-
1
-
-
84862796333
-
Anti-inflammatory effects of spermidine in lipopolysaccharide-stimulated BV2 microglial cells
-
Choi, Y.H., Park, H.Y., Anti-inflammatory effects of spermidine in lipopolysaccharide-stimulated BV2 microglial cells. J. Biomed. Sci., 19, 2012, 31.
-
(2012)
J. Biomed. Sci.
, vol.19
, pp. 31
-
-
Choi, Y.H.1
Park, H.Y.2
-
2
-
-
34347347166
-
Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism
-
Pirinen, E., Kuulasmaa, T., Pietila, M., Heikkinen, S., Tusa, M., Itkonen, P., Boman, S., Skommer, J., Virkamaki, A., Hohtola, E., Kettunen, M., Fatrai, S., Kansanen, E., Koota, S., Niiranen, K., Parkkinen, J., Levonen, A.L., Yla-Herttuala, S., Hiltunen, J.K., Alhonen, L., Smith, U., Janne, J., Laakso, M., Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism. Mol. Cell. Biol. 27 (2007), 4953–4967.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 4953-4967
-
-
Pirinen, E.1
Kuulasmaa, T.2
Pietila, M.3
Heikkinen, S.4
Tusa, M.5
Itkonen, P.6
Boman, S.7
Skommer, J.8
Virkamaki, A.9
Hohtola, E.10
Kettunen, M.11
Fatrai, S.12
Kansanen, E.13
Koota, S.14
Niiranen, K.15
Parkkinen, J.16
Levonen, A.L.17
Yla-Herttuala, S.18
Hiltunen, J.K.19
Alhonen, L.20
Smith, U.21
Janne, J.22
Laakso, M.23
more..
-
3
-
-
0034999867
-
Polyamine regulation of ornithine decarboxylase and its antizyme in intestinal epithelial cells
-
Yuan, Q., Ray, R.M., Viar, M.J., Johnson, L.R., Polyamine regulation of ornithine decarboxylase and its antizyme in intestinal epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol. 280 (2001), G130–G138.
-
(2001)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.280
, pp. G130-G138
-
-
Yuan, Q.1
Ray, R.M.2
Viar, M.J.3
Johnson, L.R.4
-
4
-
-
0033459696
-
Proton coordination by polyamine compounds in aqueous solution
-
Bencini, A., Bianchi, A., Garcia-Espana, E., Micheloni, M., Ramirez, J.A., Proton coordination by polyamine compounds in aqueous solution. Coord. Chem. Rev. 188 (1999), 97–156.
-
(1999)
Coord. Chem. Rev.
, vol.188
, pp. 97-156
-
-
Bencini, A.1
Bianchi, A.2
Garcia-Espana, E.3
Micheloni, M.4
Ramirez, J.A.5
-
5
-
-
0030220625
-
Polyamine transport in mammalian cells. An update
-
Seiler, N., Delcros, J.G., Moulinoux, J.P., Polyamine transport in mammalian cells. An update. Int. J. Biochem. Cell Biol. 28 (1996), 843–861.
-
(1996)
Int. J. Biochem. Cell Biol.
, vol.28
, pp. 843-861
-
-
Seiler, N.1
Delcros, J.G.2
Moulinoux, J.P.3
-
6
-
-
84903522116
-
Molecular basis of the ‘anti-aging’ effect of spermidine and other natural polyamines - a mini-review
-
Minois, N., Molecular basis of the ‘anti-aging’ effect of spermidine and other natural polyamines - a mini-review. Gerontology 60 (2014), 319–326.
-
(2014)
Gerontology
, vol.60
, pp. 319-326
-
-
Minois, N.1
-
8
-
-
15344340623
-
Polyamines: metabolism and implications in human diseases
-
Moinard, C., Cynober, L., de Bandt, J.P., Polyamines: metabolism and implications in human diseases. Clin. Nutr. 24 (2005), 184–197.
-
(2005)
Clin. Nutr.
, vol.24
, pp. 184-197
-
-
Moinard, C.1
Cynober, L.2
de Bandt, J.P.3
-
9
-
-
70350780368
-
Mammalian polyamine metabolism and function
-
Pegg, A.E., Mammalian polyamine metabolism and function. IUBMB Life 61 (2009), 880–894.
-
(2009)
IUBMB Life
, vol.61
, pp. 880-894
-
-
Pegg, A.E.1
-
10
-
-
84873328169
-
Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells
-
Mandal, S., Mandal, A., Johansson, H.E., Orjalo, A.V., Park, M.H., Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 2169–2174.
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 2169-2174
-
-
Mandal, S.1
Mandal, A.2
Johansson, H.E.3
Orjalo, A.V.4
Park, M.H.5
-
11
-
-
84890459089
-
Toxicity of polyamines and their metabolic products
-
Pegg, A.E., Toxicity of polyamines and their metabolic products. Chem. Res. Toxicol. 26 (2013), 1782–1800.
-
(2013)
Chem. Res. Toxicol.
, vol.26
, pp. 1782-1800
-
-
Pegg, A.E.1
-
12
-
-
33744951504
-
Regulation of ornithine decarboxylase
-
Pegg, A.E., Regulation of ornithine decarboxylase. J. Biol. Chem. 281 (2006), 14529–14532.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 14529-14532
-
-
Pegg, A.E.1
-
13
-
-
0029089005
-
Agmatine is synthesized by a mitochondrial arginine decarboxylase in rat brain
-
Li, G., Regunathan, S., Reis, D.J., Agmatine is synthesized by a mitochondrial arginine decarboxylase in rat brain. Ann. N. Y. Acad. Sci. 763 (1995), 325–329.
-
(1995)
Ann. N. Y. Acad. Sci.
, vol.763
, pp. 325-329
-
-
Li, G.1
Regunathan, S.2
Reis, D.J.3
-
14
-
-
0029091243
-
Agmatine (decarboxylated arginine) is synthesized and stored in astrocytes
-
Regunathan, S., Feinstein, D.L., Raasch, W., Reis, D.J., Agmatine (decarboxylated arginine) is synthesized and stored in astrocytes. Neuroreport 6 (1995), 1897–1900.
-
(1995)
Neuroreport
, vol.6
, pp. 1897-1900
-
-
Regunathan, S.1
Feinstein, D.L.2
Raasch, W.3
Reis, D.J.4
-
15
-
-
1642450643
-
Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine
-
Zhu, M.Y., Iyo, A., Piletz, J.E., Regunathan, S., Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine. Biochim. Biophys. Acta 1670 (2004), 156–164.
-
(2004)
Biochim. Biophys. Acta
, vol.1670
, pp. 156-164
-
-
Zhu, M.Y.1
Iyo, A.2
Piletz, J.E.3
Regunathan, S.4
-
16
-
-
38149051651
-
Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase
-
Kanerva, K., Makitie, L.T., Pelander, A., Heiskala, M., Andersson, L.C., Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. Biochem. J. 409 (2008), 187–192.
-
(2008)
Biochem. J.
, vol.409
, pp. 187-192
-
-
Kanerva, K.1
Makitie, L.T.2
Pelander, A.3
Heiskala, M.4
Andersson, L.C.5
-
17
-
-
35048891421
-
Agmatine: metabolic pathway and spectrum of activity in brain
-
Halaris, A., Plietz, J., Agmatine: metabolic pathway and spectrum of activity in brain. CNS Drugs 21 (2007), 885–900.
-
(2007)
CNS Drugs
, vol.21
, pp. 885-900
-
-
Halaris, A.1
Plietz, J.2
-
18
-
-
0034105726
-
Polyamines in the lung: polyamine uptake and polyamine-linked pathological or toxicological conditions
-
Hoet, P.H., Nemery, B., Polyamines in the lung: polyamine uptake and polyamine-linked pathological or toxicological conditions. Am. J. Phys. Lung Cell. Mol. Phys. 278 (2000), L417–L433.
-
(2000)
Am. J. Phys. Lung Cell. Mol. Phys.
, vol.278
, pp. L417-L433
-
-
Hoet, P.H.1
Nemery, B.2
-
19
-
-
0033470180
-
Healing of gastrointestinal mucosa: involvement of polyamines
-
Johnson, L.R., McCormack, S.A., Healing of gastrointestinal mucosa: involvement of polyamines. News Physiol. Sci. 14 (1999), 12–17.
-
(1999)
News Physiol. Sci.
, vol.14
, pp. 12-17
-
-
Johnson, L.R.1
McCormack, S.A.2
-
20
-
-
0027259420
-
Effect of spermine on membrane-associated and membrane-inserted forms of protein kinase C
-
Moruzzi, M.S., Marverti, G., Piccinini, G., Frassineti, C., Monti, M.G., Effect of spermine on membrane-associated and membrane-inserted forms of protein kinase C. Mol. Cell. Biochem. 124 (1993), 1–9.
-
(1993)
Mol. Cell. Biochem.
, vol.124
, pp. 1-9
-
-
Moruzzi, M.S.1
Marverti, G.2
Piccinini, G.3
Frassineti, C.4
Monti, M.G.5
-
21
-
-
85049648501
-
Polyamines: bio-molecules with diverse functions in plant and human health and disease
-
Handa, A.K., Fatima, T., Mattoo, A.K., Polyamines: bio-molecules with diverse functions in plant and human health and disease. Front. Chem., 6, 2018, 10.
-
(2018)
Front. Chem.
, vol.6
, pp. 10
-
-
Handa, A.K.1
Fatima, T.2
Mattoo, A.K.3
-
22
-
-
0025357572
-
Gastrointestinal luminal polyamines: cellular accumulation and enterohepatic circulation
-
Osborne, D.L., Seidel, E.R., Gastrointestinal luminal polyamines: cellular accumulation and enterohepatic circulation. Am. J. Phys. 258 (1990), G576–G584.
-
(1990)
Am. J. Phys.
, vol.258
, pp. G576-G584
-
-
Osborne, D.L.1
Seidel, E.R.2
-
23
-
-
84886781027
-
Involvement of polyamines in iron(III) transport in human intestinal Caco-2 cell lines
-
Lescoat, G., Gouffier, L., Cannie, I., Lowe, O., Morel, I., Lepage, S., Ropert, M., Loreal, O., Brissot, P., Gaboriau, F., Involvement of polyamines in iron(III) transport in human intestinal Caco-2 cell lines. Mol. Cell. Biochem. 378 (2013), 205–215.
-
(2013)
Mol. Cell. Biochem.
, vol.378
, pp. 205-215
-
-
Lescoat, G.1
Gouffier, L.2
Cannie, I.3
Lowe, O.4
Morel, I.5
Lepage, S.6
Ropert, M.7
Loreal, O.8
Brissot, P.9
Gaboriau, F.10
-
24
-
-
0031959821
-
Putrescine as a source of instant energy in the small intestine of the rat
-
Bardocz, S., Grant, G., Brown, D.S., Pusztai, A., Putrescine as a source of instant energy in the small intestine of the rat. Gut 42 (1998), 24–28.
-
(1998)
Gut
, vol.42
, pp. 24-28
-
-
Bardocz, S.1
Grant, G.2
Brown, D.S.3
Pusztai, A.4
-
25
-
-
0016289107
-
Putrescine catabolism in mammalian brain
-
Seiler, N., Al-Therib, M.J., Putrescine catabolism in mammalian brain. Biochem. J. 144 (1974), 29–35.
-
(1974)
Biochem. J.
, vol.144
, pp. 29-35
-
-
Seiler, N.1
Al-Therib, M.J.2
-
26
-
-
44349133214
-
Hypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidine
-
Chattopadhyay, M.K., Park, M.H., Tabor, H., Hypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidine. Proc. Natl. Acad. Sci. U. S. A. 105 (2008), 6554–6559.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 6554-6559
-
-
Chattopadhyay, M.K.1
Park, M.H.2
Tabor, H.3
-
27
-
-
84893714418
-
The function of spermine
-
Pegg, A.E., The function of spermine. IUBMB Life 66 (2014), 8–18.
-
(2014)
IUBMB Life
, vol.66
, pp. 8-18
-
-
Pegg, A.E.1
-
28
-
-
0021139698
-
The effect of testosterone on the half-life of ornithine decarboxylase-mRNA in mouse kidney
-
Laitinen, S.I., Laitinen, P.H., Pajunen, A.E., The effect of testosterone on the half-life of ornithine decarboxylase-mRNA in mouse kidney. Biochem. Int. 9 (1984), 45–50.
-
(1984)
Biochem. Int.
, vol.9
, pp. 45-50
-
-
Laitinen, S.I.1
Laitinen, P.H.2
Pajunen, A.E.3
-
29
-
-
0014512849
-
Amine synthesis in regenerating rat liver: extremely rapid turnover of ornithine decarboxylase
-
Russell, D.H., Snyder, S.H., Amine synthesis in regenerating rat liver: extremely rapid turnover of ornithine decarboxylase. Mol. Pharmacol. 5 (1969), 253–262.
-
(1969)
Mol. Pharmacol.
, vol.5
, pp. 253-262
-
-
Russell, D.H.1
Snyder, S.H.2
-
30
-
-
0016282226
-
Effect of cyclic nucleotides on the induction of ornithine decarboxylase in BHK cells by serum and insulin
-
Hogan, B., Shields, R., Curtis, D., Effect of cyclic nucleotides on the induction of ornithine decarboxylase in BHK cells by serum and insulin. Cell 2 (1974), 229–233.
