hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

Cell

Volumn 114, Issue 4, 2003, Pages 445-456

  Wu, Shian ^a   Huang, Jianbin ^a   Dong, Jixin ^a   Pan, Duojia ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INHIBITOR; CYCLIN E; PHOSPHOTRANSFERASE; PROTEIN KINASE; PROTEIN KINASE WARTS; TUMOR SUPPRESSOR PROTEIN; TUMOR SUPPRESSOR PROTEIN SALVADOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DNA TRANSCRIPTION; GENE; GENE FUNCTION; GENE IDENTIFICATION; GENE LOSS; GENETIC CODE; HIPPO GENE; MITOSIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

MAMMALIA;

EID: 0042232429     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(03)00549-X     Document Type: Article

References (30)

1. Brennecke J., Hipfner D.R., Stark A., Russell R.B., Cohen S.M. bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell. 113:2003;25-36.
2. Chen B., Chu T., Harms E., Gergen J.P., Strickland S. Mapping of Drosophila mutations using site-specific male recombination. Genetics. 149:1998;157-163.
3. Conlon I., Raff M. Size control in animal development. Cell. 96:1999;235-244.
4. Creasy C.L., Chernoff J. Cloning and characterization of a human protein kinase with homology to Ste20. J. Biol. Chem. 270:1995;21695-21700.
5. Dan I., Watanabe N.M., Kusumi A. The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol. 11:2001;220-230.
6. Duman-Scheel M., Weng L., Xin S., Du W. Hedgehog regulates cell growth and proliferation by inducing cyclin D and cyclin E. Nature. 417:2002;299-304.
7. Gao X., Pan D. TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev. 15:2001;1383-1392.
8. Glantschnig H., Rodan G.A., Reszka A.A. Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation. J. Biol. Chem. 277:2002;42987-42996.
9. Graves J.D., Gotoh Y., Draves K.E., Ambrose D., Han D.K., Wright M., Chernoff J., Clark E.A., Krebs E.G. Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO J. 17:1998;2224-2234.
10. Green D.R., Evan G.I. A matter of life and death. Cancer Cell. 1:2002;19-30.
11. Hanks S.K., Quinn A.M., Hunter T. The protein kinase family. conserved features and deduced phylogeny of the catalytic domains Science. 241:1988;42-52.
12. Hay B.A., Wassarman D.A., Rubin G.M. Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. Cell. 83:1995;1253-1262.
13. Hisaoka M., Tanaka A., Hashimoto H. Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma. Lab. Invest. 82:2002;1427-1435.
14. Johnston L.A., Gallant P. Control of growth and organ size in Drosophila. Bioessays. 24:2002;54-64.
15. Justice R.W., Zilian O., Woods D.F., Noll M., Bryant P.J. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev. 9:1995;534-546.
16. Kango-Singh M., Nolo R., Tao C., Verstreken P., Hiesinger P.R., Bellen H.J., Halder G. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development. 129:2002;5719-5730.
17. Martin S.J. Destabilizing influences in apoptosis. sowing the seeds of IAP destruction Cell. 109:2002;793-796.
18. Neufeld T.P., de la Cruz A.F.A., Johnston L.A., Edgar B.A. Coordination of growth and cell division in the Drosophila wing. Cell. 93:1998;1183-1193.
19. Newsome T.P., Asling B., Dickson B.J. Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics. Development. 127:2000;851-860.
20. Pan D., Rubin G.M. Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell. 90:1997;271-280.
21. Richardson H., O'Keefe L.V., Marty T., Saint R. Ectopic cyclin E expression induces premature entry into S phase and disrupts pattern formation in the Drosophila eye imaginal disc. Development. 121:1995;3371-3379.
22. Ryoo H.D., Bergmann A., Gonen H., Ciechanover A., Steller H. Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat. Cell Biol. 4:2002;432-438.
23. St John M.A., Tao W., Fei X., Fukumoto R., Carcangiu M.L., Brownstein D.G., Parlow A.F., McGrath J., Xu T. Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nat. Genet. 21:1999;182-186.
24. Stocker H., Hafen E. Genetic control of cell size. Curr. Opin. Genet. Dev. 10:2000;529-535.
25. Tapon N., Harvey K.F., Bell D.W., Wahrer D.C., Schiripo T.A., Haber D.A., Hariharan I.K. salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell. 110:2002;467-478.
26. Taylor L.K., Wang H.C., Erikson R.L. Newly identified stress-responsive protein kinases, Krs-1 and Krs-2. Proc. Natl. Acad. Sci. USA. 93:1996;10099-10104.
27. Wolff T., Ready D.F. Pattern formation in the Drosophila retina. Bate M., Martinez Arias A. The Development of Drosophila melanogaster. 1993;Cold Spring Harbor Laboratory Press, Plainview, New York. 1277-1325.pp.
28. Xu T., Wang W., Zhang S., Stewart R.A., Yu W. Identifying tumor suppressors in genetic mosaics. the Drosophila lats gene encodes a putative protein kinase Development. 121:1995;1053-1063.
29. Yoo S.J., Huh J.R., Muro I., Yu H., Wang L., Wang S.L., Feldman R.M., Clem R.J., Muller H.A., Hay B.A. Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms. Nat. Cell Biol. 4:2002;416-424.
30. Zallen J.A., Peckol E.L., Tobin D.M., Bargmann C.I. Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family. Mol. Biol. Cell. 11:2000;3177-3190.