Critical factors governing the difference in antizyme-binding affinities between human ornithine decarboxylase and antizyme inhibitor

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Liu, Yen Chin ^a   Liu, Yi Liang ^a,b   Su, Jia Yang ^a   Liu, Guang Yaw ^b   Hung, Hui Chih ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIZYME; ANTIZYME INHIBITOR; HETERODIMER; MUTANT PROTEIN; ORNITHINE DECARBOXYLASE; REGULATOR PROTEIN; UNCLASSIFIED DRUG; ENZYME INHIBITOR; PROTEIN; SOLVENT;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CONTROLLED STUDY; DISSOCIATION CONSTANT; ENZYME STRUCTURE; IC 50; SEQUENCE ALIGNMENT; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN BINDING; SITE DIRECTED MUTAGENESIS; STATIC ELECTRICITY;

AMINO ACID SEQUENCE; BINDING SITES; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; ORNITHINE DECARBOXYLASE; PROTEIN BINDING; PROTEINS; SOLVENTS; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY;

EID: 79955721220     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019253     Document Type: Article

References (56)

1. Pegg AE, (2006) Regulation of ornithine decarboxylase. J Biol Chem 281: 14529-14532.
2. Pegg AE, McCann PP, (1982) Polyamine metabolism and function. Am J Physiol 243: C212-221.
3. Pendeville H, Carpino N, Marine JC, Takahashi Y, Muller M, et al. (2001) The ornithine decarboxylase gene is essential for cell survival during early murine development. Mol Cell Biol 21: 6549-6558.
4. Palanimurugan R, Scheel H, Hofmann K, Dohmen RJ, (2004) Polyamines regulate their synthesis by inducing expression and blocking degradation of ODC antizyme. EMBO J 23: 4857-4867.
5. Tabor CW, Tabor H, (1984) Polyamines. Annu Rev Biochem 53: 749-790.
6. Thomas T, Thomas TJ, (2001) Polyamines in cell growth and cell death: Molecular mechanisms and therapeutic applications. Cell Mol Life Sci 58: 244-258.
7. Auvinen M, Paasinen A, Andersson LC, Holtta E, (1992) Ornithine decarboxylase activity is critical for cell transformation. Nature 360: 355-358.
8. Smith MK, Goral MA, Wright JH, Matrisian LM, Morris RJ, et al. (1997) Ornithine decarboxylase overexpression leads to increased epithelial tumor invasiveness. Cancer Res 57: 2104-2108.
9. O'Brien TG, Megosh LC, Gilliard G, Soler AP, (1997) Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin. Cancer Res 57: 2630-2637.
10. Liu GY, Hung YC, Hsu PC, Liao YF, Chang WH, et al. (2005) Ornithine decarboxylase prevents tumor necrosis factor alpha-induced apoptosis by decreasing intracellular reactive oxygen species. Apoptosis 10: 569-581.
11. Huang CC, Hsu PC, Hung YC, Liao YF, Liu CC, et al. (2005) Ornithine decarboxylase prevents methotrexate-induced apoptosis by reducing intracellular reactive oxygen species production. Apoptosis 10: 895-907.
12. Hsu PC, Hour TC, Liao YF, Hung YC, Liu CC, et al. (2006) Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: CROSSTALK BETWEEN ODC AND BCL-2. Apoptosis 11: 389-399.
13. Hayashi S, Kameji T, Fujita K, Murakami Y, Kanamoto R, et al. (1985) Molecular mechanism for the regulation of hepatic ornithine decarboxylase. Adv Enzyme Regul 23: 311-329.
14. Furumitsu Y, Yukioka K, Yukioka M, Ochi T, Morishima Y, et al. (2000) Interleukin-1beta induces elevation of spermidine/spermine N1-acetyltransferase activity and an increase in the amount of putrescine in synovial adherent cells from patients with rheumatoid arthritis. J Rheumatol 27: 1352-1357.
