Lipophilic lysine-spermine conjugates are potent polyamine transport inhibitors for use in combination with a polyamine biosynthesis inhibitor

Journal of Medicinal Chemistry

Volumn 52, Issue 7, 2009, Pages 1983-1993

  Burns, Mark R ^a,b   Graminski, Gerard F ^a,b   Weeks, Reitha S ^a,b   Chen, Yan ^a,b   O'Brien, Thomas G ^a,b  

^a MediQuest Therapeutics Inc   (United States)

^b LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EFLORNITHINE; LYSINE; ORNITHINE DECARBOXYLASE; POLYAMINE; POLYAMINE DERIVATIVE; POLYAMINE TRANSPORT INHIBITOR; SPERMIDINE; SPERMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOSYNTHESIS; CANCER COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFICACY; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIPOPHILICITY; MONOTHERAPY; MOUSE; NONHUMAN; SKIN CANCER; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BIOLOGICAL TRANSPORT; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; EFLORNITHINE; LYSINE; MICE; MICE, TRANSGENIC; NEOPLASM TRANSPLANTATION; ORNITHINE DECARBOXYLASE; POLYAMINES; SKIN NEOPLASMS; SPERMINE; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS;

EID: 64549132099     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm801580w     Document Type: Article

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