Anti-inflammatory effects of spermidine in lipopolysaccharide-stimulated BV2 microglial cells

Journal of Biomedical Science

Volumn 19, Issue 1, 2012, Pages

  Choi, Yung Hyun ^a   Park, Hye Young ^a  

^a Dong Eui University   (South Korea)

Author keywords

Akt; Inflammation; MAPKs; NF B; Spermidine

Indexed keywords

CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN E2; SPERMIDINE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; NITRIC OXIDE; NOS2 PROTEIN, MOUSE; ONCOPROTEIN; PTGS2 PROTEIN, MOUSE; RELA PROTEIN, MOUSE; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CYTOKINE PRODUCTION; ENZYME PHOSPHORYLATION; INFLAMMATION; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; CELL LINE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

MURINAE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; GENE EXPRESSION REGULATION; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MICE; MICROGLIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; SPERMIDINE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84862796333     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-19-31     Document Type: Article

References (41)

1. Inflammation in neurodegenerative diseases. Amor S, Puentes F, Baker D, van der Valk P, Immunology 2010 129 154 169 10.1111/j.1365-2567.2009.03225.x 20561356
2. The multiple roles of the innate immune system in the regulation of apoptosis and inflammation in the brain. Griffiths MR, Gasque P, Neal JW, J Neuropathol Exp Neurol 2009 68 217 226 10.1097/NEN.0b013e3181996688 19225414
3. Role of the innate immune system in autoimmune inflammatory demyelination. O'Brien K, Fitzgerald DC, Naiken K, Alugupalli KR, Rostami AM, Gran B, Curr Med Chem 2008 15 1105 1115 10.2174/092986708784221458 18473806 (Pubitemid 352002979)
4. The multifaceted profile of activated microglia. Lynch MA, Mol Neurobiol 2009 40 139 156 10.1007/s12035-009-8077-9 19629762
5. Role of cytokines as mediators and regulators of microglial activity in inflammatory demyelination of the CNS. Merson TD, Binder MD, Kilpatrick TJ, Neuromolecular Med 2010 12 99 132 10.1007/s12017-010-8112-z 20411441
6. Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease. Rojo LE, Fernández JA, Maccioni AA, Jimenez JM, Maccioni RB, Arch Med Res 2008 39 1 16 10.1016/j.arcmed.2007.10.001 18067990 (Pubitemid 350192021)
7. Microglia-biology and relevance to disease. Wirenfeldt M, Ladeby R, Dalmau I, Banati RB, Finsen B, Ugeskr Laeger 2005 2005 167 3025 3030
8. Microglia biology in health and disease. Garden GA, Möller T, J Neuroimmune Pharmacol 2006 1 127 137 10.1007/s11481-006-9015-5 18040779 (Pubitemid 44257488)
9. Biological significance of dietary polyamines. Larqué E, Sabater-Molina M, Zamora S, Nutrition 2007 23 87 95 10.1016/j.nut.2006.09.006 17113752 (Pubitemid 44959765)
10. The biological activities of new polyamine derivatives as potential therapeutic agents. Kong Thoo Lin P, Dance AM, Bestwick C, Milne L, Biochem Soc Trans 2003 31 407 410 10.1042/BST0310407 12653648 (Pubitemid 36520686)
11. Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications. Thomas T, Thomas TJ, Cell Mol Life Sci 2001 58 244 258 10.1007/PL00000852 11289306 (Pubitemid 32217356)
12. Synthetic polycation: polynucleotide interactions determined using liquid chromatography with short monolithic columns. Platonova GA, Nazarova OV, Tennikova TB, J Sep Sci 2009 32 2674 2681 10.1002/jssc.200900144 19603391
13. Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity. Hunter AC, Adv Drug Deliv Rev 2006 58 1523 1531 10.1016/j.addr.2006.09.008 17079050 (Pubitemid 44820504)
14. Naturally occurring polyamines: interaction with macromolecules. Bachrach U, Curr Protein Pept Sci 2005 6 559 566 10.2174/138920305774933240 16381604 (Pubitemid 41723525)
15. Inhibition by polyamines of lipid peroxide formation in rat liver microsomes. Kitada M, Igarashi K, Hirose S, Kitagawa H, Biochem Biophys Res Commun 1979 87 388 394 10.1016/0006-291X(79)91808-4 36078 (Pubitemid 9162079)
16. Possible mechanism of inhibition by polyamines of lipid peroxidation in rat liver microsomes. Kitada M, Naito Y, Igarashi K, Hirose S, Kanakubo Y, Kitagawa H, Res Commun Chem Pathol Pharmacol 1981 33 487 497 7330453 (Pubitemid 11014886)
17. The function of microglia through purinergic receptors: neuropathic pain and cytokine release. Inoue K, Pharmacol Ther 2006 109 210 226 10.1016/j.pharmthera.2005.07.001 16169595 (Pubitemid 41740822)
18. Polyamine lowered the hepatic lipid peroxide level in rats. Ohmori S, Misaizu T, Kitada M, Kitagawa H, Igarashi K, Hirose S, Kanakubo Y, Res Commun Chem Pathol Pharmacol 1988 62 235 249 3251335 (Pubitemid 19008043)
19. Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis. Merentie M, Uimari A, Pietilä M, Sinervirta R, Keinänen TA, Vepsäläinen J, Khomutov A, Grigorenko N, Herzig KH, Jänne J, Alhonen L, Amino Acids 2007 33 323 330 10.1007/s00726-007-0522-3 17410333 (Pubitemid 47222968)
20. Induction of autophagy by spermidine promotes longevity. Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F, Nat Cell Biol 2009 11 1305 1314 10.1038/ncb1975 19801973
21. Effect of sildenafil citrate on interleukin-1beta-induced nitric oxide synthesis and iNOS expression in SW982 cells. Kim KO, Park SY, Han CW, Chung HK, Ryu DH, Han JS, Exp Mol Med 2008 2008 40 286 293
22. Activation of nicotinic acetylcholine receptor prevents the production of reactive oxygen species in fibrillar beta amyloid peptide (1-42)-stimulated microglia. Moon JH, Kim SY, Lee HG, Kim SU, Lee YB, Exp Mol Med 2008 40 11 18 10.3858/emm.2008.40.1.11 18305393 (Pubitemid 351346812)
23. Protection of burn-induced skin injuries by the flavonoid kaempferol. Park BK, Lee S, Seo JN, Rhee JW, Park JB, Kim YS, Choi IG, Kim YE, Lee Y, Kwon HJ, BMB Rep 2010 43 46 51 10.5483/BMBRep.2010.43.1.046 20132735
24. Systemic inflammatory cells fight off neurodegenerative disease. Schwartz M, Shechter R, Nat Rev Neurol 2010 6 405 410 10.1038/nrneurol.2010.71 20531383
25. Possible roles of microglial cells for neurotoxicity in clinical neurodegenerative diseases and experimental animal models. Sugama S, Takenouchi T, Cho BP, Joh TH, Hashimoto M, Kitani H, Inflamm Allergy Drug Targets 2009 8 277 284 10.2174/187152809789352249 19754411
26. Production of nitric oxide by glial cells: regulation and potential roles in the CNS. Murphy S, GLIA 2000 29 1 13 10.1002/(SICI)1098-1136(20000101)29: 1<1::AID-GLIA1>3.0.CO;2-N 10594918 (Pubitemid 30031129)
27. Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. Minghetti L, J Neuropathol Exp Neurol 2004 63 901 910 15453089 (Pubitemid 39202493)
28. Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils. St-Onge M, Flamand N, Biarc J, Picard S, Bouchard L, Dussault AA, Laflamme C, James MJ, Caughey GE, Cleland LG, Borgeat P, Pouliot M, Biochim Biophys Acta 2007 1771 1235 1245 17643350 (Pubitemid 47411628)
29. Experimental brain inflammation and neurodegeneration as model of Alzheimer's disease: protective effects of selective COX-2 inhibitors. Giovannini MG, Scali C, Prosperi C, Bellucci A, Pepeu G, Casamenti F, Int J Immunopathol Pharmacol 2003 16 31S 40S
30. Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity. Kawano T, Anrather J, Zhou P, Park L, Wang G, Frys KA, Kunz A, Cho S, Orio M, Iadecola C, Nat Med 2006 12 225 229 10.1038/nm1362 16432513 (Pubitemid 43214750)
31. Neuroprotective role of the innate immune system by microglia. Glezer I, Simard AR, Rivest S, Neuroscience 2007 147 867 883 10.1016/j.neuroscience.2007. 02.055 17459594 (Pubitemid 47102534)
32. The role of chemokines in human cardiovascular pathology: enhanced biological insights. Shin WS, Szuba A, Rockson SG, Atherosclerosis 2002 160 91 102 10.1016/S0021-9150(01)00571-8 11755926 (Pubitemid 34076646)
33. Naturally occurring NF-kappaB inhibitors. Nam NH, Mini Rev Med Chem 2006 6 945 951 10.2174/138955706777934937 16918500 (Pubitemid 44194381)
34. NFkappaB: a promising target for natural products in cancer chemoprevention. Luqman S, Pezzuto JM, Phytother Res 2010 24 949 963 20577970
35. NF-kappaB regulation: the nuclear response. Mankan AK, Lawless MW, Gray SG, Kelleher D, McManus R, J Cell Mol Med 2009 13 631 643 10.1111/j.1582-4934. 2009.00632.x 19438970
36. NF-kappaB signaling pathway and its therapeutic implications in human diseases. Sarkar FH, Li Y, Wang Z, Kong D, Int Rev Immunol 2008 27 293 319 10.1080/08830180802276179 18853341
37. Activation of adenosine A3 receptor suppresses lipopolysaccharideinduced TNF- production through inhibition of PI3-kinase/Akt and NF-kB activation in murine BV2 microglial cells. Lee JY, Jhun BS, Oh YT, Lee JH, Choe W, Haik HH, Ha J, Yoon KS, Kim SS, Kang I, Neurosci Lett 2006 396 1 6 10.1016/j.neulet.2005. 11.004 16324785 (Pubitemid 43233777)
38. Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production. Kim SH, Smith CJ, van Eldik LJ, Neurobiol Aging 2004 25 431 439 10.1016/S0197-4580(03)00126-X 15013563 (Pubitemid 38317340)
39. Regulatory mechanisms of mitogen-activated kinase signaling. Zhang Y, Dong C, Cell Mol Life Sci 2007 64 2771 2789 10.1007/s00018-007-7012-3 17726577 (Pubitemid 351152255)
40. Role of MAP kinase cascades in inducing arginine transporters and nitric oxide synthetase in RAW 264.7 macrophages. Caivano M, FEBS Lett 1998 429 249 223 10.1016/S0014-5793(98)00578-X 9662426 (Pubitemid 28300369)
41. LPS/TLR4 signal transduction pathway. Lu YC, Yeh WC, Ohashi PS, Cytokine 2008 42 145 151 10.1016/j.cyto.2008.01.006 18304834