15. Deng A, Munger KA, Valdivielso JM, Satriano J, Lortie M, et al. (2003) Increased expression of ornithine decarboxylase in distal tubules of early diabetic rat kidneys: are polyamines paracrine hypertrophic factors? Diabetes 52: 1235-1239.
16. Schluter KD, Frischkopf K, Flesch M, Rosenkranz S, Taimor G, et al. (2000) Central role for ornithine decarboxylase in beta-adrenoceptor mediated hypertrophy. Cardiovasc Res 45: 410-417.
17. Morrison LD, Cao XC, Kish SJ, (1998) Ornithine decarboxylase in human brain: influence of aging, regional distribution, and Alzheimer's disease. J Neurochem 71: 288-294.
18. Auvinen M, Laine A, Paasinen-Sohns A, Kangas A, Kangas L, et al. (1997) Human ornithine decarboxylase-overproducing NIH3T3 cells induce rapidly growing, highly vascularized tumors in nude mice. Cancer Res 57: 3016-3025.
19. Packham G, Cleveland JL, (1994) Ornithine decarboxylase is a mediator of c-Myc-induced apoptosis. Mol Cell Biol 14: 5741-5747.
20. Gerner EW, Meyskens FL Jr, (2004) Polyamines and cancer: old molecules, new understanding. Nat Rev Cancer 4: 781-792.
21. Seiler N, Atanassov CL, Raul F, (1998) Polyamine metabolism as target for cancer chemoprevention (Review). Int J Oncol 13: 993-1006.
22. Hayashi S, Murakami Y, Matsufuji S, (1996) Ornithine decarboxylase antizyme: A novel type of regulatory protein. Trends Biochem Sci 21: 27-30.
23. Li X, Coffino P, (1992) Regulated degradation of ornithine decarboxylase requires interaction with the polyamine-inducible protein antizyme. Mol Cell Biol 12: 3556-3562.
24. Coffino P, (2001) Regulation of cellular polyamines by antizyme. Nat Rev Mol Cell Biol 2: 188-194.
25. Murakami Y, Matsufuji S, Kameji T, Hayashi S, Igarashi K, et al. (1992) Ornithine decarboxylase is degradaded by the 26S proteasome without ubiquitination. Nature 360: 597-600.
26. Coffino P, (1998) Degradation of ornithine decarboxylase, In: Peters JM, Harris JR, Finley D, editors. Ubiquitin and the Biology of the Cell pp. 411-427 Plenum Press, New York.
27. Coffino P, (2001) Antizyme, a mediator of ubiquitin-independent proteasomal degradation. Biochimie 83: 319-323.
28. Mangold U, (2005) The antizyme family: polyamines and beyond. IUBMB Life 57: 671-676.
29. Su KL, Liao YF, Hung HC, Liu GY, (2009) Critical factors determining dimerization of human antizyme inhibitor. J Biol Chem 284: 26768-26777.
30. Zhang M, Pickart CM, Coffino P, (2003) Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin independent substrate. EMBO J 22: 1488-1496.
31. Zhang M, MacDonald AI, Hoyt MA, Coffino P, (2004) Proteasomes begin ornithine decarboxylase digestion at the C-terminus. J Biol Chem 279: 20959-20965.
32. Matsufuji S, Matsufuji T, Miyazaki Y, Murakami Y, Atkins JF, et al. (1995) Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme. Cell 80: 51-60.
33. Sakata K, Kashiwagi K, Igarashi K, (2000) Properties of a polyamine transporter regulated by antizyme. Biochem J 347: 297-303.
34. Mangold U, (2006) Antizyme inhibitor: mysterious modulator of cell proliferation. Cell Mol Life Sci 63: 2095-2101.
35. Murakami Y, Ichiba T, Matsufuji S, Hayashi S, (1996) Cloning of antizyme inhibitor, a highly homologous protein to ornithine decarboxylase. J Biol Chem 271: 3340-3342.
36. Nilsson J, Grahn B, Heby O, (2000) Antizyme inhibitor is rapidly induced in growth-stimulated mouse fibroblasts and releases ornithine decarboxylase from antizyme suppression. Biochem J 346: 699-704.
37. Kahana C, (2009) Antizyme and antizyme inhibitor, a regulatory tango. Cell Mol Life Sci 66: 2479-2488.
