-
1
-
-
84883760726
-
Functional impairment of systemic scleroderma patients with digital ulcerations: Results from the DUO Registry
-
Guillevin, L. et al. Functional impairment of systemic scleroderma patients with digital ulcerations: Results from the DUO Registry. Clin. Exp. Rheumatol. 31, 71Y80 (2013
-
(2013)
Clin. Exp. Rheumatol
, vol.31
, pp. 71-80
-
-
Guillevin, L.1
-
2
-
-
84880272365
-
Race and association with disease manifestations and mortality in scleroderma: A 20-year experience at the johns hopkins scleroderma center and review of the literature
-
Gelber, A. C. et al. Race and association with disease manifestations and mortality in scleroderma: A 20-year experience at the Johns Hopkins Scleroderma Center and review of the literature. Medicine (Baltimore) 92, 191Y205 (2013
-
(2013)
Medicine (Baltimore
, vol.92
, pp. 191-205
-
-
Gelber, A.C.1
-
3
-
-
84894042138
-
Mortality in systemic sclerosis: Lessons learned from population-based and observational cohort studies
-
Nikpour, M. & Baron, M. Mortality in systemic sclerosis: Lessons learned from population-based and observational cohort studies. Curr. Opin. Rheumatol. 26, 131Y137 (2014
-
(2014)
Curr. Opin. Rheumatol
, vol.26
, pp. 131-137
-
-
Nikpour, M.1
Baron, M.2
-
4
-
-
84655175061
-
Understanding fibrosis in systemic sclerosis: Shifting paradigms, emerging opportunities
-
Bhattacharyya, S., Wei, J. & Varga, J. Understanding fibrosis in systemic sclerosis: Shifting paradigms, emerging opportunities. Nat. Rev. Rheumatol. 8, 42Y54 (2012
-
(2012)
Nat. Rev. Rheumatol
, vol.8
, pp. 42-54
-
-
Bhattacharyya, S.1
Wei, J.2
Varga, J.3
-
5
-
-
77955331793
-
Cellular and molecular aspects of vascular dysfunction in systemic sclerosis
-
Trojanowska, M. Cellular and molecular aspects of vascular dysfunction in systemic sclerosis. Nat. Rev. Rheumatol. 6, 453Y460 (2010
-
(2010)
Nat. Rev. Rheumatol
, vol.6
, pp. 453-460
-
-
Trojanowska, M.1
-
6
-
-
79951682352
-
Diagnosis and classification of systemic sclerosis
-
Hachulla, E. & Launay, D. Diagnosis and classification of systemic sclerosis. Clin. Rev. Allergy Immunol. 40, 78Y83 (2011
-
(2011)
Clin. Rev. Allergy Immunol
, vol.40
, pp. 78-83
-
-
Hachulla, E.1
Launay, D.2
-
7
-
-
0028351248
-
Elevated expression of type vii collagen in the skin of patients with systemic sclerosis regulation by transforming growth factor-beta
-
Rudnicka, L. et al. Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-beta. J. Clin. Invest. 93, 1709Y1715 (1994
-
(1994)
J. Clin. Invest
, vol.93
, pp. 1709-1715
-
-
Rudnicka, L.1
-
8
-
-
84875979967
-
The downregulation of microRNA let-7a contributes to the excessive expression of type I collagen in systemic and localized scleroderma
-
Makino, K. et al. The downregulation of microRNA let-7a contributes to the excessive expression of type I collagen in systemic and localized scleroderma. J. Immunol. 190, 3905Y3915 (2013
-
(2013)
J. Immunol
, vol.190
, pp. 3905-3915
-
-
Makino, K.1
-
9
-
-
77952946050
-
MicroRNA- ;29, a key regulator of collagen expression in systemic sclerosis
-
Maurer, B. et al. MicroRNA-29, a key regulator of collagen expression in systemic sclerosis. Arthritis Rheum. 62, 1733Y1743 (2010
-
(2010)
Arthritis Rheum
, vol.62
, pp. 1733-1743
-
-
Maurer, B.1
-
10
-
-
84871347177
-
Mir-150 down-regulation contributes to the constitutive type I collagen overexpression in scleroderma dermal fibroblasts via the induction of integrin β3
-
Honda, N. et al. miR-150 down-regulation contributes to the constitutive type I collagen overexpression in scleroderma dermal fibroblasts via the induction of integrin β3. Am. J. Pathol. 182, 206Y216 (2013
-
(2013)
Am. J. Pathol
, vol.182
, pp. 206-216
-
-
Honda, N.1
-
11
-
-
0028823816
-
Increased expression of lysyl oxidase in skin with scleroderma
-
Chanoki, M. et al. Increased expression of lysyl oxidase in skin with scleroderma. Br. J. Dermatol. 133, 710Y715 (1995
-
(1995)
Br. J. Dermatol
, vol.133
, pp. 710-715
-
-
Chanoki, M.1
-
12
-
-
67650908413
-
Cutaneous chronic graft-versus-host disease does not have the abnormal endothelial phenotype or vascular rarefaction characteristic of systemic sclerosis
-
Fleming, J. N. et al. Cutaneous chronic graft-versus-host disease does not have the abnormal endothelial phenotype or vascular rarefaction characteristic of systemic sclerosis. PLoS ONE 4, e6203 (2009
-
(2009)
PLoS ONE
, vol.4
-
-
Fleming, J.N.1
-
13
-
-
84877057102
-
Evidence for progressive reduction and loss of telocytes in the dermal cellular network of systemic sclerosis
-
Manetti, M. et al. Evidence for progressive reduction and loss of telocytes in the dermal cellular network of systemic sclerosis. J. Cell. Mol. Med. 17, 482Y496 (2013
-
(2013)
J. Cell. Mol. Med
, vol.17
, pp. 482-496
-
-
Manetti, M.1
-
14
-
-
84863109005
-
Telocytes in human skin-are they involved in skin regeneration? J
-
Ceafalan, L., Gherghiceanu, M., Popescu, L. M. & Simionescu, O. Telocytes in human skin - are they involved in skin regeneration? J. Cell. Mol. Med. 16, 1405Y1420 (2012
-
(2012)
Cell. Mol. Med
, vol.16
, pp. 1405-1420
-
-
Ceafalan, L.1
Gherghiceanu, M.2
Popescu, L.M.3
Simionescu, O.4
-
15
-
-
77958538113
-
Telocytes as supporting cells for myocardial tissue organization in developing and adult heart
-
Bani, D., Formigli, L., Gherghiceanu, M. & Faussone-Pellegrini, M. S. Telocytes as supporting cells for myocardial tissue organization in developing and adult heart. J. Cell. Mol. Med. 14, 2531Y2538 (2010
-
(2010)
J. Cell. Mol. Med
, vol.14
, pp. 2531-2538
-
-
Bani, D.1
Formigli, L.2
Gherghiceanu, M.3
Faussone-Pellegrini, M.S.4
-
16
-
-
80052708333
-
Telocytes and putative stem cells in the lungs: Electron microscopy electron tomography and laser scanning microscopy
-
Popescu, L. M., Gherghiceanu, M., Suciu, L. C., Manole, C. G. & Hinescu, M. E. Telocytes and putative stem cells in the lungs: Electron microscopy, electron tomography and laser scanning microscopy. Cell Tissue Res. 345, 391Y403 (2011
-
(2011)
Cell Tissue Res
, vol.345
, pp. 391-403
-
-
Popescu, L.M.1
Gherghiceanu, M.2
Suciu, L.C.3
Manole, C.G.4
Hinescu, M.E.5
-
17
-
-
49949114547
-
Molecular subsets in the gene expression signatures of scleroderma skin
-
Milano, A. et al. Molecular subsets in the gene expression signatures of scleroderma skin. PLoS ONE 3, e2696 (2008
-
(2008)
PLoS ONE
, vol.3
-
-
Milano, A.1
-
18
-
-
33745042859
-
Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts
-
Gardner, H. et al. Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts. Arthritis Rheum. 54, 1961Y1973 (2006
-
(2006)
Arthritis Rheum
, vol.54
, pp. 1961-1973
-
-
Gardner, H.1
-
19
-
-
34548492026
-
Vascular complications of scleroderma
-
Guiducci, S., Giacomelli, R. & Cerinic, M. M. Vascular complications of scleroderma. Autoimmun. Rev. 6, 520Y523 (2007