-
(1974)
Cell
, vol.2
, pp. 229-233
-
-
Hogan, B.1
Shields, R.2
Curtis, D.3
-
31
-
-
0018397307
-
Two distinct mechanisms for ornithine decarboxylase regulation by polyamines in rat hepatoma cells
-
McCann, P.P., Tardif, C., Hornsperger, J.M., Bohlen, P., Two distinct mechanisms for ornithine decarboxylase regulation by polyamines in rat hepatoma cells. J. Cell. Physiol. 99 (1979), 183–190.
-
(1979)
J. Cell. Physiol.
, vol.99
, pp. 183-190
-
-
McCann, P.P.1
Tardif, C.2
Hornsperger, J.M.3
Bohlen, P.4
-
32
-
-
84986505824
-
Ornithine decarboxylase as a target for chemoprevention
-
Pegg, A.E., Shantz, L.M., Coleman, C.S., Ornithine decarboxylase as a target for chemoprevention. J. Cell. Biochem. Suppl. 22 (1995), 132–138.
-
(1995)
J. Cell. Biochem. Suppl.
, vol.22
, pp. 132-138
-
-
Pegg, A.E.1
Shantz, L.M.2
Coleman, C.S.3
-
33
-
-
84857857860
-
Biochemical, mutational and in silico structural evidence for a functional dimeric form of the ornithine decarboxylase from Entamoeba histolytica
-
Preeti, S., Tapas, P., Kumar, R., Madhubala, S. Tomar, Biochemical, mutational and in silico structural evidence for a functional dimeric form of the ornithine decarboxylase from Entamoeba histolytica. PLoS Negl. Trop. Dis., 6, 2012, e1559.
-
(2012)
PLoS Negl. Trop. Dis.
, vol.6
-
-
Preeti, S.1
Tapas, P.2
Kumar, R.3
Madhubala, S.T.4
-
34
-
-
0035860704
-
Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme
-
Bauer, P.M., Buga, G.M., Fukuto, J.M., Pegg, A.E., Ignarro, L.J., Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. J. Biol. Chem. 276 (2001), 34458–34464.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 34458-34464
-
-
Bauer, P.M.1
Buga, G.M.2
Fukuto, J.M.3
Pegg, A.E.4
Ignarro, L.J.5
-
35
-
-
67449088108
-
Decrease in malonyl-CoA and its background metabolic alterations in murine model of cancer cachexia
-
Celik, A., Kano, Y., Tsujinaka, S., Okada, S., Takao, K., Takagi, M., Chohnan, S., Soda, K., Kawakami, M., Konishi, F., Decrease in malonyl-CoA and its background metabolic alterations in murine model of cancer cachexia. Oncol. Rep. 21 (2009), 1105–1111.
-
(2009)
Oncol. Rep.
, vol.21
, pp. 1105-1111
-
-
Celik, A.1
Kano, Y.2
Tsujinaka, S.3
Okada, S.4
Takao, K.5
Takagi, M.6
Chohnan, S.7
Soda, K.8
Kawakami, M.9
Konishi, F.10
-
36
-
-
77449131884
-
Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5′-methylthioadenosine
-
Albers, E., Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5′-methylthioadenosine. IUBMB Life 61 (2009), 1132–1142.
-
(2009)
IUBMB Life
, vol.61
, pp. 1132-1142
-
-
Albers, E.1
-
37
-
-
84904274447
-
ADI1, a methionine salvage pathway enzyme, is required for Drosophila fecundity
-
Chou, H.Y., Lin, Y.H., Shiu, G.L., Tang, H.Y., Cheng, M.L., Shiao, M.S., Pai, L.M., ADI1, a methionine salvage pathway enzyme, is required for Drosophila fecundity. J. Biomed. Sci., 21, 2014, 64.
-
(2014)
J. Biomed. Sci.
, vol.21
, pp. 64
-
-
Chou, H.Y.1
Lin, Y.H.2
Shiu, G.L.3
Tang, H.Y.4
Cheng, M.L.5
Shiao, M.S.6
Pai, L.M.7
-
38
-
-
4143097112
-
Methylthioadenosine
-
Avila, M.A., Garcia-Trevijano, E.R., Lu, S.C., Corrales, F.J., Mato, J.M., Methylthioadenosine. Int. J. Biochem. Cell Biol. 36 (2004), 2125–2130.
-
(2004)
Int. J. Biochem. Cell Biol.
, vol.36
, pp. 2125-2130
-
-
Avila, M.A.1
Garcia-Trevijano, E.R.2
Lu, S.C.3
Corrales, F.J.4
Mato, J.M.5
-
39
-
-
0346118938
-
Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites
-
Subhi, A.L., Diegelman, P., Porter, C.W., Tang, B., Lu, Z.J., Markham, G.D., Kruger, W.D., Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites. J. Biol. Chem. 278 (2003), 49868–49873.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 49868-49873
-
-
Subhi, A.L.1
Diegelman, P.2
Porter, C.W.3
Tang, B.4
Lu, Z.J.5
Markham, G.D.6
Kruger, W.D.7
-
40
-
-
38149021418
-
Structure of Arabidopsis thaliana 5-methylthioribose kinase reveals a more occluded active site than its bacterial homolog
-
Ku, S.Y., Cornell, K.A., Howell, P.L., Structure of Arabidopsis thaliana 5-methylthioribose kinase reveals a more occluded active site than its bacterial homolog. BMC Struct. Biol., 7, 2007, 70.
-
(2007)
BMC Struct. Biol.
, vol.7
, pp. 70
-
-
Ku, S.Y.1
Cornell, K.A.2
Howell, P.L.3
-
41
-
-
33749545777
-
One protein, two enzymes revisited: a structural entropy switch interconverts the two isoforms of acireductone dioxygenase
-
Ju, T., Goldsmith, R.B., Chai, S.C., Maroney, M.J., Pochapsky, S.S., Pochapsky, T.C., One protein, two enzymes revisited: a structural entropy switch interconverts the two isoforms of acireductone dioxygenase. J. Mol. Biol. 363 (2006), 823–834.
-
(2006)
J. Mol. Biol.
, vol.363
, pp. 823-834
-
-
Ju, T.1
Goldsmith, R.B.2
Chai, S.C.3
Maroney, M.J.4
Pochapsky, S.S.5
Pochapsky, T.C.6
-
42
-
-
84960460714
-
Metal-dependent function of a mammalian acireductone dioxygenase
-
Deshpande, A.R., Wagenpfeil, K., Pochapsky, T.C., Petsko, G.A., Ringe, D., Metal-dependent function of a mammalian acireductone dioxygenase. Biochemistry 55 (2016), 1398–1407.
-
(2016)
Biochemistry
, vol.55
, pp. 1398-1407
-
-
Deshpande, A.R.1
Wagenpfeil, K.2
Pochapsky, T.C.3
Petsko, G.A.4
Ringe, D.5
-
43
-
-
85021151485
-
Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A
-
Quinlan, C.L., Kaiser, S.E., Bolanos, B., Nowlin, D., Grantner, R., Karlicek-Bryant, S., Feng, J.L., Jenkinson, S., Freeman-Cook, K., Dann, S.G., Wang, X., Wells, P.A., Fantin, V.R., Stewart, A.E., Grant, S.K., Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A. Nat. Chem. Biol. 13 (2017), 785–792.
-
(2017)
Nat. Chem. Biol.
, vol.13
, pp. 785-792
-
-
Quinlan, C.L.1
Kaiser, S.E.2
Bolanos, B.3
Nowlin, D.4
Grantner, R.5
Karlicek-Bryant, S.6
Feng, J.L.7
Jenkinson, S.8
Freeman-Cook, K.9
Dann, S.G.10
Wang, X.11
Wells, P.A.12
Fantin, V.R.13
Stewart, A.E.14
Grant, S.K.15
-
44
-
-
0033575890
-
Half-lives of ornithine decarboxylase and S-adenosylmethionine decarboxylase activities during the cell cycle of Chinese hamster ovary cells
-
Berntsson, P.S., Alm, K., Oredsson, S.M., Half-lives of ornithine decarboxylase and S-adenosylmethionine decarboxylase activities during the cell cycle of Chinese hamster ovary cells. Biochem. Biophys. Res. Commun. 263 (1999), 13–16.
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.263
, pp. 13-16
-
-
Berntsson, P.S.1
Alm, K.2
Oredsson, S.M.3
-
45
-
-
84876302002
-
Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma
-
Gamble, L.D., Hogarty, M.D., Liu, X., Ziegler, D.S., Marshall, G., Norris, M.D., Haber, M., Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma. Front. Oncol., 2, 2012, 162.
-
(2012)
Front. Oncol.
, vol.2
, pp. 162
-
-
Gamble, L.D.1
Hogarty, M.D.2
Liu, X.3
Ziegler, D.S.4
Marshall, G.5
Norris, M.D.6
Haber, M.7
-
46
-
-
85022206445
-
mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer
-
Zabala-Letona, A., Arruabarrena-Aristorena, A., Martin-Martin, N., Fernandez-Ruiz, S., Sutherland, J.D., Clasquin, M., Tomas-Cortazar, J., Jimenez, J., Torres, I., Quang, P., Ximenez-Embun, P., Bago, R., Ugalde-Olano, A., Loizaga-Iriarte, A., Lacasa-Viscasillas, I., Unda, M., Torrano, V., Cabrera, D., van Liempd, S.M., Cendon, Y., Castro, E., Murray, S., Revandkar, A., Alimonti, A., Zhang, Y., Barnett, A., Lein, G., Pirman, D., Cortazar, A.R., Arreal, L., Prudkin, L., Astobiza, I., Valcarcel-Jimenez, L., Zuniga-Garcia, P., Fernandez-Dominguez, I., Piva, M., Caro-Maldonado, A., Sanchez-Mosquera, P., Castillo-Martin, M., Serra, V., Beraza, N., Gentilella, A., Thomas, G., Azkargorta, M., Elortza, F., Farras, R., Olmos, D., Efeyan, A., Anguita, J., Munoz, J., Falcon-Perez, J.M., Barrio, R., Macarulla, T., Mato, J.M., Martinez-Chantar, M.L., Cordon-Cardo, C., Aransay, A.M., Marks, K., Baselga, J., Tabernero, J., Nuciforo, P., Manning, B.D., Marjon, K., Carracedo, A., mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer. Nature 547 (2017), 109–113.
-
(2017)
Nature
, vol.547
, pp. 109-113
-
-
Zabala-Letona, A.1
Arruabarrena-Aristorena, A.2
Martin-Martin, N.3
Fernandez-Ruiz, S.4
Sutherland, J.D.5
Clasquin, M.6
Tomas-Cortazar, J.7
Jimenez, J.8
Torres, I.9
Quang, P.10
Ximenez-Embun, P.11
Bago, R.12
Ugalde-Olano, A.13
Loizaga-Iriarte, A.14
Lacasa-Viscasillas, I.15
Unda, M.16
Torrano, V.17
Cabrera, D.18
van Liempd, S.M.19
Cendon, Y.20
Castro, E.21
Murray, S.22
Revandkar, A.23
Alimonti, A.24
Zhang, Y.25
Barnett, A.26
Lein, G.27
Pirman, D.28
Cortazar, A.R.29
Arreal, L.30
Prudkin, L.31
Astobiza, I.32
Valcarcel-Jimenez, L.33
Zuniga-Garcia, P.34
Fernandez-Dominguez, I.35
Piva, M.36
Caro-Maldonado, A.37
Sanchez-Mosquera, P.38
Castillo-Martin, M.39
Serra, V.40
Beraza, N.41
Gentilella, A.42
Thomas, G.43
Azkargorta, M.44
Elortza, F.45
Farras, R.46
Olmos, D.47
Efeyan, A.48
Anguita, J.49
Munoz, J.50
Falcon-Perez, J.M.51
Barrio, R.52
Macarulla, T.53
Mato, J.M.54
Martinez-Chantar, M.L.55
Cordon-Cardo, C.56
Aransay, A.M.57
Marks, K.58
Baselga, J.59
Tabernero, J.60
Nuciforo, P.61
Manning, B.D.62
Marjon, K.63
Carracedo, A.64
more..
-
47
-
-
0017834414
-
Regulation of polyamine synthesis in chicken liver
-
Grillo, M.A., Bedino, S., Testore, G., Regulation of polyamine synthesis in chicken liver. Int. J. BioChemiPhysics 9 (1978), 185–189.
-
(1978)
Int. J. BioChemiPhysics
, vol.9
, pp. 185-189
-
-
Grillo, M.A.1
Bedino, S.2
Testore, G.3
-
48
-
-
0017860705
-
Stabilization of ornithine decarboxylase in rat liver
-
Poso, H., Guha, S.K., Janne, J., Stabilization of ornithine decarboxylase in rat liver. Biochim. Biophys. Acta 524 (1978), 466–473.
-
(1978)
Biochim. Biophys. Acta
, vol.524
, pp. 466-473
-
-
Poso, H.1
Guha, S.K.2
Janne, J.3
-
49
-
-
0028815692
-
Regulation of mammalian S-adenosylmethionine decarboxylase as studied in a transient expression system
-
Svensson, F., Persson, L., Regulation of mammalian S-adenosylmethionine decarboxylase as studied in a transient expression system. Biochim. Biophys. Acta 1260 (1995), 21–26.
