Effects of novel spermine analogues on cell cycle progression and apoptosis in MALME-3M human melanoma cells

Cancer Research

Volumn 57, Issue 24, 1997, Pages 5521-5527

  Kramer, Debora L ^a   Fogel Petrovic, Mirjana ^a   Diegelman, Paula ^a   Cooley, Jeanine M ^a   Bernacki, Ralph J ^a   McManis, Jim S ^b   Bergeron, Raymond J ^b   Porter, Carl W ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SPERMINE;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL GROWTH; CONTROLLED STUDY; DRUG EFFICACY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MELANOMA; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION;

ACETYLTRANSFERASES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOGENIC POLYAMINES; CELL CYCLE; CELL DIVISION; ENZYME INDUCTION; HUMANS; MELANOMA; SPERMINE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0031456453     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Meyskens, F. L., and Gerner, E. W. Development of difluoromethylornithine as a chemoprevention agent for the management of colon cancer. J. Cell. Biochem., 22: 126-131, 1995.
2. Love, R. R., Carbonne, P. P., Verma, A. R., Gilmore, D., Carey, P., Tutsch, K., Pumplun, M., and Wilding, G. Randomized phase I chemoprevention dose-seeking study of α-difluoromethyl ornithine. J. Natl. Cancer Inst., 85: 732-737, 1993.
3. Regenass, U., Mett, H., Stanek, J., Muller, M., Kramer, D., and Porter, C. W. CGP-48664, a new 5-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res., 54: 3210-3217, 1994.
4. Porter, C. W., Regenass, U., and Bergeron, R. J. Polyamine inhibitors and analogs as potential anticancer agents. In: R. H. Dowling, U. R. Folsch, and C. Loser (eds.), Falk Symposium on Polyamines in the Gastrointestinal Tract, pp. 301-322. Dordrecht: Kluwer Academic Publishers, 1992.
5. Pendyala, L., Creaven, P. J., Bhargava, A. K., and Porter, C. W. Urinary and erythrocyte polyamines during the evaluation of oral DFMO in a phase I chemoprevention clinical trial. Cancer Epidemiol. Biomarkers Prev., 2: 235-241, 1993.
6. 1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines. Cancer Res., 51: 3715-3720, 1991.
7. 12-bis(ethyl)spermine homologues against human MALME-3M melanoma xenografts. Cancer Res., 52: 2424-2430, 1992.
8. 11-diethylnorspermine. Clin. Cancer Res. 1: 847-857, 1995.
9. 11-bis(ethyl)-norspermine against human melanoma xenografts and possible biochemical correlates of drug action. Cancer Res., 53: 581-586, 1993.
10. 11-diethylnorspermine (CI-1006) delivered by continuous SC infusion against the H125 non small cell lung xenograft. Proc. Am. Assoc. Cancer Res., 37: 298, 1996.
11. 11-diethylnorspermine on a human bladder tumor xenograft in nude athymic mice. Clin. Cancer Res., 3: 1239-1244, 1997.
12. 1-acetyltransferase in human lung cancer cells by the bis(ethyl)polyamine analogues. Cancer Res., 49: 3829-3833, 1989.
13. Basu, H. S., Marton, L. J., Pellarin, M., Deen, D. F., McManis, J. S., Liu, C. Z., Bergeron, R. J., and Feuerstein, B. G. Design and testing of novel cytotoxic polyamine analogues. Cancer Res., 54: 6210-6214, 1994.
14. Basu, H. S., Pellarin, M., Feuerstein, B. G., Deen, D. F., and Marton, L. J. Effects of the polyamine analogs BE-373, 3-8-3, and BE-3-8-3 on human brain tumor cell growth and survival. Anticancer Res., 13: 1525-1532, 1993.
15. Edwards, M. L., Prakash, N. J., Stemerick, D. M., Sunkara, S. P., Bitonti, A. J., Davis, G. F., and Dumont, J. A. Polyamine analogs with antitumor activity. J. Med. Chem., 33: 1369-1375, 1990.