-
(2007)
Autoimmun. Rev
, vol.6
, pp. 520-523
-
-
Guiducci, S.1
Giacomelli, R.2
Cerinic, M.M.3
-
20
-
-
4143072810
-
Defective vasculogenesis in systemic sclerosis
-
Kuwana, M., Okazaki, Y., Yasuoka, H., Kawakami, Y. & Ikeda, Y. Defective vasculogenesis in systemic sclerosis. Lancet 364, 603Y610 (2004
-
(2004)
Lancet
, vol.364
, pp. 603-610
-
-
Kuwana, M.1
Okazaki, Y.2
Yasuoka, H.3
Kawakami, Y.4
Ikeda, Y.5
-
21
-
-
84857042496
-
Angiogenesis and vasculopathy in systemic sclerosis: Evolving concepts
-
Rabquer, B. J. & Koch, A. E. Angiogenesis and vasculopathy in systemic sclerosis: Evolving concepts. Curr. Rheumatol. Rep. 14, 56Y63 (2012
-
(2012)
Curr. Rheumatol. Rep
, vol.14
, pp. 56-63
-
-
Rabquer, B.J.1
Koch, A.E.2
-
22
-
-
79959984675
-
Thrombospondin 1 in hypoxia-conditioned media blocks the growth of human microvascular endothelial cells and is increased in systemic sclerosis tissues
-
Morgan-Rowe, L. et al. Thrombospondin 1 in hypoxia-conditioned media blocks the growth of human microvascular endothelial cells and is increased in systemic sclerosis tissues. Fibrogenesis Tissue Repair 4, 13 (2011
-
(2011)
Fibrogenesis Tissue Repair
, vol.4
, Issue.13
-
-
Morgan-Rowe, L.1
-
23
-
-
0027717313
-
In situ expression of cytokines and cellular adhesion molecules in the skin of patients with systemic sclerosis their role in early and late disease
-
Koch, A. E. et al. In situ expression of cytokines and cellular adhesion molecules in the skin of patients with systemic sclerosis. Their role in early and late disease. Pathobiology 61, 239Y246 (1993
-
(1993)
Pathobiology
, vol.61
, pp. 239-246
-
-
Koch, A.E.1
-
24
-
-
0030936758
-
Up-regulation of class II major histocompatibility complex and intercellular adhesion molecule 1 expression on scleroderma fibroblasts and endothelial cells by interferon-gamma and tumor necrosis factor alpha in the early disease stage
-
Gruschwitz, M. S. & Vieth, G. Up-regulation of class II major histocompatibility complex and intercellular adhesion molecule 1 expression on scleroderma fibroblasts and endothelial cells by interferon-gamma and tumor necrosis factor alpha in the early disease stage. Arthritis Rheum. 40, 540Y550 (1997
-
(1997)
Arthritis Rheum
, vol.40
, pp. 540-550
-
-
Gruschwitz, M.S.1
Vieth, G.2
-
25
-
-
0032929924
-
Activation of microvascular pericytes in autoimmune Raynaud's phenomenon and systemic sclerosis
-
Rajkumar, V. S., Sundberg, C., Abraham, D. J., Rubin, K. & Black, C. M. Activation of microvascular pericytes in autoimmune Raynaud's phenomenon and systemic sclerosis. Arthritis Rheum. 42, 930Y941 (1999
-
(1999)
Arthritis Rheum
, vol.42
, pp. 930-941
-
-
Rajkumar, V.S.1
Sundberg, C.2
Abraham, D.J.3
Rubin, K.4
Black, C.M.5
-
26
-
-
28444434653
-
Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis
-
Rajkumar, V. S. et al. Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis. Arthritis Res. Ther. 7, R1113YR1123 (2005
-
(2005)
Arthritis Res. Ther
, vol.7
-
-
Rajkumar, V.S.1
-
27
-
-
57149113728
-
Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney
-
Lin, S. L., Kisseleva, T., Brenner, D. A. & Duffield, J. S. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am. J. Pathol. 173, 1617Y1627 (2008
-
(2008)
Am. J. Pathol
, vol.173
, pp. 1617-1627
-
-
Lin, S.L.1
Kisseleva, T.2
Brenner, D.A.3
Duffield, J.S.4
-
28
-
-
84872175112
-
Dendritic cells a double-edge sword in autoimmune responses
-
Amodio, G. & Gregori, S. Dendritic cells a double-edge sword in autoimmune responses. Front. Immunol. 3, 233 (2012
-
(2012)
Front. Immunol
, vol.3
, Issue.233
-
-
Amodio, G.1
Gregori, S.2
-
29
-
-
83555168179
-
Dendritic cells and damage-associated molecular patterns: Endogenous danger signals linking innate and adaptive immunity
-
Nace, G., Evankovich, J., Eid, R. & Tsung, A. Dendritic cells and damage-associated molecular patterns: Endogenous danger signals linking innate and adaptive immunity. J. Innate Immun. 4, 6Y15 (2012
-
(2012)
J. Innate Immun
, vol.4
, pp. 6-15
-
-
Nace, G.1
Evankovich, J.2
Eid, R.3
Tsung, A.4
-
30
-
-
84857038564
-
Dendritic cells: Novel players in fibrosis and scleroderma
-
Lu, T. T. Dendritic cells: Novel players in fibrosis and scleroderma. Curr. Rheumatol. Rep. 14, 30Y38 (2012
-
(2012)
Curr. Rheumatol. Rep
, vol.14
, pp. 30-38
-
-
Lu, T.T.1
-
31
-
-
44749085530
-
Central role of dendritic cells in the regulation and deregulation of immune responses
-
Granucci, F., Zanoni, I. & Ricciardi-Castagnoli, P. Central role of dendritic cells in the regulation and deregulation of immune responses. Cell. Mol. Life Sci. 65, 1683Y1697 (2008
-
(2008)
Cell. Mol. Life Sci
, vol.65
, pp. 1683-1697
-
-
Granucci, F.1
Zanoni, I.2
Ricciardi-Castagnoli, P.3
-
32
-
-
85027958236
-
An update on an immune system that goes awry in systemic sclerosis
-
van Bon, L., Cossu, M. & Radstake, T. R. An update on an immune system that goes awry in systemic sclerosis. Curr. Opin. Rheumatol 23, 505Y510 (2011
-
(2011)
Curr. Opin. Rheumatol
, vol.23
, pp. 505-510
-
-
Van Bon, L.1
Cossu, M.2
Radstake, T.R.3
-
33
-
-
66349124699
-
Activation of Toll-like receptor 3 augments myofibroblast differentiation
-
Sugiura, H. et al. Activation of Toll-like receptor 3 augments myofibroblast differentiation. Am. J. Respir. Cell. Mol. Biol. 40, 654Y662 (2009
-
(2009)
Am. J. Respir. Cell. Mol. Biol
, vol.40
, pp. 654-662
-
-
Sugiura, H.1
-
34
-
-
54049116619
-
TLR9 is expressed in idiopathic interstitial pneumonia and its activation promotes in vitro myofibroblast differentiation
-
Meneghin, A. et al. TLR9 is expressed in idiopathic interstitial pneumonia and its activation promotes in vitro myofibroblast differentiation. Histochem. Cell Biol. 130, 979Y992 (2008
-
(2008)
Histochem. Cell Biol
, vol.130
, pp. 979-992
-
-
Meneghin, A.1
-
35
-
-
77957940944
-
Poly(I:C) drives type I IFN- and TGFβ-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis
-
Farina, G. A. et al. Poly(I:C) drives type I IFN- and TGFβ-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis. J. Invest. Dermatol. 130, 2583Y2593 (2010
-
(2010)
J. Invest. Dermatol
, vol.130
, pp. 2583-2593
-
-
Farina, G.A.1
-
36
-
-
70350647257
-
Enhanced interleukin-10 production by dendritic cells upon stimulation with Toll-like receptor 4 agonists in systemic sclerosis that is possibly implicated in CCL18 secretion
-
van Lieshout, A. W. et al. Enhanced interleukin-10 production by dendritic cells upon stimulation with Toll-like receptor 4 agonists in systemic sclerosis that is possibly implicated in CCL18 secretion. Scand. J. Rheumatol. 38, 282Y290 (2009
-
(2009)
Scand. J. Rheumatol
, vol.38
, pp. 282-290
-
-
Van Lieshout, A.W.1
-
37
-
-
57349109321
-
Antifibroblast antibodies in systemic sclerosis induce fibroblasts to produce profibrotic chemokines, with partial exploitation of Toll-like receptor 4
