COX-2-independent induction of apoptosis by celecoxib and polyamine naphthalimide conjugate mediated by polyamine depression in colorectal cancer cell lines

International Journal of Colorectal Disease

Volumn 27, Issue 7, 2012, Pages 861-868

  Xie, Song Qiang ^a   Zhang, Ya Hong ^a   Li, Qian ^a   Wang, Jian Hong ^a   Li, Jing Hua ^a   Zhao, Jin ^a   Wang, Chao Jie ^a  

^a HENAN UNIVERSITY   (China)

Author keywords

Apoptosis; Colorectal cancer; COX 2; NSAIDs; Polyamine conjugate

Indexed keywords

ACYLTRANSFERASE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 9; CELECOXIB; CYCLOOXYGENASE 2; NAPHTHALIMIDE DERIVATIVE; NPC 16; POLYAMINE; PROSTAGLANDIN E2; PROTEIN BAD; PROTEIN BCL 2; PROTEIN KINASE B; SPERMIDINE SPERMINE N1 ACETYLTRANSFERASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL ASSAY; CELL LEVEL; CELL PROLIFERATION; CELL STRAIN CACO 2; CELL STRAIN HCT116; CELL STRAIN HT29; COLORECTAL CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; DRUG UPTAKE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL MEMBRANE POTENTIAL; POLYAMINE METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ACETYLTRANSFERASES; AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; CYCLOOXYGENASE 2; CYTOCHROMES C; DRUG SYNERGISM; ENZYME ACTIVATION; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NAPHTHALIMIDES; POLYAMINES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRAZOLES; SULFONAMIDES; UP-REGULATION;

EID: 84864449477     PISSN: 01791958     EISSN: 14321262     Source Type: Journal    
DOI: 10.1007/s00384-011-1379-1     Document Type: Article

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