16. Igarashi, K., Koga, K., Shiogoiri, T., Ekimoto, H., Kashiwagi, K., and Shirahata, A. Inhibition of the growth of various human and mouse tumor cells by 1,15-bis(ethylamino)-4.8,12-triazapentadecane. Cancer Res., 55: 2615-2619, 1995.
17. 12-bis(ethyl)spermine and related compounds on growth and polyamine acetylation, content, and excretion in human colon tumor cells. J. Biol. Chem., 264: 11744-11749, 1989.
18. Musso, M., Thomas, T., Shirahata, A., Sigal, L. H., Van Dyke, M. W., and Thomas, T. J. Effects of chain length modification and bis(ethyl) substitution of spermine analogs on purine-purine-pyrimidine triplex DNA stabilization, aggregation, and conformational transitions. Biochemistry, 36: 1441-1449, 1997.
19. Bergeron, R. J., McManis, J. S., Liu, C. Z., Feng, Y., Weimer, W. R., Luchetta, G. R., Wu, Q., Ortiz-Ocasio, J., Vinson, J. R. T., Kramer, D., and Porter, C. W. Antiproliferative properties of polyamine analogues: a structure-activity study. J. Med. Chem., 37: 3464-3476, 1994.
20. 1-acetyltransferase on MALME-3M human melanoma cells. J. Biol. Chem., 268: 19118-19125, 1993.
21. Kramer, D. L., Diegelman, P., Vaughn, M., Bergeron, R. J., and Porter, C. W. Polyamine analogue-induced cytotoxicity in MALME-3M human melanoma cells involves a phase specific cell cycle arrest and initiation of apoptosis. Proc. Am. Assoc. Cancer Res., 38: 544, 1997.
22. 11-bis(ethyl)norspermine (DENSPM). XVI International Cancer Congress. New Delhi, India, Abstract Book 1: 313, 1994.
23. Bergeron, R. J., Neims, A. H., McManis, J. S., Hawthorne, T. R., Vinson, J. R. T., Bortell, R., and Ingeno, M. J., Synthetic polyamine analogues as antineoplastics. J. Med. Chem., 31: 1183-1190, 1988.
24. 1-acetyltransferase activity by novel spermine analogs. Mol. Pharmacol., 52: 69-74, 1997.
25. Krishan, A. Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J. Cell Biol., 66: 188-193, 1975.
26. Gavirelli, Y., Sherman, Y., and Ben-Sasson, S. A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol., 119: 493-501, 1992.
27. Schmitz, G. G., Walter, T., Seibl, R., and Kessler, C. Nonradioactive labeling of oligonucleotides in vitro with the hapten dogoxigenin by tailing with terminal transferase. Anal. Biochem., 192: 222-231, 1991.
28. Kramer, D. L., Miller, J. T., Bergeron, R. J., Khomutov, R., Khomutov, A., and Porter, C. W. Regulation of polyamine transport by polyamines and polyamine analogs. J. Cell. Physiol., 155: 399-407, 1993.
29. Snyder, R. D., Vogelpohl, S. J., Baldwin, B. L., Deaton, E. D., Baden, E., and Carter, J. H. Apparent inhibition of apoptosis by polyamines and aminothiols in DNA fragmentation assays is artifactual. Death Differ., 3: 323-330, 1996.
30. 1-acetyltransferase without cytotoxicity by the growth-supporting polyamine analogue 1,12-dimethylspermine. J. Cell. Physiol., 165: 71-76, 1995.
31. Heby, O., Gray, J. W., Lindl, P. A., Marton, L. J., and Wilson, C. B. Changes in L-ornithine decarboxylase activity during the cell cycle. Biochem. Biophys. Res. Commun., 71: 99-105, 1976.
32. 1 to S phase transition. J. Cell. Physiol., 93: 81-88, 1977.
33. Fredlund, J. O., Johansson, M. C., Dahlberg, E., and Oredsson, S. M. Ornithine decarboxylase and S-adenosylmethionine decarboxylase expression during the cell cycle of Chinese hamster ovary cells. Exp. Cell Res., 216: 86-92, 1995.