-
Fineschi, S. et al. Antifibroblast antibodies in systemic sclerosis induce fibroblasts to produce profibrotic chemokines, with partial exploitation of Toll-like receptor 4. Arthritis Rheum. 58, 3913Y3923 (2008
-
(2008)
Arthritis Rheum
, vol.58
, pp. 3913-3923
-
-
Fineschi, S.1
-
38
-
-
0021154318
-
Lymphocytes in the skin of patients with progressive systemic sclerosis quantification, subtyping, and clinical correlations
-
Roumm, A. D. et al. Lymphocytes in the skin of patients with progressive systemic sclerosis. Quantification, subtyping, and clinical correlations. Arthritis Rheum. 27, 645Y653 (1984
-
(1984)
Arthritis Rheum
, vol.27
, pp. 645-653
-
-
Roumm, A.D.1
-
39
-
-
0025173841
-
Increase in activated T cells and reduction in suppressor inducer T cells in systemic sclerosis
-
Gustafsson, R., Tötterman, T. H., Klareskog, L. & Hällgren, R. Increase in activated T cells and reduction in suppressor inducer T cells in systemic sclerosis. Ann. Rheum. Dis. 49, 40Y45 (2003
-
(2003)
Ann. Rheum. Dis
, vol.49
, pp. 40-45
-
-
Gustafsson, R.1
Tötterman, T.H.2
Klareskog, L.3
Hällgren, R.4
-
40
-
-
33749014390
-
Immunological basis of systemic sclerosis
-
Zuber, J. P. & Spertini, F. Immunological basis of systemic sclerosis. Rheumatology (Oxford) 45 (Suppl. 3), iii23Yiii25 (2006
-
(2006)
Rheumatology (Oxford
, vol.45
, Issue.SUPPL. 3
-
-
Zuber, J.P.1
Spertini, F.2
-
41
-
-
77953661570
-
Involvement of mast cells in systemic sclerosis
-
Yukawa, S. et al. Involvement of mast cells in systemic sclerosis. Nihon Rinsho Meneki Gakkai Kaishi 33, 81Y86 (2010
-
(2010)
Nihon Rinsho Meneki Gakkai Kaishi
, vol.33
, pp. 81-86
-
-
Yukawa, S.1
-
42
-
-
0025989368
-
Stimulation of collagen and glycosaminoglycan production in cultured human adult dermal fibroblasts by recombinant human interleukin 6
-
Duncan, M. R. & Berman, B. Stimulation of collagen and glycosaminoglycan production in cultured human adult dermal fibroblasts by recombinant human interleukin 6. J. Invest. Dermatol. 97, 686Y692 (1991
-
(1991)
J. Invest. Dermatol
, vol.97
, pp. 686-692
-
-
Duncan, M.R.1
Berman, B.2
-
43
-
-
3543107212
-
Fibrotic disease and the TH1/TH2 paradigm
-
Wynn, T. A. Fibrotic disease and the TH1/TH2 paradigm. Nat. Rev. Immunol. 4, 583Y594 (2004
-
(2004)
Nat. Rev. Immunol
, vol.4
, pp. 583-594
-
-
Wynn, T.A.1
-
44
-
-
0031056613
-
Elevated serum levels of interleukin 4 (il-4), il-10, and il-13 in patients with systemic sclerosis
-
Hasegawa, M., Fujimoto, M., Kikuchi, K. & Takehara, K. Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis. J. Rheumatol 24, 328Y332 (1997
-
(1997)
J. Rheumatol
, vol.24
, pp. 328-332
-
-
Hasegawa, M.1
Fujimoto, M.2
Kikuchi, K.3
Takehara, K.4
-
45
-
-
57649100177
-
Regulatory effect of extracellular signal-regulated kinases (ERK) on type I collagen synthesis in human dermal fibroblasts stimulated by IL-4 and IL
-
Bhogal, R. K. & Bona, C. A. Regulatory effect of extracellular signal-regulated kinases (ERK) on type I collagen synthesis in human dermal fibroblasts stimulated by IL-4 and IL-13. Int. Rev. Immunol. 27, 472Y496 (2008
-
(2008)
Int. Rev. Immunol
, vol.27
, Issue.13
, pp. 472-496
-
-
Bhogal, R.K.1
Bona, C.A.2
-
46
-
-
4744362174
-
Interleukin- 13 stimulates the transcription of the human α 2(I) collagen gene in human dermal fibroblasts
-
Jinnin, M., Ihn, H., Yamane, K. & Tamaki, K. Interleukin-13 stimulates the transcription of the human α2(I) collagen gene in human dermal fibroblasts. J. Biol. Chem. 279, 41783Y41791 (2004
-
(2004)
J. Biol. Chem
, vol.279
, pp. 41783-41791
-
-
Jinnin, M.1
Ihn, H.2
Yamane, K.3
Tamaki, K.4
-
47
-
-
79960380532
-
Autoimmune mechanisms of scleroderma and a role of oxidative stress
-
Yamamoto, T. Autoimmune mechanisms of scleroderma and a role of oxidative stress. Self Nonself 2, 4Y10 (2011
-
(2011)
Self Nonself
, vol.2
, pp. 4-10
-
-
Yamamoto, T.1
-
48
-
-
0036009463
-
Interleukin-4-and interleukin-13-enhanced transforming growth factor-β2 production in cultured human bronchial epithelial cells is attenuated by interferon-gamma
-
Wen, F. Q. et al. Interleukin-4-and interleukin-13-enhanced transforming growth factor-β2 production in cultured human bronchial epithelial cells is attenuated by interferon-gamma. Am. J. Respir. Cell. Mol. Biol. 26, 484Y490 (2002
-
(2002)
Am. J. Respir. Cell. Mol. Biol
, vol.26
, pp. 484-490
-
-
Wen, F.Q.1
-
49
-
-
0026752470
-
Human recombinant interleukin-4 induces proliferation and interleukin-6 production by cultured human skin fibroblasts
-
Feghali, C. A., Bost, K. L., Boulware, D. W. & Levy, L. S. Human recombinant interleukin-4 induces proliferation and interleukin-6 production by cultured human skin fibroblasts. Clin. Immunol. Immunopathol. 63, 182Y187 (1992
-
(1992)
Clin. Immunol. Immunopathol
, vol.63
, pp. 182-187
-
-
Feghali, C.A.1
Bost, K.L.2
Boulware, D.W.3
Levy, L.S.4
-
50
-
-
0035140619
-
Il-4-induced oxidative stress upregulates vcam-1 gene expression in human endothelial cells
-
Lee, Y. W., Kuhn, H., Hennig, B., Neish, A. S. & Toborek, M. IL-4-induced oxidative stress upregulates VCAM-1 gene expression in human endothelial cells. J. Mol. Cell Cardiol. 33, 83Y94 (2001
-
(2001)
J. Mol. Cell Cardiol
, vol.33
, pp. 83-94
-
-
Lee, Y.W.1
Kuhn, H.2
Hennig, B.3
Neish, A.S.4
Toborek, M.5
-
51
-
-
0033000530
-
Production of type 2 cytokines by CD8+ lung cells is associated with greater decline in pulmonary function in patients with systemic sclerosis
-
Atamas, S. P. et al. Production of type 2 cytokines by CD8+ lung cells is associated with greater decline in pulmonary function in patients with systemic sclerosis. Arthritis Rheum. 42, 1168Y1178 (1999
-
(1999)
Arthritis Rheum
, vol.42
, pp. 1168-1178
-
-
Atamas, S.P.1
-
52
-
-
0038648778
-
Interleukin-13 in systemic sclerosis: Relationship to nailfold capillaroscopy abnormalities
-
Riccieri, V. et al. Interleukin-13 in systemic sclerosis: Relationship to nailfold capillaroscopy abnormalities. Clin. Rheumatol. 22, 102Y106 (2003
-
(2003)
Clin. Rheumatol
, vol.22
, pp. 102-106
-
-
Riccieri, V.1
-
53
-
-
33847324516
-
Transcription factor t-bet regulates skin sclerosis through its function innate immunity and via il-13
-
Aliprantis, A. O. et al. Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13. Proc. Natl Acad. Sci. USA 104, 2827Y2830 (2007
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 2827-2830
-
-
Aliprantis, A.O.1
-
54
-
-
81455158849
-
Role of IL-13 in systemic sclerosis
-
Fuschiotti, P. Role of IL-13 in systemic sclerosis. Cytokine 56, 544Y549 (2011
-
(2011)
Cytokine
, vol.56
, pp. 544-549
-
-
Fuschiotti, P.1
-
55
-
-
65249173941
-
Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis
-
Fuschiotti, P., Medsger, T. A., Jr & Morel, P. A. Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis. Arthritis Rheum. 60, 1119Y1128 (2009