-
(1995)
Biochim. Biophys. Acta
, vol.1260
, pp. 21-26
-
-
Svensson, F.1
Persson, L.2
-
50
-
-
69249245459
-
Polyamine catabolism and disease
-
Casero, R.A., Pegg, A.E., Polyamine catabolism and disease. Biochem. J. 421 (2009), 323–338.
-
(2009)
Biochem. J.
, vol.421
, pp. 323-338
-
-
Casero, R.A.1
Pegg, A.E.2
-
51
-
-
0020077166
-
Trends in the biochemical pharmacology of 5′-deoxy-5′-methylthioadenosine
-
Williams-Ashman, H.G., Seidenfeld, J., Galletti, P., Trends in the biochemical pharmacology of 5′-deoxy-5′-methylthioadenosine. Biochem. Pharmacol. 31 (1982), 277–288.
-
(1982)
Biochem. Pharmacol.
, vol.31
, pp. 277-288
-
-
Williams-Ashman, H.G.1
Seidenfeld, J.2
Galletti, P.3
-
52
-
-
18844473484
-
L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine
-
Martinez-Chantar, M.L., Latasa, M.U., Varela-Rey, M., Lu, S.C., Garcia-Trevijano, E.R., Mato, J.M., Avila, M.A., L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine. J. Biol. Chem. 278 (2003), 19885–19890.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 19885-19890
-
-
Martinez-Chantar, M.L.1
Latasa, M.U.2
Varela-Rey, M.3
Lu, S.C.4
Garcia-Trevijano, E.R.5
Mato, J.M.6
Avila, M.A.7
-
53
-
-
47549106852
-
1 -acetyltransferase: a key metabolic regulator
-
1 -acetyltransferase: a key metabolic regulator. Am. J. Physiol. Endocrinol. Metab. 294 (2008), E995–1010.
-
(2008)
Am. J. Physiol. Endocrinol. Metab.
, vol.294
, pp. E995-1010
-
-
Pegg, A.E.1
-
54
-
-
33746556526
-
Polyamine-regulated unproductive splicing and translation of spermidine/spermine N1-acetyltransferase
-
Hyvonen, M.T., Uimari, A., Keinanen, T.A., Heikkinen, S., Pellinen, R., Wahlfors, T., Korhonen, A., Narvanen, A., Wahlfors, J., Alhonen, L., Janne, J., Polyamine-regulated unproductive splicing and translation of spermidine/spermine N1-acetyltransferase. RNA 12 (2006), 1569–1582.
-
(2006)
RNA
, vol.12
, pp. 1569-1582
-
-
Hyvonen, M.T.1
Uimari, A.2
Keinanen, T.A.3
Heikkinen, S.4
Pellinen, R.5
Wahlfors, T.6
Korhonen, A.7
Narvanen, A.8
Wahlfors, J.9
Alhonen, L.10
Janne, J.11
-
55
-
-
84932194289
-
Expression of spermidine/spermine N(1)-acetyl transferase (SSAT) in human prostate tissues is related to prostate cancer progression and metastasis
-
Huang, W., Eickhoff, J.C., Mehraein-Ghomi, F., Church, D.R., Wilding, G., Basu, H.S., Expression of spermidine/spermine N(1)-acetyl transferase (SSAT) in human prostate tissues is related to prostate cancer progression and metastasis. Prostate 75 (2015), 1150–1159.
-
(2015)
Prostate
, vol.75
, pp. 1150-1159
-
-
Huang, W.1
Eickhoff, J.C.2
Mehraein-Ghomi, F.3
Church, D.R.4
Wilding, G.5
Basu, H.S.6
-
56
-
-
77955358041
-
Synthesis and biological characterization of novel charge-deficient spermine analogues
-
Weisell, J., Hyvonen, M.T., Hakkinen, M.R., Grigorenko, N.A., Pietila, M., Lampinen, A., Kochetkov, S.N., Alhonen, L., Vepsalainen, J., Keinanen, T.A., Khomutov, A.R., Synthesis and biological characterization of novel charge-deficient spermine analogues. J. Med. Chem. 53 (2010), 5738–5748.
-
(2010)
J. Med. Chem.
, vol.53
, pp. 5738-5748
-
-
Weisell, J.1
Hyvonen, M.T.2
Hakkinen, M.R.3
Grigorenko, N.A.4
Pietila, M.5
Lampinen, A.6
Kochetkov, S.N.7
Alhonen, L.8
Vepsalainen, J.9
Keinanen, T.A.10
Khomutov, A.R.11
-
57
-
-
84880515627
-
Polyamines and cancer: implications for chemotherapy and chemoprevention
-
Nowotarski, S.L., Woster, P.M., Casero, R.A. Jr., Polyamines and cancer: implications for chemotherapy and chemoprevention. Expert Rev. Mol. Med., 15, 2013, e3.
-
(2013)
Expert Rev. Mol. Med.
, vol.15
, pp. e3
-
-
Nowotarski, S.L.1
Woster, P.M.2
Casero, R.A.3
-
58
-
-
36348938850
-
Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha
-
Baek, J.H., Liu, Y.V., McDonald, K.R., Wesley, J.B., Zhang, H., Semenza, G.L., Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha. J. Biol. Chem. 282 (2007), 33358–33366.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 33358-33366
-
-
Baek, J.H.1
Liu, Y.V.2
McDonald, K.R.3
Wesley, J.B.4
Zhang, H.5
Semenza, G.L.6
-
59
-
-
33646176032
-
Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase
-
Jarvinen, A., Keinanen, T.A., Grigorenko, N.A., Khomutov, A.R., Uimari, A., Vepsalainen, J., Narvanen, A., Alhonen, L., Janne, J., Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase. J. Biol. Chem. 281 (2006), 4589–4595.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 4589-4595
-
-
Jarvinen, A.1
Keinanen, T.A.2
Grigorenko, N.A.3
Khomutov, A.R.4
Uimari, A.5
Vepsalainen, J.6
Narvanen, A.7
Alhonen, L.8
Janne, J.9
-
60
-
-
0037442525
-
Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion
-
Vujcic, S., Liang, P., Diegelman, P., Kramer, D.L., Porter, C.W., Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. Biochem. J. 370 (2003), 19–28.
-
(2003)
Biochem. J.
, vol.370
, pp. 19-28
-
-
Vujcic, S.1
Liang, P.2
Diegelman, P.3
Kramer, D.L.4
Porter, C.W.5
-
61
-
-
0038419788
-
Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase
-
Wu, T., Yankovskaya, V., Mcintire, W.S., Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase. J. Biol. Chem. 278 (2003), 20514–20525.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 20514-20525
-
-
Wu, T.1
Yankovskaya, V.2
Mcintire, W.S.3
-
62
-
-
3042653176
-
Catabolism of polyamines
-
Seiler, N., Catabolism of polyamines. Amino Acids 26 (2004), 217–233.
-
(2004)
Amino Acids
, vol.26
, pp. 217-233
-
-
Seiler, N.1
-
63
-
-
78649869949
-
Characteristics of cellular polyamine transport in prokaryotes and eukaryotes
-
Igarashi, K., Kashiwagi, K., Characteristics of cellular polyamine transport in prokaryotes and eukaryotes. Plant Physiol. Biochem. 48 (2010), 506–512.
-
(2010)
Plant Physiol. Biochem.
, vol.48
, pp. 506-512
-
-
Igarashi, K.1
Kashiwagi, K.2
-
64
-
-
84861677889
-
Recent advances in the molecular biology of metazoan polyamine transport
-
Poulin, R., Casero, R.A., Soulet, D., Recent advances in the molecular biology of metazoan polyamine transport. Amino Acids 42 (2012), 711–723.
-
(2012)
Amino Acids
, vol.42
, pp. 711-723
-
-
Poulin, R.1
Casero, R.A.2
Soulet, D.3
-
65
-
-
10444227401
-
A fluorescent probe of polyamine transport accumulates into intracellular acidic vesicles via a two-step mechanism
-
Soulet, D., Gagnon, B., Rivest, S., Audette, M., Poulin, R., A fluorescent probe of polyamine transport accumulates into intracellular acidic vesicles via a two-step mechanism. J. Biol. Chem. 279 (2004), 49355–49366.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 49355-49366
-
-
Soulet, D.1
Gagnon, B.2
Rivest, S.3
Audette, M.4
Poulin, R.5
-
66
-
-
0345689423
-
Glypican-1 is a vehicle for polyamine uptake in mammalian cells: a pivital role for nitrosothiol-derived nitric oxide
-
Belting, M., Mani, K., Jonsson, M., Cheng, F., Sandgren, S., Jonsson, S., Ding, K., Delcros, J.G., Fransson, L.A., Glypican-1 is a vehicle for polyamine uptake in mammalian cells: a pivital role for nitrosothiol-derived nitric oxide. J. Biol. Chem. 278 (2003), 47181–47189.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 47181-47189
-
-
Belting, M.1
Mani, K.2
Jonsson, M.3
Cheng, F.4
Sandgren, S.5
Jonsson, S.6
Ding, K.7
Delcros, J.G.8
Fransson, L.A.9
-
67
-
-
2442656740
-
Novel aspects of glypican glycobiology
-
Fransson, L.A., Belting, M., Cheng, F., Jonsson, M., Mani, K., Sandgren, S., Novel aspects of glypican glycobiology. Cell. Mol. Life Sci. 61 (2004), 1016–1024.
-
(2004)
Cell. Mol. Life Sci.
, vol.61
, pp. 1016-1024
-
-
Fransson, L.A.1
Belting, M.2
Cheng, F.3
Jonsson, M.4
Mani, K.5
Sandgren, S.6
-
68
-
-
44449117559
-
Single chain fragment anti-heparan sulfate antibody targets the polyamine transport system and attenuates polyamine-dependent cell proliferation
-
Welch, J.E., Bengtson, P., Svensson, K., Wittrup, A., Jenniskens, G.J., Ten Dam, G.B., Van Kuppevelt, T.H., Belting, M., Single chain fragment anti-heparan sulfate antibody targets the polyamine transport system and attenuates polyamine-dependent cell proliferation. Int. J. Oncol. 32 (2008), 749–756.
-
(2008)
Int. J. Oncol.
, vol.32
, pp. 749-756
-
-
Welch, J.E.1
Bengtson, P.2
Svensson, K.3
Wittrup, A.4
Jenniskens, G.J.5
Ten Dam, G.B.6
Van Kuppevelt, T.H.7
Belting, M.8
-
69
-
-
45949103740
-
Activated K-RAS increases polyamine uptake in human colon cancer cells through modulation of caveolar endocytosis
-
Roy, U.K., Rial, N.S., Kachel, K.L., Gerner, E.W., Activated K-RAS increases polyamine uptake in human colon cancer cells through modulation of caveolar endocytosis. Mol. Carcinog. 47 (2008), 538–553.
-
(2008)
Mol. Carcinog.
, vol.47
, pp. 538-553
-
-
Roy, U.K.1
Rial, N.S.2
Kachel, K.L.3
Gerner, E.W.4
-
70
-
-
77949909138
-
The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5
-
Aouida, M., Poulin, R., Ramotar, D., The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5. J. Biol. Chem. 285 (2010), 6275–6284.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 6275-6284
-
-
Aouida, M.1
Poulin, R.2
Ramotar, D.3
-
71
-
-
0032930166
-
Interaction of asparagine and EGF in the regulation of ornithine decarboxylase in IEC-6 cells
-
Ray, R.M., Viar, M.J., Patel, T.B., Johnson, L.R., Interaction of asparagine and EGF in the regulation of ornithine decarboxylase in IEC-6 cells. Am. J. Phys. 276 (1999), G773–G780.
-
(1999)
Am. J. Phys.
, vol.276
, pp. G773-G780
-
-
Ray, R.M.1
Viar, M.J.2
Patel, T.B.3
Johnson, L.R.4
-
72
-
-
14644446056
-
20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1
-
Asher, G., Bercovich, Z., Tsvetkov, P., Shaul, Y., Kahana, C., 20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1. Mol. Cell 17 (2005), 645–655.
-
(2005)
Mol. Cell
, vol.17
, pp. 645-655
-
-
Asher, G.1
Bercovich, Z.2
Tsvetkov, P.3
Shaul, Y.4
Kahana, C.5
-
73
-
-
0036440584
-
Putrescine activates oxidative stress dependent apoptotic death in ornithine decarboxylase overproducing mouse myeloma cells
-
Erez, O., Goldstaub, D., Friedman, J., Kahana, C., Putrescine activates oxidative stress dependent apoptotic death in ornithine decarboxylase overproducing mouse myeloma cells. Exp. Cell Res. 281 (2002), 148–156.
-
(2002)
Exp. Cell Res.
, vol.281
, pp. 148-156
-
-
Erez, O.1
Goldstaub, D.2
Friedman, J.3
Kahana, C.4
-
74
-
-
77957057022
-
-
M. Maines Academic Press
-
Richardson, D.R., Ponka, P., Maines, M., (eds.) Effects of Nitrogen Monoxide on Cellular Iron Metabolism, Methods in Neuroscience, 31, 1996, Academic Press, 329–345.
-
(1996)
Effects of Nitrogen Monoxide on Cellular Iron Metabolism, Methods in Neuroscience
, vol.31
, pp. 329-345
-
-
Richardson, D.R.1
Ponka, P.2
-
75
-
-
0028784211
-
The effect of redox-related species of nitrogen monoxide on transferrin and iron uptake and cellular proliferation of erythroleukemia (K562) cells
-
Richardson, D.R., Neumannova, V., Nagy, E., Ponka, P., The effect of redox-related species of nitrogen monoxide on transferrin and iron uptake and cellular proliferation of erythroleukemia (K562) cells. Blood 86 (1995), 3211–3219.