38. Bercovich Z, Kahana C, (2004) Degradation of antizyme inhibitor, an ornithine decarboxylase homologous protein, is ubiquitin-dependent and is inhibited by antizyme. J Biol Chem 279: 54097-54102.
39. Mangold U, Leberer E, (2005) Regulation of all members of the antizyme family by antizyme inhibitor. Biochem J 385: 21-28.
40. Keren-Paz A, Bercovich Z, Porat Z, Erez O, Brener O, et al. (2006) Overexpression of antizyme-inhibitor in NIH3T3 fibroblasts provides growth advantage through neutralization of antizyme functions. Oncogene 25: 5163-5172.
41. Kim SW, Mangold U, Waghorne C, Mobascher A, Shantz LM, et al. (2006) Regulation of cell proliferation by the antizyme inhibitor: evidence for an antizyme independent mechanism. J Cell Sci 119: 2583-2591.
42. Choi KS, Suh YH, Kim WH, Lee TH, Jung MH, (2005) Stable siRNA-mediated silencing of antizyme inhibitor: regulation of ornithine decarboxylase activity. Res Commun 328: 206-212.
43. Kern AD, Oliveira MA, Coffino P, Hackert ML, (1999) Structure of mammalian ornithine decarboxylase at 1.6 A resolution: stereochemical implications of PLP-dependent amino acid decarboxylases. Structure 7: 567-581.
44. Almrud JJ, Oliveira MA, Kern AD, Grishin NV, Phillips MA, et al. (2000) Crystal structure of human ornithine decarboxylase at 2.1 Å resolution: structural insights to antizyme binding. J Mol Biol 295: 7-16.
45. Solano F, Penafiel R, Solano ME, Lozano JA, (1985) Equilibrium between active and inactive forms of rat liver ornithine decarboxylase mediated by L-ornithine and salts. FEBS Lett 190: 324-328.
46. Jackson LK, Baldwin J, Akella R, Goldsmith EJ, Phillips MA, (2004) Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase. Biochemistry 43: 12990-12999.
47. Jackson LK, Goldsmith EJ, Phillips MA, (2003) X-ray structure determination of Trypanosoma brucei ornithine decarboxylase bound to D-ornithine and to G418: insights into substrate binding and ODC conformational flexibility. J Biol Chem 278: 22037-22043.
48. Albeck S, Dym O, Unger T, Snapir Z, Bercovich Z, et al. (2008) Crystallographic and biochemical studies revealing the structural basis for antizyme inhibitor function. Protein Sci 17: 793-802.
49. Cohavi O, Tobi D, Schreiber G, (2009) Docking of antizyme to ornithine decarboxylase and antizyme inhibitor using experimental mutant and double-mutant cycle data. J Mol Biol 390: 503-515.
50. Krissinel E, Henrick K, (2007) Inference of macromolecular assemblies from crystalline state. J Mol Biol 372: 774-797.
51. Bradford MM, (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
52. Schuck P, Perugini MA, Gonzales NR, Howlett GJ, Schubert D, (2002) Size distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systems. Biophys J 82: 1096-1111.
53. Schuck P, (2003) On the analysis of protein self-association by sedimentation velocity analytical ultracentrifugation. Anal Biochem 320: 104-124.
54. Brown PH, Balbo A, Schuck P, (2008) Characterizing protein-protein interactions by sedimentation velocity analytical ultracentrifugation. Curr Protoc Immunol Chapter 18: Unit 18 15.
55. Dam J, Schuck P, (2005) Sedimentation velocity analysis of heterogeneous protein-protein interactions: sedimentation coefficient distributions c(s) and asymptotic boundary profiles from Gilbert-Jenkins theory. Biophys J 89: 651-666.
56. Laue TM, Shah BD, Ridgeway TM, Pelleter SL, (1992) Analytical Ultracentrifugation in Biochemistry and Polymer Science, The Royal Society of Chemistry, Cambridge, UK.