-
(2009)
Arthritis Rheum
, vol.60
, pp. 1119-1128
-
-
Fuschiotti, P.1
Medsger Jr., T.A.2
Morel, P.A.3
-
56
-
-
0031058726
-
Interleukin il)-6 directs the differentiation of il-4-producing cd4+ t cells
-
Rincon, M., Anguita, J., Nakamura, T., Fikrig, E. & Flavell, R. A. Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. J. Exp. Med. 185, 461Y469 (1997
-
(1997)
J. Exp. Med
, vol.185
, pp. 461-469
-
-
Rincon, M.1
Anguita, J.2
Nakamura, T.3
Fikrig, E.4
Flavell, R.A.5
-
57
-
-
0026648380
-
Differential regulation of t helper phenotype development by interleukins 4 and 10 in an αβ t-cell-receptor transgenic system
-
Hsieh, C. S., Heimberger, A. B., Gold, J. S., O'Garra, A. & Murphy, K. M. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T-cell-receptor transgenic system. Proc. Natl Acad. Sci. USA 89, 6065Y6069 (1992
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 6065-6069
-
-
Hsieh, C.S.1
Heimberger, A.B.2
Gold, J.S.3
O'Garra, A.4
Murphy, K.M.5
-
58
-
-
84892476632
-
Interleukin-6 signaling drives fibrosis in unresolved inflammation
-
Fielding, C. A. et al. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity 40, 40Y50 (2014
-
(2014)
Immunity
, vol.40
, pp. 40-50
-
-
Fielding, C.A.1
-
59
-
-
0031911610
-
Serum levels of interleukin 6 (IL-6), oncostatin M, soluble IL-6 receptor, and soluble gp130 in patients with systemic sclerosis
-
Hasegawa, M. et al. Serum levels of interleukin 6 (IL-6), oncostatin M, soluble IL-6 receptor, and soluble gp130 in patients with systemic sclerosis. J. Rheumatol 25, 308Y313 (1998
-
(1998)
J. Rheumatol
, vol.25
, pp. 308-313
-
-
Hasegawa, M.1
-
60
-
-
32844464795
-
IL-6 modulates alpha-smooth muscle actin expression in dermal fibroblasts from IL-6-deficient mice
-
Gallucci, R. M., Lee, E. G. & Tomasek, J. J. IL-6 modulates alpha-smooth muscle actin expression in dermal fibroblasts from IL-6-deficient mice. J. Invest. Dermatol. 126, 561Y568 (2006
-
(2006)
J. Invest. Dermatol
, vol.126
, pp. 561-568
-
-
Gallucci, R.M.1
Lee, E.G.2
Tomasek, J.J.3
-
61
-
-
84878404903
-
Outcomes of patients with systemic sclerosis-associated polyarthritis and myopathy treated with tocilizumab or abatacept: A EUSTAR observational study
-
Elhai, M. et al. Outcomes of patients with systemic sclerosis-associated polyarthritis and myopathy treated with tocilizumab or abatacept: A EUSTAR observational study. Ann. Rheum. Dis. 72, 1217Y1220 (2013
-
(2013)
Ann. Rheum. Dis
, vol.72
, pp. 1217-1220
-
-
Elhai, M.1
-
62
-
-
78049421175
-
The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab
-
Shima, Y. et al. The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab. Rheumatology (Oxford) 49, 2408Y2412 (2010
-
(2010)
Rheumatology (Oxford
, vol.49
, pp. 2408-2412
-
-
Shima, Y.1
-
63
-
-
84878843826
-
Targeting interleukin-6 in rheumatoid arthritis
-
Md Yusof, M. Y. & Emery, P. Targeting interleukin-6 in rheumatoid arthritis. Drugs 73, 341Y356 (2013
-
(2013)
Drugs
, vol.73
, pp. 341-356
-
-
Md Yusof, M.Y.1
Emery, P.2
-
64
-
-
7044253658
-
Autoantibodies in systemic sclerosis and fibrosing syndromes: Clinical indications and relevance
-
Cepeda, E. J. & Reveille, J. D. Autoantibodies in systemic sclerosis and fibrosing syndromes: Clinical indications and relevance. Curr. Opin. Rheumatol. 16, 723Y732 (2004
-
(2004)
Curr. Opin. Rheumatol
, vol.16
, pp. 723-732
-
-
Cepeda, E.J.1
Reveille, J.D.2
-
65
-
-
0034782087
-
Clinical significance of anti-topoisomerase I antibody levels determined by ELISA in systemic sclerosis
-
Sato, S., Hamaguchi, Y., Hasegawa, M. & Takehara, K. Clinical significance of anti-topoisomerase I antibody levels determined by ELISA in systemic sclerosis. Rheumatology (Oxford) 40, 1135Y1140 (2001
-
(2001)
Rheumatology (Oxford
, vol.40
, pp. 1135-1140
-
-
Sato, S.1
Hamaguchi, Y.2
Hasegawa, M.3
Takehara, K.4
-
66
-
-
33745277147
-
Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis
-
Baroni, S. S. et al. Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N. Engl. J. Med. 354, 2667Y2676 (2006
-
(2006)
N. Engl. J. Med
, vol.354
, pp. 2667-2676
-
-
Baroni, S.S.1
-
67
-
-
0036272386
-
Antifibroblast antibodies from systemic sclerosis patients are internalized by fibroblasts via a caveolin-linked pathway
-
Ronda, N. et al. Antifibroblast antibodies from systemic sclerosis patients are internalized by fibroblasts via a caveolin-linked pathway. Arthritis Rheum. 46, 1595Y1601 (2002
-
(2002)
Arthritis Rheum
, vol.46
, pp. 1595-1601
-
-
Ronda, N.1
-
68
-
-
0033768505
-
Autoantibodies to fibrillin 1 in systemic sclerosis: Ethnic differences in antigen recognition and lack of correlation with specific clinical features or HLA alleles
-
Tan, F. K. et al. Autoantibodies to fibrillin 1 in systemic sclerosis: Ethnic differences in antigen recognition and lack of correlation with specific clinical features or HLA alleles. Arthritis Rheum. 43, 2464Y2471 (2000
-
(2000)
Arthritis Rheum
, vol.43
, pp. 2464-2471
-
-
Tan, F.K.1
-
69
-
-
8144228787
-
Autoantibody against matrix metalloproteinase-3 in patients with systemic sclerosis
-
Nishijima, C. et al. Autoantibody against matrix metalloproteinase-3 in patients with systemic sclerosis. Clin. Exp. Immunol. 138, 357Y363 (2004
-
(2004)
Clin. Exp. Immunol
, vol.138
, pp. 357-363
-
-
Nishijima, C.1
-
70
-
-
84867006695
-
The role of endoplasmic reticulum stress and the unfolded protein response in fibrosis
-
Lenna, S. & Trojanowska, M. The role of endoplasmic reticulum stress and the unfolded protein response in fibrosis. Curr. Opin. Rheumatol. 24, 663Y668 (2012
-
(2012)
Curr. Opin. Rheumatol
, vol.24
, pp. 663-668
-
-
Lenna, S.1
Trojanowska, M.2
-
72
-
-
0033782015
-
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
-
Bertolotti, A., Zhang, Y., Hendershot, L. M., Harding, H. P. & Ron, D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol. 2, 326Y332 (2000
-
(2000)
Nat. Cell Biol
, vol.2
, pp. 326-332
-
-
Bertolotti, A.1
Zhang, Y.2
Hendershot, L.M.3
Harding, H.P.4
Ron, D.5
-
73
-
-
84870166429
-
The unfolded protein response in secretory cell function
-
Moore, K. A. & Hollien, J. The unfolded protein response in secretory cell function. Annu. Rev. Genet. 46, 165Y183 (2012
-
(2012)
Annu. Rev. Genet
, vol.46
, pp. 165-183
-
-
Moore, K.A.1
Hollien, J.2
-
74
-
-
84876523418
-
Increased expression of endoplasmic reticulum stress and unfolded protein response genes in peripheral blood mononuclear cells from patients with limited cutaneous systemic sclerosis and pulmonary arterial hypertension
-
Lenna, S. et al. Increased expression of endoplasmic reticulum stress and unfolded protein response genes in peripheral blood mononuclear cells from patients with limited cutaneous systemic sclerosis and pulmonary arterial hypertension. Arthritis Rheum. 65, 1357Y1366 (2013