-
(1995)
Blood
, vol.86
, pp. 3211-3219
-
-
Richardson, D.R.1
Neumannova, V.2
Nagy, E.3
Ponka, P.4
-
76
-
-
67650815445
-
Antizyme and antizyme inhibitor, a regulatory tango
-
Kahana, C., Antizyme and antizyme inhibitor, a regulatory tango. Cell. Mol. Life Sci. 66 (2009), 2479–2488.
-
(2009)
Cell. Mol. Life Sci.
, vol.66
, pp. 2479-2488
-
-
Kahana, C.1
-
77
-
-
84861684351
-
Knockdown of antizyme inhibitor decreases prostate tumor growth in vivo
-
Olsen, R.R., Chung, I., Zetter, B.R., Knockdown of antizyme inhibitor decreases prostate tumor growth in vivo. Amino Acids 42 (2012), 549–558.
-
(2012)
Amino Acids
, vol.42
, pp. 549-558
-
-
Olsen, R.R.1
Chung, I.2
Zetter, B.R.3
-
78
-
-
4744339875
-
Antizyme targets cyclin D1 for degradation. A novel mechanism for cell growth repression
-
Newman, R.M., Mobascher, A., Mangold, U., Koike, C., Diah, S., Schmidt, M., Finley, D., Zetter, B.R., Antizyme targets cyclin D1 for degradation. A novel mechanism for cell growth repression. J. Biol. Chem. 279 (2004), 41504–41511.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 41504-41511
-
-
Newman, R.M.1
Mobascher, A.2
Mangold, U.3
Koike, C.4
Diah, S.5
Schmidt, M.6
Finley, D.7
Zetter, B.R.8
-
79
-
-
79955721220
-
Critical factors governing the difference in antizyme-binding affinities between human ornithine decarboxylase and antizyme inhibitor
-
Liu, Y.C., Liu, Y.L., Su, J.Y., Liu, G.Y., Hung, H.C., Critical factors governing the difference in antizyme-binding affinities between human ornithine decarboxylase and antizyme inhibitor. PLoS One, 6, 2011, e19253.
-
(2011)
PLoS One
, vol.6
, pp. e19253
-
-
Liu, Y.C.1
Liu, Y.L.2
Su, J.Y.3
Liu, G.Y.4
Hung, H.C.5
-
80
-
-
0035291218
-
Regulation of cellular polyamines by antizyme
-
Coffino, P., Regulation of cellular polyamines by antizyme. Nat. Rev. Mol. Cell Biol. 2 (2001), 188–194.
-
(2001)
Nat. Rev. Mol. Cell Biol.
, vol.2
, pp. 188-194
-
-
Coffino, P.1
-
81
-
-
0028799607
-
Rapid and regulated degradation of ornithine decarboxylase
-
Hayashi, S., Murakami, Y., Rapid and regulated degradation of ornithine decarboxylase. Biochem. J. 306:Pt 1 (1995), 1–10.
-
(1995)
Biochem. J.
, vol.306
, pp. 1-10
-
-
Hayashi, S.1
Murakami, Y.2
-
82
-
-
27744492409
-
Mechanisms of protein degradation: an odyssey with ODC
-
Kahana, C., Asher, G., Shaul, Y., Mechanisms of protein degradation: an odyssey with ODC. Cell Cycle 4 (2005), 1461–1464.
-
(2005)
Cell Cycle
, vol.4
, pp. 1461-1464
-
-
Kahana, C.1
Asher, G.2
Shaul, Y.3
-
83
-
-
27644538375
-
The antizyme family: polyamines and beyond
-
Mangold, U., The antizyme family: polyamines and beyond. IUBMB Life 57 (2005), 671–676.
-
(2005)
IUBMB Life
, vol.57
, pp. 671-676
-
-
Mangold, U.1
-
84
-
-
0033017981
-
Coordinate changes of polyamine metabolism regulatory proteins during the cell cycle of normal human dermal fibroblasts
-
Bettuzzi, S., Davalli, P., Astancolle, S., Pinna, C., Roncaglia, R., Boraldi, F., Tiozzo, R., Sharrard, M., Corti, A., Coordinate changes of polyamine metabolism regulatory proteins during the cell cycle of normal human dermal fibroblasts. FEBS Lett. 446 (1999), 18–22.
-
(1999)
FEBS Lett.
, vol.446
, pp. 18-22
-
-
Bettuzzi, S.1
Davalli, P.2
Astancolle, S.3
Pinna, C.4
Roncaglia, R.5
Boraldi, F.6
Tiozzo, R.7
Sharrard, M.8
Corti, A.9
-
85
-
-
84867783560
-
Expression profiling and biochemical analysis suggest stress response as a potential mechanism inhibiting proliferation of polyamine-depleted cells
-
Landau, G., Ran, A., Bercovich, Z., Feldmesser, E., Horn-Saban, S., Korkotian, E., Jacob-Hirsh, J., Rechavi, G., Ron, D., Kahana, C., Expression profiling and biochemical analysis suggest stress response as a potential mechanism inhibiting proliferation of polyamine-depleted cells. J. Biol. Chem. 287 (2012), 35825–35837.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 35825-35837
-
-
Landau, G.1
Ran, A.2
Bercovich, Z.3
Feldmesser, E.4
Horn-Saban, S.5
Korkotian, E.6
Jacob-Hirsh, J.7
Rechavi, G.8
Ron, D.9
Kahana, C.10
-
86
-
-
1542330759
-
Effects of polyamines on mitochondrial Ca(2+) transport
-
Salvi, M., Toninello, A., Effects of polyamines on mitochondrial Ca(2+) transport. Biochim. Biophys. Acta 1661 (2004), 113–124.
-
(2004)
Biochim. Biophys. Acta
, vol.1661
, pp. 113-124
-
-
Salvi, M.1
Toninello, A.2
-
87
-
-
0035913954
-
Oxidation products of polyamines induce mitochondrial uncoupling and cytochrome c release
-
Maccarrone, M., Bari, M., Battista, N., Di Rienzo, M., Falciglia, K., Finazzi Agro, A., Oxidation products of polyamines induce mitochondrial uncoupling and cytochrome c release. FEBS Lett. 507 (2001), 30–34.
-
(2001)
FEBS Lett.
, vol.507
, pp. 30-34
-
-
Maccarrone, M.1
Bari, M.2
Battista, N.3
Di Rienzo, M.4
Falciglia, K.5
Finazzi Agro, A.6
-
88
-
-
0034193223
-
Polyamines directly induce release of cytochrome c from heart mitochondria
-
Stefanelli, C., Stanic, I., Zini, M., Bonavita, F., Flamigni, F., Zambonin, L., Landi, L., Pignatti, C., Guarnieri, C., Caldarera, C.M., Polyamines directly induce release of cytochrome c from heart mitochondria. Biochem. J. 347:Pt 3 (2000), 875–880.
-
(2000)
Biochem. J.
, vol.347
, pp. 875-880
-
-
Stefanelli, C.1
Stanic, I.2
Zini, M.3
Bonavita, F.4
Flamigni, F.5
Zambonin, L.6
Landi, L.7
Pignatti, C.8
Guarnieri, C.9
Caldarera, C.M.10
-
89
-
-
0034066525
-
Polyamine depletion delays apoptosis of rat intestinal epithelial cells
-
Ray, R.M., Viar, M.J., Yuan, Q., Johnson, L.R., Polyamine depletion delays apoptosis of rat intestinal epithelial cells. Am. J. Phys. Cell Phys. 278 (2000), C480–C489.
-
(2000)
Am. J. Phys. Cell Phys.
, vol.278
, pp. C480-C489
-
-
Ray, R.M.1
Viar, M.J.2
Yuan, Q.3
Johnson, L.R.4
-
90
-
-
70449529855
-
Induction of autophagy by spermidine promotes longevity
-
Eisenberg, T., Knauer, H., Schauer, A., Buttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., Ring, J., Schroeder, S., Magnes, C., Antonacci, L., Fussi, H., Deszcz, L., Hartl, R., Schraml, E., Criollo, A., Megalou, E., Weiskopf, D., Laun, P., Heeren, G., Breitenbach, M., Grubeck-Loebenstein, B., Herker, E., Fahrenkrog, B., Frohlich, K.U., Sinner, F., Tavernarakis, N., Minois, N., Kroemer, G., Madeo, F., Induction of autophagy by spermidine promotes longevity. Nat. Cell Biol. 11 (2009), 1305–1314.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1305-1314
-
-
Eisenberg, T.1
Knauer, H.2
Schauer, A.3
Buttner, S.4
Ruckenstuhl, C.5
Carmona-Gutierrez, D.6
Ring, J.7
Schroeder, S.8
Magnes, C.9
Antonacci, L.10
Fussi, H.11
Deszcz, L.12
Hartl, R.13
Schraml, E.14
Criollo, A.15
Megalou, E.16
Weiskopf, D.17
Laun, P.18
Heeren, G.19
Breitenbach, M.20
Grubeck-Loebenstein, B.21
Herker, E.22
Fahrenkrog, B.23
Frohlich, K.U.24
Sinner, F.25
Tavernarakis, N.26
Minois, N.27
Kroemer, G.28
Madeo, F.29
more..
-
91
-
-
84870487733
-
Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways
-
Minois, N., Carmona-Gutierrez, D., Bauer, M.A., Rockenfeller, P., Eisenberg, T., Brandhorst, S., Sigrist, S.J., Kroemer, G., Madeo, F., Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways. Cell Death Dis., 3, 2012, e401.
-
(2012)
Cell Death Dis.
, vol.3
-
-
Minois, N.1
Carmona-Gutierrez, D.2
Bauer, M.A.3
Rockenfeller, P.4
Eisenberg, T.5
Brandhorst, S.6
Sigrist, S.J.7
Kroemer, G.8
Madeo, F.9
-
92
-
-
79951889242
-
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome
-
Morselli, E., Marino, G., Bennetzen, M.V., Eisenberg, T., Megalou, E., Schroeder, S., Cabrera, S., Benit, P., Rustin, P., Criollo, A., Kepp, O., Galluzzi, L., Shen, S., Malik, S.A., Maiuri, M.C., Horio, Y., Lopez-Otin, C., Andersen, J.S., Tavernarakis, N., Madeo, F., Kroemer, G., Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J. Cell Biol. 192 (2011), 615–629.
-
(2011)
J. Cell Biol.
, vol.192
, pp. 615-629
-
-
Morselli, E.1
Marino, G.2
Bennetzen, M.V.3
Eisenberg, T.4
Megalou, E.5
Schroeder, S.6
Cabrera, S.7
Benit, P.8
Rustin, P.9
Criollo, A.10
Kepp, O.11
Galluzzi, L.12
Shen, S.13
Malik, S.A.14
Maiuri, M.C.15
Horio, Y.16
Lopez-Otin, C.17
Andersen, J.S.18
Tavernarakis, N.19
Madeo, F.20
Kroemer, G.21
more..
-
93
-
-
84922581317
-
Spermidine induces autophagy by inhibiting the acetyltransferase EP300
-
Pietrocola, F., Lachkar, S., Enot, D.P., Niso-Santano, M., Bravo-San Pedro, J.M., Sica, V., Izzo, V., Maiuri, M.C., Madeo, F., Marino, G., Kroemer, G., Spermidine induces autophagy by inhibiting the acetyltransferase EP300. Cell Death Differ. 22 (2015), 509–516.
-
(2015)
Cell Death Differ.
, vol.22
, pp. 509-516
-
-
Pietrocola, F.1
Lachkar, S.2
Enot, D.P.3
Niso-Santano, M.4
Bravo-San Pedro, J.M.5
Sica, V.6
Izzo, V.7
Maiuri, M.C.8
Madeo, F.9
Marino, G.10
Kroemer, G.11
-
94
-
-
85029386115
-
Induction of autophagy by spermidine is neuroprotective via inhibition of caspase 3-mediated Beclin 1 cleavage
-
Yang, Y., Chen, S., Zhang, Y., Lin, X., Song, Y., Xue, Z., Qian, H., Wang, S., Wan, G., Zheng, X., Zhang, L., Induction of autophagy by spermidine is neuroprotective via inhibition of caspase 3-mediated Beclin 1 cleavage. Cell Death Dis., 8, 2017, e2738.
-
(2017)
Cell Death Dis.
, vol.8
-
-
Yang, Y.1
Chen, S.2
Zhang, Y.3
Lin, X.4
Song, Y.5
Xue, Z.6
Qian, H.7
Wang, S.8
Wan, G.9
Zheng, X.10
Zhang, L.11
-
95
-
-
0028598524
-
Antizyme protects against abnormal accumulation and toxicity of polyamines in ornithine decarboxylase-overproducing cells
-
Suzuki, T., He, Y., Kashiwagi, K., Murakami, Y., Hayashi, S., Igarashi, K., Antizyme protects against abnormal accumulation and toxicity of polyamines in ornithine decarboxylase-overproducing cells. Proc. Natl. Acad. Sci. U. S. A. 91 (1994), 8930–8934.
-
(1994)
Proc. Natl. Acad. Sci. U. S. A.
