613 scopus 로고    scopus 로고
    • Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins
    • X. Liu, J.S. Rubin, and A.R. Kimmel Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins Curr. Biol. 15 2005 1989 1997
    • (2005) Curr. Biol. , vol.15 , pp. 1989-1997
    • Liu, X.1    Rubin, J.S.2    Kimmel, A.R.3
  • 24
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • C.Y. Logan, and R. Nusse The Wnt signaling pathway in development and disease Annu. Rev. Cell Dev. Biol. 20 2004 781 810
    • (2004) Annu. Rev. Cell Dev. Biol. , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 28
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: Components, mechanisms, and diseases
    • B.T. MacDonald, K. Tamai, and X. He Wnt/beta-catenin signaling: components, mechanisms, and diseases Dev. Cell 17 2009 9 26
    • (2009) Dev. Cell , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 29
    • 77956300964 scopus 로고    scopus 로고
    • Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: Implications for signaling
    • M.T. Maher, R. Mo, A.S. Flozak, O.N. Peled, and C.J. Gottardi Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling PLoS ONE 5 2010 e10184
    • (2010) PLoS ONE , vol.5 , pp. 10184
    • Maher, M.T.1    Mo, R.2    Flozak, A.S.3    Peled, O.N.4    Gottardi, C.J.5
  • 31
    • 33645888429 scopus 로고    scopus 로고
    • Dishevelled: A mobile scaffold catalyzing development
    • C.C. Malbon, and H.Y. Wang Dishevelled: a mobile scaffold catalyzing development Curr. Top. Dev. Biol. 72 2006 153 166
    • (2006) Curr. Top. Dev. Biol. , vol.72 , pp. 153-166
    • Malbon, C.C.1    Wang, H.Y.2
  • 32
  • 35
    • 0030949463 scopus 로고    scopus 로고
    • Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    • P.J. Morin, A.B. Sparks, V. Korinek, N. Barker, H. Clevers, B. Vogelstein, and K.W. Kinzler Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC Science 275 1997 1787 1790
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5    Vogelstein, B.6    Kinzler, K.W.7
  • 36
    • 0028987249 scopus 로고
    • Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
    • S. Munemitsu, I. Albert, B. Souza, B. Rubinfeld, and P. Polakis Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein Proc. Natl. Acad. Sci. USA 92 1995 3046 3050
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3046-3050
    • Munemitsu, S.1    Albert, I.2    Souza, B.3    Rubinfeld, B.4    Polakis, P.5
  • 37
    • 0027146559 scopus 로고
    • Mutations of the APC (adenomatous polyposis coli) gene
    • H. Nagase, and Y. Nakamura Mutations of the APC (adenomatous polyposis coli) gene Hum. Mutat. 2 1993 425 434
    • (1993) Hum. Mutat. , vol.2 , pp. 425-434
    • Nagase, H.1    Nakamura, Y.2
  • 39
    • 58149185151 scopus 로고    scopus 로고
    • Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling
    • S. Piao, S.H. Lee, H. Kim, S. Yum, J.L. Stamos, Y. Xu, S.J. Lee, J. Lee, S. Oh, and J.K. Han Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling PLoS ONE 3 2008 e4046
    • (2008) PLoS ONE , vol.3 , pp. 4046
    • Piao, S.1    Lee, S.H.2    Kim, H.3    Yum, S.4    Stamos, J.L.5    Xu, Y.6    Lee, S.J.7    Lee, J.8    Oh, S.9    Han, J.K.10
  • 40
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • T. Reya, and H. Clevers Wnt signalling in stem cells and cancer Nature 434 2005 843 850
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 41
    • 79957597124 scopus 로고    scopus 로고
    • Deconstructing the ßcatenin destruction complex: Mechanistic roles for the tumor suppressor APC in regulating Wnt signaling
    • D.M. Roberts, M.I. Pronobis, J.S. Poulton, J.D. Waldmann, E.M. Stephenson, S. Hanna, and M. Peifer Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling Mol. Biol. Cell 22 2011 1845 1863
    • (2011) Mol. Biol. Cell , vol.22 , pp. 1845-1863