34. 1. J. Cell. Physiol., 94: 161-170, 1978.
35. Seidenfeld, J., Block, A. L., Komar, K. A., and Naujokas, M. F. Altered cell cycle phase distributions in cultured human carcinoma cells partially depleted of polyamines by treatment with difluoromethylornithine. Cancer Res., 46: 47-53, 1986.
36. Milan, K. M., Deen, D. F., and Marton, L. J. Cell proliferation and polyamine metabolism in 9L cells treated with (2R,5R)-6 heptyne-2,5-diamine or α-difluoromethylornithine. Cell Tissue Kinet., 22: 269-277, 1989.
37. Koza, R. A., and Herbst, E. J. Deficiencies in DNA replication and cell-cycle progression in polyamine-depleted HeLa cells. Biochem. J., 281: 87-93, 1992.
38. Harada, J. J., and Morris, D. R. Cell cycle parameters of Chinese hamster ovary cells during exponential polyamine-linlited growth. Mol. Cell. Biol., 1: 594-599, 1981.
39. Packham, G., Porter, C. W., and Cleveland, J. L. c-Myc induces apoptosis and cell cycle progression by separable, yet overlapping, pathways. Oncogene, 13: 461-469, 1996.
40. Oredsson, S. M., Nicander, B., and Heby, O. Implications for a reduced DNA-elongation rate in polyamine-depleted cells. Eur. J. Biochem., 190: 483-489, 1990.
41. Sunkara, P. S., Fowler, S. K., Nishioka, K., and Rao, P. N. Inhibition of polyamine biosynthesis by α-difluoromethyl ornithine potentiates the cytotoxic effects of 1-β-D-arabinofuranoxylcytosine in HeLa cells. Biochem. Biophys. Res. Commun., 95: 423-430, 1980.
42. Kramer, D. L. Polyamine inhibitors and analogs. In: K. Nishioka (ed.), Critical Roles of Polyamines in Cancer: Basic Mechanisms and Clinical Approaches, pp. 151-189. New York: R. G. Landes Co., 1996.
43. 12-bis(ethyl)spermine, and its relationship to polyamine structure and function. Mol. Pharmacol., 39: 487-494, 1991.
44. He, Y., Kashiwagi, K., Kusama-Eguchi, K., Shirahata, A., and Igarashi, K. Correlation between the inhibition of cell growth by bis(ethyl)polyamine analogues and the decrease in function of mitochondria. Eur. J. Biochem., 221: 391-398, 1994.
45. Snyder, R. D., Beach, D. C., and Loudy, D. E. Antimitochondrial effects of bisethyl polyamines in mammalian cells. Anticancer Res., 14: 347-356, 1994.
46. Hartwell, L. H., and Kastan, M. B. Cell cycle control and cancer. Science (Washington DC), 266: 1821-1828, 1994.
47. MeCloskey, D. E., Casero, R. A., Woster, P. M., and Davidson, N. E. Induction of programmed cell death in human breast cancer cells by an unsymmetrically alkylated polyamine analog. Cancer Res., 55: 3233-3236, 1995.
48. McCloskey, D. E., Yang, J., Woster, P. M., Davidson, N. E., and Casero, R. A., Polyamine analogue induction of programmed cell death in human lung tumor cells. Clin. Cancer Res., 2: 441-446, 1996
49. 12-bis(ethyl) spermine in human cell lines representing the major forms of lung cancer. Cancer Res., 52: 5359-5363, 1992.
50. 12-bis(ethyl)-spermine, on polyamine metabolism and cell growth in human melanoma cell lines and melanocytes. Anticancer Res., 12: 1083-1090, 1992.
51. Ha, H. C., Woster, P. M., Yager, J. D., and Casero, R. A. Potential mechanism of polyamine analogue induced apoptosis. Proc. Am. Assoc. Cancer Res., 37: 27, 1996.