, vol.91
, pp. 8930-8934
-
-
Suzuki, T.1
He, Y.2
Kashiwagi, K.3
Murakami, Y.4
Hayashi, S.5
Igarashi, K.6
-
96
-
-
84877815726
-
Increased polyamine intake inhibits age-associated alteration in global DNA methylation and 1,2-dimethylhydrazine-induced tumorigenesis
-
Soda, K., Kano, Y., Chiba, F., Koizumi, K., Miyaki, Y., Increased polyamine intake inhibits age-associated alteration in global DNA methylation and 1,2-dimethylhydrazine-induced tumorigenesis. PLoS One, 8, 2013, e64357.
-
(2013)
PLoS One
, vol.8
-
-
Soda, K.1
Kano, Y.2
Chiba, F.3
Koizumi, K.4
Miyaki, Y.5
-
97
-
-
1842628584
-
Polyamine synthesis inhibition attenuates vascular smooth muscle cell migration
-
Liang, M., Ekblad, E., Hellstrand, P., Nilsson, B.O., Polyamine synthesis inhibition attenuates vascular smooth muscle cell migration. J. Vasc. Res. 41 (2004), 141–147.
-
(2004)
J. Vasc. Res.
, vol.41
, pp. 141-147
-
-
Liang, M.1
Ekblad, E.2
Hellstrand, P.3
Nilsson, B.O.4
-
98
-
-
0034830491
-
Polyamine depletion stabilizes p53 resulting in inhibition of normal intestinal epithelial cell proliferation
-
Li, L., Rao, J.N., Guo, X., Liu, L., Santora, R., Bass, B.L., Wang, J.Y., Polyamine depletion stabilizes p53 resulting in inhibition of normal intestinal epithelial cell proliferation. Am. J. Phys. Cell Phys. 281 (2001), C941–C953.
-
(2001)
Am. J. Phys. Cell Phys.
, vol.281
, pp. C941-C953
-
-
Li, L.1
Rao, J.N.2
Guo, X.3
Liu, L.4
Santora, R.5
Bass, B.L.6
Wang, J.Y.7
-
99
-
-
33644757915
-
The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A)
-
Park, M.H., The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A). J. Biochem. 139 (2006), 161–169.
-
(2006)
J. Biochem.
, vol.139
, pp. 161-169
-
-
Park, M.H.1
-
100
-
-
0034712967
-
Polyamines in spermiogenesis: not now, darling
-
Coffino, P., Polyamines in spermiogenesis: not now, darling. Proc. Natl. Acad. Sci. U. S. A. 97 (2000), 4421–4423.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 4421-4423
-
-
Coffino, P.1
-
101
-
-
0035844218
-
Polyamine enhancement of the synthesis of adenylate cyclase at the translational level and the consequential stimulation of the synthesis of the RNA polymerase sigma 28 subunit
-
Yoshida, M., Kashiwagi, K., Kawai, G., Ishihama, A., Igarashi, K., Polyamine enhancement of the synthesis of adenylate cyclase at the translational level and the consequential stimulation of the synthesis of the RNA polymerase sigma 28 subunit. J. Biol. Chem. 276 (2001), 16289–16295.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 16289-16295
-
-
Yoshida, M.1
Kashiwagi, K.2
Kawai, G.3
Ishihama, A.4
Igarashi, K.5
-
102
-
-
0030853492
-
Interactions of polyamines with ion channels
-
Williams, K., Interactions of polyamines with ion channels. Biochem. J. 325:Pt 2 (1997), 289–297.
-
(1997)
Biochem. J.
, vol.325
, pp. 289-297
-
-
Williams, K.1
-
103
-
-
0035824608
-
Polyamine depletion induces rapid NF-kappa B activation in IEC-6 cells
-
Pfeffer, L.M., Yang, C.H., Murti, A., McCormack, S.A., Viar, M.J., Ray, R.M., Johnson, L.R., Polyamine depletion induces rapid NF-kappa B activation in IEC-6 cells. J. Biol. Chem. 276 (2001), 45909–45913.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 45909-45913
-
-
Pfeffer, L.M.1
Yang, C.H.2
Murti, A.3
McCormack, S.A.4
Viar, M.J.5
Ray, R.M.6
Johnson, L.R.7
-
104
-
-
84860717549
-
Phosphoproteomic analysis of cells treated with longevity-related autophagy inducers
-
Bennetzen, M.V., Marino, G., Pultz, D., Morselli, E., Faergeman, N.J., Kroemer, G., Andersen, J.S., Phosphoproteomic analysis of cells treated with longevity-related autophagy inducers. Cell Cycle 11 (2012), 1827–1840.
-
(2012)
Cell Cycle
, vol.11
, pp. 1827-1840
-
-
Bennetzen, M.V.1
Marino, G.2
Pultz, D.3
Morselli, E.4
Faergeman, N.J.5
Kroemer, G.6
Andersen, J.S.7
-
105
-
-
77953615892
-
Metabolic correlations of glucocorticoids and polyamines in inflammation and apoptosis
-
Bjelakovic, G., Stojanovic, I., Jevtovic Stoimenov, T., Pavlovic, D., Kocic, G., Rossi, S., Tabolacci, C., Nikolic, J., Sokolovic, D., Bjelakovic, L., Metabolic correlations of glucocorticoids and polyamines in inflammation and apoptosis. Amino Acids 39 (2010), 29–43.
-
(2010)
Amino Acids
, vol.39
, pp. 29-43
-
-
Bjelakovic, G.1
Stojanovic, I.2
Jevtovic Stoimenov, T.3
Pavlovic, D.4
Kocic, G.5
Rossi, S.6
Tabolacci, C.7
Nikolic, J.8
Sokolovic, D.9
Bjelakovic, L.10
-
106
-
-
84879241308
-
Natural polyamine inhibits mouse skin inflammation and macrophage activation
-
Paul, S., Kang, S.C., Natural polyamine inhibits mouse skin inflammation and macrophage activation. Inflamm. Res. 62 (2013), 681–688.
-
(2013)
Inflamm. Res.
, vol.62
, pp. 681-688
-
-
Paul, S.1
Kang, S.C.2
-
107
-
-
0031000901
-
Differential regulation of macrophage arginine metabolism: a proposed role in wound healing
-
Shearer, J.D., Richards, J.R., Mills, C.D., Caldwell, M.D., Differential regulation of macrophage arginine metabolism: a proposed role in wound healing. Am. J. Phys. 272 (1997), E181–E190.
-
(1997)
Am. J. Phys.
, vol.272
, pp. E181-E190
-
-
Shearer, J.D.1
Richards, J.R.2
Mills, C.D.3
Caldwell, M.D.4
-
108
-
-
0034544353
-
Nuclear factor-kappaB mediates simultaneous induction of inducible nitric-oxide synthase and up-regulation of the cationic amino acid transporter CAT-2B in rat alveolar macrophages
-
Hammermann, R., Dreissig, M.D., Mossner, J., Fuhrmann, M., Berrino, L., Gothert, M., Racke, K., Nuclear factor-kappaB mediates simultaneous induction of inducible nitric-oxide synthase and up-regulation of the cationic amino acid transporter CAT-2B in rat alveolar macrophages. Mol. Pharmacol. 58 (2000), 1294–1302.
-
(2000)
Mol. Pharmacol.
, vol.58
, pp. 1294-1302
-
-
Hammermann, R.1
Dreissig, M.D.2
Mossner, J.3
Fuhrmann, M.4
Berrino, L.5
Gothert, M.6
Racke, K.7
-
109
-
-
0032948085
-
Regulation of intracellular polyamine biosynthesis and transport by NO and cytokines TNF-alpha and IFN-gamma
-
Satriano, J., Ishizuka, S., Archer, D.C., Blantz, R.C., Kelly, C.J., Regulation of intracellular polyamine biosynthesis and transport by NO and cytokines TNF-alpha and IFN-gamma. Am. J. Phys. 276 (1999), C892–C899.
-
(1999)
Am. J. Phys.
, vol.276
, pp. C892-C899
-
-
Satriano, J.1
Ishizuka, S.2
Archer, D.C.3
Blantz, R.C.4
Kelly, C.J.5
-
110
-
-
0034887609
-
Suppression of inducible nitric oxide generation by agmatine aldehyde: beneficial effects in sepsis
-
Satriano, J., Schwartz, D., Ishizuka, S., Lortie, M.J., Thomson, S.C., Gabbai, F., Kelly, C.J., Blantz, R.C., Suppression of inducible nitric oxide generation by agmatine aldehyde: beneficial effects in sepsis. J. Cell. Physiol. 188 (2001), 313–320.
-
(2001)
J. Cell. Physiol.
, vol.188
, pp. 313-320
-
-
Satriano, J.1
Schwartz, D.2
Ishizuka, S.3
Lortie, M.J.4
Thomson, S.C.5
Gabbai, F.6
Kelly, C.J.7
Blantz, R.C.8
-
111
-
-
0032824155
-
Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis
-
Haroon, Z.A., Hettasch, J.M., Lai, T.S., Dewhirst, M.W., Greenberg, C.S., Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis. FASEB J. 13 (1999), 1787–1795.
-
(1999)
FASEB J.
, vol.13
, pp. 1787-1795
-
-
Haroon, Z.A.1
Hettasch, J.M.2
Lai, T.S.3
Dewhirst, M.W.4
Greenberg, C.S.5
-
112
-
-
0034856827
-
Glutamine and cancer
-
(discussion 2550S–2531S)
-
Medina, M.A., Glutamine and cancer. J. Nutr. 131 (2001), 2539S–2542S (discussion 2550S–2531S).
-
(2001)
J. Nutr.
, vol.131
, pp. 2539S-2542S
-
-
Medina, M.A.1
-
113
-
-
0026039979
-
Spermine: an anti-oxidant and anti-inflammatory agent
-
Lovaas, E., Carlin, G., Spermine: an anti-oxidant and anti-inflammatory agent. Free Radic. Biol. Med. 11 (1991), 455–461.
-
(1991)
Free Radic. Biol. Med.
, vol.11
, pp. 455-461
-
-
Lovaas, E.1
Carlin, G.2
-
114
-
-
84880061760
-
Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A
-
Hyvonen, M.T., Koponen, T., Weisell, J., Pietila, M., Khomutov, A.R., Vepsalainen, J., Alhonen, L., Keinanen, T.A., Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A. Biochem. J. 453 (2013), 467–474.
-
(2013)
Biochem. J.
, vol.453
, pp. 467-474
-
-
Hyvonen, M.T.1
Koponen, T.2
Weisell, J.3
Pietila, M.4
Khomutov, A.R.5
Vepsalainen, J.6
Alhonen, L.7
Keinanen, T.A.8
-
115
-
-
77955141952
-
Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes
-
Vuohelainen, S., Pirinen, E., Cerrada-Gimenez, M., Keinanen, T.A., Uimari, A., Pietila, M., Khomutov, A.R., Janne, J., Alhonen, L., Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes. J. Cell. Mol. Med. 14 (2010), 1683–1692.
-
(2010)
J. Cell. Mol. Med.
, vol.14
, pp. 1683-1692
-
-
Vuohelainen, S.1
Pirinen, E.2
Cerrada-Gimenez, M.3
Keinanen, T.A.4
Uimari, A.5
Pietila, M.6
Khomutov, A.R.7
Janne, J.8
Alhonen, L.9
-
116
-
-
34247243232
-
Genetically altered expression of spermidine/spermine N1-acetyltransferase affects fat metabolism in mice via acetyl-CoA
-
Jell, J., Merali, S., Hensen, M.L., Mazurchuk, R., Spernyak, J.A., Diegelman, P., Kisiel, N.D., Barrero, C., Deeb, K.K., Alhonen, L., Patel, M.S., Porter, C.W., Genetically altered expression of spermidine/spermine N1-acetyltransferase affects fat metabolism in mice via acetyl-CoA. J. Biol. Chem. 282 (2007), 8404–8413.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 8404-8413
-
-
Jell, J.1
Merali, S.2
Hensen, M.L.3
Mazurchuk, R.4
Spernyak, J.A.5
Diegelman, P.6
Kisiel, N.D.7
Barrero, C.8
Deeb, K.K.9
Alhonen, L.10
Patel, M.S.11
Porter, C.W.12
-
117
-
-
42949166398
-
Polyamine acetylation modulates polyamine metabolic flux, a prelude to broader metabolic consequences
-
Kramer, D.L., Diegelman, P., Jell, J., Vujcic, S., Merali, S., Porter, C.W., Polyamine acetylation modulates polyamine metabolic flux, a prelude to broader metabolic consequences. J. Biol. Chem. 283 (2008), 4241–4251.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 4241-4251
-
-
Kramer, D.L.1
Diegelman, P.2
Jell, J.3
Vujcic, S.4
Merali, S.5
Porter, C.W.6
-
118
-
-
34548580317
-
Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells
-
Beckers, A., Organe, S., Timmermans, L., Scheys, K., Peeters, A., Brusselmans, K., Verhoeven, G., Swinnen, J.V., Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells. Cancer Res. 67 (2007), 8180–8187.
-
(2007)
Cancer Res.
, vol.67
, pp. 8180-8187
-
-
Beckers, A.1
Organe, S.2
Timmermans, L.3
Scheys, K.4
Peeters, A.5
Brusselmans, K.6
Verhoeven, G.7
Swinnen, J.V.8
-
119
-
-
84857704648
-
Polyamines in aging and disease
-
Minois, N., Carmona-Gutierrez, D., Madeo, F., Polyamines in aging and disease. Aging (Albany NY) 3 (2011), 716–732.