    • Roberts, D.M.1    Pronobis, M.I.2    Poulton, J.S.3    Waldmann, J.D.4    Stephenson, E.M.5    Hanna, S.6    Peifer, M.7
  • 43
    • 0029664368 scopus 로고    scopus 로고
    • Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
    • B. Rubinfeld, I. Albert, E. Porfiri, C. Fiol, S. Munemitsu, and P. Polakis Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly Science 272 1996 1023 1026
    • (1996) Science , vol.272 , pp. 1023-1026
    • Rubinfeld, B.1    Albert, I.2    Porfiri, E.3    Fiol, C.4    Munemitsu, S.5    Polakis, P.6
  • 44
    • 0032539945 scopus 로고    scopus 로고
    • Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription
    • C. Sakanaka, J.B. Weiss, and L.T. Williams Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription Proc. Natl. Acad. Sci. USA 95 1998 3020 3023
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3020-3023
    • Sakanaka, C.1    Weiss, J.B.2    Williams, L.T.3
  • 46
    • 0036166297 scopus 로고    scopus 로고
    • Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin
    • F.J. Staal, M. Noort Mv, G.J. Strous, and H.C. Clevers Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin EMBO Rep. 3 2002 63 68
    • (2002) EMBO Rep. , vol.3 , pp. 63-68
    • Staal, F.J.1    Noort Mv, M.2    Strous, G.J.3    Clevers, H.C.4
  • 47
    • 0034723073 scopus 로고    scopus 로고
    • Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription
    • E.T. Strovel, D. Wu, and D.J. Sussman Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription J. Biol. Chem. 275 2000 2399 2403
    • (2000) J. Biol. Chem. , vol.275 , pp. 2399-2403
    • Strovel, E.T.1    Wu, D.2    Sussman, D.J.3
  • 52
    • 0033119801 scopus 로고    scopus 로고
    • Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    • O. Tetsu, and F. McCormick Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells Nature 398 1999 422 426
    • (1999) Nature , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 53
    • 0037343952 scopus 로고    scopus 로고
    • Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity
    • N.S. Tolwinski, M. Wehrli, A. Rives, N. Erdeniz, S. DiNardo, and E. Wieschaus Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity Dev. Cell 4 2003 407 418
    • (2003) Dev. Cell , vol.4 , pp. 407-418
    • Tolwinski, N.S.1    Wehrli, M.2    Rives, A.3    Erdeniz, N.4    Dinardo, S.5    Wieschaus, E.6
  • 54
    • 25444513654 scopus 로고    scopus 로고
    • Re-evaluating the role of Frat in Wnt-signal transduction
    • R. van Amerongen, and A. Berns Re-evaluating the role of Frat in Wnt-signal transduction Cell Cycle 4 2005 1065 1072
    • (2005) Cell Cycle , vol.4 , pp. 1065-1072
    • Van Amerongen, R.1    Berns, A.2
  • 59
    • 62849125293 scopus 로고    scopus 로고
    • Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6
    • G. Wu, H. Huang, J. Garcia Abreu, and X. He Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6 PLoS ONE 4 2009 e4926
    • (2009) PLoS ONE , vol.4 , pp. 4926
    • Wu, G.1    Huang, H.2    Garcia Abreu, J.3    He, X.4
  • 60
    • 0344442773 scopus 로고    scopus 로고
    • Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex
    • Y. Xing, W.K. Clements, D. Kimelman, and W. Xu Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex Genes Dev. 17 2003 2753 2764
    • (2003) Genes Dev. , vol.17 , pp. 2753-2764
    • Xing, Y.1    Clements, W.K.2    Kimelman, D.3    Xu, W.4
  • 63
    • 56149086397 scopus 로고    scopus 로고
    • Decision tree-driven tandem mass spectrometry for shotgun proteomics
    • Swaney, D.L.; McAlister, G.C.; and Coon, J.J. (2008). Decision tree-driven tandem mass spectrometry for shotgun proteomics. Nat. Methods 5, 959-964.
    • (2008) Nat. Methods , vol.5 , pp. 959-964
    • Swaney, D.L.1    McAlister, G.C.2    Coon, J.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.