-
(2013)
Arthritis Rheum
, vol.65
, pp. 1357-1366
-
-
Lenna, S.1
-
75
-
-
38949096081
-
Sorting recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome
-
Ding, W. X. & Yin, X. M. Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome. Autophagy 4, 141Y150 (2008
-
(2008)
Autophagy
, vol.4
, pp. 141-150
-
-
Ding, W.X.1
Yin, X.M.2
-
76
-
-
73449083755
-
Autophagy eliminates a specific species of misfolded procollagen and plays a protective role in cell survival against ER stress
-
Ishida, Y. & Nagata, K. Autophagy eliminates a specific species of misfolded procollagen and plays a protective role in cell survival against ER stress. Autophagy 5, 1217Y1219 (2009
-
(2009)
Autophagy
, vol.5
, pp. 1217-1219
-
-
Ishida, Y.1
Nagata, K.2
-
77
-
-
79959966425
-
Scleroderma-like properties of skin from caveolin-1-deficient mice: Implications for new treatment strategies in patients with fibrosis and systemic sclerosis
-
Castello-Cros, R. et al. Scleroderma-like properties of skin from caveolin-1-deficient mice: Implications for new treatment strategies in patients with fibrosis and systemic sclerosis. Cell Cycle 10, 2140Y2150 (2011
-
(2011)
Cell Cycle
, vol.10
, pp. 2140-2150
-
-
Castello-Cros, R.1
-
78
-
-
0036810352
-
Heat-shock protein 90, a chaperone for folding and regulation
-
Picard, D. Heat-shock protein 90, a chaperone for folding and regulation. Cell. Mol. Life Sci. 59, 1640Y1648 (2002
-
(2002)
Cell. Mol. Life Sci
, vol.59
, pp. 1640-1648
-
-
Picard, D.1
-
79
-
-
48249099342
-
Critical regulation of TGFβ signaling by Hsp90
-
Wrighton, K. H., Lin, X. & Feng, X. H. Critical regulation of TGFβ signaling by Hsp90. Proc. Natl Acad. Sci. USA 105, 9244Y9249 (2008
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 9244-9249
-
-
Wrighton, K.H.1
Lin, X.2
Feng, X.H.3
-
80
-
-
84899975158
-
Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis
-
Tomcik, M. et al. Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2012-203095
-
Ann. Rheum. Dis
-
-
Tomcik, M.1
-
81
-
-
84861206640
-
The hsp90 inhibitor 17-aag represses calcium-induced cytokeratin 1 and 10 expression in hacat keratinocytes
-
Miyoshi, S., Yamazaki, S., Uchiumi, A. & Katagata, Y. The Hsp90 inhibitor 17-AAG represses calcium-induced cytokeratin 1 and 10 expression in HaCaT keratinocytes. FEBS Open Bio. 2, 47Y50 (2012
-
(2012)
FEBS Open Bio
, vol.2
, pp. 47-50
-
-
Miyoshi, S.1
Yamazaki, S.2
Uchiumi, A.3
Katagata, Y.4
-
82
-
-
84868553748
-
Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor-beta type II receptor
-
Noh, H. et al. Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor-beta type II receptor. Lab. Invest. 92, 1583Y1596 (2012
-
(2012)
Lab. Invest
, vol.92
, pp. 1583-1596
-
-
Noh, H.1
-
83
-
-
0034945771
-
Decreased susceptibility to Fas-induced apoptosis of systemic sclerosis dermal fibroblasts
-
Santiago, B., Galindo, M., Rivero, M. & Pablos, J. L. Decreased susceptibility to Fas-induced apoptosis of systemic sclerosis dermal fibroblasts. Arthritis Rheum. 44, 1667Y1676 (2001
-
(2001)
Arthritis Rheum
, vol.44
, pp. 1667-1676
-
-
Santiago, B.1
Galindo, M.2
Rivero, M.3
Pablos, J.L.4
-
84
-
-
0037632844
-
Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts
-
Hinz, B., Dugina, V., Ballestrem, C., Wehrle-Haller, B. & Chaponnier, C. Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts. Mol. Biol. Cell 14, 2508Y2519 (2003
-
(2003)
Mol. Biol. Cell
, vol.14
, pp. 2508-2519
-
-
Hinz, B.1
Dugina, V.2
Ballestrem, C.3
Wehrle-Haller, B.4
Chaponnier, C.5
-
85
-
-
0029765057
-
Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts increased proportion of high collagen-producing cells in systemic sclerosis fibroblasts
-
Jelaska, A., Arakawa, M., Broketa, G. & Korn, J. H. Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts. Increased proportion of high collagen-producing cells in systemic sclerosis fibroblasts. Arthritis Rheum. 39, 1338Y1346 (1996
-
(1996)
Arthritis Rheum
, vol.39
, pp. 1338-1346
-
-
Jelaska, A.1
Arakawa, M.2
Broketa, G.3
Korn, J.H.4
-
86
-
-
1242294533
-
Normal skin wound and hypertrophic scar myofibroblasts have differential responses to apoptotic inductors
-
Moulin, V. et al. Normal skin wound and hypertrophic scar myofibroblasts have differential responses to apoptotic inductors. J. Cell Physiol. 198, 350Y358 (2004
-
(2004)
J. Cell Physiol
, vol.198
, pp. 350-358
-
-
Moulin, V.1
-
87
-
-
78751694228
-
An essential role for resident fibroblasts in experimental lung fibrosis is defined by lineage-specific deletion of high-affinity type II transforming growth factor beta receptor
-
Hoyles, R. K. et al. An essential role for resident fibroblasts in experimental lung fibrosis is defined by lineage-specific deletion of high-affinity type II transforming growth factor beta receptor. Am. J. Respir. Crit. Care Med. 183, 249Y261 (2011
-
(2011)
Am. J. Respir. Crit. Care Med
, vol.183
, pp. 249-261
-
-
Hoyles, R.K.1
-
88
-
-
38849161533
-
Cysteinyl leukotrienes are autocrine and paracrine regulators of fibrocyte function
-
Vannella, K. M. et al. Cysteinyl leukotrienes are autocrine and paracrine regulators of fibrocyte function. J. Immunol. 179, 7883Y7890 (2007
-
(2007)
J. Immunol
, vol.179
, pp. 7883-7890
-
-
Vannella, K.M.1
-
89
-
-
67349261972
-
Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis
-
Mehrad, B., Burdick, M. D. & Strieter, R. M. Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis. Int. J. Biochem. Cell Biol. 41, 1708Y1718 (2009
-
(2009)
Int. J. Biochem. Cell Biol
, vol.41
, pp. 1708-1718
-
-
Mehrad, B.1
Burdick, M.D.2
Strieter, R.M.3
-
90
-
-
37149006718
-
Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis
-
Distler, J. H. et al. Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis. Arthritis Rheum. 56, 4203Y4215 (2007
-
(2007)
Arthritis Rheum
, vol.56
, pp. 4203-4215
-
-
Distler, J.H.1
-
91
-
-
73949096744
-
Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis
-
Humphreys, B. D. et al. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am. J. Pathol. 176, 85Y97 (2010
-
(2010)
Am. J. Pathol
, vol.176
, pp. 85-97
-
-
Humphreys, B.D.1
-
92
-
-
77950597707
-
Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice
-
Taura, K. et al. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology 51, 1027Y1036 (2010
-
(2010)
Hepatology
, vol.51
, pp. 1027-1036
-
-
Taura, K.1
-
93
-
-
84855511323
-
Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
-
Rock, J. R. et al. Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc. Natl Acad. Sci. USA 108, E1475YE1483 (2011
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
-
-
Rock, J.R.1
-
94
-
-
34547676391
-
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
-
Zeisberg, E. M. et al. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat. Med. 13, 952Y961 (2007