-
(2011)
Aging (Albany NY)
, vol.3
, pp. 716-732
-
-
Minois, N.1
Carmona-Gutierrez, D.2
Madeo, F.3
-
120
-
-
84872744709
-
Spermidine and spermine are enriched in whole blood of nona/centenarians
-
Pucciarelli, S., Moreschini, B., Micozzi, D., De Fronzo, G.S., Carpi, F.M., Polzonetti, V., Vincenzetti, S., Mignini, F., Napolioni, V., Spermidine and spermine are enriched in whole blood of nona/centenarians. Rejuvenation Res. 15 (2012), 590–595.
-
(2012)
Rejuvenation Res.
, vol.15
, pp. 590-595
-
-
Pucciarelli, S.1
Moreschini, B.2
Micozzi, D.3
De Fronzo, G.S.4
Carpi, F.M.5
Polzonetti, V.6
Vincenzetti, S.7
Mignini, F.8
Napolioni, V.9
-
121
-
-
70350425215
-
Polyamine-rich food decreases age-associated pathology and mortality in aged mice
-
Soda, K., Dobashi, Y., Kano, Y., Tsujinaka, S., Konishi, F., Polyamine-rich food decreases age-associated pathology and mortality in aged mice. Exp. Gerontol. 44 (2009), 727–732.
-
(2009)
Exp. Gerontol.
, vol.44
, pp. 727-732
-
-
Soda, K.1
Dobashi, Y.2
Kano, Y.3
Tsujinaka, S.4
Konishi, F.5
-
122
-
-
84911983994
-
Polyamines metabolism and breast cancer: state of the art and perspectives
-
Cervelli, M., Pietropaoli, S., Signore, F., Amendola, R., Mariottini, P., Polyamines metabolism and breast cancer: state of the art and perspectives. Breast Cancer Res. Treat. 148 (2014), 233–248.
-
(2014)
Breast Cancer Res. Treat.
, vol.148
, pp. 233-248
-
-
Cervelli, M.1
Pietropaoli, S.2
Signore, F.3
Amendola, R.4
Mariottini, P.5
-
123
-
-
41049086348
-
Role of ornithine decarboxylase in breast cancer
-
Deng, W., Jiang, X., Mei, Y., Sun, J., Ma, R., Liu, X., Sun, H., Tian, H., Sun, X., Role of ornithine decarboxylase in breast cancer. Acta Biochim. Biophys. Sin. Shanghai 40 (2008), 235–243.
-
(2008)
Acta Biochim. Biophys. Sin. Shanghai
, vol.40
, pp. 235-243
-
-
Deng, W.1
Jiang, X.2
Mei, Y.3
Sun, J.4
Ma, R.5
Liu, X.6
Sun, H.7
Tian, H.8
Sun, X.9
-
124
-
-
33747830765
-
Overexpression of antizyme-inhibitor in NIH3T3 fibroblasts provides growth advantage through neutralization of antizyme functions
-
Keren-Paz, A., Bercovich, Z., Porat, Z., Erez, O., Brener, O., Kahana, C., Overexpression of antizyme-inhibitor in NIH3T3 fibroblasts provides growth advantage through neutralization of antizyme functions. Oncogene 25 (2006), 5163–5172.
-
(2006)
Oncogene
, vol.25
, pp. 5163-5172
-
-
Keren-Paz, A.1
Bercovich, Z.2
Porat, Z.3
Erez, O.4
Brener, O.5
Kahana, C.6
-
125
-
-
56449109565
-
Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase
-
Svensson, K.J., Welch, J.E., Kucharzewska, P., Bengtson, P., Bjurberg, M., Pahlman, S., Ten Dam, G.B., Persson, L., Belting, M., Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase. Cancer Res. 68 (2008), 9291–9301.
-
(2008)
Cancer Res.
, vol.68
, pp. 9291-9301
-
-
Svensson, K.J.1
Welch, J.E.2
Kucharzewska, P.3
Bengtson, P.4
Bjurberg, M.5
Pahlman, S.6
Ten Dam, G.B.7
Persson, L.8
Belting, M.9
-
126
-
-
79953319582
-
Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: current strategies
-
Bertino, J.R., Waud, W.R., Parker, W.B., Lubin, M., Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: current strategies. Cancer Biol. Ther. 11 (2011), 627–632.
-
(2011)
Cancer Biol. Ther.
, vol.11
, pp. 627-632
-
-
Bertino, J.R.1
Waud, W.R.2
Parker, W.B.3
Lubin, M.4
-
127
-
-
0033812886
-
Alterations in polyamine catabolic enzymes in human breast cancer tissue
-
Wallace, H.M., Duthie, J., Evans, D.M., Lamond, S., Nicoll, K.M., Heys, S.D., Alterations in polyamine catabolic enzymes in human breast cancer tissue. Clin. Cancer Res. 6 (2000), 3657–3661.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 3657-3661
-
-
Wallace, H.M.1
Duthie, J.2
Evans, D.M.3
Lamond, S.4
Nicoll, K.M.5
Heys, S.D.6
-
128
-
-
33745261785
-
The new orally active iron chelator ICL670A exhibits a higher antiproliferative effect in human hepatocyte cultures than O-trensox
-
Chantrel-Groussard, K., Gaboriau, F., Pasdeloup, N., Havouis, R., Nick, H., Pierre, J.L., Brissot, P., Lescoat, G., The new orally active iron chelator ICL670A exhibits a higher antiproliferative effect in human hepatocyte cultures than O-trensox. Eur. J. Pharmacol. 541 (2006), 129–137.
-
(2006)
Eur. J. Pharmacol.
, vol.541
, pp. 129-137
-
-
Chantrel-Groussard, K.1
Gaboriau, F.2
Pasdeloup, N.3
Havouis, R.4
Nick, H.5
Pierre, J.L.6
Brissot, P.7
Lescoat, G.8
-
129
-
-
77957788933
-
Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm
-
Cervelli, M., Bellavia, G., Fratini, E., Amendola, R., Polticelli, F., Barba, M., Federico, R., Signore, F., Gucciardo, G., Grillo, R., Woster, P.M., Casero, R.A. Jr., Mariottini, P., Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm. BMC Cancer, 10, 2010, 555.
-
(2010)
BMC Cancer
, vol.10
, pp. 555
-
-
Cervelli, M.1
Bellavia, G.2
Fratini, E.3
Amendola, R.4
Polticelli, F.5
Barba, M.6
Federico, R.7
Signore, F.8
Gucciardo, G.9
Grillo, R.10
Woster, P.M.11
Casero, R.A.12
Mariottini, P.13
-
130
-
-
0036794934
-
A phase II breast cancer chemoprevention trial of oral alpha-difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkers
-
Fabian, C.J., Kimler, B.F., Brady, D.A., Mayo, M.S., Chang, C.H., Ferraro, J.A., Zalles, C.M., Stanton, A.L., Masood, S., Grizzle, W.E., Boyd, N.F., Arneson, D.W., Johnson, K.A., A phase II breast cancer chemoprevention trial of oral alpha-difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkers. Clin. Cancer Res. 8 (2002), 3105–3117.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 3105-3117
-
-
Fabian, C.J.1
Kimler, B.F.2
Brady, D.A.3
Mayo, M.S.4
Chang, C.H.5
Ferraro, J.A.6
Zalles, C.M.7
Stanton, A.L.8
Masood, S.9
Grizzle, W.E.10
Boyd, N.F.11
Arneson, D.W.12
Johnson, K.A.13
-
131
-
-
0037342691
-
Phase III randomized study of postradiotherapy chemotherapy with combination alpha-difluoromethylornithine-PCV versus PCV for anaplastic gliomas
-
Levin, V.A., Hess, K.R., Choucair, A., Flynn, P.J., Jaeckle, K.A., Kyritsis, A.P., Yung, W.K., Prados, M.D., Bruner, J.M., Ictech, S., Gleason, M.J., Kim, H.W., Phase III randomized study of postradiotherapy chemotherapy with combination alpha-difluoromethylornithine-PCV versus PCV for anaplastic gliomas. Clin. Cancer Res. 9 (2003), 981–990.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 981-990
-
-
Levin, V.A.1
Hess, K.R.2
Choucair, A.3
Flynn, P.J.4
Jaeckle, K.A.5
Kyritsis, A.P.6
Yung, W.K.7
Prados, M.D.8
Bruner, J.M.9
Ictech, S.10
Gleason, M.J.11
Kim, H.W.12
-
132
-
-
0033755187
-
Phase III randomized study of postradiotherapy chemotherapy with alpha-difluoromethylornithine-procarbazine, N-(2-chloroethyl)-N’-cyclohexyl-N-nitrosurea, vincristine (DFMO-PCV) versus PCV for glioblastoma multiforme
-
Levin, V.A., Uhm, J.H., Jaeckle, K.A., Choucair, A., Flynn, P.J., Yung, W.K.A., Prados, M.D., Bruner, J.M., Chang, S.M., Kyritsis, A.P., Gleason, M.J., Hess, K.R., Phase III randomized study of postradiotherapy chemotherapy with alpha-difluoromethylornithine-procarbazine, N-(2-chloroethyl)-N’-cyclohexyl-N-nitrosurea, vincristine (DFMO-PCV) versus PCV for glioblastoma multiforme. Clin. Cancer Res. 6 (2000), 3878–3884.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 3878-3884
-
-
Levin, V.A.1
Uhm, J.H.2
Jaeckle, K.A.3
Choucair, A.4
Flynn, P.J.5
Yung, W.K.A.6
Prados, M.D.7
Bruner, J.M.8
Chang, S.M.9
Kyritsis, A.P.10
Gleason, M.J.11
Hess, K.R.12
-
133
-
-
0034650470
-
Alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model
-
Takahashi, Y., Mai, M., Nishioka, K., Alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model. Int. J. Cancer 85 (2000), 243–247.
-
(2000)
Int. J. Cancer
, vol.85
, pp. 243-247
-
-
Takahashi, Y.1
Mai, M.2
Nishioka, K.3
-
134
-
-
0020471939
-
Accumulation of decarboxylated S-adenosyl-L-methionine in mammalian cells as a consequence of the inhibition of putrescine biosynthesis
-
Mamont, P.S., Danzin, C., Wagner, J., Siat, M., Joder-Ohlenbusch, A.M., Claverie, N., Accumulation of decarboxylated S-adenosyl-L-methionine in mammalian cells as a consequence of the inhibition of putrescine biosynthesis. Eur. J. Biochem. 123 (1982), 499–504.
-
(1982)
Eur. J. Biochem.
, vol.123
, pp. 499-504
-
-
Mamont, P.S.1
Danzin, C.2
Wagner, J.3
Siat, M.4
Joder-Ohlenbusch, A.M.5
Claverie, N.6
-
135
-
-
0023100851
-
Antimetastatic activity of DL-alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis, in mice
-
Sunkara, P.S., Rosenberger, A.L., Antimetastatic activity of DL-alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis, in mice. Cancer Res. 47 (1987), 933–935.
-
(1987)
Cancer Res.
, vol.47
, pp. 933-935
-
-
Sunkara, P.S.1
Rosenberger, A.L.2
-
136
-
-
34248228763
-
Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases
-
Casero, R.A. Jr., Marton, L.J., Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases. Nat. Rev. Drug Discov. 6 (2007), 373–390.
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 373-390
-
-
Casero, R.A.1
Marton, L.J.2
-
137
-
-
0021140869
-
Analysis of methylglyoxal bis(guanylhydrazone)-induced alterations of hamster tumor mitochondria by correlated studies of selective rhodamine binding, ultrastructural damage, DNA replication, and reversibility
-
Nass, M.M., Analysis of methylglyoxal bis(guanylhydrazone)-induced alterations of hamster tumor mitochondria by correlated studies of selective rhodamine binding, ultrastructural damage, DNA replication, and reversibility. Cancer Res. 44 (1984), 2677–2688.
-
(1984)
Cancer Res.
, vol.44
, pp. 2677-2688
-
-
Nass, M.M.1
-
138
-
-
0025180260
-
Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase
-
Bitonti, A.J., Byers, T.L., Bush, T.L., Casara, P.J., Bacchi, C.J., Clarkson, A.B. Jr., McCann, P.P., Sjoerdsma, A., Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase. Antimicrob. Agents Chemother. 34 (1990), 1485–1490.
-
(1990)
Antimicrob. Agents Chemother.
, vol.34
, pp. 1485-1490
-
-
Bitonti, A.J.1
Byers, T.L.2
Bush, T.L.3
Casara, P.J.4
Bacchi, C.J.5
Clarkson, A.B.6
McCann, P.P.7
Sjoerdsma, A.8
-
139
-
-
67651183766
-
Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma
-
Koomoa, D.L., Borsics, T., Feith, D.J., Coleman, C.C., Wallick, C.J., Gamper, I., Pegg, A.E., Bachmann, A.S., Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma. Mol. Cancer Ther. 8 (2009), 2067–2075.