-
(2007)
Nat. Med
, vol.13
, pp. 952-961
-
-
Zeisberg, E.M.1
-
95
-
-
80052875424
-
TGF-β signaling in fibrosis
-
Biernacka, A., Dobaczewski, M. & Frangogiannis, N. G. TGF-β signaling in fibrosis. Growth Factors 29, 196Y202 (2011
-
(2011)
Growth Factors
, vol.29
, pp. 196-202
-
-
Biernacka, A.1
Dobaczewski, M.2
Frangogiannis, N.G.3
-
96
-
-
0142219250
-
Transforming growth factor (TGF)-β1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-β1-mediated fibrosis
-
Kitani, A. et al. Transforming growth factor (TGF)-β1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-β1-mediated fibrosis. J. Exp. Med. 198, 1179Y1188 (2003
-
(2003)
J. Exp. Med
, vol.198
, pp. 1179-1188
-
-
Kitani, A.1
-
97
-
-
67650128154
-
Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFβ expression
-
Radstake, T. R. et al. Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFβ expression. PLoS ONE 4, e5981 (2009
-
(2009)
PLoS ONE
, vol.4
-
-
Radstake, T.R.1
-
98
-
-
33846250366
-
Recombinant human anti-transforming growth factor β1 antibody therapy in systemic sclerosis: A multicenter, randomized, placebo-controlled phase I/II trial of CAT-192
-
Denton, C. P. et al. Recombinant human anti-transforming growth factor β1 antibody therapy in systemic sclerosis: A multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. Arthritis Rheum. 56, 323Y333 (2007
-
(2007)
Arthritis Rheum
, vol.56
, pp. 323-333
-
-
Denton, C.P.1
-
99
-
-
38049091636
-
The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
-
Tager, A. M. et al. The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat. Med. 14, 45Y54 (2008
-
(2008)
Nat. Med
, vol.14
, pp. 45-54
-
-
Tager, A.M.1
-
100
-
-
36849012184
-
LPA1 receptor activation promotes renal interstitial fibrosis
-
Pradere, J. P. et al. LPA1 receptor activation promotes renal interstitial fibrosis. J. Am. Soc. Nephrol. 18, 3110Y3118 (2007
-
(2007)
J. Am. Soc. Nephrol
, vol.18
, pp. 3110-3118
-
-
Pradere, J.P.1
-
101
-
-
84877102431
-
LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation
-
Sakai, N. et al. LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation. FASEB J. 27, 1830Y1846 (2013
-
(2013)
FASEB J.
, vol.27
, pp. 1830-1846
-
-
Sakai, N.1
-
102
-
-
34548567217
-
Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity
-
Watanabe, N. et al. Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity. Life Sci. 81, 1009Y1015 (2007
-
(2007)
Life Sci
, vol.81
, pp. 1009-1015
-
-
Watanabe, N.1
-
103
-
-
34250770503
-
Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C
-
Watanabe, N. et al. Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C. J. Clin. Gastroenterol. 41, 616Y623 (2007
-
(2007)
J. Clin. Gastroenterol
, vol.41
, pp. 616-623
-
-
Watanabe, N.1
-
104
-
-
84863793425
-
Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis
-
Nikitopoulou, I. et al. Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis. J. Exp. Med. 209, 925Y933 (2012
-
(2012)
J. Exp. Med
, vol.209
, pp. 925-933
-
-
Nikitopoulou, I.1
-
105
-
-
77952141210
-
Autotaxin and lysophospholipids in rheumatoid arthritis
-
Bourgoin, S. G. & Zhao, C. Autotaxin and lysophospholipids in rheumatoid arthritis. Curr. Opin. Investig. Drugs 11, 515Y526 (2010
-
(2010)
Curr. Opin. Investig. Drugs
, vol.11
, pp. 515-526
-
-
Bourgoin, S.G.1
Zhao, C.2
-
106
-
-
79953661423
-
A role for lysophosphatidic acid and sphingosine 1-phosphate in the pathogenesis of systemic sclerosis
-
Pattanaik, D. & Postlethwaite, A. E. A role for lysophosphatidic acid and sphingosine 1-phosphate in the pathogenesis of systemic sclerosis. Discov. Med. 10, 161Y167 (2010
-
(2010)
Discov. Med
, vol.10
, pp. 161-167
-
-
Pattanaik, D.1
Postlethwaite, A.E.2
-
107
-
-
84866994374
-
Lipids and eicosanoids in fibrosis: Emerging targets for therapy
-
Castelino, F. V. Lipids and eicosanoids in fibrosis: Emerging targets for therapy. Curr. Opin. Rheumatol. 24, 649Y655 (2012
-
(2012)
Curr. Opin. Rheumatol
, vol.24
, pp. 649-655
-
-
Castelino, F.V.1
-
108
-
-
84868526523
-
Lysoglycerophospholipids in chronic inflammatory disorders: The PLA (2)/LPC and ATX/LPA axes
-
Sevastou, I., Kaffe, E., Mouratis, M. A. & Aidinis, V. Lysoglycerophospholipids in chronic inflammatory disorders: The PLA(2)/LPC and ATX/LPA axes. Biochim. Biophys. Acta 1831, 42Y60 (2013
-
(2013)
Biochim. Biophys. Acta
, vol.1831
, pp. 42-60
-
-
Sevastou, I.1
Kaffe, E.2
Mouratis, M.A.3
Aidinis, V.4
-
109
-
-
84856265412
-
Insights into the pharmacological relevance of lysophospholipid receptors
-
Mutoh, T., Rivera, R. & Chun, J. Insights into the pharmacological relevance of lysophospholipid receptors. Br. J. Pharmacol. 165, 829Y844 (2012
-
(2012)
Br. J. Pharmacol
, vol.165
, pp. 829-844
-
-
Mutoh, T.1
Rivera, R.2
Chun, J.3
-
110
-
-
79955559412
-
Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma
-
Castelino, F. V. et al. Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma. Arthritis Rheum. 63, 1405Y1415 (2011
-
(2011)
Arthritis Rheum
, vol.63
, pp. 1405-1415
-
-
Castelino, F.V.1
-
111
-
-
27144527959
-
Production of lysophosphatidic acid in blister fluid: Involvement of a lysophospholipase D activity
-
Mazereeuw-Hautier, J. et al. Production of lysophosphatidic acid in blister fluid: Involvement of a lysophospholipase D activity. J. Invest. Dermatol. 125, 421Y427 (2005
-
(2005)
J. Invest. Dermatol
, vol.125
, pp. 421-427
-
-
Mazereeuw-Hautier, J.1
-
112
-
-
67649196923
-
Elevated serum levels of arachidonoyl-lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis
-
Tokumura, A. et al. Elevated serum levels of arachidonoyl- lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis. Int. J. Med. Sci. 6, 168Y176 (2009
-
(2009)
Int. J. Med. Sci
, vol.6
, pp. 168-176
-
-
Tokumura, A.1
-
113
-
-
84867911904
-
-
US National Library Of Medicine
-
US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/show/NCT01651143 (2014
-
(2014)
Clinical Trials.gov [online]
-
-
-
114
-
-
0033695790
-
Up-regulation of peroxisome proliferator-activated receptors (PPAR-α) and PPAR-γ messenger ribonucleic acid expression in the liver in murine obesity: Troglitazone induces expression of PPAR-γ- responsive adipose tissue-specific genes in the liver of obese diabetic mice
-
Memon, R. A. et al. Up-regulation of peroxisome proliferator-activated receptors (PPAR-α) and PPAR-γ messenger ribonucleic acid expression in the liver in murine obesity: Troglitazone induces expression of PPAR-γ-responsive adipose tissue-specific genes in the liver of obese diabetic mice. Endocrinology 141, 4021Y4031 (2000
-
(2000)
Endocrinology
, vol.141
, pp. 4021-4031
-
-
Memon, R.A.1
-
115
-
-
70349331686
-
Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator
-
Ghosh, A. K. et al. Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator. FASEB J. 23, 2968Y2977 (2009
-
(2009)
FASEB J.
, vol.23
, pp. 2968-2977
-
-
Ghosh, A.K.1
-
116
-
-
59649085854
-
Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-γ
-
Wu, M. et al. Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-γ. Am. J. Pathol. 174, 519Y533 (2009
-
(2009)
Am. J. Pathol
, vol.174
, pp. 519-533
-
-
Wu, M.1
-
117
-
-
84891678660
-
A synthetic PPAR-γ agonist triterpenoid ameliorates experimental fibrosis: PPAR-gamma-independent suppression of fibrotic responses
-
Wei, J. et al. A synthetic PPAR-γ agonist triterpenoid ameliorates experimental fibrosis: PPAR-gamma-independent suppression of fibrotic responses. Ann. Rheum. Dis. 73, 446Y454 (2013
-
(2013)
Ann. Rheum. Dis
, vol.73
, pp. 446-454
-
-
Wei, J.1
-
118
-
-
0035873953
-
Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN
-
Patel, L. et al. Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN. Curr. Biol. 11, 764Y768 (2001
-
(2001)
Curr. Biol
, vol.11
, pp. 764-768
-
-
Patel, L.1
-
119
-
-
78349281192
-
PPARγ downregulation by TGFβ in fibroblast and impaired expression and function in systemic sclerosis: A novel mechanism for progressive fibrogenesis
-
Wei, J. et al. PPARγ downregulation by TGFβ in fibroblast and impaired expression and function in systemic sclerosis: A novel mechanism for progressive fibrogenesis. PLoS ONE 5, e13778 (2010
-
(2010)
PLoS ONE
, vol.5
-
-
Wei, J.1
-
120
-
-
69449094871
-
Loss of peroxisome proliferator-activated receptor γ in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis
-
Kapoor, M. et al. Loss of peroxisome proliferator-activated receptor γ in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis. Arthritis Rheum. 60, 2822Y2829 (2009
-
(2009)
Arthritis Rheum
, vol.60
, pp. 2822-2829
-
-
Kapoor, M.1
-
121
-
-
84867068023
-
Inhibition of Notch signaling by a γ-secretase inhibitor attenuates hepatic fibrosis in rats
-
Chen, Y. et al. Inhibition of Notch signaling by a γ-secretase inhibitor attenuates hepatic fibrosis in rats. PLoS ONE 7, e46512 (2012
-
(2012)
PLoS ONE
, vol.7
-
-
Chen, Y.1
-
122
-
-
79957637197
-
Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis
-
Dees, C. et al. Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis. Ann. Rheum. Dis. 70, 1304Y1310 (2011
-
(2011)
Ann. Rheum. Dis
, vol.70
, pp. 1304-1310
-
-
Dees, C.1
-
123
-
-
79955567838
-
Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis
-
Dees, C. et al. Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis. Arthritis Rheum. 63, 1396Y1404 (2011
-
(2011)
Arthritis Rheum
, vol.63
, pp. 1396-1404
-
-
Dees, C.1
-
124
-
-
84863923526
-
Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells
-
Wei, J. et al. Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells. Arthritis Rheum. 64, 2734Y2745 (2012
-
(2012)
Arthritis Rheum
, vol.64
, pp. 2734-2745
-
-
Wei, J.1
-
125
-
-
79958036406
-
Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?
-
Wei, J et al. Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma? Arthritis Rheum. 63, 1707Y1717 (2011
-
(2011)
Arthritis Rheum
, vol.63
, pp. 1707-1717
-
-
Wei, J.1
-
126
-
-
64849091190
-
Thiazolidinediones downregulate Wnt/β-catenin signaling via multiple mechanisms in breast cancer cells
-
Wang, P. S. et al. Thiazolidinediones downregulate Wnt/β-catenin signaling via multiple mechanisms in breast cancer cells. J. Surg. Res. 153, 210Y216 (2009
-
(2009)
J. Surg. Res
, vol.153
, pp. 210-216
-
-
Wang, P.S.1
-
127
-
-
33845912937
-
Calcification inhibitors and Wnt signaling proteins are implicated in bovine artery smooth muscle cell calcification in the presence of phosphate and vitamin D sterols
-
Shalhoub, V. et al. Calcification inhibitors and Wnt signaling proteins are implicated in bovine artery smooth muscle cell calcification in the presence of phosphate and vitamin D sterols. Calcif. Tissue Int. 79, 431Y442 (2006
-
(2006)
Calcif. Tissue Int
, vol.79
, pp. 431-442
-
-
Shalhoub, V.1
-
128
-
-
77958171338
-
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1alpha
-
Thorne, C. A. et al. Small-molecule inhibition of Wnt signaling through activation of casein kinase 1alpha. Nat. Chem. Biol. 6, 829Y836 (2010
-
(2010)
Nat. Chem. Biol
, vol.6
, pp. 829-836
-
-
Thorne, C.A.1
-
129
-
-
33748156090
-
Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia
-
Li, J. et al. Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone 39, 754Y766 (2006
-
(2006)
Bone
, vol.39
, pp. 754-766
-
-
Li, J.1
-
130
-
-
72949104604
-
Surface morphology and mechanical properties of fibroblasts from scleroderma patients
-
Reich, A., Meurer, M., Eckes, B., Friedrichs, J. & Muller, D. J. Surface morphology and mechanical properties of fibroblasts from scleroderma patients. J. Cell. Mol. Med. 13, 1644Y1652 (2009
-
(2009)
J. Cell. Mol. Med
, vol.13
, pp. 1644-1652
-
-
Reich, A.1
Meurer, M.2
Eckes, B.3
Friedrichs, J.4
Muller, D.J.5
-
131
-
-
84871248579
-
Biomechanical regulation of mesenchymal cell function
-
Tschumperlin, D. J., Liu, F. & Tager, A. M. Biomechanical regulation of mesenchymal cell function. Curr. Opin. Rheumatol. 25, 92Y100 (2013
-
(2013)
Curr. Opin. Rheumatol
, vol.25
, pp. 92-100
-
-
Tschumperlin, D.J.1
Liu, F.2
Tager, A.M.3
-
132
-
-
77955914547
-
Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression
-
Liu, F. et al. Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. J. Cell Biol. 190, 693Y706 (2010
-
(2010)
J. Cell Biol
, vol.190
, pp. 693-706
-
-
Liu, F.1
-
133
-
-
77956425361
-
Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment
-
Barry-Hamilton, V. et al. Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment. Nat. Med. 16, 1009Y1017 (2010
-
(2010)
Nat. Med
, vol.16
, pp. 1009-1017
-
-
Barry-Hamilton, V.1
-
134
-
-
0037371153
-
Lysyl oxidase: Properties, specificity, and biological roles inside and outside of the cell
-
Kagan, H. M. & Li, W. Lysyl oxidase: Properties, specificity, and biological roles inside and outside of the cell. J. Cell. Biochem. 88, 660Y672 (2003
-
(2003)
J. Cell. Biochem
, vol.88
, pp. 660-672
-
-
Kagan, H.M.1
Li, W.2
-
135
-
-
84864350704
-
The rationale for targeting the lox family in cancer
-
Barker, H. E., Cox, T. R. & Erler, J. T. The rationale for targeting the LOX family in cancer. Nat. Rev. Cancer 12, 540Y552 (2012
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 540-552
-
-
Barker, H.E.1
Cox, T.R.2
Erler, J.T.3
-
136
-
-
34247395864
-
Analysis of gene expression patterns in systemic sclerosis fibroblasts using RNA arbitrarily primed-polymerase chain reaction for differential display