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 2067-2075
-
-
Koomoa, D.L.1
Borsics, T.2
Feith, D.J.3
Coleman, C.C.4
Wallick, C.J.5
Gamper, I.6
Pegg, A.E.7
Bachmann, A.S.8
-
140
-
-
24644520814
-
Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells
-
Wallick, C.J., Gamper, I., Thorne, M., Feith, D.J., Takasaki, K.Y., Wilson, S.M., Seki, J.A., Pegg, A.E., Byus, C.V., Bachmann, A.S., Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells. Oncogene 24 (2005), 5606–5618.
-
(2005)
Oncogene
, vol.24
, pp. 5606-5618
-
-
Wallick, C.J.1
Gamper, I.2
Thorne, M.3
Feith, D.J.4
Takasaki, K.Y.5
Wilson, S.M.6
Seki, J.A.7
Pegg, A.E.8
Byus, C.V.9
Bachmann, A.S.10
-
141
-
-
77949715975
-
Chemoprevention of B-cell lymphomas by inhibition of the Myc target spermidine synthase
-
Forshell, T.P., Rimpi, S., Nilsson, J.A., Chemoprevention of B-cell lymphomas by inhibition of the Myc target spermidine synthase. Cancer Prev. Res. (Phila.) 3 (2010), 140–147.
-
(2010)
Cancer Prev. Res. (Phila.)
, vol.3
, pp. 140-147
-
-
Forshell, T.P.1
Rimpi, S.2
Nilsson, J.A.3
-
142
-
-
0027264131
-
Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues
-
Shirahata, A., Takahashi, N., Beppu, T., Hosoda, H., Samejima, K., Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues. Biochem. Pharmacol. 45 (1993), 1897–1903.
-
(1993)
Biochem. Pharmacol.
, vol.45
, pp. 1897-1903
-
-
Shirahata, A.1
Takahashi, N.2
Beppu, T.3
Hosoda, H.4
Samejima, K.5
-
143
-
-
0032790812
-
The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11-bis(ethyl)norspermine
-
Gabrielson, E.W., Pegg, A.E., Casero, R.A. Jr., The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11-bis(ethyl)norspermine. Clin. Cancer Res. 5 (1999), 1638–1641.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 1638-1641
-
-
Gabrielson, E.W.1
Pegg, A.E.2
Casero, R.A.3
-
144
-
-
0031456453
-
Effects of novel spermine analogues on cell cycle progression and apoptosis in MALME-3M human melanoma cells
-
Kramer, D.L., Fogel-Petrovic, M., Diegelman, P., Cooley, J.M., Bernacki, R.J., McManis, J.S., Bergeron, R.J., Porter, C.W., Effects of novel spermine analogues on cell cycle progression and apoptosis in MALME-3M human melanoma cells. Cancer Res. 57 (1997), 5521–5527.
-
(1997)
Cancer Res.
, vol.57
, pp. 5521-5527
-
-
Kramer, D.L.1
Fogel-Petrovic, M.2
Diegelman, P.3
Cooley, J.M.4
Bernacki, R.J.5
McManis, J.S.6
Bergeron, R.J.7
Porter, C.W.8
-
145
-
-
0033843957
-
Antitumor activity of the polyamine analog N(1), N(11)-diethylnorspermine against human prostate carcinoma cells
-
Schipper, R.G., Deli, G., Deloyer, P., Lange, W.P., Schalken, J.A., Verhofstad, A.A., Antitumor activity of the polyamine analog N(1), N(11)-diethylnorspermine against human prostate carcinoma cells. Prostate 44 (2000), 313–321.
-
(2000)
Prostate
, vol.44
, pp. 313-321
-
-
Schipper, R.G.1
Deli, G.2
Deloyer, P.3
Lange, W.P.4
Schalken, J.A.5
Verhofstad, A.A.6
-
146
-
-
0030659113
-
Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy
-
Creaven, P.J., Perez, R., Pendyala, L., Meropol, N.J., Loewen, G., Levine, E., Berghorn, E., Raghavan, D., Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy. Investig. New Drugs 15 (1997), 227–234.
-
(1997)
Investig. New Drugs
, vol.15
, pp. 227-234
-
-
Creaven, P.J.1
Perez, R.2
Pendyala, L.3
Meropol, N.J.4
Loewen, G.5
Levine, E.6
Berghorn, E.7
Raghavan, D.8
-
147
-
-
0036306242
-
Phase I study of N(1),N(11)-diethylnorspermine in patients with non-small cell lung cancer
-
Hahm, H.A., Ettinger, D.S., Bowling, K., Hoker, B., Chen, T.L., Zabelina, Y., Casero, R.A. Jr., Phase I study of N(1),N(11)-diethylnorspermine in patients with non-small cell lung cancer. Clin. Cancer Res. 8 (2002), 684–690.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 684-690
-
-
Hahm, H.A.1
Ettinger, D.S.2
Bowling, K.3
Hoker, B.4
Chen, T.L.5
Zabelina, Y.6
Casero, R.A.7
-
148
-
-
0346734280
-
A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer
-
Wolff, A.C., Armstrong, D.K., Fetting, J.H., Carducci, M.K., Riley, C.D., Bender, J.F., Casero, R.A. Jr., Davidson, N.E., A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer. Clin. Cancer Res. 9 (2003), 5922–5928.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 5922-5928
-
-
Wolff, A.C.1
Armstrong, D.K.2
Fetting, J.H.3
Carducci, M.K.4
Riley, C.D.5
Bender, J.F.6
Casero, R.A.7
Davidson, N.E.8
-
149
-
-
0031595242
-
N1,N12-bis(ethyl)spermine effect on growth of cis-diamminedichloroplatinum(II)-sensitive and -resistant human ovarian-carcinoma cell lines
-
Marverti, G., Piccinini, G., Ghiaroni, S., Barbieri, D., Quaglino, D., Moruzzi, M.S., N1,N12-bis(ethyl)spermine effect on growth of cis-diamminedichloroplatinum(II)-sensitive and -resistant human ovarian-carcinoma cell lines. Int. J. Cancer 78 (1998), 33–40.
-
(1998)
Int. J. Cancer
, vol.78
, pp. 33-40
-
-
Marverti, G.1
Piccinini, G.2
Ghiaroni, S.3
Barbieri, D.4
Quaglino, D.5
Moruzzi, M.S.6
-
150
-
-
79953794810
-
Combination effects of platinum drugs and N1, N11 diethylnorspermine on spermidine/spermine N1-acetyltransferase, polyamines and growth inhibition in A2780 human ovarian carcinoma cells and their oxaliplatin and cisplatin-resistant variants
-
Tummala, R., Diegelman, P., Hector, S., Kramer, D.L., Clark, K., Zagst, P., Fetterly, G., Porter, C.W., Pendyala, L., Combination effects of platinum drugs and N1, N11 diethylnorspermine on spermidine/spermine N1-acetyltransferase, polyamines and growth inhibition in A2780 human ovarian carcinoma cells and their oxaliplatin and cisplatin-resistant variants. Cancer Chemother. Pharmacol. 67 (2011), 401–414.
-
(2011)
Cancer Chemother. Pharmacol.
, vol.67
, pp. 401-414
-
-
Tummala, R.1
Diegelman, P.2
Hector, S.3
Kramer, D.L.4
Clark, K.5
Zagst, P.6
Fetterly, G.7
Porter, C.W.8
Pendyala, L.9
-
151
-
-
0028967677
-
Growth and biochemical effects of unsymmetrically substituted polyamine analogues in human lung tumor cells 1
-
Casero, R.A. Jr., Mank, A.R., Saab, N.H., Wu, R., Dyer, W.J., Woster, P.M., Growth and biochemical effects of unsymmetrically substituted polyamine analogues in human lung tumor cells 1. Cancer Chemother. Pharmacol. 36 (1995), 69–74.
-
(1995)
Cancer Chemother. Pharmacol.
, vol.36
, pp. 69-74
-
-
Casero, R.A.1
Mank, A.R.2
Saab, N.H.3
Wu, R.4
Dyer, W.J.5
Woster, P.M.6
-
152
-
-
0035804314
-
Terminally alkylated polyamine analogues as chemotherapeutic agents
-
Casero, R.A. Jr., Woster, P.M., Terminally alkylated polyamine analogues as chemotherapeutic agents. J. Med. Chem. 44 (2001), 1–26.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 1-26
-
-
Casero, R.A.1
Woster, P.M.2
-
153
-
-
0008104328
-
Unsymmetrically substituted polyamine analogue induces caspase-independent programmed cell death in Bcl-2-overexpressing cells
-
Ha, H.C., Woster, P.M., Casero, R.A. Jr., Unsymmetrically substituted polyamine analogue induces caspase-independent programmed cell death in Bcl-2-overexpressing cells. Cancer Res. 58 (1998), 2711–2714.
-
(1998)
Cancer Res.
, vol.58
, pp. 2711-2714
-
-
Ha, H.C.1
Woster, P.M.2
Casero, R.A.3
-
154
-
-
0033594448
-
1-(N-alkylamino)-11-(N-ethylamino)-4,8-diazaundecanes: simple synthetic polyamine analogues that differentially alter tubulin polymerization
-
Webb, H.K., Wu, Z., Sirisoma, N., Ha, H.C., Casero, R.A. Jr., Woster, P.M., 1-(N-alkylamino)-11-(N-ethylamino)-4,8-diazaundecanes: simple synthetic polyamine analogues that differentially alter tubulin polymerization. J. Med. Chem. 42 (1999), 1415–1421.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 1415-1421
-
-
Webb, H.K.1
Wu, Z.2
Sirisoma, N.3
Ha, H.C.4
Casero, R.A.5
Woster, P.M.6
-
155
-
-
0001547001
-
The role of polyamine catabolism in polyamine analogue-induced programmed cell death
-
Ha, H.C., Woster, P.M., Yager, J.D., Casero, R.A. Jr., The role of polyamine catabolism in polyamine analogue-induced programmed cell death. Proc. Natl. Acad. Sci. U. S. A. 94 (1997), 11557–11562.
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 11557-11562
-
-
Ha, H.C.1
Woster, P.M.2
Yager, J.D.3
Casero, R.A.4
-
156
-
-
0242298099
-
Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells
-
Devereux, W., Wang, Y., Stewart, T.M., Hacker, A., Smith, R., Frydman, B., Valasinas, A.L., Reddy, V.K., Marton, L.J., Ward, T.D., Woster, P.M., Casero, R.A., Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells. Cancer Chemother. Pharmacol. 52 (2003), 383–390.
-
(2003)
Cancer Chemother. Pharmacol.
, vol.52
, pp. 383-390
-
-
Devereux, W.1
Wang, Y.2
Stewart, T.M.3
Hacker, A.4
Smith, R.5
Frydman, B.6
Valasinas, A.L.7
Reddy, V.K.8
Marton, L.J.9
Ward, T.D.10
Woster, P.M.11
Casero, R.A.12
-
157
-
-
0032547998
-
Conformationally restricted analogues of 1N,12N-bisethylspermine: synthesis and growth inhibitory effects on human tumor cell lines
-
Reddy, V.K., Valasinas, A., Sarkar, A., Basu, H.S., Marton, L.J., Frydman, B., Conformationally restricted analogues of 1N,12N-bisethylspermine: synthesis and growth inhibitory effects on human tumor cell lines. J. Med. Chem. 41 (1998), 4723–4732.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 4723-4732
-
-
Reddy, V.K.1
Valasinas, A.2
Sarkar, A.3
Basu, H.S.4
Marton, L.J.5
Frydman, B.6
-
158
-
-
70349621130
-
The polyamine analog PG11047 potentiates the antitumor activity of cisplatin and bevacizumab in preclinical models of lung and prostate cancer
-
Dredge, K., Kink, J.A., Johnson, R.M., Bytheway, I., Marton, L.J., The polyamine analog PG11047 potentiates the antitumor activity of cisplatin and bevacizumab in preclinical models of lung and prostate cancer. Cancer Chemother. Pharmacol. 65 (2009), 191–195.
-
(2009)
Cancer Chemother. Pharmacol.
, vol.65
, pp. 191-195
-
-
Dredge, K.1
Kink, J.A.2
Johnson, R.M.3
Bytheway, I.4
Marton, L.J.5
-
159
-
-
53149113412
-
In vitro and in vivo effects of the conformationally restricted polyamine analogue CGC-11047 on small cell and non-small cell lung cancer cells
-
Hacker, A., Marton, L.J., Sobolewski, M., Casero, R.A. Jr., In vitro and in vivo effects of the conformationally restricted polyamine analogue CGC-11047 on small cell and non-small cell lung cancer cells. Cancer Chemother. Pharmacol. 63 (2008), 45–53.
-
(2008)
Cancer Chemother. Pharmacol.
, vol.63
, pp. 45-53
-
-
Hacker, A.1
Marton, L.J.2
Sobolewski, M.3
Casero, R.A.4
-
160
-
-
79958797801
-
Initial testing (stage 1) of the polyamine analog PG11047 by the pediatric preclinical testing program
-
Smith, M.A., Maris, J.M., Lock, R., Kolb, E.A., Gorlick, R., Keir, S.T., Carol, H., Morton, C.L., Reynolds, C.P., Kang, M.H., Houghton, P.J., Initial testing (stage 1) of the polyamine analog PG11047 by the pediatric preclinical testing program. Pediatr. Blood Cancer 57 (2011), 268–274.