-
Meyringer, R. et al. Analysis of gene expression patterns in systemic sclerosis fibroblasts using RNA arbitrarily primed-polymerase chain reaction for differential display. J. Rheumatol. 34, 747Y753 (2007
-
(2007)
J. Rheumatol
, vol.34
, pp. 747-753
-
-
Meyringer, R.1
-
137
-
-
84861726854
-
-
Clinical Trials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/ct2/show/NCT01362231?term=NCT01362231&rank=1 (2013
-
(2013)
US National Library Of Medicine
-
-
-
138
-
-
0035516140
-
Transmembrane crosstalk between the extracellular matrix-cytoskeleton crosstalk
-
Geiger, B., Bershadsky, A., Pankov, R. & Yamada, K. M. Transmembrane crosstalk between the extracellular matrix - cytoskeleton crosstalk. Nat. Rev. Mol. Cell Biol. 2, 793Y805 (2001
-
(2001)
Nat. Rev. Mol. Cell Biol
, vol.2
, pp. 793-805
-
-
Geiger, B.1
Bershadsky, A.2
Pankov, R.3
Yamada, K.M.4
-
139
-
-
84870319857
-
Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts
-
Shi-wen, X. et al. Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts. Rheumatology (Oxford) 51, 2146Y2154 (2012
-
(2012)
Rheumatology (Oxford
, vol.51
, pp. 2146-2154
-
-
Shi-wen, X.1
-
140
-
-
84855555498
-
Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling
-
Wong, V. W. et al. Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling. Nat. Med. 18, 148Y152 (2012
-
(2012)
Nat. Med
, vol.18
, pp. 148-152
-
-
Wong, V.W.1
-
141
-
-
77952469195
-
Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer
-
Schultze, A. & Fiedler, W. Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer. Expert Opin. Investig. Drugs 19, 777Y788 (2010
-
(2010)
Expert Opin. Investig. Drugs
, vol.19
, pp. 777-788
-
-
Schultze, A.1
Fiedler, W.2
-
142
-
-
84860487954
-
Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation
-
Lagares, D. et al. Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation. Arthritis Rheum. 64, 1653Y1664 (2012
-
(2012)
Arthritis Rheum
, vol.64
, pp. 1653-1664
-
-
Lagares, D.1
-
143
-
-
49449087811
-
Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts
-
Akhmetshina, A. et al. Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts. Arthritis Rheum. 58, 2553Y2564 (2008
-
(2008)
Arthritis Rheum
, vol.58
, pp. 2553-2564
-
-
Akhmetshina, A.1
-
144
-
-
81255157548
-
Relaxin regulates myofibroblast contractility and protects against lung fibrosis
-
Huang, X. et al. Relaxin regulates myofibroblast contractility and protects against lung fibrosis. Am. J. Pathol. 179, 2751Y2765 (2011
-
(2011)
Am. J. Pathol
, vol.179
, pp. 2751-2765
-
-
Huang, X.1
-
145
-
-
84864371060
-
Fasudil, a rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice
-
Jiang, C. et al. Fasudil, a rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice. Int. J. Mol. Sci. 13, 8293Y8307 (2012
-
(2012)
Int. J. Mol. Sci
, vol.13
, pp. 8293-8307
-
-
Jiang, C.1
-
146
-
-
80053187979
-
Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis
-
Washida, N. et al. Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis. Nephrol. Dial. Transplant. 26, 2770Y2779 (2011
-
(2011)
Nephrol. Dial. Transplant
, vol.26
, pp. 2770-2779
-
-
Washida, N.1
-
147
-
-
34547945446
-
Fasudil attenuates myocardial fibrosis in association with inhibition of monocyte/macrophage infiltration in the heart of DOCA/salt hypertensive rats
-
Ishimaru, K. et al. Fasudil attenuates myocardial fibrosis in association with inhibition of monocyte/macrophage infiltration in the heart of DOCA/salt hypertensive rats. J. Cardiovasc. Pharmacol. 50, 187Y194 (2007
-
(2007)
J. Cardiovasc. Pharmacol
, vol.50
, pp. 187-194
-
-
Ishimaru, K.1
-
148
-
-
84874609382
-
Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis
-
Zhou, Y. et al. Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis. J. Clin. Investig. 123, 1096Y1108 (2013
-
(2013)
J. Clin. Investig
, vol.123
, pp. 1096-1108
-
-
Zhou, Y.1
-
149
-
-
84885710467
-
Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing
-
Velasquez, L. S. et al. Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing. Proc. Natl Acad. Sci. USA 110, 16850Y16855 (2013
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 16850-16855
-
-
Velasquez, L.S.1
-
150
-
-
84877102431
-
LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation
-
Sakai, N. et al. LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation. FASEB J. 27, 1830Y1846 (2013
-
(2013)
FASEB J.
, vol.27
, pp. 1830-1846
-
-
Sakai, N.1
-
151
-
-
77955173404
-
Myocardin-related transcription factor-A controls myofibroblast activation and fibrosis in response to myocardial infarction
-
Small, E. M. et al. Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction. Circulation Res. 107, 294Y304 (2010
-
(2010)
Circulation Res
, vol.107
, pp. 294-304
-
-
Small, E.M.1
-
152
-
-
83755162557
-
Myocardin-related transcription factor-A complexes activate type I collagen expression in lung fibroblasts
-
Luchsinger, L. L., Patenaude, C. A., Smith, B. D. & Layne, M. D. Myocardin-related transcription factor-A complexes activate type I collagen expression in lung fibroblasts. J. Biol. Chem. 286, 44116Y44125 (2011
-
(2011)
J. Biol. Chem
, vol.286
, pp. 44116-44125
-
-
Luchsinger, L.L.1
Patenaude, C.A.2
Smith, B.D.3
Layne, M.D.4
-
153
-
-
79958284636
-
Role of YAP/TAZ in mechanotransduction
-
Dupont, S. et al. Role of YAP/TAZ in mechanotransduction. Nature 474, 179Y183 (2011
-
(2011)
Nature
, vol.474
, pp. 179-183
-
-
Dupont, S.1
-
154
-
-
84865260845
-
Regulation of the hippo-yap pathway by g-protein-coupled receptor signaling
-
Yu, F. X. et al. Regulation of the Hippo-YAP pathway by G.-protein-coupled receptor signaling. Cell 150, 780Y791 (2012
-
(2012)
Cell
, vol.150
, pp. 780-791
-
-
Yu, F.X.1
-
155
-
-
46049087598
-
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
-
Varelas, X. et al. TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat. Cell Biol. 10, 837Y848 (2008
-
(2008)
Nat. Cell Biol
, vol.10
, pp. 837-848
-
-
Varelas, X.1
-
156
-
-
84862605178
-
Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP
-
Liu-Chittenden, Y. et al. Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev. 26, 1300Y1305 (2012
-
(2012)
Genes Dev
, vol.26
, pp. 1300-1305
-
-
Liu-Chittenden, Y.1
-
157
-
-
84881138875
-
Targeted therapies for systemic sclerosis
-
Denton, C. P. & Ong, V. H. Targeted therapies for systemic sclerosis. Nat. Rev. Rheumatol. 9, 451Y464 (2013.
-
(2013)
Nat. Rev. Rheumatol
, vol.9
, pp. 451-464
-
-
Denton, C.P.1
Ong, V.H.2
|