-
(2011)
Pediatr. Blood Cancer
, vol.57
, pp. 268-274
-
-
Smith, M.A.1
Maris, J.M.2
Lock, R.3
Kolb, E.A.4
Gorlick, R.5
Keir, S.T.6
Carol, H.7
Morton, C.L.8
Reynolds, C.P.9
Kang, M.H.10
Houghton, P.J.11
-
161
-
-
64549132099
-
Lipophilic lysine-spermine conjugates are potent polyamine transport inhibitors for use in combination with a polyamine biosynthesis inhibitor
-
Burns, M.R., Graminski, G.F., Weeks, R.S., Chen, Y., O'Brien, T.G., Lipophilic lysine-spermine conjugates are potent polyamine transport inhibitors for use in combination with a polyamine biosynthesis inhibitor. J. Med. Chem. 52 (2009), 1983–1993.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 1983-1993
-
-
Burns, M.R.1
Graminski, G.F.2
Weeks, R.S.3
Chen, Y.4
O'Brien, T.G.5
-
162
-
-
33645682384
-
Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma
-
Chen, Y., Weeks, R.S., Burns, M.R., Boorman, D.W., Klein-Szanto, A., O'Brien, T.G., Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma. Int. J. Cancer 118 (2006), 2344–2349.
-
(2006)
Int. J. Cancer
, vol.118
, pp. 2344-2349
-
-
Chen, Y.1
Weeks, R.S.2
Burns, M.R.3
Boorman, D.W.4
Klein-Szanto, A.5
O'Brien, T.G.6
-
163
-
-
0034715957
-
Novel lysine-spermine conjugate inhibits polyamine transport and inhibits cell growth when given with DFMO
-
Weeks, R.S., Vanderwerf, S.M., Carlson, C.L., Burns, M.R., O'Day, C.L., Cai, F., Devens, B.H., Webb, H.K., Novel lysine-spermine conjugate inhibits polyamine transport and inhibits cell growth when given with DFMO. Exp. Cell Res. 261 (2000), 293–302.
-
(2000)
Exp. Cell Res.
, vol.261
, pp. 293-302
-
-
Weeks, R.S.1
Vanderwerf, S.M.2
Carlson, C.L.3
Burns, M.R.4
O'Day, C.L.5
Cai, F.6
Devens, B.H.7
Webb, H.K.8
-
164
-
-
55549132996
-
Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial
-
Meyskens, F.L. Jr., McLaren, C.E., Pelot, D., Fujikawa-Brooks, S., Carpenter, P.M., Hawk, E., Kelloff, G., Lawson, M.J., Kidao, J., McCracken, J., Albers, C.G., Ahnen, D.J., Turgeon, D.K., Goldschmid, S., Lance, P., Hagedorn, C.H., Gillen, D.L., Gerner, E.W., Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial. Cancer Prev. Res. (Phila.) 1 (2008), 32–38.
-
(2008)
Cancer Prev. Res. (Phila.)
, vol.1
, pp. 32-38
-
-
Meyskens, F.L.1
McLaren, C.E.2
Pelot, D.3
Fujikawa-Brooks, S.4
Carpenter, P.M.5
Hawk, E.6
Kelloff, G.7
Lawson, M.J.8
Kidao, J.9
McCracken, J.10
Albers, C.G.11
Ahnen, D.J.12
Turgeon, D.K.13
Goldschmid, S.14
Lance, P.15
Hagedorn, C.H.16
Gillen, D.L.17
Gerner, E.W.18
-
165
-
-
57949098095
-
Synthesis, cytotoxicity and apoptosis of naphthalimide polyamine conjugates as antitumor agents
-
Tian, Z.Y., Xie, S.Q., Du, Y.W., Ma, Y.F., Zhao, J., Gao, W.Y., Wang, C.J., Synthesis, cytotoxicity and apoptosis of naphthalimide polyamine conjugates as antitumor agents. Eur. J. Med. Chem. 44 (2009), 393–399.
-
(2009)
Eur. J. Med. Chem.
, vol.44
, pp. 393-399
-
-
Tian, Z.Y.1
Xie, S.Q.2
Du, Y.W.3
Ma, Y.F.4
Zhao, J.5
Gao, W.Y.6
Wang, C.J.7
-
166
-
-
79951555085
-
NPC-16, a novel naphthalimide-polyamine conjugate, induced apoptosis and autophagy in human hepatoma HepG2 cells and Bel-7402 cells
-
Xie, S.Q., Li, Q., Zhang, Y.H., Wang, J.H., Mei, Z.H., Zhao, J., Wang, C.J., NPC-16, a novel naphthalimide-polyamine conjugate, induced apoptosis and autophagy in human hepatoma HepG2 cells and Bel-7402 cells. Apoptosis 16 (2011), 27–34.
-
(2011)
Apoptosis
, vol.16
, pp. 27-34
-
-
Xie, S.Q.1
Li, Q.2
Zhang, Y.H.3
Wang, J.H.4
Mei, Z.H.5
Zhao, J.6
Wang, C.J.7
-
167
-
-
84864449477
-
COX-2-independent induction of apoptosis by celecoxib and polyamine naphthalimide conjugate mediated by polyamine depression in colorectal cancer cell lines
-
Xie, S.Q., Zhang, Y.H., Li, Q., Wang, J.H., Li, J.H., Zhao, J., Wang, C.J., COX-2-independent induction of apoptosis by celecoxib and polyamine naphthalimide conjugate mediated by polyamine depression in colorectal cancer cell lines. Int. J. Color. Dis. 27 (2012), 861–868.
-
(2012)
Int. J. Color. Dis.
, vol.27
, pp. 861-868
-
-
Xie, S.Q.1
Zhang, Y.H.2
Li, Q.3
Wang, J.H.4
Li, J.H.5
Zhao, J.6
Wang, C.J.7
-
168
-
-
73149104152
-
A putrescine-anthracene conjugate: a paradigm for selective drug delivery
-
Palmer, A.J., Ghani, R.A., Kaur, N., Phanstiel, O., Wallace, H.M., A putrescine-anthracene conjugate: a paradigm for selective drug delivery. Biochem. J. 424 (2009), 431–438.
-
(2009)
Biochem. J.
, vol.424
, pp. 431-438
-
-
Palmer, A.J.1
Ghani, R.A.2
Kaur, N.3
Phanstiel, O.4
Wallace, H.M.5
-
169
-
-
57149094031
-
F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system
-
Barret, J.M., Kruczynski, A., Vispe, S., Annereau, J.P., Brel, V., Guminski, Y., Delcros, J.G., Lansiaux, A., Guilbaud, N., Imbert, T., Bailly, C., F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system. Cancer Res. 68 (2008), 9845–9853.
-
(2008)
Cancer Res.
, vol.68
, pp. 9845-9853
-
-
Barret, J.M.1
Kruczynski, A.2
Vispe, S.3
Annereau, J.P.4
Brel, V.5
Guminski, Y.6
Delcros, J.G.7
Lansiaux, A.8
Guilbaud, N.9
Imbert, T.10
Bailly, C.11
-
170
-
-
84896695093
-
Expanding horizons in iron chelation and the treatment of cancer: role of iron in the regulation of ER stress and the epithelial-mesenchymal transition
-
Lane, D.J.R., Mills, T.M., Shafie, N.H., Merlot, A.M., Saleh Moussa, R., Kalinowski, D.S., Kovacevic, Z., Richardson, D.R., Expanding horizons in iron chelation and the treatment of cancer: role of iron in the regulation of ER stress and the epithelial-mesenchymal transition. Biochim. Biophys. Acta 1845 (2014), 166–181.
-
(2014)
Biochim. Biophys. Acta
, vol.1845
, pp. 166-181
-
-
Lane, D.J.R.1
Mills, T.M.2
Shafie, N.H.3
Merlot, A.M.4
Saleh Moussa, R.5
Kalinowski, D.S.6
Kovacevic, Z.7
Richardson, D.R.8
-
171
-
-
34547137681
-
Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1 by iron depletion
-
Fu, D., Richardson, D.R., Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1 by iron depletion. Blood 110 (2007), 752–761.
-
(2007)
Blood
, vol.110
, pp. 752-761
-
-
Fu, D.1
Richardson, D.R.2
-
172
-
-
0029379698
-
Iron deprivation results in an increase in p53 expression
-
Fukuchi, K., Tomoyasu, S., Watanabe, H., Kaetsu, S., Tsuruoka, N., Gomi, K., Iron deprivation results in an increase in p53 expression. Biol. Chem. Hoppe Seyler 376 (1995), 627–630.
-
(1995)
Biol. Chem. Hoppe Seyler
, vol.376
, pp. 627-630
-
-
Fukuchi, K.1
Tomoyasu, S.2
Watanabe, H.3
Kaetsu, S.4
Tsuruoka, N.5
Gomi, K.6
-
173
-
-
84874303394
-
N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion
-
Lane, D.J.R., Saletta, F., Suryo Rahmanto, Y., Kovacevic, Z., Richardson, D.R., N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion. PLoS One, 8, 2013, e57273.
-
(2013)
PLoS One
, vol.8
-
-
Lane, D.J.R.1
Saletta, F.2
Suryo Rahmanto, Y.3
Kovacevic, Z.4
Richardson, D.R.5
-
174
-
-
7244239197
-
Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation
-
Le, N.T., Richardson, D.R., Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation. Blood 104 (2004), 2967–2975.
-
(2004)
Blood
, vol.104
, pp. 2967-2975
-
-
Le, N.T.1
Richardson, D.R.2
-
175
-
-
34548675357
-
Antiproliferative and apoptotic effects in rat and human hepatoma cell cultures of the orally active iron chelator ICL670 compared to CP20: a possible relationship with polyamine metabolism
-
Lescoat, G., Chantrel-Groussard, K., Pasdeloup, N., Nick, H., Brissot, P., Gaboriau, F., Antiproliferative and apoptotic effects in rat and human hepatoma cell cultures of the orally active iron chelator ICL670 compared to CP20: a possible relationship with polyamine metabolism. Cell Prolif. 40 (2007), 755–767.
-
(2007)
Cell Prolif.
, vol.40
, pp. 755-767
-
-
Lescoat, G.1
Chantrel-Groussard, K.2
Pasdeloup, N.3
Nick, H.4
Brissot, P.5
Gaboriau, F.6
-
176
-
-
0142154312
-
The effect of potent iron chelators on the regulation of p53: examination of the expression, localization and DNA-binding activity of p53 and the transactivation of WAF1
-
Liang, S.X., Richardson, D.R., The effect of potent iron chelators on the regulation of p53: examination of the expression, localization and DNA-binding activity of p53 and the transactivation of WAF1. Carcinogenesis 24 (2003), 1601–1614.
-
(2003)
Carcinogenesis
, vol.24
, pp. 1601-1614
-
-
Liang, S.X.1
Richardson, D.R.2
-
177
-
-
34247373460
-
Iron chelation regulates cyclin D1 expression via the proteasome: a link to iron deficiency-mediated growth suppression
-
Nurtjahja-Tjendraputra, E., Fu, D., Phang, J.M., Richardson, D.R., Iron chelation regulates cyclin D1 expression via the proteasome: a link to iron deficiency-mediated growth suppression. Blood 109 (2007), 4045–4054.
-
(2007)
Blood
, vol.109
, pp. 4045-4054
-
-
Nurtjahja-Tjendraputra, E.1
Fu, D.2
Phang, J.M.3
Richardson, D.R.4
-
178
-
-
85047961643
-
Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes
-
(Epub ahead of print)
-
Lane, D.J.R., Bae, D.H., Siafakas, A.R., Rahmanto, Y.S., Al-Akra, L., Jansson, P.J., Casero, R.A. Jr., Richardson, D.R., Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes. Biochim. Biophys. Acta, 2018, 10.1016/j.bbadis.2018.05.007 (Epub ahead of print).
-
(2018)
Biochim. Biophys. Acta
-
-
Lane, D.J.R.1
Bae, D.H.2
Siafakas, A.R.3
Rahmanto, Y.S.4
Al-Akra, L.5
Jansson, P.J.6
Casero, R.A.7
Richardson, D.R.8
-
179
-
-
33750613624
-
Modulation of cell proliferation and polyamine metabolism in rat liver cell cultures by the iron chelator O-trensox
-
Gaboriau, F., Laupen-Chassay, C., Pasdeloup, N., Pierre, J.L., Brissot, P., Lescoat, G., Modulation of cell proliferation and polyamine metabolism in rat liver cell cultures by the iron chelator O-trensox. Biometals 19 (2006), 623–632.
-
(2006)
Biometals
, vol.19
, pp. 623-632
-
-
Gaboriau, F.1
Laupen-Chassay, C.2
Pasdeloup, N.3
Pierre, J.L.4
Brissot, P.5
Lescoat, G.6
-
180
-
-
77149125234
-
Iron chelator-mediated alterations in gene expression: identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53
-
Saletta, F., Suryo Rahmanto, Y., Noulsri, E., Richardson, D.R., Iron chelator-mediated alterations in gene expression: identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53. Mol. Pharmacol. 77 (2010), 443–458.
-
(2010)
Mol. Pharmacol.
, vol.77
, pp. 443-458
-
-
Saletta, F.1
Suryo Rahmanto, Y.2
Noulsri, E.3
Richardson, D.R.4
-
181
-
-
84976426614
-
Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer
-
Nakanishi, S., Cleveland, J.L., Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer. Amino Acids 48 (2016), 2353–2362.
-
(2016)
Amino Acids
, vol.48
, pp. 2353-2362
-
-
Nakanishi, S.1
Cleveland, J.L.2
|